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https://read.qxmd.com/read/30870031/effect-of-low-intensity-pulsed-ultrasound-after-autologous-adipose-derived-stromal-cell-transplantation-for-bone-tendon-healing-in-a-rabbit-model
#1
Can Chen, Tao Zhang, Fei Liu, Jin Qu, Yang Chen, Silong Fan, Huabin Chen, Lunquan Sun, Chunfeng Zhao, Jianzhong Hu, Hongbin Lu
BACKGROUND: Low-intensity pulsed ultrasound (LIPUS), as a safe biophysiotherapy, can enhance bone-tendon (B-T) healing in vivo and induce osteogenic or chondrogenic differentiation of mesenchymal stromal cells in vitro. This study aimed to determine whether LIPUS can improve the efficacy of transplanted mesenchymal stromal cells on B-T healing. HYPOTHESIS: LIPUS can induce lineage-specific differentiation of transplanted adipose-derived stromal cells (ASCs) at the B-T healing site, thus resulting in superior healing quality when compared with LIPUS or ASCs alone...
March 2019: American Journal of Sports Medicine
https://read.qxmd.com/read/30858324/detection-of-early-stage-hepatocellular-carcinoma-in-asymptomatic-hbsag-seropositive-individuals-by-liquid-biopsy
#2
Chunfeng Qu, Yuting Wang, Pei Wang, Kun Chen, Minjie Wang, Hongmei Zeng, Jianquan Lu, Qianqian Song, Bill H Diplas, Da Tan, Chunsun Fan, Qigao Guo, Zheng Zhu, Huihui Yin, Liping Jiang, Xixi Chen, Hui Zhao, Huan He, Yong Wang, Guangyu Li, Xinyu Bi, Xinming Zhao, Taoyang Chen, Hongping Tang, Chuanguo Lv, Dongmei Wang, Wanqing Chen, Jianguo Zhou, Hong Zhao, Jianqiang Cai, Xiaoyue Wang, Sizhen Wang, Hai Yan, Yi-Xin Zeng, Webster K Cavenee, Yuchen Jiao
Liquid biopsies, based on cell free DNA (cfDNA) and proteins, have shown the potential to detect early stage cancers of diverse tissue types. However, most of these studies were retrospective, using individuals previously diagnosed with cancer as cases and healthy individuals as controls. Here, we developed a liquid biopsy assay, named the hepatocellular carcinoma screen (HCCscreen), to identify HCC from the surface antigen of hepatitis B virus (HBsAg) positive asymptomatic individuals in the community population...
March 11, 2019: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/30811208/optical-gain-from-biexcitons-in-cspbbr-3-nanocrystals-revealed-by-two-dimensional-electronic-spectroscopy
#3
Wei Zhao, Zhengyuan Qin, Chunfeng Zhang, Guodong Wang, Xinyu Huang, Bin Li, Xingcan Dai, Min Xiao
Perovskite semiconductor nanocrystals (NCs) exhibit highly efficient optical gain which is promising for laser applications. However, the intrinsic mechanism of optical gain in perovskite NCs, particularly whether more than one exciton per NCs is required, remains to be poorly understood. Here, we use two-dimensional electronic spectroscopy to resonantly probe the interplay between near-band-edge transitions during the buildup of optical gain in CsPbBr3 NCs. We find compelling evidences to conclude that optical gain in CsPbBr3 NCs is generated through stimulated emission from strongly-interacting biexcitons...
February 27, 2019: Journal of Physical Chemistry Letters
https://read.qxmd.com/read/30792111/calculation-of-flexor-pollicis-longus-moment-arm-for-wrist-motion-in-a-cadaver-model-validates-the-tenodesis-effect-for-therapy
#4
Andrew R Thoreson, Patricia O Rappaport, Tai-Hua Yang, Ramona L Reisdorf, Chunfeng Zhao, Kai-Nan An, Peter C Amadio
INTRODUCTION: Synergies of fingers and wrist motion have been incorporated into therapies for finger flexor tendon injuries to improve repair outcomes. Similar synergistic therapy strategies have not been well documented for the thumb. PURPOSE OF THE STUDY: The purpose of this study was to investigate the extent to which wrist motion enables a synergistic effect at the thumb in a cadaveric model by measuring flexor pollicis longus excursion and calculating the moment arm of this tendon at the wrist joint...
February 18, 2019: Journal of Hand Therapy: Official Journal of the American Society of Hand Therapists
https://read.qxmd.com/read/30620556/book-shaped-acellular-fibrocartilage-scaffold-with-cell-loading-capability-and-chondrogenic-inducibility-for-tissue-engineered-fibrocartilage-and-bone-tendon-healing
#5
Can Chen, Fei Liu, Yifu Tang, Jin Qu, Yong Cao, Cheng Zheng, Yang Chen, Muzhi Li, Chunfeng Zhao, Lunquan Sun, Jianzhong Hu, Hongbin Lu
Functional fibrocartilage regeneration is a bottleneck during bone-tendon healing, and the currently available tissue-engineering strategies for fibrocartilage regeneration are insufficient because of a lack of appropriate scaffold that can load large seeding-cells and induce chondrogenesis of stem cells. The acellular fibrocartilage scaffold (AFS) contains active growth factors as well as tissue-specific epitopes for cell-matrix interactions, which make it a potential scaffold for tissue-engineered fibrocartilage...
January 8, 2019: ACS Applied Materials & Interfaces
https://read.qxmd.com/read/30616627/tumor-associated-neutrophils-induce-emt-by-il-17a-to-promote-migration-and-invasion-in-gastric-cancer-cells
#6
Sen Li, Xiliang Cong, Hongyu Gao, Xiuwen Lan, Zhiguo Li, Wenpeng Wang, Shubin Song, Yimin Wang, Chunfeng Li, Hongfeng Zhang, Yingwei Xue, Yuzhou Zhao
PURPOSE: Epithelial to mesenchymal transition (EMT) can contribute to gastric cancer (GC) progression and recurrence following therapy. Tumor-associated neutrophils (TANs) are associated with poor outcomes in a variety of cancers. However, it is not clear whether TANs interact with the EMT process during GC development. METHODS: Immunohistochemistry was performed to examine the distribution and levels of CD66 + neutrophils in samples from 327 patients with GC...
January 7, 2019: Journal of Experimental & Clinical Cancer Research: CR
https://read.qxmd.com/read/30600683/copper-catalyzed-c4-h-regioselective-phosphorylation-trifluoromethylation-of-free-1-naphthylamines
#7
Chunfeng Jing, Xiaolan Chen, Kai Sun, Yongkang Yang, Tong Chen, Yan Liu, Lingbo Qu, Yufen Zhao, Bing Yu
A novel and facile copper-catalyzed synthetic methodology was developed to access a large variety of 4-phosphoryl-substituted 1-naphthylamines by reacting various 1-naphthylamines with different diarylphosphine oxides in the presence of Cu(OAc)2 and Ag2 CO3 in one pot under mild reaction conditions. This copper-catalyzed synthetic system was also suitable for being employed to synthesize 4-trifluoromethyl-substituted 1-naphthylamines by reacting various 1-naphthylamines with Togni's reagent in the presence of CuI and NaOAc in DMSO in one pot under mild reaction conditions...
January 2, 2019: Organic Letters
https://read.qxmd.com/read/30548886/isolation-and-characterization-of-turkey-bone-marrow-derived-mesenchymal-stem-cells
#8
Qian Liu, Yaxi Zhu, Jun Qi, Peter C Amadio, Steven L Moran, Anne Gingery, Chunfeng Zhao
Flexor tendon injury is often associated with suboptimal outcomes and results in substantial digit dysfunction. Stem cells have been isolated from several experimental animals for the growing interest and needs of utilizing cell-based therapies. Recently, turkey has been developed as a new large animal model for flexor tendon research. In the present study, we reported the isolation and characterization of bone marrow-derived mesenchymal stem cells (BMSCs) from 8- to 12-month-old heritage-breed turkeys. The isolated cells demonstrated fibroblast-like morphology, clonogenic capacity, and high proliferation rate...
December 13, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://read.qxmd.com/read/30546860/yatcm-yet-another-traditional-chinese-medicine-database-for-drug-discovery
#9
Baiqing Li, Chunfeng Ma, Xiaoyong Zhao, Zhigang Hu, Tengfei Du, Xuanming Xu, Zhonghua Wang, Jianping Lin
Traditional Chinese Medicine (TCM) has a long history of widespread clinical applications, especially in East Asia, and is becoming frequently used in Western countries. However, owing to extreme complicacy in both chemical ingredients and mechanism of action, a deep understanding of TCM is still difficult. To accelerate the modernization and popularization of TCM, a single comprehensive database is required, containing a wealth of TCM-related information and equipped with complete analytical tools. Here we present YaTCM (Yet another Traditional Chinese Medicine database), a free web-based toolkit, which provides comprehensive TCM information and is furnished with analysis tools...
2018: Computational and Structural Biotechnology Journal
https://read.qxmd.com/read/30534374/efficacy-and-safety-of-rasagiline-in-chinese-patients-with-early-parkinson-s-disease-a-randomized-double-blind-parallel-placebo-controlled-fixed-dose-study
#10
Zhenxin Zhang, Jian Wang, Shengdi Chen, Chunfeng Liu, Baorong Zhang, Rong Peng, Shenggang Sun, Xiangru Sun, Gang Zhao, Qiumin Qu, Yansheng Li, Suiqiang Zhu, Xiaoping Pan, Ming Shao, Yanping Wang
Background: Rasagiline is a monoamine oxidase-B inhibitor used for Parkinson's disease (PD) treatment, but its effectiveness on Chinese patients is unclear. This study aimed to evaluate the efficacy and safety of rasagiline monotherapy in Chinese patients with early PD. Methods: A 26-weeks, randomized, double-blind, placebo-controlled study has been performed at 15 sites in China and enrolled outpatients (≥35 years old) with idiopathic PD without a history of using any dopaminergic drugs...
2018: Translational Neurodegeneration
https://read.qxmd.com/read/30459653/a-community-based-addiction-rehabilitation-electronic-system-to-improve-treatment-outcomes-in-drug-abusers-protocol-for-a-randomized-controlled-trial
#11
Zhe Wang, Shujuan Chen, Junning Chen, Chunfeng Xu, Zhikang Chen, Wenxu Zhuang, Xu Li, Min Zhao, Jiang Haifeng
Introduction: Relapse is very common in drug abusers and contributes to a series of negative consequences. Effective addiction treatment exists but there are some problems in the implementation process. Mobile health (mHealth) offers a potential solution to improving recovery outcome for drug abusers in the community. The research team developed a community-based addiction rehabilitation electronic system (CAREs). The primary aim of this study is to explore whether the integrated rehabilitation based on program CAREs promotes drug abusers to keep abstinence...
2018: Frontiers in Psychiatry
https://read.qxmd.com/read/30453215/engineered-tendon-fibrocartilage-bone-composite-and-bone-marrow-derived-mesenchymal-stem-cell-sheet-augmentation-promotes-rotator-cuff-healing-in-a-non-weight-bearing-canine-model
#12
Qian Liu, Yinxian Yu, Ramona L Reisdorf, Jun Qi, Chun-Kuan Lu, Lawrence J Berglund, Peter C Amadio, Steven L Moran, Scott P Steinmann, Kai-Nan An, Anne Gingery, Chunfeng Zhao
Reducing rotator cuff failure after repair remains a challenge due to suboptimal tendon-to-bone healing. In this study we report a novel biomaterial with engineered tendon-fibrocartilage-bone composite (TFBC) and bone marrow-derived mesenchymal stem cell sheet (BMSCS); this construct was tested for augmentation of rotator cuff repair using a canine non-weight-bearing (NWB) model. A total of 42 mixed-breed dogs were randomly allocated to 3 groups (n = 14 each). Unilateral infraspinatus tendon underwent suture repair only (control); augmentation with engineered TFBC alone (TFBC), or augmentation with engineered TFBC and BMSCS (TFBC + BMSCS)...
October 29, 2018: Biomaterials
https://read.qxmd.com/read/30333476/zika-virus-shedding-in-the-stool-and-infection-through-the-anorectal-mucosa-in-mice
#13
Chunfeng Li, Yong-Qiang Deng, Shulong Zu, Natalie Quanquin, Jingzhe Shang, Min Tian, Xue Ji, Na-Na Zhang, Hao-Long Dong, Yan-Peng Xu, Ling-Zhai Zhao, Fu-Chun Zhang, Xiao-Feng Li, Aiping Wu, Genhong Cheng, Cheng-Feng Qin
Zika virus (ZIKV) has elicited global concern due to its unique biological features, unusual transmission routes, and unexpected clinical outcomes. Although ZIKV transmission through anal intercourse has been reported in humans, it remains unclear if ZIKV is detectable in the stool, if it can infect the host through the anal canal mucosa, and what the pathogenesis of such a route of infection might be in the mouse model. Herein, we demonstrate that ZIKV RNA can be recovered from stools in multiple mouse models, as well as from the stool of a ZIKV patient...
October 17, 2018: Emerging Microbes & Infections
https://read.qxmd.com/read/30243295/triamcinolone-acetonide-affects-tgf-%C3%AE-signaling-regulation-of-fibrosis-in-idiopathic-carpal-tunnel-syndrome
#14
Tai-Hua Yang, Anne Gingery, Andrew R Thoreson, Dirk R Larson, Chunfeng Zhao, Peter C Amadio
BACKGROUND: Fibroblast behavior and cell-matrix interactions of cells from normal and idiopathic carpal tunnel syndrome (CTS) subsynovial connective tissue (SSCT) with and without Triamcinolone Acetonide (TA) were compared in this study. A cell-seeded gel contraction model was applied to investigate the effect of steroid treatment on SSCT fibroblast gene expression and function. METHODS: SSCT cells were obtained from CTS patients and fresh cadavers. Cells were isolated by mechanical and collagenase digestion...
September 22, 2018: BMC Musculoskeletal Disorders
https://read.qxmd.com/read/30242176/new-transgenic-nis-reporter-rats-for-longitudinal-tracking-of-fibrogenesis-by-high-resolution-imaging
#15
Bethany Brunton, Lukkana Suksanpaisan, Hongtao Li, Qian Liu, Yinxian Yu, Alyssa Vrieze, Lianwen Zhang, Nathan Jenks, Huailei Jiang, Timothy R DeGrado, Chunfeng Zhao, Stephen J Russell, Kah-Whye Peng
Fibrogenesis is the underlying mechanism of wound healing and repair. Animal models that enable longitudinal monitoring of fibrogenesis are needed to improve traditional tissue analysis post-mortem. Here, we generated transgenic reporter rats expressing the sodium iodide symporter (NIS) driven by the rat collagen type-1 alpha-1 (Col1α1) promoter and demonstrated that fibrogenesis can be visualized over time using SPECT or PET imaging following activation of NIS expression by rotator cuff (RC) injury. Radiotracer uptake was first detected in and around the injury site day 3 following surgery, increasing through day 7-14, and declining by day 21, revealing for the first time, the kinetics of Col1α1 promoter activity in situ...
September 21, 2018: Scientific Reports
https://read.qxmd.com/read/30228241/treatment-of-human-glioblastoma-with-a-live-attenuated-zika-virus-vaccine-candidate
#16
Qi Chen, Jin Wu, Qing Ye, Feng Ma, Qian Zhu, Yan Wu, Chao Shan, Xuping Xie, Dapei Li, Xiaoyan Zhan, Chunfeng Li, Xiao-Feng Li, Xiaoling Qin, Tongyang Zhao, Haitao Wu, Pei-Yong Shi, Jianghong Man, Cheng-Feng Qin
Glioblastoma (GBM) is the deadliest type of brain tumor, and glioma stem cells (GSCs) contribute to tumor recurrence and therapeutic resistance. Thus, an oncolytic virus targeting GSCs may be useful for improving GBM treatment. Because Zika virus (ZIKV) has an oncolytic tropism for infecting GSCs, we investigated the safety and efficacy of a live attenuated ZIKV vaccine candidate (ZIKV-LAV) for the treatment of human GBM in a GSC-derived orthotopic model. Intracerebral injection of ZIKV-LAV into mice caused no neurological symptoms or behavioral abnormalities...
September 18, 2018: MBio
https://read.qxmd.com/read/30211918/first-principles-study-of-anion-diffusion-in-lead-free-halide-double-perovskites
#17
Chunfeng Lan, Shuai Zhao, Jingting Luo, Ping Fan
Halide ion diffusion in organolead halide perovskites has raised great concern in recent years and been considered as the reason for the hysteresis of current-voltage curves and degradation of perovskite solar cells. In this work, X-site halide ion diffusion in lead-free double perovskites Cs2 AgBiX6 (X = Cl, Br), Cs2 AgSbCl6 and Cs2 AgInCl6 is investigated by first-principles calculations. The formation energies of X-site vacancies are calculated for these double perovskites, and predicted to be related to the electronic configurations of B-site cations...
October 7, 2018: Physical Chemistry Chemical Physics: PCCP
https://read.qxmd.com/read/29993698/drpocs-drug-repositioning-based-on-projection-onto-convex-sets
#18
Yin-Ying Wang, Chunfeng Cui, Liqun Qi, Hong Yan, Xingming Zhao
Drug repositioning, i.e. identifying new indications for known drugs, has attracted a lot of attentions recently and is becoming an effective strategy in drug development. In literature, several computational approaches have been proposed to identify potential indications of old drugs based on various types of data sources. In this paper, by formulating the drug-disease associations as a low-rank matrix, we propose a novel method, namely DrPOCS, to identify candidate indications of old drugs based on projection onto convex sets (POCS)...
April 26, 2018: IEEE/ACM Transactions on Computational Biology and Bioinformatics
https://read.qxmd.com/read/29988514/adjunct-rasagiline-to-treat-parkinson-s-disease-with-motor-fluctuations-a-randomized-double-blind-study-in-china
#19
Zhenxin Zhang, Ming Shao, Shengdi Chen, Chunfeng Liu, Rong Peng, Yansheng Li, Jian Wang, Suiqiang Zhu, Qiumin Qu, Xiaoying Zhang, Haibo Chen, Xiangru Sun, Yanping Wang, Shenggang Sun, Baorong Zhang, Jimei Li, Xiaoping Pan, Gang Zhao
Background: The use of adjunct rasagiline in levodopa-treated patients with Parkinson's disease and motor fluctuations is supported by findings from large-scale clinical studies. This study is to investigate the efficacy and safety of adjunct rasagiline in Chinese patients with Parkinson's disease, as a product registration study. Methods: This 16-week, randomized, double-blind, parallel-group, multicenter, placebo-controlled study of rasagiline 1 mg/day included levodopa-treated patients with Parkinson's disease and motor fluctuations...
2018: Translational Neurodegeneration
https://read.qxmd.com/read/29977306/isolation-and-characterization-of-multipotent-turkey-tendon-derived-stem-cells
#20
Qian Liu, Yaxi Zhu, Peter C Amadio, Steven L Moran, Anne Gingery, Chunfeng Zhao
Tendon injuries are among the most common and severe hand injuries with a high demand for functional recovery. Stem cells have been identified and isolated from different species and a variety of tissues for the sake of regenerative medicine. Recently, turkey has been suggested as a potential new large animal model for flexor tendon-related research. However, turkey tissue-specific stem cells have not been investigated. Here, we presented the isolation and verification of tendon-derived stem cells (TDSCs) from 6- to 8-month-old heritage-breed turkey...
2018: Stem Cells International
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