Xinyue Zhu, Quan Zuo, Xueting Xie, Zhongxian Chen, Lixin Wang, Linyue Chang, Yangli Liu, Jiaojiao Luo, Cheng Fang, Linlin Che, Xinyue Zhou, Chao Yao, Chenyuan Gong, Dan Hu, Weimin Zhao, Yufu Zhou, Shiguo Zhu
The anemia of inflammation (AI) is characterized by the presence of inflammation and abnormal elevation of hepcidin. Accumulating evidence has proved that Rocaglamide (RocA) was involved in inflammation regulation. Nevertheless, the role of RocA in AI, especially in iron metabolism, has not been investigated, and its underlying mechanism remains elusive. Here, we demonstrated that RocA dramatically suppressed the elevation of hepcidin and ferritin in LPS-treated mice cell line RAW264.7 and peritoneal macrophages...
April 22, 2024: Free Radical Biology & Medicine