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Urinary bladder cancers

François Audenet, Kyrollis Attalla, Morgane Giordano, John Pfail, Marc A Lubin, Nikhil Waingankar, Daniel Gainsburg, Ketan K Badani, Alan Sim, John P Sfakianos
OBJECTIVES: To evaluate the feasibility and outcomes of a nonopioid (NOP) perioperative pain management protocol for patients undergoing robot-assisted radical cystectomy (RARC). MATERIALS AND METHODS: We prospectively included 52 consecutive patients undergoing RARC at our institution for bladder cancer. Patients received a multimodal pain management protocol, including a combination of nonopioid pain medications and regional anesthesia. For comparison, we retrospectively included 41 consecutive patients who received the same procedure before implementation of the NOP protocol...
February 15, 2019: Urologic Oncology
Michael Chao, Daryl Lim Joon, Vincent Khoo, Sandra Spencer, Huong Ho, Mario Guerrieri, Farshad Foroudi, Damien Bolton
INTRODUCTION: This is a retrospective study conducted to report the tumor control and late toxicity outcomes of patients with intermediate-risk prostate cancer undergoing combination external beam radiation therapy and low dose rate brachytherapy (LDR-PB). METHODS AND MATERIALS: Thirty-one patients received 45 Gray (Gy) of external beam radiation therapy to the prostate and seminal vesicles, together with a brachytherapy boost via a transperineal prostate implant of I125 (108 Gy)...
March 2019: Journal of Medical Imaging and Radiation Sciences
S Spampinato, L Fokdal, E Marinovskij, S Axelsen, E M Pedersen, R Pötter, J C Lindegaard, K Tanderup
PURPOSE: To provide an analysis of dose distribution in sub-structures that could be responsible for urinary toxicity after Image-Guided Adaptive BrachyTherapy (IGABT) in Locally Advanced Cervical Cancer (LACC). METHODS: 105 LACC patients treated with radiochemotherapy and IGABT were selected. Sub-structures (bladder wall, trigone, bladder neck, urethra) were contoured on IGABT-planning MRIs. D2cm3 and D0.1cm3 , ICRU Bladder-Point (ICRU BP) and Posterior-Inferior Border of Symphysis points (PIBS, PIBS + 2 cm, PIBS - 2 cm) doses were extracted...
February 13, 2019: Physica Medica: PM
Francesco A Mistretta, Elio Mazzone, Sophie Knipper, Carlotta Palumbo, Zhe Tian, Sebastiano Nazzani, Fred Saad, Emanuele Montanari, Derya Tilki, Alberto Briganti, Shahrokh F Shariat, Ottavio de Cobelli, Pierre I Karakiewicz
BACKGROUND: We analysed contemporary pelvic lymph node dissection (PLND) trend during radical cystectomy (RC) for urothelial carcinoma of urinary bladder (UCUB), as well as PLND association with cancer specific mortality (CSM) and complications after stratification according to octogenarian vs. younger age. MATERIALS AND METHODS: Within the SEER and NIS databases, respectively 10,427 (T2 and T3 stages) and 19,203 (all T-stages) RC patients (2004-2015) for UCUB were identified...
February 13, 2019: Cancer Epidemiology
Ruth Montalbo, Juan J Lozano, Laura Izquierdo, Mercedes Ingelmo-Torres, Carmen BaÑos, Joan Palou, Antoine G Van der Heijden, Rafael Medina, Joerg Schmidbauer, Aleix Prat, Maria J Ribal, Antonio Alcaraz, Lourdes Mengual
This study aimed to improve our previous urine gene expression classifiers focusing on the detection of non-high-risk non-muscle-invasive bladder cancer (NMIBC), and develop a new classifier able to decrease the frequency of cystoscopies during bladder cancer (BC) patients' surveillance. A total of 597 urines from BC patients, controls and patients in follow-up for BC (PFBC) were included. The study has 3 phases. In the urinary biomarker discovery phase, 84 urines from BC and control patients were retrospectively included and analyzed by RNA sequencing...
February 7, 2019: Translational Research: the Journal of Laboratory and Clinical Medicine
Lai Xu, Zhi-Yan Tao, Jun-Yang Lu, Guan-Nan Zhang, Hui-Zhong Qiu, Bin Wu, Guo-Le Lin, Tao Xu, Yi Xiao
BACKGROUND: Urinary catheter placement is essential before laparoscopic anterior resection for rectal cancer. Whether early removal of the catheter increases the incidence of urinary retention and urinary tract infection (UTI) is not clear. This study aims to determine the optimal time for removal of the urinary catheter after laparoscopic anterior resection of the rectum. METHODS/DESIGN: A total of 220 participants meeting the inclusion criteria will be randomly assigned to an experimental group or a control group...
February 15, 2019: Trials
Eline Oeyen, Lucien Hoekx, Stefan De Wachter, Marcella Baldewijns, Filip Ameye, Inge Mertens
Diagnostic methods currently used for bladder cancer are cystoscopy and urine cytology. Cystoscopy is an invasive tool and has low sensitivity for carcinoma in situ. Urine cytology is non-invasive, is a low-cost method, and has a high specificity but low sensitivity for low-grade urothelial tumors. Despite the search for urinary biomarkers for the early and non-invasive detection of bladder cancer, no biomarkers are used at the present in daily clinical practice. Extracellular vesicles (EVs) have been recently studied as a promising source of biomarkers because of their role in intercellular communication and tumor progression...
February 14, 2019: International Journal of Molecular Sciences
Yue-Peng Cao, Jing-Ya Sun, Mei-Qian Li, Yu Dong, Yuan-Heng Zhang, Jun Yan, Rui-Min Huang, Xiang Yan
Urinary bladder cancer (UBC) is characterized by frequent recurrence and metastasis despite the standard chemotherapy with gemcitabine and cisplatin combination. Histone modifiers are often dysregulated in cancer development, thus they can serve as an excellent drug targets for cancer therapy. Here, we investigated whether G9a, one of the histone H3 methyltransferases, was associated with UBC development. We first analyzed clinical data from public databases and found that G9a was significantly overexpressed in UBC patients...
February 14, 2019: Acta Pharmacologica Sinica
Deborah W Bruner, Stephanie L Pugh, W Robert Lee, James J Dignam, Daniel Low, Gregory P Swanson, Amit B Shah, Shawn Malone, Jeff M Michalski, Ian S Dayes, Samantha A Seaward, Paul L Nguyen, William A Hall, Thomas M Pisansky, Yuhchyau Chen, Howard M Sandler, Benjamin Movsas
Importance: Hypofractionated radiotherapy (HRT) would be more convenient for men with low-risk prostate cancer and cost less than conventional radiotherapy (CRT) as long as HRT is noninferior to CRT in terms of survival and quality of life (QOL) is not found to be worse. Objective: To assess differences in QOL between men with low-risk prostate cancer who are treated with HRT vs CRT. Design, Setting, and Participants: In this phase 3 randomized clinical trial, men with low-risk prostate cancer were enrolled from sites within the National Cancer Institute's National Clinical Trials Network in the United States, Canada, and Switzerland...
February 14, 2019: JAMA Oncology
Aurash Naser-Tavakolian, Saum Ghodoussipour, Hooman Djaladat
PURPOSE OF REVIEW: Our aim is to review recent investigations into the recurrence of urothelial carcinoma in the upper urinary tract following bladder cancer therapy focusing on surveillance and management. RECENT FINDINGS: After radical cystectomy, rates of recurrence in the upper tract are between 0.75 and 6.4%. The poor prognosis of upper tract urothelial carcinoma (UTUC) is in part attributable to delayed diagnosis. Guidelines recommend a gradual de-escalation of surveillance in disease-free patients with the potential for discontinuation beyond 5 years...
February 11, 2019: Current Opinion in Urology
T N Musayev, F A Guliev
AIM: To investigate the rates, types and risk factors for intraoperative complications in patients with bladder cancer undergoing radical cystectomy with various types of urinary diversions. MATERIAL AND METHODS: The study comprised 257 patients, including 241 (93.8%) men and 16 (6.2%) women who underwent radical cystectomy. The mean age of the patients was 58.5 (37-81) years. The analysis included intraoperative blood loss and blood transfusion, the rates of vascular, rectum and nerve injury, and operative time as a function of type of urinary diversion and cystectomy, the type of surgery, tumor stage (pT and pN), body mass index, and the total number of radical cystectomies performed by the surgical team...
October 2018: Urologii︠a︡
Malgorzata Maj, Anna Kokocha, Anna Bajek, Tomasz Drewa
Mesenchymal stem cells (MSCs) hold great promise as therapeutic agents in regenerative medicine. They are also considered as a preferred cell source for urinary tract reconstruction. However, as MSCs exhibit affinity to tumor microenvironment, possible activation of tumor-initiating cells remains a major concern in the application of stem cell-based therapies for patients with a bladder cancer history. To analyze the influence of adipose-derived stem cells (ASCs) on bladder cancer cells with stem cell-like properties, we isolated CD133-positive bladder cancer cells and cultured them in conditioned medium from ASCs (ASC-CM)...
February 11, 2019: Journal of Cellular Biochemistry
Hikaru Ihira, Norie Sawada, Taiki Yamaji, Atsushi Goto, Taichi Shimazu, Manami Inoue, Motoki Iwasaki, Shoichiro Tsugane
BACKGROUND: Although physical activity has been reported as a protective factor for kidney and bladder cancer in epidemiological studies, it is not clear. METHODS: In a population-based prospective study of 76,795 Japanese aged 45-74 years, participants were evaluated physical activity by self-administered questionnaire. Hazard ratios (HRs) and 95% confidence intervals (CIs) of the risk of urological cancer were calculated by the Cox proportional hazards models...
February 12, 2019: British Journal of Cancer
I A Aboyan, V E Aboyan, Yu N Orlov, S M Pakus, D I Pakus
AIM: Radical treatment of prostate cancer (PCa) is often associated with the development of urinary incontinence (UI). The etiology of UI after prostatectomy is multifactorial and can be caused by both urethral sphincter deficiency and bladder dysfunction. To date, there are no comparative studies of the development of UI in patients after either organ-preserving treatment or radical prostatectomy (RP). Considering this fact, our aim was to carry out the comparative assessment of urodynamic changes in these categories of patients...
December 2018: Urologii︠a︡
Fatai Oluyadi, Preethi Ramachandran, Vladmir Gotlieb
Female urethral diverticular cancer is a very rare entity with only around 100 cases reported so far in literature and accounts for <1% of all malignancies. In this article, we present a 47-year-old African American female with repeated hospital visits for urinary retention, hematuria, and urinary tract infections. Initial computed tomography imaging and cystoscopy was unremarkable except for a distended urinary bladder. Subsequent magnetic resonance imaging and corresponding cystoscopy eventually indicated the presence of a urethral diverticulum...
January 2019: Journal of Investigative Medicine High Impact Case Reports
Kavitha Donthiboina, Pratibha Anchi, P V Sri Ramya, Shailaja Karri, Gannoju Srinivasulu, Chandraiah Godugu, Nagula Shankaraiah, Ahmed Kamal
A new series of biphenyl methylene indolinones has been designed, synthesized and evaluated for their in vitro antiproliferative activity against various cancer cell lines like DU-145 (prostate cancer cell line), 4T1 (mouse breast cancer cell line), MDA-MB-231 (human breast cancer cell line), BT-549 (human breast cancer cell line), T24 (human urinary bladder carcinoma cell line), and HeLa (cervical cancer cell line). Among the series, compound 10e showed potent in vitro cytotoxic activity against HeLa and DU-145 cancer cell lines with IC50 value of 1...
January 29, 2019: Bioorganic Chemistry
Eugenia Mylona, Oscar Acosta, Thibaut Lizee, Caroline Lafond, Gilles Crehange, Nicolas Magné, Sophie Chiavassa, Stéphane Supiot, Juan David Arango Ospina, Borris Campillo-Gimenez, Joel Castelli, Renaud de Crevoisier
BACKGROUND AND PURPOSE: To apply a voxel-based analysis to identify urethro-vesical symptom-related subregions (SRSs) associated with acute and late urinary toxicity in prostate cancer radiotherapy. MATERIALS AND METHODS: A total of 272 prostate cancer patients treated with IMRT/IGRT were prospectively analyzed. Each patient's CT was spatially normalized to a common coordinate system (CCS) via nonrigid registration. The obtained deformation fields were used to map the dose of each patient to the CCS...
February 1, 2019: International Journal of Radiation Oncology, Biology, Physics
Jessica A Lavery, Allison Lipitz-Snyderman, Diane G Li, Peter B Bach, Katherine S Panageas
PURPOSE: Medicare claims provide a rich data source for large-scale quality assessment because data are available for all beneficiaries nationally. For cancer surgery, the absence of information regarding site of cancer and date of diagnosis on an administrative claim necessitates testing to ensure accurate quality assessment and public reporting. METHODS: Using the SEER Medicare-linked database as the gold standard, we developed and tested an approach to identify cancer-directed surgeries from Medicare fee-for-service claims alone...
February 2019: JCO Clinical Cancer Informatics
Chia-Hung Huang, Ying-Hsiang Chou, Han-Wei Yeh, Jing-Yang Huang, Shun-Fa Yang, Chao-Bin Yeh
To investigate the association among lower urinary tract infection (UTI), the type and timing of antibiotic usage, and the subsequent risk of developing cancers, especially genitourinary cancers (GUC), in Taiwan. This retrospective population-based cohort study was conducted using 2009⁻2013 data from the Longitudinal Health Insurance Database. This study enrolled patients who were diagnosed with a UTI between 2010 and 2012. A 1:2 propensity score-matched control population without UTI served as the control group...
January 30, 2019: International Journal of Environmental Research and Public Health
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