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Amir Schechter, Anat Gafter-Gvili, Daniel Shepshelovich, Ruth Rahamimov, Uzi Gafter, Eytan Mor, Avry Chagnac, Benaya Rozen-Zvi
BACKGROUND: Post transplantation anemia (PTA) is common among kidney transplant patients. PTA is associated with increased graft loss and in most studies with increased mortality. However, the effect of the severity of anemia on this associations was not thoroughly evaluated. METHODS: Patients who underwent kidney transplantation in Rabin Medical Center (RMC) were included in the study. Data were collected during the years 2002-2016. Anemia was defined as hemoglobin (Hb) level less than 12 g/dL in women and less than 13 g/dL in men, in accordance with World Health Organization (WHO) criteria...
February 13, 2019: BMC Nephrology
Sarit Avraham, Liat Zakar, Sharon Maslovitz, Jenna Zoabi, Anat Lavie, Yariv Yogev, Ariel Many
AIM: To compare pregnancy outcome of immigrant women who became pregnant to a same ethnicity partner versus a partner from a different ethnicity. METHODS: A retrospective cohort study on all singleton pregnancies of immigrant women who delivered between the years 2011-2015 in a single tertiary University affiliated Hospital. Demographic and obstetrical data were collected. Same ethnicity couples and mixed couples were compared using Pearson chi-square test for dichotomous variables, and Student's T-test for normally distributed continuous variables...
February 13, 2019: Journal of Maternal-fetal & Neonatal Medicine
Tair Ben-Porat, Anat Weiss-Sadan, Amihai Rottenstreich, Shiri Sherf-Dagan, Chaya Schweiger, Irit Mor Yosef-Levi, Dana Weiner, Odile Azulay, Nasser Sakran, Rivki Harari, Ram Elazary
Bariatric surgery (BS) may be effective for chronic kidney disease (CKD) patients by reducing microalbuminuria and proteinuria, and by facilitating their meeting inclusion criteria for kidney transplantation. However, nutritional management for this population is complex and specific guidelines are scarce. A literature search was performed to create dietetic practice for these patients based on the most recent evidence. For the purposes of nutritional recommendations, we divided the patients into 2 subgroups: 1) patients with CKD and dialysis, and 2) patients after kidney transplantation...
January 1, 2019: Advances in Nutrition
Tut Galai, Shlomi Cohen, Anat Yerushalmy-Feler, Yael Weintraub, Hadar Moran-Lev, Achiya Z Amir
OBJECTIVES: The course and evolution of pediatric acute pancreatitis (AP) is poorly understood. Prognostication models in children perform poorly and lack consensus. We aimed to identify predictors of AP severity, and the risk for AP recurrence. METHODS: We retrospectively studied all patients hospitalized with AP at a single tertiary center, between January 1995 and June 2016. Patient demographics and admission laboratory data were assessed for severity and recurrence prediction...
February 7, 2019: Journal of Pediatric Gastroenterology and Nutrition
Anat Feldman, Yafit Oscar-Strom, Joseph Tzelgov, Andrea Berger
The well-known spatial-numerical association of response code (SNARC) effect supports the idea that the mental number line (MNL) is organized from left to right in participants writing from left to right. In Arabic speakers writing from right to left, the direction of the SNARC effect is reversed. Until recently, no consistent numerical-spatial associations were reported in Hebrew speakers, who write letters from right to left and write numbers from left to right. However, a left-to-right SNARC effect was recently demonstrated in adult Hebrew readers by reducing the markedness association of response code (MARC) effect, which masks the SNARC effect...
February 5, 2019: Journal of Experimental Child Psychology
Yael Lahav, Anat Talmon, Karni Ginzburg, David Spiegel
Childhood sexual abuse (CSA) poses a risk for sexual revictimization. Additionally, according to theory CSA may lead to identification with the aggressor, expressed by adopting the perpetrator's experience concerning the abuse; identifying with the perpetrator's aggression; replacing one's agency with that of the perpetrator; and becoming hyper-sensitive to the perpetrator. Although clinical impressions suggest that identification with the aggressor underlies reenactment of trauma, this linkage between identification with the aggressor and sexual revictimization remains largely uninvestigated...
February 8, 2019: Journal of Trauma & Dissociation
Iuliana Vaxman, Hanna Bernstine, Geffen Kleinstern, Natav Hendin, Shai Shimony, Liran Domachevsky, Ronit Gurion, David Groshar, Pia Raanani, Anat Gafter-Gvili
We evaluated the role of 18-Fluoro-2-deoxy-D-glucose positron emission tomography ([18F] FDG-PET) with computed tomography (CT) (PET/CT) as a diagnostic and prognostic tool in newly diagnosed marginal zone lymphoma (MZL) patients. This is a retrospective cohort study of patients with newly diagnosed MZL, treated with immunotherapy, chemotherapy regimens, surgery or helicobacter pylori eradication between 2008 and 2016 in a single tertiary center. Only patients who had a pre-treatment PET/CT (P-PET/CT) were included...
February 8, 2019: Hematological Oncology
Lotem Zinger, Keren Merenbakh-Lamin, Anat Klein Goldberg, Adi Elazar, Shani Journo, Tomer Boldes, Metsada Pasmanik-Chor, Avishay Spitzer, Tamar Rubinek, Ido Wolf
PURPOSE: Mutations in the ligand binding domain (LBD) of estrogen receptor α (ER) confer constitutive transcriptional activity and resistance to endocrine therapies in breast cancer patients. Accumulating clinical data suggest adverse outcome for patients harboring tumors expressing these mutations. We aimed to elucidate mechanisms conferring this aggressive phenotype. EXPERIMENTAL DESIGN: Cells constitutively expressing physiologic levels of ER harboring activating LBD mutations were generated and characterized for viability, invasiveness and tumor formation in vivo...
February 7, 2019: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
Susmita Ghosh, Manu Prasad, Kiran Kundu, Limor Cohen, Ksenia M Yegodayev, Jonathan Zorea, Ben-Zion Joshua, Batel Lasry, Orr Dimitstein, Anat Bahat-Dinur, Aviram Mizrachi, Vladimir Lazar, Moshe Elkabets, Angel Porgador
Despite of remarkable progress made in the head and neck cancer (HNC) therapy, the survival rate of this metastatic disease remain low. Tailoring the appropriate therapy to patients is a major challenge and highlights the unmet need to have a good preclinical model that will predict clinical response. Hence, we developed an accurate and time efficient drug screening method of tumor ex vivo analysis (TEVA) system, which can predict patient-specific drug responses. In this study, we generated six patient derived xenografts (PDXs) which were utilized for TEVA...
2019: Frontiers in Oncology
Hadas Biran, Martin Kupiec, Roded Sharan
Network propagation is a central tool in biological research. While a number of variants and normalizations have been proposed for this method, each has its own shortcomings and no large scale assessment of those variants is available. Here we propose a novel normalization method for network propagation that is based on evaluating the propagation results against those obtained on randomized networks that preserve node degrees. In this way, our method overcomes potential biases of previous methods. We evaluate its performance on multiple large scale datasets and find that it compares favorably to previous approaches in diverse gene prioritization tasks...
2019: Frontiers in Genetics
Rachel Yamin, Orit Berhani, Hagit Peleg, Suhail Aamar, Natan Stein, Moriya Gamliel, Issam Hindi, Anat Scheiman-Elazary, Chamutal Gur
Rheumatoid Arthritis (RA) causes chronic inflammation of joints. The cytokines TNFα and IFNγ are central players in RA, however their source has not been fully elucidated. Natural Killer (NK) cells are best known for their role in elimination of viral-infected and transformed cells, and they secrete pro-inflammatory cytokines. NK cells are present in the synovial fluids (SFs) of RA patients and are considered to be important in bone destruction. However, the phenotype and function of NK cells in the SFs of patients with erosive deformative RA (DRA) versus non-deformative RA (NDRA) is poorly characterized...
February 4, 2019: Scientific Reports
Irina Galperin, Inbar Hillel, Silvia Del Din, Esther M J Bekkers, Alice Nieuwboer, Giovanni Abbruzzese, Laura Avanzino, Freek Nieuwhof, Bastiaan R Bloem, Lynn Rochester, Ugo Della Croce, Andrea Cereatti, Nir Giladi, Anat Mirelman, Jeffrey M Hausdorff
INTRODUCTION: Recent work suggests that wearables can augment conventional measures of Parkinson's disease (PD). We evaluated the relationship between conventional measures of disease and motor severity (e.g., MDS-UPDRS part III), laboratory-based measures of gait and balance, and daily-living physical activity measures in patients with PD. METHODS: Data from 125 patients (age: 71.7 ± 6.5 years, Hoehn and Yahr: 1-3, 60.5% men) were analyzed. The MDS-UPDRS-part III was used as the gold standard of motor symptom severity...
January 29, 2019: Parkinsonism & related Disorders
Anat Marom, Yulia Berkovitch, Samer Toume, Martha B Alvarez-Elizondo, Daphne Weihs
BACKGROUND: Sustained, low- and mid-level (3-6%), radial stretching combined with varying concentrations of sodium pyruvate (NaPy) supplement increase the migration rate during microscale gap closure following an in vitro injury; NaPy is a physiological supplement often used in cell-culture media. Recently we showed that low-level tensile strains accelerate in vitro kinematics during en masse cell migration; topically applied mechanical deformations also accelerate in vivo healing in larger wounds...
January 28, 2019: Clinical Biomechanics
Shulamit Geller, Sigal Levy, Gil Goldzweig, Sami Hamdan, Anat Manor, Shiran Dahan, Eyal Rothschild, Yelena Stukalin, Subhi Abu-Abeid
The increased risk of psychological distress among bariatric surgery candidates may be attributed, at least in part, to body image dissatisfaction (BID). The aim of the present study was to test the hypotheses that body image could be correlated with the psychological distress variables, and that emotional eating behaviours could mediate the relationship between body image and psychological distress. A sample of consecutive participants seeking bariatric surgery (N = 169, 67% females, mean age, 41.8 years [SD = 11...
February 1, 2019: Clinical Obesity
Gilad Rabina, Nur Azem, Dana Barequet, Adiel Barak, Anat Loewenstein, Shulamit Schwartz
PURPOSE: To evaluate the influence of silicone oil (SO) tamponade on retinal layers thickness and visual acuity in patients who underwent pars plana vitrectomy for rhegmatogenous retinal detachment. METHODS: This is a retrospective case series of consecutive patients who underwent pars plana vitrectomy for rhegmatogenous retinal detachment with SO tamponade. Visual acuity and central macular thickness were measured with SO and at least a month after SO removal (SOR)...
January 29, 2019: Retina
Anat Lavie, Lee Reicher, Sarit Avraham, Maya Ram, Sharon Maslovitz
OBJECTIVE: To determine optimum timing of external cephalic version (ECV). METHODS: A retrospective cohort study was conducted at a tertiary hospital in Israel between February 1st, 2016, and July 1st, 2017. Healthy primiparous women with breech presentation were offered either early ECV (35-36 weeks; n=54) or late ECV (37-38 weeks; n=106). Group assignment was according to the patient's preference and physician availability. The primary outcome was the rate of cephalic presentation at delivery...
February 1, 2019: International Journal of Gynaecology and Obstetrics
Oren Ziv, Mordechai Kraus, Racheli Holcberg, Anat Bahat Dinur, Sofia Kordeluk, Dan Kaplan, Hadar Naidorf Rosenblatt, Shalom Ben-Shimol, David Greenberg, Eugene Leibovitz
OBJECTIVES: To evaluate the epidemiology, microbiology, Streptococcus pneumoniae serotypes distribution and serious bacterial infections (SBIs) occurrence in infants <2 months of age with tympanocentesis-documented acute otitis media (AOM), before and after the introduction of pneumococcal conjugate vaccines (PCVs). METHODS: The medical records of all hospitalized infants with AOM who underwent tympanocentesis during 2005-2014 were reviewed. RESULTS: Of the 303 infants with AOM who were diagnosed by an ENT specialist, 182 underwent tympanocentesis, 92 during 2005-2009 (prevaccine period) and 90 during 2010-2014 (postvaccine period)...
January 23, 2019: International Journal of Pediatric Otorhinolaryngology
Itay Cohen, Matt Coban, Anat Shahar, Banumathi Sankaran, Alexandra Hockla, Shiran Lacham, Thomas R Caulfield, Evette S Radisky, Niv Papo
Serine protease inhibitors of the Kunitz-bovine pancreatic trypsin inhibitor (BPTI) family are ubiquitous biological regulators of proteolysis. These small proteins are resistant to proteolysis, but can be slowly cleaved within the protease binding loop by target proteases, thereby compromising their activity. For the human protease, mesotrypsin, this cleavage is especially rapid. Here, we aimed to stabilize the Kunitz domain structure against proteolysis through disulfide engineering. Substitution within the Kunitz inhibitor domain of the amyloid precursor protein (APPI) that incorporated a new disulfide bond between residues 17 and 34 reduced proteolysis by mesotrypsin 54-fold...
January 30, 2019: Journal of Biological Chemistry
Ido Goldenberg, Tal Mor, Eyal Nof, Arwa Younis, Anat Berkovitch, Raphael Rosso, Alon Barsheshet, Mahmoud Suleiman, Roy Beinart
Aims: Heart failure patients with advanced chronic kidney disease (CKD) may experience an increased rate of non-arrhythmic mortality due to associated comorbidities. We aimed to evaluate the risk of mortality without appropriate implantable cardioverter-defibrillator (ICD) shocks in this high-risk population. Methods and results: The study population comprised 3542 patients who received an ICD, were enrolled, and prospectively followed-up in the Israeli ICD registry...
January 23, 2019: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
Elad Moisseiev, Anat Loewenstein
Exudative age-related macular degeneration (AMD) is a major indication for the administration of intravitreal injections of anti-VEGF agents, which have been established as a very effective pharmacotherapy for this disease. However, treatment with anti-VEGF agents requires a very large number of patient visits for monitoring and treatment. Strategies for achieving a longer duration of pharmacological action are currently being developed. These include the development of longer-acting drugs, and of novel technologies to increase the duration of action of administered agents...
January 23, 2019: Current Pharmaceutical Design
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