keyword
https://read.qxmd.com/read/38452225/enhancing-photothermal-photodynamic-therapy-for-glioblastoma-by-tumor-hypoxia-alleviation-and-heat-shock-protein-inhibition-using-ir820-conjugated-reduced-graphene-oxide-quantum-dots
#21
JOURNAL ARTICLE
Banendu Sunder Dash, Yu-Jen Lu, Jyh-Ping Chen
We use low-molecular-weight branched polyethylenimine (PEI) to produce cytocompatible reduced graphene oxide quantum dots (rGOQD) as a photothermal agent and covalently bind it with the photosensitizer IR-820. The rGOQD/IR820 shows high photothermal conversion efficiency and produces reactive oxygen species (ROS) after irradiation with near-infrared (NIR) light for photothermal/photodynamic therapy (PTT/PDT). To improve suspension stability, rGOQD/IR820 was PEGylated by anchoring with the DSPE hydrophobic tails in DSPE-PEG-Mal, leaving the maleimide (Mal) end group for covalent binding with manganese dioxide/bovine serum albumin (MnO2 /BSA) and targeting ligand cell-penetrating peptide (CPP) to synthesize rGOQD/IR820/MnO2 /CPP...
March 7, 2024: ACS Applied Materials & Interfaces
https://read.qxmd.com/read/38449663/novel-near-infrared-bodipy-cyclodextrin-complexes-for-photodynamic-therapy
#22
JOURNAL ARTICLE
Bowei Lu, Xu Lu, Manman Mu, Shuxian Meng, Yaqing Feng, Yi Zhang
To meet the requirements of diagnosis and treatment, photodynamic therapy (PDT) is a promising cancer treatment with less side-effect. A series of novel BODIPY complexes (BODIPY-CDs) served as PDT agents were first reported to enhance the biocompatibility and water solubility of BODIPY matrix through the click reaction of alkynyl-containing BODIPY and azide-modified cyclodextrin (CD). BODIPY-CDs possessed superior water solubility due to the introduction of CD and their fluorescence emission apparently redshifted (>90 nm) on account of triazole units as the linkers compared to alkynyl-containing BODIPY...
March 15, 2024: Heliyon
https://read.qxmd.com/read/38444045/biotin-new-indocyanine-green-conjugate-synthesis-in%C3%A2-vitro-photocytotoxicity-and-in%C3%A2-vivo-biodistribution
#23
JOURNAL ARTICLE
Shengping Liu, Fang Ding, Wei Xu, Liangrui Miu, Yuxiang Tang, Defeng Xu, Tianyu Zhu, Hang Hu
New indocyanine green (ICG) (IR820) is one of the ICG derivatives and attracts increasing attention for cancer management. However, the unsatisfactory tumor targeting ability of IR820 significantly limits its applications for cancer theranostics. Biotin receptor is overexpressed on the membrane of various tumor cells and biotin modified nanocarriers have been reported to enhance the tumor targeting ability on several tumor types. In this work, biotin-new ICG conjugate (Biotin-SS-IR820) was prepared for tumor-targeted IR820 delivery...
March 2024: Chemical Biology & Drug Design
https://read.qxmd.com/read/38434718/synergistic-chemotherapy-ptt-oxygen-enrichment-by-multifunctional-liposomal-polydopamine-nanoparticles-for-rheumatoid-arthritis-treatment
#24
JOURNAL ARTICLE
Xiaoling Fu, Yutong Song, Xianquan Feng, Zhihong Liu, Wenhao Gao, Hongtao Song, Qian Zhang
Amultifunctional liposomal polydopamine nanoparticle (MPM@Lipo) was designed in this study, to combine chemotherapy, photothermal therapy (PTT) and oxygen enrichment to clear hyperproliferating inflammatory cells and improve the hypoxic microenvironment for rheumatoid arthritis (RA) treatment. MPM@Lipo significantly scavenged intracellular reactive oxygen species and relieved joint hypoxia, thus contributing to the repolarization of M1 macrophages into M2 phenotype. Furthermore, MPM@Lipo could accumulate at inflammatory joints, inhibit the production of inflammatory factors, and protect cartilage in vivo , effectively alleviating RA progression in a rat adjuvant-induced arthritis model...
February 2024: Asian journal of pharmaceutical sciences
https://read.qxmd.com/read/38426957/vascular-targeted-optical-theranostics-enhanced-photoplethysmography-imaging-of-laser-induced-singlet-oxygen-effects
#25
JOURNAL ARTICLE
I Makovik, M Volkov, L Eratova, V Dremin
The work considers a theranostic system that implements a multimodal approach allowing the simultaneous generation of singlet oxygen and visualization of the various parameters of the vascular bed. The system, together with the developed data processing algorithm, has the ability to assess architectural changes in the vascular network and its blood supply, as well as to identify periodic signal changes associated with mechanisms of blood flow oscillation of various natures. The use of this system seems promising in studying the effect of laser-induced singlet oxygen on the state of the vascular bed, as well as within the framework of the theranostic concept of treatment and diagnosis of oncological diseases and non-oncological vascular anomalies...
March 1, 2024: Optics Letters
https://read.qxmd.com/read/38423948/assessment-of-oxygen-saturation-in-breast-lesions-using-photoacoustic-imaging-correlation-with-benign-and-malignant-disease
#26
JOURNAL ARTICLE
Zhibin Huang, Hongtian Tian, Hui Luo, Keen Yang, Jing Chen, Guoqiu Li, Zhimin Ding, Yuwei Luo, Shuzhen Tang, Jinfeng Xu, Huaiyu Wu, Fajin Dong
BACKGROUND: Hypoxia is a hallmark of breast cancer (BC). Photoacoustic (PA) imaging, based on the use of laser-generated ultrasound (US), can detect oxygen saturation (So2 ) in the tissues of breast lesion patients. PURPOSE: To measure the oxygenation status of tissue in and on both sides of the lesion in breast lesion participants using a multimodal Photoacoustic/ultrasound (PA/US) imaging system and to determine the correlation between So2 measured by PA imaging and benign or malignant disease...
January 17, 2024: Clinical Breast Cancer
https://read.qxmd.com/read/38423154/macrophage-mannose-receptor-targeted-photoactivatable-agent-for-in-vivo-imaging-and-treatment-of-atherosclerosis
#27
JOURNAL ARTICLE
Seung-Yul Lee, Jin Hyuk Kim, Joon Woo Song, Ji Seon Min, Hyun Jung Kim, Ryeong Hyun Kim, Jae Won Ahn, Hongki Yoo, Kyeongsoon Park, Jin Won Kim
Previous studies have demonstrated the effects of theranostic agents on atherosclerotic plaques. However, there is limited information on targeted theranostics for photodynamic treatment of atherosclerosis. This study aimed to develop a macrophage-mannose-receptor-targeted photoactivatable nanoagent that regulates atherosclerosis and to evaluate its efficacy as well as safety in atherosclerotic mice. We synthesised and characterised D-mannosamine (MAN)-polyethylene glycol (PEG)-chlorin e6 (Ce6) for phototheranostic treatment of atherosclerosis...
February 27, 2024: International Journal of Pharmaceutics
https://read.qxmd.com/read/38416419/schottky-barrier-based-built-in-electric-field-for-enhanced-tumor-photodynamic-therapy
#28
JOURNAL ARTICLE
Yun Sun, Hongyu Wang, Yuhan Yang, Shunhao Wang, Bolong Xu, Zhijun Huang, Huiyu Liu
Photodynamic therapy's antitumor efficacy is hindered by the inefficient generation of reactive oxygen species (ROS) due to the photogenerated electron-hole pairs recombination of photosensitizers (PS). Therefore, there is an urgent need to develop efficient PSs with enhanced carrier dynamics. Herein, we designed Schottky junctions composed of cobalt tetroxide and palladium nanocubes (Co3 O4 @Pd) with a built-in electric field as effective PS. The built-in electric field enhanced photogenerated charge separation and migration, resulting in the generation of abundant electron-hole pairs and allowing effective production of ROS...
February 28, 2024: ACS Applied Materials & Interfaces
https://read.qxmd.com/read/38409815/temperature-and-thermal-diffusivity-diagnostics-in-laminar-methane-flames-using-infrared-four-wave-mixing-techniques
#29
JOURNAL ARTICLE
Zihao Song, Xing Chao, Anna-Lena Sahlberg
Four-wave mixing techniques, such as coherent anti-Stokes Raman spectroscopy (CARS), laser-induced grating spectroscopy (LIGS), and degenerate four-wave mixing (DFWM), have been widely used in combustion diagnostics due to their advantages of high signal-to-noise ratio (S/N), coherent signal, and spatial resolution. In this work, a nano-second pulsed laser is utilized to generate mid-infrared (near 3 µm) pump beams, exciting the rovibrational transitions of nascent water in flames. Combined LIGS and DFWM measurements are demonstrated in premixed laminar CH4 /O2 /N2 flames with equivalence ratios from 0...
February 26, 2024: Applied Spectroscopy
https://read.qxmd.com/read/38408124/treatment-of-acute-wound-infections-by-degradable-polymer-nanoparticle-with-a-synergistic-photothermal-and-chemodynamic-strategy
#30
JOURNAL ARTICLE
Fangzhou Chen, Lin Liu, Dongsheng Tang, Hanchen Zhang, Nier Wu, Lin Wang, Hongbo Li, Haihua Xiao, Dongsheng Zhou
Mild-heat photothermal antibacterial therapy avoids heat-induced damage to normal tissues but causes bacterial tolerance. The use of photothermal therapy in synergy with chemodynamic therapy is expected to address this issue. Herein, two pseudo-conjugated polymers PM123 with photothermal units and PFc with ferrocene (Fc) units are designed to co-assemble with DSPE-mPEG2000 into nanoparticle NPM123/Fc . NPM123/Fc under 1064 nm laser irradiation (NPM123/Fc +NIR-II) generates mild heat and additionally more toxic ∙OH from endogenous H2 O2 , displaying a strong synergistic photothermal and chemodynamic effect...
February 26, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://read.qxmd.com/read/38399337/triphenylphosphonium-functionalized-gold-nanorod-zinc-oxide-core-shell-nanocomposites-for-mitochondrial-targeted-phototherapy
#31
JOURNAL ARTICLE
Ara Joe, Hyo-Won Han, Yu-Ra Lim, Panchanathan Manivasagan, Eue-Soon Jang
Phototherapies, such as photothermal therapy (PTT) and photodynamic therapy (PDT), combined with novel all-in-one light-responsive nanocomposites have recently emerged as new therapeutic modalities for the treatment of cancer. Herein, we developed novel all-in-one triphenylphosphonium-functionalized gold nanorod/zinc oxide core-shell nanocomposites (CTPP-GNR@ZnO) for mitochondrial-targeted PTT/PDT owing to their good biocompatibility, tunable and high optical absorption, photothermal conversion efficiency, highest reactive oxygen species (ROS) generation, and high mitochondrial-targeting capability...
February 16, 2024: Pharmaceutics
https://read.qxmd.com/read/38394244/laser-direct-overall-water-splitting-for-h-2-and-h-2-o-2-production
#32
JOURNAL ARTICLE
Bo Yan, Qunfang Gu, Weiwei Cao, Biao Cai, Yinwu Li, Zhiping Zeng, Pu Liu, Zhuofeng Ke, Sheng Meng, Gang Ouyang, Guowei Yang
Hydrogen (H2 ) and hydrogen peroxide (H2 O2 ) play crucial roles as energy carriers and raw materials for industrial production. However, the current techniques for H2 and H2 O2 production rely on complex catalysts and involve multiple intermediate steps. In this study, we present a straightforward, environmentally friendly, and highly efficient laser-induced conversion method for overall water splitting to simultaneously generate H2 and H2 O2 at ambient conditions without any catalysts. The laser direct overall water splitting approach achieves an impressive light-to-hydrogen energy conversion efficiency of 2...
February 27, 2024: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/38383862/effect-of-photobiomodulation-therapy-on-the-morphology-intracellular-calcium-concentration-free-radical-generation-apoptosis-and-necrosis-of-human-mesenchymal-stem-cells-an-in-vitro-study
#33
JOURNAL ARTICLE
Kamila Pasternak-Mnich, Aleksandra Szwed-Georgiou, Barbara Ziemba, Ireneusz Pieszyński, Maria Bryszewska, Jolanta Kujawa
The aim of the study was to investigate the impact of multiwave locked system (MLS M1) emitting synchronized laser radiation at 2 wavelength simultaneous (λ = 808 nm, λ = 905 nm) on the mesenchymal stem cells (MSCs). Human MSCs were exposed to MLS M1 system laser radiation with the power density 195-318 mW/cm2 and doses of energy 3-20 J, in continuous wave emission (CW) or pulsed emission (PE). After irradiation exposure in doses of energy 3 J, 10 J (CW, ƒ = 1000 Hz), and 20 J (ƒ = 2000 Hz), increased proliferation of MSCs was observed...
February 22, 2024: Lasers in Medical Science
https://read.qxmd.com/read/38381004/aibi-modified-mesoporous-copper-sulfide-nanocomposites-for-efficient-non-oxygen-dependent-free-radicals-assisted-photothermal-therapy-in-uveal-melanoma
#34
JOURNAL ARTICLE
Pingping Huang, Lingdan Kong, Feiyi Zhang, Linxin Chen, Yue Zhang, Xiaoqian Shi, Tom Lawson, Shulei Chou, Yong Liu, Wencan Wu
Uveal melanoma (UM) is an ocular cancer predominantly affecting adults, characterized by challenging diagnostic outcomes. This research endeavors to develop an innovative multifunctional nanocomposite system sensitive to near-infrared (NIR) radiation, serving as both a non-oxygen free-radical generator and a photothermal agent. The designed system combines azobis isobutyl imidazoline hydrochloride (AIBI) with mesoporous copper sulfide (MCuS) nanoparticles. MCuS harnesses NIR laser energy to induce photothermal therapy, converting light energy into heat to destroy cancer cells...
February 21, 2024: Small
https://read.qxmd.com/read/38380497/in-vitro-synergistic-photodynamic-photothermal-chemodynamic-and-starvation-therapy-performance-of-chlorin-e6-immobilized-polydopamine-coated-hollow-porous-ceria-based-hypoxia-tolerant-nanozymes-carrying-a-cascade-system
#35
JOURNAL ARTICLE
Çağıl Zeynep Süngü Akdogan, Esin Akbay Çetin, Mehmet Ali Onur, Selis Önel, Ali Tuncel
A synergistic therapy agent (STA) with photothermal, photodynamic, chemodynamic, and starvation therapy (PTT, PDT, CDT, and ST) functions was developed. Hollow, mesoporous, and nearly uniform CeO2 nanoparticles (H-CeO2 NPs) were synthesized using a staged shape templating sol-gel protocol. Chlorin e6 (Ce6) was adsorbed onto H-CeO2 NPs, and a thin polydopamine (PDA) layer was formed on Ce6-adsorbed H-CeO2 NPs. Glucose oxidase (GOx) was bound onto PDA-coated Ce6-adsorbed H-CeO2 NPs to obtain the targeted STA (H-CeO2 @Ce6@PDA@GOx NPs)...
February 21, 2024: ACS Applied Bio Materials
https://read.qxmd.com/read/38374663/atomistic-probing-of-defect-engineered-2h-mote-2-monolayers
#36
JOURNAL ARTICLE
Odongo Francis Ngome Okello, Dong-Hwan Yang, Seung-Young Seo, Jewook Park, Gunho Moon, Dongwon Shin, Yu-Seong Chu, Sejung Yang, Teruyasu Mizoguchi, Moon-Ho Jo, Si-Young Choi
Point defects dictate various physical, chemical, and optoelectronic properties of two-dimensional (2D) materials, and therefore, a rudimentary understanding of the formation and spatial distribution of point defects is a key to advancement in 2D material-based nanotechnology. In this work, we performed the demonstration to directly probe the point defects in 2H-MoTe2 monolayers that are tactically exposed to (i) 200 °C-vacuum-annealing and (ii) 532 nm-laser-illumination; and accordingly, we utilize a deep learning algorithm to classify and quantify the generated point defects...
February 19, 2024: ACS Nano
https://read.qxmd.com/read/38372142/optimized-silicate-nanozymes-with-atomically-incorporated-iron-and-manganese-for-intratumoral-coordination-enhanced-once-for-all-catalytic-therapy
#37
JOURNAL ARTICLE
Xiuping Xu, Shuang Liu, Jin Ye, Qiang Wang, Mengting Liu, Yunlong Li, Hang Shangguan, Kefen Zhang, Yujie Fu, Jiating Xu
Although plant-derived cancer therapeutic products possess great promise in clinical translations, they still suffer from quick degradation and low targeting rates. Herein, based on the oxygen vacancy (OV)-immobilization strategy, an OV-enriched biodegradable silicate nanoplatform with atomically dispersed Fe/Mn active species and polyethylene glycol modification was innovated for loading gallic acid (GA) (noted as FMMPG) for intratumoral coordination-enhanced multicatalytic cancer therapy. The OV-enriched FMMPG nanozymes with a narrow band gap (1...
February 19, 2024: Journal of Materials Chemistry. B, Materials for Biology and Medicine
https://read.qxmd.com/read/38372029/devastating-the-supply-wagons-multifaceted-liposomes-capable-of-exhausting-tumor-to-death-via-triple-energy-depletion
#38
JOURNAL ARTICLE
Tian-Yu Wang, Xiao-Yu Zhu, Hao-Ran Jia, Ya-Xuan Zhu, Yong-Xi Zhou, Yan-Hong Li, Cheng-Zhe Gao, Guang-Yu Pan, Fu-Gen Wu
The anabolism of tumor cells can not only support their proliferation, but also endow them with a steady influx of exogenous nutrients. Therefore, consuming metabolic substrates or limiting access to energy supply can be an effective strategy to impede tumor growth. Herein, a novel treatment paradigm of starving-like therapy-triple energy-depleting therapy-is illustrated by glucose oxidase (GOx)/dc-IR825/sorafenib liposomes (termed GISLs), and such a triple energy-depleting therapy exhibits a more effective tumor-killing effect than conventional starvation therapy that only cuts off one of the energy supplies...
February 19, 2024: Small
https://read.qxmd.com/read/38364565/ultrasensitive-fluorescence-microrna-biosensor-by-coupling-hybridization-initiated-exonuclease-i-protection-and-tyramine-signal-amplification
#39
JOURNAL ARTICLE
Fenghui Qi, Yong Ju, Yanian Xiong, Jianzhong Lu, Yuhao Zhang
Tyramine signal amplification (TSA) has made its mark in immunoassay due to its excellent signal amplification ability and short reaction time, but its application in nucleic acid detection is still very limited. Herein, an ultrasensitive microRNA (miRNA) biosensor by coupling hybridization-initiated exonuclease I (Exo I) protection and TSA strategy was established. Target miRNA is complementarily hybridized to the biotin-modified DNA probe to form a double strand, which protects the DNA probe from Exo I hydrolysis...
February 9, 2024: Talanta
https://read.qxmd.com/read/38364370/microviscosity-assisted-disaggregation-of-a-model-ophthalmic-drug-and-fret-controlled-singlet-oxygen-generation-in-lyotropic-liquid-crystals
#40
JOURNAL ARTICLE
Arunavo Chatterjee, Athira Joy, Pradipta Purkayastha
Different phases of lyotropic liquid crystals (LLCs), made up of mesogen-like sodium dodecyl sulfate (SDS), mainly bestow different bulk viscosities. Along with this, the role of microviscosities of the individual LLC phases is of immense interest because a minute change in it due to guest incorporation can cause significant alteration in their property as a potential energy transfer scaffold. Recently, LLCs have been identified as plausible drug delivery agents for ocular treatments. In this direction, the present work illustrates photophysical modulations of an important laser dye as well as an ophthalmic medicine, coumarin 6 (C6), inside different LLC phases in an aqueous medium...
February 16, 2024: Langmuir: the ACS Journal of Surfaces and Colloids
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