Hakki Cetinkaya, Meltem Gursu, Halil Yazici, Egemen Cebeci, Necmi Eren, Mehmet Riza Altiparmak, Omer Faruk Akcay, Gulizar Sahin, Hamad Dheir, Taner Basturk, Kadir Gokhan Atilgan, Nihal Aydemir, Kenan Turgutalp, Murvet Yilmaz, Semahat Karahisar Sirali, Erhan Tatar, Elif Gullulu Boz, Safak Mirioglu, Sinan Kazan, Emre Aydin, Zeki Aydin, Kultigin Turkmen, Sim Kutlay, Ferdi Karagoz, Melike Betul Ogutmen, Savas Ozturk, Oktay Ozkan, Nuriye Yildiz, Tamer Dincer, Emre Yasar, Mahmut Gok, Aydın Turkmen, Fatih Dede, Ulver Derici
BACKGROUND: Immunoglobulin A nephropathy (IgAN) is a common primary glomerulonephropathy. There is evidence that mesangial C3 deposition plays a role in the development of the disease. The aim of this study was to examine the effect of C3 deposition on the prognosis of IgAN patients. METHOD: The study included 1135 patients with biopsy-confirmed IgAN from the database of the Turkish Nephrology Association Glomerular Diseases Working Group (TSN-GOLD). Patients were excluded from the study if they were aged < 18 or > 75 years or if C3 staining had not been performed in the immunofluorescent analysis...
November 10, 2023: Journal of Nephrology