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8 arm radial maze

Barbara Shukitt-Hale, Nopporn Thangthaeng, Marshall G Miller, Shibu M Poulose, Amanda N Carey, Derek R Fisher
Daily supplementation of blueberries (BBs) reverses age-related deficits in behavior in aged rats. However, it is unknown whether BB is more beneficial to one subset of the population dependent on baseline cognitive performance and inflammatory status. To examine the effect of individual differences on the efficacy of BB, aged rats (17 mo old) were assessed for cognition in the radial arm water maze (RAWM) and divided into good, average, and poor performers based on navigation errors. Half of the rats in each cognitive group were then fed a control or a 2% BB diet for 8 weeks before re-testing...
February 17, 2019: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
Seung Ah Choi, Sangjoon Chong, Pil Ae Kwak, Youn Joo Moon, Anshika Jangra, Ji Hoon Phi, Ji Yeoun Lee, Sung-Hye Park, Seung-Ki Kim
OBJECTIVEEndothelial colony-forming cells (ECFCs) isolated from pediatric patients with moyamoya disease (MMD) have demonstrated decreased numbers and defective functioning in in vitro experiments. However, the function of ECFCs has not been evaluated using in vivo animal models. In this study, the authors compared normal and MMD ECFCs using a chronic cerebral hypoperfusion (CCH) rat model.METHODSA CCH rat model was made via ligation of the bilateral common carotid arteries (2-vessel occlusion [2-VO]). The rats were divided into three experimental groups: vehicle-treated (n = 8), normal ECFC-treated (n = 8), and MMD ECFC-treated (n = 8)...
November 1, 2018: Journal of Neurosurgery. Pediatrics
Yuxiao Chen, Marija Milenkovic, Wendy Horsfall, Ali Salahpour, Scott H Soderling, Amy J Ramsey
NMDA receptors are important for cognition and are implicated in neuropsychiatric disorders. GluN1 knockdown (GluN1KD) mice have reduced NMDA receptor levels, striatal spine density deficits, and cognitive impairments. However, how NMDA depletion leads to these effects is unclear. Since Rho GTPases are known to regulate spine density and cognition, we examined the levels of RhoA, Rac1, and Cdc42 signaling proteins. Striatal Rac1-pathway components are reduced in GluN1KD mice, with Rac1 and WAVE-1 deficits at 6 and 12 weeks of age...
2018: PloS One
Ayşe İkinci Keleş, Mehmet Yıldırım, Öznur Gedikli, Sedar Çolakoğlu, Haydar Kaya, Orhan Baş, Osman Fikret Sönmez, Ersan Odacı
The purpose of this study was to investigate hippocampus morphology and changes in learning behavior in male rats in late adolescence exposed to the effect of a continuous 1-h a day 900-megahertz (MHz) electromagnetic field (EMF). Twenty-four male Sprague Dawley rats aged 3-weeks were divided equally into control, sham and EMF groups. EMF group rats were exposed to a 900-MHz EMF inside an EMF cage, while the sham group rats were placed in the same cage but were not exposed to such an effect. No procedure was performed on the control group...
September 3, 2018: Journal of Chemical Neuroanatomy
Katelyn L Black, Nina E Baumgartner, Jill M Daniel
We previously demonstrated that 40 days of prior midlife estradiol treatment results in enhanced spatial memory in aging ovariectomized rats long after termination of the estradiol treatment. Our current goal was to determine whether this benefit is due to lasting impacts on memory specifically of previous exogenous estradiol treatment or simply due to delaying cognitive deficits that occur following loss of ovarian hormones. Middle-aged rats were ovariectomized or underwent sham surgery. Ovariectomized rats received estradiol (Previous Estradiol) or vehicle (Previous Vehicle) implants...
December 2018: Behavioral Neuroscience
Il-Gyu Ko, Sung-Eun Kim, Lakkyong Hwang, Jun-Jang Jin, Chang-Ju Kim, Bo-Kyun Kim, Hong Kim
Traumatic brain injury (TBI) causes deficit in spatial learning and memory function. Physical activity ameliorates neurological dysfunction after TBI. We investigated the effect of late starting treadmill exercise on spatial learning ability in relation with cAMP-response element binding protein (CREB)/brain-derived neurotrophic factor (BDNF) signaling pathway using TBI rats. For this study, radial 8-arm maze test, TUNEL (terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling) staining, caspase-3 immunohistochemistry, and western blot for Bax, Bcl-2, BDNF, tyrosine kinase B (TrkB), CREB, and phosphorylated CREP (p-CREB) were performed...
June 2018: Journal of Exercise Rehabilitation
Zohreh Ghotbeddin, Ahmad Ali Moazedi, Ali Yadollahpour, Faezeh Rendi, Mostafa Jalilifar
Numerous studies indicate that one of the bad effects of epilepsy is cognitive impairment. In this study we focused on the effect of LFS as a potential anticonvulsant agent, during epileptogenesis on cognitive impairments induced by amygdala kindling in rat. Twenty-one adult rats were divided into 3 groups including control (n = 7), kindled (n = 7), and Kindled+LFS (KLFS) (n = 7). Animals in the kindled group received kindling stimulation in a rapid kindling manner (a 3 s train of 50 Hz monophasic pulses of 1 ms duration, 12 times a day) in amygdala whereas control animals had no stimulation...
October 2018: Metabolic Brain Disease
Hui-Qin Li, Siu-Po Ip, Guo-Qing Zheng, Yan-Fang Xian, Zhi-Xiu Lin
Background: To evaluate the effect of Isorhynchophylline (IRN) on the learning and memory impairments induced by aluminum chloride (AlCl3 ) in mice. Methods: Fifty male Balb-c mice (4-month-old) were randomly divided into five groups: control, AlCl3 plus vehicle, AlCl3 plus IRN (20 mg/kg), AlCl3 plus IRN (40 mg/kg) and AlCl3 plus donepezil (5 mg/kg). Learning and memory impairments were induced in mice by subcutaneously injecting with AlCl3 (50 mg/kg) once a day for 8 consecutive weeks...
2018: Chinese Medicine
Ingryd Fortes Souza Lipaus, Elisa Fraga Gomes, Cleciane Waldetário Martins, Cristina Martins E Silva, Rita Gomes Wanderley Pires, Fernanda Malgarin, Patrícia Fernanda Schuck, Ester Miyuki Nakamura Palacios, Lívia Carla de Melo Rodrigues
Crack cocaine is a highly toxic drug with great potential to induce addiction. It produces more intense effects than cocaine powder, with its use having grown worldwide. However, few studies have focused on the cognitive and biochemical consequences that result from crack cocaine inhalation. This study examined the effects of direct crack cocaine inhalation on spatial working memory and brain oxidative stress parameters in rats. Male adult Wistar rats, well-trained in an eight-arm radial maze (8-RM), underwent five sessions of crack cocaine inhalation (crack cocaine group) once a day or inhalation simulation (sham group), being tested in 1-h delayed tasks 24 h after the last inhalation...
June 20, 2018: Behavioural Brain Research
Aanchal Aggarwal, Inderjit Singh, Rajat Sandhir
Diabetes is associated with increased blood brain barrier (BBB) permeability resulting in neurological deficits. The present study investigated the role of S-nitrosoglutathione (GSNO) on tight junction proteins and cell adhesion molecules in streptozotocin-induced diabetic mice. Diabetes was induced by intraperitoneal injection of streptozotocin (40 mg/kg body weight) for 5 days in mice. GSNO was administered daily (100 μg/kg body weight, orally) for 8 weeks after the induction of diabetes. A significant decline was observed in the cognitive ability of diabetic animals assessed using radial arm maze test...
September 2018: Neurochemistry International
Hongxia Che, Qian Li, Tiantian Zhang, Dandan Wang, Lu Yang, Jie Xu, Teruyoshi Yanagita, Changhu Xue, Yaoguang Chang, Yuming Wang
Alzheimer's disease (AD) is a progressive neurodegenerative disorder with the characteristics of senile plaques, neuroinflammation, neurofibrillary tangles, and destruction of synapse structure stability. Previous studies have verified the protective effects of astaxanthin (AST). However, whether synthesized docosahexaenoic-acid-acylated AST diesters (AST-DHA) could delay AD pathogenesis remains unclear. In the present study, APP/PSEN1 (APP/PS1) double-transgenic mice were administrated with AST and AST-DHA for 2 months...
May 16, 2018: Journal of Agricultural and Food Chemistry
Soichi Kawaharada, Miki Nakanishi, Nobuto Nakanishi, Keisuke Hazama, Masato Higashino, Tetsuya Yasuhiro, Arwel Lewis, Gary S Clark, Mark S Chambers, Scott A Maidment, Seishi Katsumata, Shuji Kaneko
GABAA receptors containing α 5 subunits (GABAA α 5) are highly expressed in the hippocampus and negatively involved in memory processing, as shown by the fact that GABAA α 5-deficient mice show higher hippocampus-dependent performance than wild-type mice. Accordingly, small-molecule GABAA α 5 negative allosteric modulators (NAMs) are known to enhance spatial learning and memory in rodents. Here we introduce a new, orally available GABAA α 5 NAM that improves hippocampal functions. ONO-8590580 [1-(cyclopropylmethyl)-5-fluoro-4-methyl- N -[5-(1-methyl-1H-imidazol-4-yl)-2-pyridinyl]-1H-benzimidazol-6-amine] binds to the benzodiazepine binding sites on recombinant human α 5-containing GABAA receptors with a K i of 7...
July 2018: Journal of Pharmacology and Experimental Therapeutics
Jorge A Avila, Roseanna M Zanca, Denis Shor, Nicholas Paleologos, Amber A Alliger, Maria E Figueiredo-Pereira, Peter A Serrano
Methamphetamine (MA) is an addictive drug with neurotoxic effects on the brain producing cognitive impairment and increasing the risk for neurodegenerative disease. Research has focused largely on examining the neurochemical and behavioral deficits induced by injecting relatively high doses of MA [30 mg/kg of body weight (bw)] identifying the upper limits of MA-induced neurotoxicity. Accordingly, we have developed an appetitive mouse model of voluntary oral MA administration (VOMA) based on the consumption of a palatable sweetened oatmeal mash containing a known amount of MA...
February 2018: Heliyon
Abeer M Rababa'h, Karem H Alzoubi, Ala'a Atmeh
Impairment of learning and memory has been associated with accumulation of reactive oxygen species in the body. It has also been found that antioxidants enhance learning and memory. Levosimendan is a cardiac inotropic and vasodilator agent that has pleotropic effects including antioxidant, anti-inflammatory, and smooth muscle vasodilatory actions. In this study, we investigated the effect of levosimendan on learning and memory in rats. Levosimendan (12 µg/kg, intraperitoneally) or vehicle was administered once a week for 8 weeks...
June 2018: Behavioural Pharmacology
Ali Rafati, Ali Noorafshan, Mahboubeh Jahangir, Leila Hosseini, Saied Karbalay-Doust
Aspartame is an artificial sweetener used in about 6000 sugar-free products. Aspartame consumption could be associated with various neurological disorders. This study aimed to evaluate the effect of aspartame onmedial Prefrontal Cortex (mPFC) as well as neuroprotective effects of vitamin E. The rats were divided into seven groups, including distilled water, corn oil, vitamin E (100mg/kg/day), and low (acceptable daily dose) and high doses of aspartame (40 and 200mg/kg/day) respectively, with or without vitamin E consumption, for 8 weeks...
January 2018: Acta Histochemica
Jun-Jang Jin, Il-Gyu Ko, Sung-Eun Kim, Lakkyong Hwang, Man-Gyoon Lee, Dae-Young Kim, Sun-Young Jung
The effect of exercise, which increases hippocampal neurogenesis and improves memory function, is well documented, however, differences in the effect of exercise on young children and adults are not yet known. In the present study, age-dependent differences of treadmill exercise on spatial learning ability between young- and adult-age rats were investigated. The rats in the exercise groups were forced to run on a motorized treadmill for 30 min once a day for 6 weeks. Radial 8-arm maze test was conducted for the determination of spatial learning ability...
August 2017: Journal of Exercise Rehabilitation
Maxym Myroshnychenko, Jeremy K Seamans, Anthony G Phillips, Christopher C Lapish
Connections between the hippocampus (HC) and medial prefrontal cortex (mPFC) are critical for working memory; however, the precise contribution of this pathway is a matter of debate. One suggestion is that it may stabilize retrospective memories of recently encountered task-relevant information. Alternatively, it may be involved in encoding prospective memories, or the internal representation of future goals. To explore these possibilities, simultaneous extracellular recordings were made from mPFC and HC of rats performing the delayed spatial win-shift on a radial maze...
November 1, 2017: Cerebral Cortex
Elisa Fraga Gomes, Ingryd Fortes Souza Lipaus, Cleciane Waldetário Martins, Andrezza Menezes Araújo, Josidéia Barreto Mendonça, Fabrício Souza Pelição, Evandro Carlos Lebarch, Lívia Carla de Melo Rodrigues, Ester Miyuki Nakamura-Palacios
When burning crack cocaine, the pyrolysis of cocaine generates anhydroecgonine methyl ester (AEME). AEME has been shown to be highly neurotoxic but its effects on cognitive function and oxidative stress are still unknown. Thus, this study investigated the effects of AEME on spatial working memory and on parameters of oxidative stress in the prefrontal cortex, hippocampus, and striatum. First, 18 well-trained rats in 8-arm radial maze (8-RM) procedures received acute intracerebroventricular (icv) administration of AEME at doses of 10, 32, or 100 μg or saline (SAL) in a counterbalanced order and were tested 5 min later in 1-h delayed tasks in the 8-RM...
November 2018: Neurotoxicity Research
Min-Kyun Oh, Kyung Jae Yoon, Yong-Taek Lee, Seoung Wan Chae, Hye Young Choi, Hee Suk Shin, Yun Hee Park, Se-Woong Chun, Young Sook Park
Objective To evaluate the effects of zolpidem on functional recovery in a rat model of acute ischemic stroke. Methods Following ischemic stroke procedures, 42 rats (six in each group) were randomly assigned to receive zolpidem (0.1, 0.25, 0.5, 1.0, 2.0 or 4.0 mg/kg) or normal saline administer intraperitoneally once daily for two weeks. Motor behavioural index (MBI) scores, radial 8-arm maze (RAM) test times and brain MRI scans were obtained 24 hours (Day 1) and two weeks (Day 14) post-procedure. Immunohistochemistry was performed on Day 14...
January 2018: Journal of International Medical Research
Arati Patel, Alimohammad Moalem, Hank Cheng, Robin M Babadjouni, Kaleena Patel, Drew M Hodis, Deep Chandegara, Steven Cen, Shuhan He, Qinghai Liu, William J Mack
OBJECTIVES: Chronic cerebral hypoperfusion (CCH) can result in vascular dementia and small vessel white matter ischemic injury. These findings have previously been demonstrated in a murine experimental model of CCH secondary to bilateral common carotid artery stenosis (BCAS). This study sought to elucidate the effects of CCH on recognition memory as assessed by the novel object recognition (NOR) test and histological analysis of the hippocampus and perirhinal cortex. METHODS: Studies were performed on ten-week-old male mice using bilateral 0...
October 2017: Neurological Research
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