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metabolomics hypertension

Vanessa L Z Gordon-Dseagu, Andriy Derkach, Qian Xiao, Ishmael Williams, Joshua Sampson, Rachael Z Stolzenberg-Solomon
INTRODUCTION: Sleep is increasingly being viewed as an issue of public health concern, yet few epidemiologic studies have explored associations between sleep habits and metabolomic profile. OBJECTIVES: To assess the association between sleep and blood metabolites. METHODS: We examined the association between sleep and 891 fasting plasma metabolites in a subgroup of 106 participants from the Dietary Approaches to Stop Hypertension (DASH)-Sodium feeding trial (1997-1999)...
March 16, 2019: Metabolomics: Official Journal of the Metabolomic Society
Daokun Sun, Steffen Tiedt, Bing Yu, Xueqiu Jian, Rebecca F Gottesman, Thomas H Mosley, Eric Boerwinkle, Martin Dichgans, Myriam Fornage
OBJECTIVE: To identify promising blood-based biomarkers and novel etiologic pathways of disease risk, we applied an untargeted serum metabolomics profiling in a community-based prospective study of ischemic stroke (IS). METHODS: In 3,904 men and women from the Atherosclerosis Risk In Communities study, Cox proportional hazard models were used to estimate the association of incident IS with the standardized level of 245 fasting serum metabolites individually, adjusting for age, sex, race, field center, batch, diabetes, hypertension, current smoking status, body mass index, and estimated glomerular filtration rate...
March 13, 2019: Neurology
Martina Cermakova, Helena Pelantová, Barbora Neprasova, Blanka Sediva, Lenka Maletinska, Jaroslav Kunes, Petra Tomasova, Blanka Zelezna, Marek Kuzma
In this study, the combination of metabolomics and standard biochemical and biometric parameters was used to describe the metabolic effects of diet-induced obesity and its treatment with the novel anti-obesity compound palm11 -PrRP31 (palmitoylated prolactin-releasing peptide) in spontaneously hypertensive rats (SHR) and normotensive Wistar Kyoto rats (WKY). The results showed that SHR on a high-fat (HF) diet were normoglycemic with obesity and hypertension, while WKY on the HF diet were normotensive and obese with prediabetes...
February 27, 2019: Journal of Proteome Research
Toshiaki Matsutomo, Mitsuyasu Ushijima, Kayo Kunimura, Masahiro Ohtani
Our previous study has shown that a single dose of S-1-propenylcysteine (S1PC) exerted an antihypertensive effect in spontaneously hypertensive rats (SHR), while its mode of action remained to be further investigated. The aim of this study was to explore the potential mechanism of the antihypertensive effect of S1PC in SHR using a liquid chromatography-mass spectrometry (LC-MS)-based metabolomic approach. Blood samples were serially collected from SHR after a single oral administration of S1PC (6.5 mg/kg body weight)...
February 12, 2019: Journal of Pharmaceutical and Biomedical Analysis
Takayuki Wakasugi, Ippei Shimizu, Yohko Yoshida, Yuka Hayashi, Ryutaro Ikegami, Masayoshi Suda, Goro Katsuumi, Masaaki Nakao, Makoto Hoyano, Takeshi Kashimura, Kazufumi Nakamura, Hiroshi Ito, Takashi Nojiri, Tomoyoshi Soga, Tohru Minamino
Pulmonary arterial hypertension (PAH) is characterized by remodeling and narrowing of the pulmonary arteries, which lead to elevation of right ventricular pressure, heart failure, and death. Proliferation of pulmonary artery smooth muscle cells (PASMCs) is thought to be central to the pathogenesis of PAH, although the underlying mechanisms are still being explored. The protein p53 is involved in cell cycle coordination, DNA repair, apoptosis, and cellular senescence, but its role in pulmonary hypertension (PH) is not fully known...
2019: PloS One
Kyoungmi Kim, Josephine F Trott, Guimin Gao, Arlene Chapman, Robert H Weiss
BACKGROUND: Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary kidney disease and is characterized by gradual cyst growth and expansion, increase in kidney volume with an ultimate decline in kidney function leading to end stage renal disease (ESRD). Given the decades long period of stable kidney function while cyst growth occurs, it is important to identify those patients who will progress to ESRD. Recent data from our and other laboratories have demonstrated that metabolic reprogramming may play a key role in cystic epithelial proliferation resulting in cyst growth in ADPKD...
February 25, 2019: BMC Nephrology
Catharina M Mels, Christian Delles, Roan Louw, Aletta E Schutte
OBJECTIVES: Early-life exposures to cardiovascular risk factors may manifest as early vascular ageing, a phenomenon to which black populations are more prone. The metabolome provides insight into the current state and regulation of physiological processes and was used to investigate the early molecular determinants of arterial stiffness. METHODS: Black (N = 80) and white (N = 80) men and women (aged 20-30 years, clinic blood pressure <140 and 90 mmHg) across the arterial stiffness spectrum were included...
February 18, 2019: Journal of Hypertension
Junichi Sugawara, Daisuke Ochi, Riu Yamashita, Takafumi Yamauchi, Daisuke Saigusa, Maiko Wagata, Taku Obara, Mami Ishikuro, Yoshiki Tsunemoto, Yuki Harada, Tomoko Shibata, Takahiro Mimori, Junko Kawashima, Fumiki Katsuoka, Takako Igarashi-Takai, Soichi Ogishima, Hirohito Metoki, Hiroaki Hashizume, Nobuo Fuse, Naoko Minegishi, Seizo Koshiba, Osamu Tanabe, Shinichi Kuriyama, Kengo Kinoshita, Shigeo Kure, Nobuo Yaegashi, Masayuki Yamamoto, Satoshi Hiyama, Masao Nagasaki
PURPOSE: A prospective cohort study for pregnant women, the Maternity Log study, was designed to construct a time-course high-resolution reference catalogue of bioinformatic data in pregnancy and explore the associations between genomic and environmental factors and the onset of pregnancy complications, such as hypertensive disorders of pregnancy, gestational diabetes mellitus and preterm labour, using continuous lifestyle monitoring combined with multiomics data on the genome, transcriptome, proteome, metabolome and microbiome...
February 19, 2019: BMJ Open
Marius A Øvrehus, Per Bruheim, Wenjun Ju, Leila R Zelnick, Knut A Langlo, Kumar Sharma, Ian H de Boer, Stein I Hallan
Introduction: Hypertensive nephrosclerosis is among the leading causes of end-stage renal disease, but its pathophysiology is poorly understood. We wanted to explore early metabolic changes using gene expression and targeted metabolomics analysis. Methods: We analyzed gene expression in kidneys biopsied from 20 patients with nephrosclerosis and 31 healthy controls with an Affymetrix array. Thirty-one amino acids were measured by liquid chromatography coupled with mass spectrometry (LC-MS) in urine samples from 62 patients with clinical hypertensive nephrosclerosis and 33 age- and sex-matched healthy controls, and major findings were confirmed in an independent cohort of 45 cases and 15 controls...
February 2019: KI Reports
Michael W O'Reilly, Connar Sj Westgate, Catherine Hornby, Hannah Botfield, Angela E Taylor, Keira Markey, James L Mitchell, William J Scotton, Susan P Mollan, Andreas Yiangou, Carl Jenkinson, Lorna C Gilligan, Mark Sherlock, James Gibney, Jeremy W Tomlinson, Gareth G Lavery, David J Hodson, Wiebke Arlt, Alexandra J Sinclair
Idiopathic intracranial hypertension (IIH) is a condition of unknown etiology, characterized by elevated intracranial pressure frequently manifesting with chronic headaches and visual loss. Similar to polycystic ovary syndrome (PCOS), IIH predominantly affects obese women of reproductive age. In this study, we comprehensively examined the systemic and cerebrospinal fluid (CSF) androgen metabolome in women with IIH in comparison to sex-, body mass index- and age-matched control groups with either simple obesity and PCOS, i...
February 12, 2019: JCI Insight
Shengyuan Luo, Josef Coresh, Adrienne Tin, Casey M Rebholz, Lawrence J Appel, Jingsha Chen, Ramachandran S Vasan, Amanda H Anderson, Harold I Feldman, Paul L Kimmel, Sushrut S Waikar, Anna Köttgen, Anne M Evans, Andrew S Levey, Lesley A Inker, Mark J Sarnak, Morgan Erika Grams
BACKGROUND AND OBJECTIVES: Data are scarce on blood metabolite associations with proteinuria, a strong risk factor for adverse kidney outcomes. We sought to investigate associations of proteinuria with serum metabolites identified using untargeted profiling in populations with CKD. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Using stored serum samples from the African American Study of Kidney Disease and Hypertension (AASK; n =962) and the Modification of Diet in Renal Disease (MDRD) study ( n =620), two rigorously conducted clinical trials with per-protocol measures of 24-hour proteinuria and GFR, we evaluated cross-sectional associations between urine protein-to-creatinine ratio and 637 known, nondrug metabolites, adjusting for key clinical covariables...
March 7, 2019: Clinical Journal of the American Society of Nephrology: CJASN
Violeta Stojanovska, Dorieke J Dijkstra, Rebekka Vogtmann, Alexandra Gellhaus, Sicco A Scherjon, Torsten Plösch
Pre-eclampsia is a multifactorial pregnancy-associated disorder characterized by angiogenic dysbalance and systemic inflammation; however, animal models that combine these two pathophysiological conditions are missing. Here, we introduce a novel double-hit pre-eclampsia mouse model that mimics the complex multifactorial conditions present during pre-eclampsia and allows for the investigation of early consequences for the fetus. Adenoviral overexpression of soluble fms-like tyrosine kinase (sFlt-1) and lipopolysaccharide (LPS) administration at mid-gestation in pregnant mice resulted in hypertension and albuminuria comparable to that of the manifestation in humans...
February 8, 2019: Disease Models & Mechanisms
Xuewei Zheng, Xiaoxue Li, Meng Chen, Pengfei Yang, Xinrui Zhao, Li Zeng, Yanan OuYang, Zhe Yang, Zhongmin Tian
In the present study, the renal-protective effect of hawthorn fruit extract (HW) on high-salt hypertension and its effect on metabolic patterns are determined. High salt causes hypertension in Dahl salt sensitive (SS) rats, while HW can effectively attenuate high-salt induced hypertension, and, various antihypertensive ingredients of HW have also been successfully identified using GC/MS. Of note, the biochemical assay indicates that HW significantly increases the concentration of nitric oxide (NO) and decreases the concentration of H2O2 and malonaldehyde...
January 25, 2019: Food & Function
Magdalena Buszewska-Forajta, Dominik Rachoń, Anna Stefaniak, Renata Wawrzyniak, Aleksandra Konieczna, Agnieszka Kowalewska, Michał Jan Markuszewski
In addition to chronic anovulation and clinical signs of hyperandrogenism women with polycystic ovary syndrome (PCOS) are insulin resistant and therefore, develop central obesity with its long term consequences such as dyslipidaemia, hypertension, atherosclerosis and type 2 diabetes mellitus (T2DM), which all lead to the development of cardiovascular disease (CVD). Due to the polysymptomatic nature of this syndrome and lack of consensus on its diagnostic criteria there is a strong need of finding a reliable biochemical or molecular marker, which would facilitate making the accurate diagnosis of PCOS...
February 2019: Journal of Steroid Biochemistry and Molecular Biology
Sarah E Hogan, Maria Pia Rodriguez Salazar, John Cheadle, Rachel Glenn, Carolina Medrano, Thomas H Petersen, Roger M Ilagan
Secreted exosomes are bioactive particles that elicit profound responses in target cells. Using targeted metabolomics and global microarray analysis, we identified a role of exosomes in promoting mitochondrial function in the context of pulmonary arterial hypertension (PAH). While chronic hypoxia results in a glycolytic shift in pulmonary artery smooth muscle cells (PASMC), exosomes restore energy balance and improve O2 consumption. These results were confirmed in a hypoxia-induced mouse model and a semaxinib/hypoxia rat model of PAH wherein exosomes improved the mitochondrial dysfunction associated with disease...
January 17, 2019: American Journal of Physiology. Lung Cellular and Molecular Physiology
Xiaofan Guo, Zhao Li, Ying Zhou, Shasha Yu, Hongmei Yang, Liqiang Zheng, Yamin Liu, Yingxian Sun
BACKGROUND: Stroke burden is extremely high in Chinese hypertensive population. Novel biomarkers for cardiovascular diseases can be detected by metabolomic profiling of human fluids. We aim to find a panel of distinctive plasma metabolites for predicting incident ischemic stroke in hypertensive patients. METHODS: This is a nested case-control study from a prospective cohort design. Baseline plasma samples were collected from 66 newly developed ischemic stroke cases and 66 matched controls...
January 11, 2019: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
Anna R Hemnes, J Matthew Luther, Christopher J Rhodes, Jason P Burgess, James Carlson, Run Fan, Joshua P Fessel, Niki Fortune, Robert E Gerszten, Stephen J Halliday, Rezzan Hekmat, Luke Howard, John H Newman, Kevin D Niswender, Meredith E Pugh, Ivan M Robbins, Quanhu Sheng, Cyndya A Shibao, Yu Shyr, Susan Sumner, Megha Talati, John Wharton, Martin R Wilkins, Fei Ye, Chang Yu, James West, Evan L Brittain
BACKGROUND: Pulmonary arterial hypertension (PAH) is a deadly disease of the small pulmonary vasculature with an increased prevalence of insulin resistance (IR). Insulin regulates both glucose and lipid homeostasis. We sought to quantify glucose- and lipid-related IR in human PAH, testing the hypothesis that lipoprotein indices are more sensitive indices of IR in PAH. METHODS: Oral glucose tolerance testing in PAH patients and triglyceride-matched (TG-matched) controls and proteomic, metabolomics, and lipoprotein analyses were performed in PAH and controls...
January 10, 2019: JCI Insight
Kyumin Shim, Radhika Gulhar, Ishwarlal Jialal
INTRODUCTION: Metabolic syndrome (MetS) is a disorder defined by having three of five features: increased waist circumference (WC), hypertriglyceridemia, decreased high-density lipoprotein-cholesterol, hypertension and an elevated blood glucose (BG). Metabolic Syndrome ( MetS) affects 35% of American adults and significantly increases risk for Atherosclerotic cardiovascular disease (ASCVD) and type-2 diabetes (T2DM). An understanding of the metabolome will help elucidate the pathogenesis of MetS and lead to better management...
December 10, 2018: Journal of Diabetes and its Complications
Yuan-Yuan Chen, Dan-Qian Chen, Lin Chen, Jing-Ru Liu, Nosratola D Vaziri, Yan Guo, Ying-Yong Zhao
Dysbiosis represents changes in composition and structure of the gut microbiome community (microbiome), which may dictate the physiological phenotype (health or disease). Recent technological advances and efforts in metagenomic and metabolomic analyses have led to a dramatical growth in our understanding of microbiome, but still, the mechanisms underlying gut microbiome-host interactions in healthy or diseased state remain elusive and their elucidation is in infancy. Disruption of the normal gut microbiota may lead to intestinal dysbiosis, intestinal barrier dysfunction, and bacterial translocation...
January 3, 2019: Journal of Translational Medicine
Alessandro Lana, Keisha Alexander, Annalisa Castagna, Angelo D'Alessandro, Francesca Morandini, Francesca Pizzolo, Francesco Zorzi, Paolo Mulatero, Lello Zolla, Oliviero Olivieri
PURPOSE: The current clinical investigation for primary aldosteronism (PA) diagnosis requires complex expensive tests from the initial suspicion to the final subtype classification, including invasive approaches; therefore, appropriate markers for subtype definition are greatly desirable. The present study performed a metabolomics analysis to further examine specific molecular signatures of PA urines EXPERIMENTAL DESIGN: : The study considered PA subtype and gender-related differences using two orthogonal advanced UHPLC-MS metabolomics approaches...
December 23, 2018: Proteomics. Clinical Applications
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