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Safi U Khan, Ahmad N Lone, Zain Ul Abideen Asad, Hammad Rahman, Muhammad Shahzeb Khan, Muhammad A Saleem, Adeel Arshad, Najma Nawaz, Sudhakar Sattur, Edo Kaluski
BACKGROUND: There is inconsistency in the literature regarding the clinical effects of proton pump inhibitors (PPI) when added to dual antiplatelet therapy (DAPT) in subjects with coronary artery disease (CAD). We performed meta-analysis stratified by study design to explore these differences. METHODS AND RESULTS: 39 studies [4 randomized controlled trials (RCTs) and 35 observational studies) were selected using MEDLINE, EMBASE and CENTRAL (Inception-January 2018)...
February 10, 2019: Cardiovascular Revascularization Medicine: Including Molecular Interventions
Bilal Tahir, Sajid Iqbal, M Usman Ghani Khan, Tanzila Saba, Zahid Mehmood, Adeel Anjum, Toqeer Mahmood
Automatic medical image analysis is one of the key tasks being used by the medical community for disease diagnosis and treatment planning. Statistical methods are the major algorithms used and consist of few steps including preprocessing, feature extraction, segmentation, and classification. Performance of such statistical methods is an important factor for their successful adaptation. The results of these algorithms depend on the quality of images fed to the processing pipeline: better the images, higher the results...
February 15, 2019: Microscopy Research and Technique
Brittanny M Polanka, Suman Kundu, Kaku A So-Armah, Matthew S Freiberg, Samir K Gupta, Roger J Bedimo, Matthew J Budoff, Adeel A Butt, Chung-Chou H Chang, Stephen S Gottlieb, Vincent C Marconi, Julie A Womack, Jesse C Stewart
BACKGROUND: Insomnia is associated with increased cardiovascular disease (CVD) risk in the general population and is highly prevalent in people with HIV. The CVD risk conferred by insomnia in the HIV population is unknown. METHODS: Using the Veterans Aging Cohort Study-Survey Cohort, insomnia symptoms were measured and dummy coded with the item, "Difficulty falling or staying asleep?" (5-point scale from no difficulty to bothers a lot). Incident CVD event ICD-9 codes (acute myocardial infarction, stroke, or coronary artery revascularization) were identified with VA and Medicare administrative data and VA fee-for-service data...
February 7, 2019: Journal of Acquired Immune Deficiency Syndromes: JAIDS
Adeel Nazir Ahmad, Geraldine McLeod, Nada Al Zahrani, Haneen Al Zahrani
Sleep apnea is a potentially serious but under-diagnosed sleep disorder. Saudi Arabia has a high prevalence of hypertension, diabetes, obesity, and smoking, which are all major risk factors for sleep apnea. However, few studies report screening for sleep apnea in Saudi Arabia. A three-month prospective, questionnaire-based study, using the Berlin Questionnaire (BQ) and the Epworth Sleepiness Scale (ESS), screened 319 patients attending a family medicine clinic in Saudi Arabia for risk of sleep apnea. The results showed that when using the BQ and the ESS, 95 (29...
February 5, 2019: International Journal of Environmental Research and Public Health
Muhammad Shaheryar Ahmed Rajput, Ahmad Nawaz Ahmad, Asif Ali Arain, Mohammad Adeel, Saeed Akram, Muhammad Sohail Awan, Muhammad Ehsan Bari
Introduction Vestibular schwannomas (VS) are the most common benign neoplasms of a cerebellopontine angle (CPA), which arise from the Schwann cells of the vestibulocochlear nerve. Eighty percent of CPA tumors are VS followed by meningioma as the second common mass lesion in this critical potential space. Treatment options range from watchful waiting with serial imaging studies to radiosurgery or a microsurgical excision or a combination of surgery and radiation therapy. The primary objective of the study was to assess hearing and facial nerve status before and after the surgery via the retrosigmoid approach...
December 4, 2018: Curēus
Bing Yu, Qiaohong Peng, Muhammad Usman, Adeel Ahmed, Yao Chen, Xin Chen, Yifan Wang, Youqing Shen, Hailin Cong
In this paper, we have developed a novel method for the preparation of covalently connected capillary coatings in which diazotized poly (vinyl alcohol-b-styrene) (diazo-P(VA-b-St)) was used as a photosensitive coating agent. Firstly, the diazo-P(VA-b-St) coating was self-assembled on the inner surface of the capillary, and then irradiated by ultraviolet (UV) light to convert the ionic bonding into covalent bonding through the unique photochemical reaction of diazo groups. The covalently connected coatings inhibited the protein adsorption on the inner surface of the capillary, as a result, the baseline protein separation of ribonuclease A (RNase A), lysozyme (Lyz) and bovine serum albumin (BSA) were attained by utilizing the capillary electrophoresis (CE)...
February 4, 2019: Journal of Chromatography. A
Muhammad Ahsan Iqbal, Cui Menghua, Adeel Liaqat, Rakba Faiz, Mongur Hossain, Xinsheng Wang, Sabir Hussain, Dang Chunhe, Liu Haining, Wen Wen, Wu Juanxia, Liming Xie
Photodetectors have widespread applications in telecommunication, thermal imaging, bio-medical imaging and so on. Photogating effect, arising from charge trapping at defects and/or interfaces, can have extremely high photoelectric gain, which can benefit to high-sensitivity room temperature photodetection. Here, we introduce thin layered organic CPXs integrated on graphene transistors for the development of hybrid phototransistors with ultra-high photoresponsivity of ~106 A/W in near infrared (NIR) region at room temperature...
February 11, 2019: Nanotechnology
Sarah R Blake, Adeel Shahzad, Suneil K Aggarwal, Abhishek Kumar, Adnan Khan, Rod H Stables
BACKGROUND: Recent randomized controlled trials comparing femoral and radial access in primary percutaneous coronary intervention (PPCI) have shown conflicting results regarding the incidence of major adverse cardiovascular events (MACE) and major bleeding. METHODS: Using data from the HEAT-PPCI trial, we compared the primary efficacy (all-cause mortality, stroke, new myocardial infarction or unplanned repeat revascularization) and safety (major bleeding BARC 3-5) outcomes at 28 days, by final access site used (radial or femoral) and by default operator type...
January 16, 2019: American Heart Journal
Doaa Alkhalidi, Shazia Qasim Jamshed, Ramadan Mohamed Elkalmi, Mirza Rafi Baig, Adeel Aslam, Mohamed Azmi Hassali
Ensuring drug safety among the patients is the main domain of pharmacovigilance activities worldwide. A pharmacovigilance system was established in the United Arab Emirates (UAE) in 2008. Research evidence reflects that the current system is lacking in active participation from patients, and also, the inadequate role of healthcare professionals is anticipated. In this context, it is pertinent to know the general public's understandings and their patterns of safe use of medication, which are unexplored areas in Dubai, UAE...
February 7, 2019: Pharmacy (Basel, Switzerland)
Paul M Foreman, James Mooney, Adeel Ilyas, Bonita Agee, Sheela Vivekanandan, Reginald P Fong, Mamerhi O Okor, Kristen O Riley, Christoph J Griessenauer
BACKGROUND: Antiplatelet therapy is common and complicates the operative management of subdural hematomas (SDH). The risk of reoperation inferred by antiplatelet medication and the ability of platelet transfusion to reduce hemorrhagic complications in patients presenting with antiplatelet associated SDHs is poorly defined. METHODS: We performed a retrospective review of consecutive patients treated with craniotomy or craniectomy for evacuation of an acute or mixed density SDH between 2012-2017 at two academic institutions...
February 5, 2019: World Neurosurgery
Adeel Ahmed, Imran Shafique
Water pollution is one of the main threats to public health in Pakistan. The watchdogs for drinking water quality are toothless, hence Pakistan's ranking in maintaining water quality standards is 80th out of 122 nations. Despite such alarming situation coupled with violation of various drinking water quality parameters set by WHO, the risk perception of people remains an unfolded area of research. This paper examines the risk perception of household regarding water pollution in Pakistan and its potential effect on human health...
January 31, 2019: Environmental Science and Pollution Research International
Chang Park, Adeel Ikram, Hani B Abdul-Jabar, Warwick J P Radford
Neuritis of the sciatic nerve is a rare complication of total hip replacements. It is characterized by symptoms of neuropathic pain with or without motor and or sensory symptoms. Causes include direct intra-operative trauma or mechanical lengthening of the nerve. Cases of sciatic nerve neuritis without an organic cause however, are rarer still. We present two cases of sciatic nerve neuritis post total hip replacement with no identified organic cause. Whereas the reversal of the underlying cause has shown improvement in symptoms, in cases without an organic cause our experience advocates close observation and conservative management with spontaneous resolution of symptoms...
January 2019: Journal of Clinical Orthopaedics and Trauma
Tanzila Saba, Sana Ullah Khan, Naveed Islam, Naveed Abbas, Amjad Rehman, Nadeem Javaid, Adeel Anjum
The advancement of computer- and internet-based technologies has transformed the nature of services in healthcare by using mobile devices in conjunction with cloud computing. The classical phenomenon of patient-doctor diagnostics is extended to a more robust advanced concept of E-health, where remote online/offline treatment and diagnostics can be performed. In this article, we propose a framework which incorporates a cloud-based decision support system for the detection and classification of malignant cells in breast cancer, while using breast cytology images...
January 29, 2019: Microscopy Research and Technique
Muhammad Adeel, Muhammad Asif, Muhammad Naeem Faisal, Muhammad Hasanain Chaudary, Muhammad Sheraz Malik, Muhammad Khalid
Purpose: This retrospective study presents a comparative analysis of the overall survival and toxicities, as side effects, of docetaxel plus cyclophosphamide (TC) and doxorubicin plus cyclophosphamide (AC). The study measured their efficacies during adjuvant chemotherapy, treating Pakistani breast cancer patients by validating the results obtained, with the published analysis of the same treatment given to US patients. Patients and methods: Between June 2015 and September 2017, for four chemotherapy cycles, 189 patients out of 358 received TC (75 mg/m2 of docetaxel, 600 mg/m2 of cyclophosphamide) and 169 were treated with AC (60 mg/m2 of doxorubicin, 600 mg/m2 of cyclophosphamide)...
2019: Cancer Management and Research
Muhammad Faisal, Mohammad Adeel, Sheryar Riaz, Abdullah Anwar, Asma Rashid, Sadaf Usman, Arif Jamshed, Raza Hussain
Objectives: The submental flap provides an alternative technique in orofacial reconstruction, especially in situations where free flap services are not available. The objective of this study is to demonstrate the oncological safety and benefits of this flap in oral cavity reconstruction in a tertiary care cancer hospital. Materials and Methods: A total of 27 patients with oral cavity cancers, which underwent submental flap reconstruction from 2015 to 2017 at Shaukat Khanum Cancer Memorial Hospital, were included in the study...
July 2018: Annals of Maxillofacial Surgery
Katrin H Preller, Adeel Razi, Peter Zeidman, Philipp Stämpfli, Karl J Friston, Franz X Vollenweider
Psychedelics exert unique effects on human consciousness. The thalamic filter model suggests that core effects of psychedelics may result from gating deficits, based on a disintegration of information processing within cortico-striato-thalamo-cortical (CSTC) feedback loops. To test this hypothesis, we characterized changes in directed (effective) connectivity between selected CTSC regions after acute administration of lysergic acid diethylamide (LSD), and after pretreatment with Ketanserin (a selective serotonin 2A receptor antagonist) plus LSD in a double-blind, randomized, placebo-controlled, cross-over study in 25 healthy participants...
January 28, 2019: Proceedings of the National Academy of Sciences of the United States of America
Frederik Van de Steen, Hannes Almgren, Adeel Razi, Karl Friston, Daniele Marinazzo
Functional and effective connectivity are known to change systematically over time. These changes might be explained by several factors, including intrinsic fluctuations in activity-dependent neuronal coupling and contextual factors, like experimental condition and time. Furthermore, contextual effects may be subject-specific or conserved over subjects. To characterize fluctuations in effective connectivity, we used dynamic causal modelling (DCM) of cross spectral responses over 1 min of electroencephalogram (EEG) recordings during rest, divided into 1-sec windows...
January 25, 2019: NeuroImage
Hidayat Ullah, Tanzila Saba, Naveed Islam, Naveed Abbas, Amjad Rehman, Zahid Mehmood, Adeel Anjum
Atomic recognition of the Exudates (EXs), the major symbol of diabetic retinopathy is essential for automated retinal images analysis. In this article, we proposed a novel machine learning technique for early detection and classification of EXs in color fundus images. The major challenge observed in the classification technique is the selection of optimal features to reduce computational time and space complexity and to provide a high degree of classification accuracy. To address these challenges, this article proposed an evolutionary algorithm based solution for optimal feature selection, which accelerates the classification process and reduces computational complexity...
January 24, 2019: Microscopy Research and Technique
Jiro Kusakabe, Blaire Anderson, Jingxia Liu, Gregory A Williams, William C Chapman, Majella M B Doyle, Adeel S Khan, Dominic E Sanford, Chet W Hammill, Steven M Strasberg, William G Hawkins, Ryan C Fields
PURPOSE: To identify peri-operative risk factors and time to onset of pancreatic endocrine/exocrine insufficiency. METHODS: We retrospectively analyzed a single institutional series of patients who underwent pancreaticoduodenectomy (PD) or distal pancreatectomy (DP) between 2000 and 2015. Endocrine/exocrine insufficiencies were defined as need for new pharmacologic intervention. Cox proportional modeling was used to identify peri-operative variables to determine their impact on post-operative pancreatic insufficiency...
January 22, 2019: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
Muhammad Bilal, Muhammad Adeel, Tahir Rasheed, Yuping Zhao, Hafiz M N Iqbal
The widespread occurrence and adverse environmental and health-related impacts of various types of emerging contaminants (ECs) have become an issue of high concern. With ever increasing scientific knowledge, socio-economic awareness, health-related problems and ecological apprehensions, people are more concerned about the widespread ECs, around the globe. Among ECs, biologically active compounds from pharmaceutical, cosmeceutical, biomedical, personal care products (PPCPs), endocrine-disrupting chemicals (EDCs), and flame-retardants are of paramount concern...
January 17, 2019: Environment International
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