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mortality atrial fibrillation

David Pilecky, Mate Vamos, Peter Bogyi, Balazs Muk, Dora Stauder, Hajnalka Racz, Noemi Nyolczas, Gabor Z Duray, Gabor Zacher, Endre Zima
OBJECTIVE: Patients with electrical injury are considered to be at high risk of cardiac arrhythmias. Due to the small number of studies, there is no widely accepted guideline regarding the risk assessment and management of arrhythmic complications after electrical accident (EA). Our retrospective observational study was designed to determine the prevalence of ECG abnormalities and cardiac arrhythmias after EA, to evaluate the predictive value of cardiac biomarkers for this condition and to assess in-hospital and 30-day mortality...
February 15, 2019: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
Karsten Keller, Lukas Hobohm, Thomas Münzel, Mir Abolfazl Ostad
AIMS: Syncope is a common phenomenon in the general population. Although most of the causes are of benign origin, some comorbidities are accompanied by high mortality. We aimed to compare the in-hospital mortality of patients with syncope related to different comorbities and investigate the impact of syncope in patients with atrial fibrillation/flutter (AF). METHODS: The nationwide inpatient sample of Germany of the years 2011-2014 was used for this analysis. Patients with syncope (ICD-code R55) were stratified by presence of selected comorbidities...
February 13, 2019: European Journal of Internal Medicine
In-Soo Kim, Hyun-Jung Kim, Hee Tae Yu, Tae-Hoon Kim, Jae-Sun Uhm, Jong-Youn Kim, Boyoung Joung, Moon-Hyoung Lee, Hui-Nam Pak
BACKGROUND: Amiodarone, which inhibits CYP2C9 and P-glycoprotein, is commonly prescribed with non-vitamin K antagonist oral anticoagulants (NOACs) and polypharmacy in high-risk atrial fibrillation (AF) patients. We studied efficacy and safety of NOACs in AF patients receiving amiodarone, P-glycoprotein inhibitor, or polypharmacy. METHODS: After a systematic database search (Medline, EMBASE, CENTRAL, SCOPUS, and Web of Science), four phase-III randomized trials comparing NOACs and warfarin in "with/without amiodarone," "with/without P-glycoprotein inhibitors," or "with/without multiple (≥5, polypharmacy) concomitant drugs" subgroups were included...
February 12, 2019: Journal of Cardiology
Sjaak Pouwels, Besir Topal, Mireille T Knook, Alper Celik, Magnus Sundbom, Rui Ribeiro, Chetan Parmar, Surendra Ugale
Obesity, defined as a Body Mass Index (BMI) of ≥30 kg/m2, is the most common chronic metabolic disease worldwide and its prevalence has been strongly increasing. Obesity is associated with various diseases such as cardiovascular disease, type 2 diabetes and hypertension. Regarding heart rhythm disorders, obesity is associated with an increase in atrial fibrillation (AF), the most common arrhythmia in clinical practice. AF is associated with an increased cardiovascular morbidity and mortality. Obesity, a novel risk factor, is responsible for a 50%-increased incidence of AF...
February 13, 2019: Expert Review of Cardiovascular Therapy
Tobias Schupp, Ibrahim Akin, Linda Reiser, Armin Bollow, Gabriel Taton, Thomas Reichelt, Dominik Ellguth, Niko Engelke, Uzair Ansari, Kambis Mashayekhi, Christel Weiß, Christoph Nienaber, Muharrem Akin, Martin Borggrefe, Michael Behnes
PURPOSE: The study sought to evaluate the prognostic impact of recurrences of ventricular tachyarrhythmias in consecutive ICD recipients with ventricular tachyarrhythmias on admission. METHODS: All consecutive patients surviving at least one episode of ventricular tachyarrhythmias from 2002 to 2016 and discharged with an ICD (pre-existing ICD or ICD implantation at index hospitalization) were included. The primary endpoint was all-cause mortality according to the presence or absence of recurrences of ventricular tachyarrhythmias at 5 years...
February 12, 2019: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
Konstantinos N Aronis, Rheeda Ali, Natalia A Trayanova
Atrial fibrillation is the most common arrhythmia in humans and is associated with high morbidity, mortality and health-related expenses. Computational approaches have been increasingly utilized in atrial electrophysiology. In this review we summarize the recent advancements in atrial fibrillation modeling at the organ scale. Multi-scale atrial models now incorporate high level detail of atrial anatomy, tissue ultrastructure and fibrosis distribution. We provide the state-of-the art methodologies in developing personalized atrial fibrillation models with realistic geometry and tissue properties...
January 31, 2019: International Journal of Cardiology
Raul Caso, Thomas J Watson, Puja G Khaitan, M Blair Marshall
Background: Sleeve resection allows for preservation of lung parenchyma and improved long-term outcomes when compared with pneumonectomy. Little is known about minimally invasive sleeve resection, especially indications, feasibility, technical aspects, complications, and outcomes. We reviewed our institutional experience with sleeve resections via a minimally invasive approach. Methods: We performed a retrospective review of a prospectively maintained database from 01/01/2010 to 11/01/2017...
December 2018: Journal of Thoracic Disease
Masaru Yamamoto, Katsunori Okajima, Akira Shimane, Tomoya Ozawa, Itsuro Morishima, Toru Asai, Masahiko Takagi, Atsunobu Kasai, Eitaro Fujii, Ken Kiyono, Eiichi Watanabe, Yukio Ozaki
Implantable cardioverter-defibrillators (ICDs) improve survival in patients who are at risk of sudden death. However, inappropriate therapy is commonly given to ICD recipients, and this situation may be associated with an increased risk of death. This study aimed to construct a risk stratification scheme by using decision tree analysis in patients who received inappropriate ICD therapy.Mortality was calculated from a retrospective data analysis of a multicenter cohort involving 417 ICD recipients. Inappropriate therapy was defined as therapy for nonventricular arrhythmias, including sinus tachycardia, supraventricular tachycardia, atrial fibrillation/flutter, oversensing, and lead failure...
February 8, 2019: International Heart Journal
Nagisa Morikawa, Hisashi Adachi, Mika Enomoto, Ako Fukami, Eita Kumagai, Sachiko Nakamura, Yume Nohara, Erika Nakao, Shoko Kono, Tomoko Tsuru, Akiko Sakaue, Hitoshi Hamamura, Yoshihiro Fukumoto
Serum thrombospondin-2 (TSP-2) is a glycoprotein expressed in the extracellular matrix (ECM), which increases during tissue remodeling. It has been shown in recent studies that TSP-2 is a useful predictor of cardiovascular death in patients with heart failure (HF). However, the clinical importance of serum TSP-2 levels in a general population is still unknown. Therefore, we aimed to clarify the association between TSP-2 and clinical risk factors. A periodic epidemiological survey was performed in a community dwelling in the town of Uku, Nagasaki, Japan...
February 8, 2019: International Heart Journal
Chien-Ming Cheng, Ching-Heng Lin, Pesus Chou, Gwo-Ping Jong
In clinical practice, some atrial fibrillation (AF) patients were classified as having low and moderate stroke risk by the CHADS2 score (≤ 1) in 2001 but in 2012 they were not truly classified as low risk of stroke according to the CHA2 DS2 -VASc score (≥ 2) (defined gray zone). Therefore, a treatment gap exists in gray zone AF patients. This study aimed to evaluate whether gray zone AF patients could benefit from reduced all-cause mortality under antithrombotic treatment. This was a longitudinal cohort study performed using data from claim forms submitted to the Taiwan Bureau of National Health Insurance from January 2000 to December 2011...
February 8, 2019: International Heart Journal
Hyung Ki Jeong, Ki Hong Lee, Hyung Wook Park, Nam Sik Yoon, Min Chul Kim, Nuri Lee, Ji Sung Kim, Youngkeun Ahn, Myung Ho Jeong, Jong Chun Park, Jeong Gwan Cho
Rivaroxaban has emerged as a potential alternative to warfarin for the prevention of thromboembolism in patients with atrial fibrillation (AF). However, there has been concern for the risk of major bleeding, especially in Asian patients. We investigated the efficacy and safety of rivaroxaban compared to warfarin in Korean real world practice. A total of 2,208 consecutive non-valvular AF patients were divided into the Warfarin group (n=990) and the Rivaroxaban group (n=1218). Propensity matched 1-year clinical outcomes were compared (Warfarin, n=804; Rivaroxaban, n=804)...
January 2019: Chonnam Medical Journal
Monique Young
The purpose of this article is to educate staff nurses and advanced practice nurses the importance of identifying, diagnosing, and making appropriate clinical decisions when treating patients with atrial fibrillation. Atrial fibrillation is a supraventricular arrhythmia characterized by uncoordinated, chaotic electrical activity and deterioration of proper atrial mechanical function, with an irregular ventricular response. Poorly controlled or undiagnosed atrial fibrillation increases the risk of mortality and may decrease quality of life...
March 2019: Critical Care Nursing Clinics of North America
Lucas Van Hoof, Kristof De Brabandere, Steffen Fieuws, Bernard Stockman, Herbert Gutermann, Filip Rega
BACKGROUND: The Belgian 'National Institute for Health and Disability Insurance (RIZIV-INAMI)' requested prospective collection of data on all ablations in Belgium to determine the outcomes of surgical ablation of atrial fibrillation (AF) during concomitant cardiac surgery. METHODS: 890 patients undergoing concomitant ablation for AF between 2011 and 2016 were prospectively followed. Freedom from AF with and without anti-arrhythmic drugs was calculated for 817 patients with follow-up beyond the 3-month blanking period and for 574 patients with sufficient rhythm-related follow-up consisting of at least one Holter registration or a skipped Holter due to AF being evident on ECG...
February 8, 2019: Acta Cardiologica
Guanyi Liao, Siyang Chen, Haoyang Cao, Wuwan Wang, Qing Gao
BACKGROUND: Acute mesenteric ischemia (AMI) is a life-threatening medical condition that occurs when a sudden decreased perfusion to the intestines which leads to bowel infarction, and acute superior mesenteric artery embolism (ASMAE) is the main cause of AMI. Unfortunately, with the improvement of diagnosis and treatment technology, the mortality remains high due to less frequent clinical suspicion resulted from the unclear clinical manifestation and non-specific laboratory findings...
February 2019: Medicine (Baltimore)
Miho Fukui, Aman Gupta, Islam Abdelkarim, Michael S Sharbaugh, Andrew D Althouse, Hesham Elzomor, Suresh Mulukutla, Joon S Lee, John T Schindler, Thomas G Gleason, João L Cavalcante
Importance: Severe aortic stenosis causes pressure overload of the left ventricle, resulting in progressive cardiac dysfunction that can extend beyond the left ventricle. A staging system for aortic stenosis has been recently proposed that quantifies the extent of structural and functional cardiac changes in aortic stenosis. Objectives: To confirm the reproducibility of a proposed staging system and expand the study findings by performing a survival analysis and to evaluate the association of aortic stenosis staging with both cardiac and noncardiac post-transcatheter aortic valve replacement (TAVR) readmissions...
February 6, 2019: JAMA Cardiology
Paul Gressenberger
Administration of direct oral anticoagulants (DOACs) for the treatment of venous thrombotic events (VTE) or non-valvular atrial fibrillation (AF) is now standard of care and has demonstrated clinical efficacy and safety in numerous clinical studies. Usually these substances have lower overall mortality and less risk of cerebral hemorrhage, but depending on the substance and study, they are more likely to cause gastrointestinal bleeding than vitamin K antagonists (VKA), the medication that used to be standard for VTE and AF...
February 5, 2019: VASA. Zeitschrift Für Gefässkrankheiten
Surbhi Sidana, Nidhi Tandon, Peter A Brady, Martha Grogan, Morie A Gertz, Angela Dispenzieri, Grace Lin, David Dingli, Francis K Buadi, Martha Q Lacy, Prashant Kapoor, Wilson I Gonsalves, Eli Muchtar, Rahma Warsame, Shaji K Kumar, Taxiarchis V Kourelis
OBJECTIVE: To evaluate the prognostic impact of Holter findings in patients with light chain amyloidosis. PATIENTS AND METHODS: We evaluated 239 patients in whom light chain amyloidosis was diagnosed from January 1, 2010, through December 31, 2015, who underwent 24-hour Holter monitoring. RESULTS: Holter testing was done before stem cell transplant evaluation in 183 of the 239 patients (76.6%) and at diagnosis in 50 (20.9%). Holter findings were nonsustained ventricular tachycardia (NSVT) in 60 patients (25...
February 1, 2019: Mayo Clinic Proceedings
Shinya Goto, Pantep Angchaisuksiri, Jean-Pierre Bassand, A John Camm, Helena Dominguez, Laura Illingworth, Harry Gibbs, Samuel Z Goldhaber, Shinichi Goto, Zhi-Cheng Jing, Sylvia Haas, Gloria Kayani, Yukihiro Koretsune, Toon Wei Lim, Seil Oh, Jitendra P S Sawhney, Alexander G G Turpie, Martin van Eickels, Freek W A Verheugt, Ajay K Kakkar
Background Using data from the GARFIELD - AF (Global Anticoagulant Registry in the FIELD -Atrial Fibrillation), we evaluated the impact of chronic kidney disease ( CKD ) stage on clinical outcomes in patients with newly diagnosed atrial fibrillation ( AF ). Methods and Results GARFIELD - AF is a prospective registry of patients from 35 countries, including patients from Asia (China, India, Japan, Singapore, South Korea, and Thailand). Consecutive patients enrolled (2013-2016) were classified with no, mild, or moderate-to-severe CKD , based on the National Kidney Foundation's Kidney Disease Outcomes Quality Initiative guidelines...
February 5, 2019: Journal of the American Heart Association
Dong Seop Jeong, Kiick Sung, Wook Sung Kim, Carriere Kc, Pyo Won Park
BACKGROUND: Currently, two types of cryoprobes are available: N2 O-based and argon gas-based. However, few studies have compared the outcomes obtained with these two cryoprobe types. The aim of this study was to compare the early outcomes of a concomitant maze procedure using N2 O-based cryoablation (the N2 O group) versus argon gas-based cryoablation (the Argon group) in patients with persistent atrial fibrillation (AF). METHODS: This study was a single-center, prospective, randomized controlled clinical trial...
February 1, 2019: Annals of Thoracic Surgery
Sahereh Mirzaei, Patricia E Hershberger, Holli A DeVon
BACKGROUND: Bleeding is a serious complication of coronary artery bypass grafting that often leads to blood transfusion. Approximately 50% of patients who have the surgery receive blood products, and blood transfusions play a role in adverse outcomes after the surgery. OBJECTIVE: To examine the association between perioperative blood transfusion and postoperative adverse outcomes in patients undergoing coronary artery bypass grafting. METHODS: A systematic review of the literature, via the matrix method of quality evaluation, was conducted...
February 2019: Critical Care Nurse
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