Zhaoyang Qian, Junbo Liang, Rong Huang, Wei Song, Jianming Ying, Xinyu Bi, Jianjun Zhao, Zhenyu Shi, Wenjie Liu, Jianmei Liu, Zhiyu Li, Jianguo Zhou, Zhen Huang, Yefan Zhang, Dongbing Zhao, Jianxiong Wu, Liming Wang, Xiao Chen, Rui Mao, Yanchi Zhou, Lei Guo, Hanjie Hu, Dazhuang Ge, Xingchen Li, Zhiwen Luo, Jinjie Yao, Tengyan Li, Qichen Chen, Bingzhi Wang, Zhewen Wei, Kun Chen, Chunfeng Qu, Jianqiang Cai, Yuchen Jiao, Li Bao, Hong Zhao
OBJECTIVE: Hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC), mostly characterised by HBV integrations, is prevalent worldwide. Previous HBV studies mainly focused on a few hotspot integrations. However, the oncogenic role of the other HBV integrations remains unclear. This study aimed to elucidate HBV integration-induced tumourigenesis further. DESIGN: Here, we illuminated the genomic structures encompassing HBV integrations in 124 HCCs across ages using whole genome sequencing and Nanopore long reads...
February 23, 2024: Gut