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https://read.qxmd.com/read/30742148/a-nd-3-sensitized-upconversion-nanosystem-with-dual-photosensitizers-for-improving-photodynamic-therapy-efficacy
#1
Man Yang, Han Wang, Zhaohui Wang, Zhihao Han, Yueqing Gu
The efficacy of photodynamic therapy (PDT) was greatly hindered by the use of a 980 nm laser with undesired overheating effects as well as low reactive oxygen species (ROS) yields. Herein, we address these problems using a dual-photosensitizer (PS) loaded upconversion nanoparticle (UCNP) system. In detail, the NaYF4:Yb/Er/Nd@NaYF4:Nd core-shell UCNP system was designed to exhibit 808 nm laser excitation ability to avoid unfavorable thermal effects. More importantly, the co-encapsulation of dual PS, in terms of merocyanine 540 (MC540) and zinc phthalocyanine (ZnPc), could be respectively triggered by the dual emissions of UCNPs, which could generate sufficient ROS with improved efficiency...
February 11, 2019: Biomaterials Science
https://read.qxmd.com/read/30716690/a-hybrid-nanomaterial-with-nir-induced-heat-and-associated-hydroxyl-radical-generation-for-synergistic-tumor-therapy
#2
Cheng Zhang, Wen-Long Liu, Xue-Feng Bai, Si-Xue Cheng, Zhen-Lin Zhong, Xian-Zheng Zhang
Although photothermal therapy (PTT) and photodynamic therapy (PDT) are widely commended for tumor treatment recently, they still suffer severe challenges due to the non-specificity of photothermal agents (PTAs)/photosensitizers (PSs) and hypoxic tumor microenvironment. Here, an oxygen independent biomimetic nanoplatform based on carbon sphere dotted with cerium oxide and coated by cell membrane (MCSCe) was designed and synthesized with good biocompatibility, homologous targeting ability, and improved photophysical activity...
January 31, 2019: Biomaterials
https://read.qxmd.com/read/30714319/porous-cobalt-nickel-hydroxide-nanosheets-with-active-cobalt-ions-for-overall-water-splitting
#3
Xiao Wang, Zhe Li, De-Yao Wu, Gu-Rong Shen, Chengqin Zou, Yi Feng, Hui Liu, Cun-Ku Dong, Xi-Wen Du
Low-cost and high-performance catalysts are of great significance for electrochemical water splitting. Here, it is reported that a laser-synthesized catalyst, porous Co0.75 Ni0.25 (OH)2 nanosheets, is highly active for catalyzing overall water splitting. The porous nanosheets exhibit low overpotentials for hydrogen evolution reaction (95 mV@10 mA cm-2 ) and oxygen evolution reaction (235 mV@10 mA cm-2 ). As both anode and cathode catalysts, the porous nanosheets achieve a current density of 10 mA cm-2 at an external voltage of 1...
February 4, 2019: Small
https://read.qxmd.com/read/30711005/from-one-to-all-self-assembled-theranostic-nanoparticles-for-tumor-targeted-imaging-and-programmed-photoactive-therapy
#4
Xianlei Li, Xuan Wang, Caiyan Zhao, Leihou Shao, Jianqing Lu, Yujia Tong, Long Chen, Xinyue Cui, Huiling Sun, Junxing Liu, Mingjun Li, Xiongwei Deng, Yan Wu
BACKGROUND: In recent years, multifunctional theranostic nanoparticles have been fabricated by integrating imaging and therapeutic moieties into one single nano-formulations. However, Complexity of production and safety issues limits their further application. RESULTS: Herein, we demonstrated self-assembled nanoparticles with single structure as a "from one to all" theranostic platform for tumor-targeted dual-modal imaging and programmed photoactive therapy (PPAT)...
February 2, 2019: Journal of Nanobiotechnology
https://read.qxmd.com/read/30696249/the-effect-of-gold-nanoparticles-concentration-and-laser-fluence-on-the-laser-induced-water-decomposition
#5
Aleksander V Simakin, Maxim E Astashev, Ilya V Baimler, Oleg V Uvarov, Valery V Voronov, Maria V Vedunova, Mikhail A Sevost'yanov, Konstantin N Belosludtsev, Sergey Vladimirovich Gudkov
The article covers the influence of concentration of gold nanoparticles on laser-induced wated decomposition. It was established that addition of gold nanoparticles intensifies laser-induced water decomposition by almost two orders of magnitude. Water decomposition rate was shown to be maximal at nanoparticles concentration around 1010 NP/ml, whereas decrease or increase of nanoparticles concentration leads to decrease of water decomposition rate. It was demonstrated that if concentration of nanoparticles in water-based colloid was less than 1010 NP/ml, laser irradiation of the colloid caused formation of molecular hydrogen, hydrogen peroxide and molecular oxygen...
January 29, 2019: Journal of Physical Chemistry. B
https://read.qxmd.com/read/30668358/chidamide-induced-ros-accumulation-and-mir-129-3p-dependent-cell-cycle-arrest-in-non-small-lung-cancer-cells
#6
Yueh-Feng Wu, Chu-Chyn Ou, Peng-Ju Chien, Hui-Yi Chang, Jiunn-Liang Ko, Bing-Yen Wang
BACKGROUND: Epigenetic therapy is a promising popular treatment modality for various cancers. Histone modification and miRNA should not be underestimated in lung cancer. This study aimed to investigate whether chidamide, a histone deacetylase inhibitor (HDACi), which inhibits telomerase activity and induces cell cycle arrest, influences ROS and miRNA production in non-small cell lung cancer (NSCLC) cells. METHODS: H1355 and A549 were treated with chidamide. The analysis of DNA content was measured by FACSCalibur equipped with a 488 nm laser...
October 2, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://read.qxmd.com/read/30667014/titania-coated-2d-gold-nanoplates-as-nanoagents-for-synergistic-photothermal-sonodynamic-therapy-in-the-second-near-infrared-window
#7
Fengli Gao, Guangli He, Hang Yin, Jian Chen, Yibiao Liu, Chong Lan, Shouren Zhang, Baocheng Yang
The development of efficient nanomedicines to improve anticancer therapeutic effects is highly attractive. In this work, we firstly report titania-coated Au nanoplate (Au NPL@TiO2) heterostructures, which play dual roles as nanoagents for synergistic photothermal/sonodynamic therapy in the second near-infrared (NIR) window. On the one hand, because the controlled TiO2 shells endow the Au NPL@TiO2 nanostructures with a red shift to the NIR II region, the as-prepared Au NPL@TiO2 nanostructures possess a high photothermal conversion efficiency of 42...
January 22, 2019: Nanoscale
https://read.qxmd.com/read/30662560/enhancement-of-mitochondrial-ros-accumulation-and-radiotherapeutic-efficacy-using-a-gd-doped-titania-nanosensitizer
#8
Yuanyuan Chen, Na Li, Jianbo Wang, Xia Zhang, Wei Pan, Longhai Yu, Bo Tang
Radiotherapy is an extensively used treatment modality in the clinic and can kill malignant cells by generating cytotoxic reactive oxygen species (ROS). Unfortunately, excessive dosages of radiation are typically required because only a small proportion of the radiative energy is adsorbed by the soft tissues of a tumor, which results in the nonselective killing of normal cells and severe systemic side effects. An efficient nanosensitizer that makes cancer cells more sensitive to radiotherapy under a relatively low radiation dose would be highly desirable...
2019: Theranostics
https://read.qxmd.com/read/30658388/empirical-modeling-of-zn-zno-nanoparticles-decorated-conjugated-with-fotolon-chlorine-e6-based-photodynamic-therapy-towards-liver-cancer-treatment
#9
Seemab Iqbal, Muhammad Fakhar-E-Alam, M Atif, Nasar Ahmed, Aqrab -Ul-Ahmad, N Amin, Raed Ahmed Alghamdi, Atif Hanif, W Aslam Farooq
The current study is based on Zn/ZnO nanoparticles photodynamic therapy (PDT) mediated effects on healthy liver cells and cancerous cells. The synthesis of Zn/ZnO nanoparticles was accomplished using chemical and hydrothermal methods. The characterization of the synthesized nanoparticles was carried out using manifold techniques (e.g., transmission electron microscopy (TEM), X-ray diffraction (XRD), and energy dispersive X-ray spectroscopy (EDS)). In order to study the biotoxicity of the grown nanoparticles, they were applied individually and in conjunction with the third generation photosensitiser Fotolon (Chlorine e6) in the in vivo model of the normal liver of the Wister rat, and in the in vitro cancerous liver (HepG2) model both in the dark and under a variety of laser exposures (630 nm, Ultraviolet (UV) light)...
January 17, 2019: Micromachines
https://read.qxmd.com/read/30648639/cucurbit-7-uril-enhance-the-photosensitization-of-porphyrins-in-neuroblastoma-cells
#10
Xiaoyu Li, Xiao Bo, Yan Guo, Yan Xiao, Song Xiao
Neuroblastoma is the most common extracranial solid tumor of childhood. Advancements in treatments have improved survival rate of child suffering from this ailment. Novel therapeutic techniques may further reduce cancer related mortality. One of the several emerging therapeutic options is Photodynamic Therapy (PDT) that uses light activated photosensitizer (PS) inducing cell death by apoptosis and/or necrosis. Nanotechnology has contributed to improving photosensitizer for PDT, and increasing the efficiency of therapy using porphyrins and their derivatives...
January 12, 2019: Photodiagnosis and Photodynamic Therapy
https://read.qxmd.com/read/30648227/laser-ablation-generation-of-antimony-selenide-clusters-laser-desorption-ionization-ldi-quadrupole-ion-trap-time-of-flight-mass-spectrometry
#11
Fei Huang, Lubomír Prokeš, Josef Havel
The binary system Sb-Se was studied via laser ablation using antimony-selenium mixtures made from powdered elements in various ratios generating new Sbm Sen clusters. The results show that in addition to Sbm + (m = 1-8) and Sen + (n = 2-9) clusters, a series of Sbm Sen + clusters such as SbSe1-8 + , Sb2 Se1-6 + , Sb3 Se1-5 + , Sb4 Se1-3 + , and Sb5 Se1,2 + is generated. In addition, some low intensity oxidized clusters like Se6 O2 + , Se7 O2 + , and SbSe2-6 O5 + and partially hydroxylated clusters (SbSeO2 H7 + , SbSe5 O4 H+ ) are also formed...
January 15, 2019: Journal of the American Society for Mass Spectrometry
https://read.qxmd.com/read/30639569/pro-and-anti-oxidant-properties-of-near-infrared-nir-light-responsive-carbon-nanoparticles
#12
Ida Kokalari, Riccardo Gassino, Andrea M Giovannozzi, Luca Croin, Elena Gazzano, Enrico Bergamaschi, Andrea M Rossi, Guido Perrone, Chiara Riganti, Jessica Ponti, Ivana Fenoglio
Elemental carbon nanomaterials (ECNMs) are redox active agents that can be exploited to purposely modify the redox balance of cells. Both pro- or antioxidant properties have been reported. However, to the best of our knowledge, there are not comprehensive studies exploring both properties on the same material in view of a potential application in medicine. At the same time, the effect of the bulk structure on the pro/antioxidant properties is poorly known. Here, carbon nanoparticles (CNPs) derived by glucose with definite size and shape have been prepared, and their redox properties evaluated in cell free systems in the dark or following activation with a Near Infrared (NIR) laser beam (945nm, 1...
January 10, 2019: Free Radical Biology & Medicine
https://read.qxmd.com/read/30634697/new-oxidovanadium-iv-coordination-complex-containing-2-methylnitrilotriacetate-ligands-induces-cell-cycle-arrest-and-autophagy-in-human-pancreatic-ductal-adenocarcinoma-cell-lines
#13
Szymon Kowalski, Dariusz Wyrzykowski, Stanislaw Hac, Michal Rychlowski, Marek Witold Radomski, Iwona Inkielewicz-Stepniak
Pancreatic cancer is characterized by one of the lowest five-year survival rates. In search for new treatments, some studies explored several metal complexes as potential anticancer drugs. Therefore, we investigated three newly synthesized oxidovanadium(IV) complexes with 2-methylnitrilotriacetate (bcma3- ), N -(2-carbamoylethyl)iminodiacetate (ceida3- ) and N -(phosphonomethyl)-iminodiacetate (pmida4- ) ligands as potential anticancer compounds using pancreatic cancer cell lines. We measured: Cytotoxicity using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), neutral red (NR) and lactate dehydrogenase (LDH) assay; antiproliferative activity by bromodeoxyuridine BrdU assay; reactive oxygen species (ROS) generation and cell cycle analysis by flow cytometry; protein level by Western blot and cellular morphology by confocal laser scanning microscopy...
January 10, 2019: International Journal of Molecular Sciences
https://read.qxmd.com/read/30633400/bismuth-sulfide-nanorods-with-retractable-zinc-protoporphyrin-molecules-for-suppressing-innate-antioxidant-defense-system-and-strengthening-phototherapeutic-effects
#14
Yan Cheng, Yun Chang, Yanlin Feng, Hui Jian, Xiaqing Wu, Runxiao Zheng, Keqiang Xu, Haiyuan Zhang
Bismuth (Bi)-based nanomaterials (NMs) are widely used for computed tomography (CT) imaging guided photothermal therapy, however, the photodynamic property is hardly exhibited by these NMs due to the fast electron-hole recombination within their narrow bandgap. Herein, a sophisticated nanosystem is designed to endow bismuth sulfide (Bi2 S3 ) nanorods (NRs) with potent photodynamic property. Zinc protoporphyrin IX (ZP) is linked to Bi2 S3 NRs through a thermoresponsive polymer to form BPZP nanosystems. The stretching ZP could prebind to the active site of heme oxygenase-1 overexpressed in cancer cells, suppressing the cellular antioxidant defense capability...
January 11, 2019: Advanced Materials
https://read.qxmd.com/read/30624041/hypoxia-irrelevant-photonic-thermodynamic-cancer-nanomedicine
#15
Hui-Jing Xiang, Han Lin, Luodan Yu, Yu Chen
The hypoxic tumor microenvironment severely lowers the therapeutic efficacy of oxygen-dependent anticancer modalities because tumor hypoxia hinders the generation of toxic reactive oxygen species. Here we report a thermodynamic cancer-therapeutic modality that employs oxygen-irrelevant free radicals generated from thermo-labile initiators for inducing cancer-cell death. Free radical nanogenerator was engineered via direct growth of mesoporous silica layer onto the surface of two-dimensional Nb2C MXene nanosheets towards multifunctionality, where the mesopore provided the reservoirs for initiators and MXene core acted as the photonic-thermal trigger at near infrared-II biowindow (NIR-II)...
January 9, 2019: ACS Nano
https://read.qxmd.com/read/30620607/plasmonic-enhanced-oxygen-reduction-reaction-of-silver-graphene-electrocatalysts
#16
Fenglei Shi, Jing He, Baiyu Zhang, Jiaheng Peng, Yanling Ma, Wenlong Chen, Fan Li, Yong Qin, Yang Liu, Wen Shang, Peng Tao, Chengyi Song, Tao Deng, Xiaofeng Qian, Jian Ye, Jianbo Wu
Oxygen reduction reaction (ORR) is of paramount importance in polymer electrolyte membrane fuel cell (PEMFC) due to its sluggish kinetics. In this work, a plasmon-induced hot electrons enhancement (PIHEE) method is introduced to enhance ORR property of the silver (Ag)-based electrocatalysts. Three types of Ag nanostructures with differently localized surface plasmon resonances (LSPR) have been used as electrocatalysts. The thermal effect of plasmonic-enhanced ORR can be minimized in our work by using graphene as the support of Ag nanoparticles...
January 8, 2019: Nano Letters
https://read.qxmd.com/read/30601523/synthesis-and-antimicrobial-photodynamic-effect-of-methylene-blue-conjugated-carbon-nanotubes-on-e-coli-and-s-aureus
#17
Paramanantham Parasuraman, V T Anju, S B Sruthil Lal, Alok Sharan, Siddhardha Busi, K Kaviyarasu, Mohammed Arshad, Turki M S Dawoud, Asad Syed
Catheter-related bloodstream infections (CRBSIs) are one of the leading causes of high morbidity and mortality in hospitalized patients. The proper management, prevention and treatment of CRBSIs rely on the understanding of these highly resistant bacterial infections. The emergence of such a challenge to public health has resulted in the development of an alternative antimicrobial strategy called antimicrobial photodynamic therapy (aPDT). In the presence of a photosensitizer (PS), light of the appropriate wavelength, and molecular oxygen, aPDT generates reactive oxygen species (ROS) which lead to microbial cell death and cell damage...
January 2, 2019: Photochemical & Photobiological Sciences
https://read.qxmd.com/read/30599381/efficacy-of-photoactivated-myrciaria-cauliflora-extract-against-staphylococcus-aureus-infection-a-pilot-study
#18
Denisar Palmito Dos Santos, Diego Patrick Soares Lopes, Stefano Pedro de Melo Calado, Caroline Vieira Gonçalves, Igor Pereira Ribeiro Muniz, Israel Souza Ribeiro, Maria Poliana Leite Galantini, Robson Amaro Augusto da Silva
Staphylococcus aureus is one of the major microorganisms that cause human diseases, leading from mild skin infections to serious diseases. With the use of semi-synthetic penicillins, methicillin-resistant strains called Methicillin-resistant Staphylococcus aureus (MRSA) have emerged, whose resistance pattern extends to other beta-lactam antibiotics. It has already been shown that photodynamic therapy is capable of inactivating MRSA as the laser excites the photosensitizer responsible for transferring its electrons to the molecular oxygen, generating extremely reactive molecules, such as singlet oxygen, being these reactive components the chemicals that promote the bacterial clearance...
December 17, 2018: Journal of Photochemistry and Photobiology. B, Biology
https://read.qxmd.com/read/30597365/new-insights-into-mechanism-of-direct-uv-photolysis-of-p-arsanilic-acid
#19
Yuliya E Tyutereva, Petr S Sherin, Marina V Parkhats, Zizheng Liu, Jing Xu, Feng Wu, Victor F Plyusnin, Ivan P Pozdnyakov
The mechanism of direct UV photolysis of p-arsanilic acid (p-ASA), a widely used veterinary drug, was revised by means of laser flash photolysis coupled with high resolution liquid chromatography - mass spectrometry (LC-MS). None of p-ASA triplet state or singlet oxygen was found to directly participate in the photodegradation of p-ASA as it was assumed in previous works. Here we demonstrate that the main primary photoprocess is a monophotonic ionization (ϕion 266nm  = 0.032) leading to the formation of hydrated electron and corresponding anilinyl cation radical...
December 26, 2018: Chemosphere
https://read.qxmd.com/read/30589536/microwave-assisted-synthesis-of-black-titanium-monoxide-for-synergistic-tumor-phototherapy
#20
Gang Shu, Hong Wang, Xuejun Zhang
Black titanium oxide has attracted tremendous interest in tumor phototherapy via converting light energy to heat and reactive oxygen species (ROS). Nevertheless, current synthesis methods suffer from inert gas shielding, high costs, complicated procedures and expensive facilities, which are fairly impractical for treatment application. Herein, we propose a one-step strategy for fast facile synthesis of black TiO nanoparticles via a microwave-assisted hydrothermal synthesis approach with Ti power, hydrochloric acid and hydrofluoric acid without the requirement of reducing agent and high-temperature calcination...
December 27, 2018: ACS Applied Materials & Interfaces
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