Caroline Ovadia, Paul T Seed, Alexandros Sklavounos, Victoria Geenes, Chiara Di Ilio, Jenny Chambers, Katherine Kohari, Yannick Bacq, Nuray Bozkurt, Romana Brun-Furrer, Laura Bull, Maria C Estiú, Monika Grymowicz, Berrin Gunaydin, William M Hague, Christian Haslinger, Yayi Hu, Tetsuya Kawakita, Ayse G Kebapcilar, Levent Kebapcilar, Jūratė Kondrackienė, Maria P H Koster, Aneta Kowalska-Kańka, Limas Kupčinskas, Richard H Lee, Anna Locatelli, Rocio I R Macias, Hanns-Ulrich Marschall, Martijn A Oudijk, Yael Raz, Eli Rimon, Dan Shan, Yong Shao, Rachel Tribe, Valeria Tripodi, Cigdem Yayla Abide, Ilter Yenidede, Jim G Thornton, Lucy C Chappell, Catherine Williamson
BACKGROUND: Intrahepatic cholestasis of pregnancy is associated with adverse perinatal outcomes, but the association with the concentration of specific biochemical markers is unclear. We aimed to quantify the adverse perinatal effects of intrahepatic cholestasis of pregnancy in women with increased serum bile acid concentrations and determine whether elevated bile acid concentrations were associated with the risk of stillbirth and preterm birth. METHODS: We did a systematic review by searching PubMed, Web of Science, and Embase databases for studies published from database inception to June 1, 2018, reporting perinatal outcomes for women with intrahepatic cholestasis of pregnancy when serum bile acid concentrations were available...
March 2, 2019: Lancet