keyword
https://read.qxmd.com/read/38532454/immature-central-tumor-tertiary-lymphoid-structures-are-associated-with-better-prognosis-in-non-small-cell-lung-cancer
#1
JOURNAL ARTICLE
Deng Xiaoxu, Xu Min, Cao Chengcheng
BACKGROUND & AIMS: Tertiary lymphoid structures (TLSs) are predictive biomarkers of favorable clinical outcomes and immunotherapy response in several solid malignancies, including non-small cell lung cancer (NSCLC). However, the relationship between TLSs and NSCLC prognosis has not been eludicated from the aspects of location, density, and maturity. This study aimed to investigate the clinicopathological and prognostic significance of TLSs in NSCLC. METHODS: A collection of 151 resected pulmonary nodules in patients with NSCLC was retrospectively analyzed...
March 26, 2024: BMC Pulmonary Medicine
https://read.qxmd.com/read/38531958/comparing-deep-learning-and-pathologist-quantification-of-cell-level-pd-l1-expression-in-non-small-cell-lung-cancer-whole-slide-images
#2
JOURNAL ARTICLE
Leander van Eekelen, Joey Spronck, Monika Looijen-Salamon, Shoko Vos, Enrico Munari, Ilaria Girolami, Albino Eccher, Balazs Acs, Ceren Boyaci, Gabriel Silva de Souza, Muradije Demirel-Andishmand, Luca Dulce Meesters, Daan Zegers, Lieke van der Woude, Willemijn Theelen, Michel van den Heuvel, Katrien Grünberg, Bram van Ginneken, Jeroen van der Laak, Francesco Ciompi
Programmed death-ligand 1 (PD-L1) expression is currently used in the clinic to assess eligibility for immune-checkpoint inhibitors via the tumor proportion score (TPS), but its efficacy is limited by high interobserver variability. Multiple papers have presented systems for the automatic quantification of TPS, but none report on the task of determining cell-level PD-L1 expression and often reserve their evaluation to a single PD-L1 monoclonal antibody or clinical center. In this paper, we report on a deep learning algorithm for detecting PD-L1 negative and positive tumor cells at a cellular level and evaluate it on a cell-level reference standard established by six readers on a multi-centric, multi PD-L1 assay dataset...
March 26, 2024: Scientific Reports
https://read.qxmd.com/read/38526414/a-prospective-double-blinded-comparison-of-reflectance-confocal-microscopy-with-conventional-histopathology-for-in-vivo-assessment-in-oral-cancer
#3
JOURNAL ARTICLE
Daniella K Zanoni, Paula Demétrio De Souza França, Cristina Valero, Gary Peterson, Marco Ardigo, Ronald Ghossein, Stephen W Dusza, Danielli Matsuura, Daniel W Scholfield, Dauren Adilbay, Pablo H Montero, Jocelyn Migliacci, Naga Vara Kishore Pillarsetty, Kivanc Kose, Ian Ganly, Milind Rajadhyaksha, Snehal G Patel
PURPOSE: We investigated reflectance confocal microscopy (RCM) as a possible non-invasive approach for the diagnosis of cancer and real-time assessment of surgical margins. PATIENTS AND METHODS: In a phase I study on 20 patients, we established the RCM imaging morphological features that distinguish OSCC from normal tissue with a newly developed intra-oral RCM probe. Our subsequent phase II prospective double-blinded study in 60 patients tested the diagnostic accuracy of RCM against histopathology...
March 25, 2024: Clinical Cancer Research
https://read.qxmd.com/read/38520994/is-oncotype-dx-testing-informative-for-breast-cancers-with-low-er-expression-a-retrospective-review-from-a-biomarker-testing-referral-center
#4
JOURNAL ARTICLE
John Loggie, Penelope J Barnes, Michael D Carter, Daniel Rayson, Gillian C Bethune
PURPOSE: It remains unclear whether patients with HER2-negative, low-estrogen receptor (ER-low)-positive early breast cancer (BC) benefit from Oncotype DX® (ODX) testing. METHODS: We conducted a retrospective review of cases referred for ODX testing over a seven-year period from a breast biomarker testing referral center (n = 854). For each case, we recorded the ODX Recurrence Score (RS) along with percentage of ER nuclear positivity and staining intensity on immunohistochemistry...
March 19, 2024: Breast: Official Journal of the European Society of Mastology
https://read.qxmd.com/read/38519745/artificial-intelligence-algorithm-accurately-assesses-oestrogen-receptor-immunohistochemistry-in-metastatic-breast-cancer-cytology-specimens-a-pilot-study
#5
JOURNAL ARTICLE
Brenna C Li, Scott Hammond, Anil V Parwani, Rulong Shen
OBJECTIVE: The Visiopharm artificial intelligence (AI) algorithm for oestrogen receptor (ER) immunohistochemistry (IHC) in whole slide images (WSIs) has been successfully validated in surgical pathology. This study aimed to assess its efficacy in cytology specimens. METHODS: The study cohort comprised 105 consecutive cytology specimens with metastatic breast carcinoma. ER IHC WSIs were seamlessly integrated into the Visiopharm platform from the Image Management System (IMS) during our routine digital workflow, and an AI algorithm was employed for analysis...
March 22, 2024: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://read.qxmd.com/read/38518215/clinicopathologic-overlap-of-vulvar-psoriasis-and-candidiasis
#6
JOURNAL ARTICLE
Tania Day, Erika Chapman-Burgess, James Scurry
OBJECTIVES: The study's aim is to assess if vulvar psoriasis and candidiasis may be distinguished by clinical presentation and histopathologic appearance. METHODS: The pathology database identified biopsies with corneal or subcorneal neutrophils, acanthosis, and dermal lymphocytic infiltrate. Exclusions were age younger than 18 years and unavailable or uninterpretable slides. Clinical data included demographics, comorbid conditions, symptoms, examination, microbiology, treatment, and response...
April 1, 2024: Journal of Lower Genital Tract Disease
https://read.qxmd.com/read/38517439/clinical-epidemiologic-and-pathologic-significance-of-erbb2-low-expression-in-breast-cancer
#7
JOURNAL ARTICLE
Thaer Khoury, Lucas Mendicino, Rochelle Payne Ondracek, Song Yao, Warren Davis, Angela R Omilian, Marilyn L Kwan, Janise M Roh, Lia D'Addario, Emily Valice, Daniel Fernandez, Isaac J Ergas, Alfredo V Chua, Christine B Ambrosone, Lawrence H Kushi
IMPORTANCE: It is unclear whether breast cancer (BC) with low ERBB2 expression (ERBB2-low) is a distinct clinical, pathological, and epidemiological entity from BC classified as no ERBB2 expression (ERBB2-negative). OBJECTIVE: To evaluate the clinical, pathological, and epidemiologic features of BC with ERBB2-low expression compared with ERBB2-negative BC in a large population study. DESIGN, SETTING, AND PARTICIPANTS: This cohort study was conducted as part of the Pathways Study, a prospective, racially and ethnically diverse cohort study of women with BC enrolled between 2006 and 2013 in Kaiser Permanente Northern California (KPNC)...
March 4, 2024: JAMA Network Open
https://read.qxmd.com/read/38514174/evaluating-acidic-gastroesophageal-reflux-with-wireless-ph-monitoring-in-french-bulldogs-with-sliding-hiatal-herniation
#8
JOURNAL ARTICLE
Tarini V Ullal, Stanley L Marks, Nuen Tsang Yang, Sandra L Taylor
BACKGROUND: Sliding hiatal herniation (SHH) and gastroesophageal reflux (GER) commonly occur in French bulldogs. Wireless pH monitoring can quantitatively assess acidic GER in dogs affected by SHH. HYPOTHESIS/OBJECTIVES: Measure acidic GER in French bulldogs with SHH, pre- and post-brachycephalic obstructive airway syndrome (BOAS) surgery, utilizing a wireless pH capsule (Bravo Calibration-free, Medtronic, Minnesota), and correlate with owners' observations of regurgitation...
March 21, 2024: Journal of Veterinary Internal Medicine
https://read.qxmd.com/read/38507433/predicting-hypertension-control-using-machine-learning
#9
JOURNAL ARTICLE
Thomas Mroz, Michael Griffin, Richard Cartabuke, Luke Laffin, Giavanna Russo-Alvarez, George Thomas, Nicholas Smedira, Thad Meese, Michael Shost, Ghaith Habboub
Hypertension is a widely prevalent disease and uncontrolled hypertension predisposes affected individuals to severe adverse effects. Though the importance of controlling hypertension is clear, the multitude of therapeutic regimens and patient factors that affect the success of blood pressure control makes it difficult to predict the likelihood to predict whether a patient's blood pressure will be controlled. This project endeavors to investigate whether machine learning can accurately predict the control of a patient's hypertension within 12 months of a clinical encounter...
2024: PloS One
https://read.qxmd.com/read/38506525/performance-evaluation-of-machine-assisted-interpretation-of-gram-stains-from-positive-blood-cultures
#10
JOURNAL ARTICLE
Christian Walter, Christoph Weissert, Eve Gizewski, Irene Burckhardt, Heiko Mannsperger, Siegfried Hänselmann, Winfried Busch, Stefan Zimmermann, Oliver Nolte
Manual microscopy of Gram stains from positive blood cultures (PBCs) is crucial for diagnosing bloodstream infections but remains labor intensive, time consuming, and subjective. This study aimed to evaluate a scan and analysis system that combines fully automated digital microscopy with deep convolutional neural networks (CNNs) to assist the interpretation of Gram stains from PBCs for routine laboratory use. The CNN was trained to classify images of Gram stains based on staining and morphology into seven different classes: background/false-positive, Gram-positive cocci in clusters (GPCCL), Gram-positive cocci in pairs (GPCP), Gram-positive cocci in chains (GPCC), rod-shaped bacilli (RSB), yeasts, and polymicrobial specimens...
March 20, 2024: Journal of Clinical Microbiology
https://read.qxmd.com/read/38505576/unravelling-the-quality-of-malaria-microscopy-across-kinshasa-dr-congo
#11
JOURNAL ARTICLE
Pierre Mukadi-Kaningu, Fortunat Kandanda Muele, Nestor Tshimanga, Joel Unandu, Brigitte Mbuyam-Ba Mbamba, Eric Mukomena Sompwe
INTRODUCTION: In the current study we assessed clinical laboratories' staff ability across the city of Kinshasa with particular focus on their practices and performance regarding malaria microscopy. MATERIALS AND METHODS: This was a non-random cross-sectional study included clinical laboratories in Kinshasa and focused on cross-checking of blood slides, a questionnaire and checklist according to standardised analytic malaria microscopy procedures. Regarding the cross-checking of slides, participant responses were considered 'corrects' in cases of complete congruence with the reference; 'acceptable' for malaria-positive slides but no identification of Plasmodium species, stage of development, parasite density and/or reported as P...
2024: MalariaWorld Journal
https://read.qxmd.com/read/38500812/increased-functional-connectivity-between-default-mode-network-and-visual-network-potentially-correlates-with-duration-of-residual-dizziness-in-patients-with-benign-paroxysmal-positional-vertigo
#12
JOURNAL ARTICLE
Zhengwei Chen, Yaxian Cai, Lijie Xiao, Xiu-E Wei, Yueji Liu, Cunxin Lin, Dan Liu, Haiyan Liu, Liangqun Rong
OBJECTIVE: To assess changes in static and dynamic functional network connectivity (sFNC and dFNC) and explore their correlations with clinical features in benign paroxysmal positional vertigo (BPPV) patients with residual dizziness (RD) after successful canalith repositioning maneuvers (CRM) using resting-state fMRI. METHODS: We studied resting-state fMRI data from 39 BPPV patients with RD compared to 38 BPPV patients without RD after successful CRM. Independent component analysis and methods of sliding window and k-means clustering were adopted to investigate the changes in dFNC and sFNC between the two groups...
2024: Frontiers in Neurology
https://read.qxmd.com/read/38479020/brain-connectivity-patterns-derived-from-aging-related-alterations-in-dynamic-brain-functional-networks-and-their-potential-as-features-for-brain-age-classification
#13
JOURNAL ARTICLE
Han Hongfang, Jiang Jiuchuan, Gu Lingyun, John Qiang Gan, Haixian Wang
OBJECTIVE: Recent studies have demonstrated that the analysis of brain functional networks (BFN) is a powerful tool for exploring brain aging and age-related neurodegenerative diseases. However, investigating the mechanism of brain aging associated with dynamic BFN is still limited. The purpose of this study is to develop a novel scheme to explore brain aging patterns by constructing dynamic BFN using resting-state functional magnetic resonance imaging (rs-fMRI) data. APPROACH: A dynamic sliding-windowed non-negative block-diagonal representation (dNBDR) method is proposed for constructing dynamic BFN, based on which a collection of dynamic BFN measures are suggested for examining age-related differences at the group level and used as features for brain age classification at the individual level...
March 13, 2024: Journal of Neural Engineering
https://read.qxmd.com/read/38475215/wrist-based-fall-detection-towards-generalization-across-datasets
#14
JOURNAL ARTICLE
Vanilson Fula, Plinio Moreno
Increasing age is related to a decrease in independence of movement and with this decrease comes falls, millions of falls occur every year and the most affected people are the older adults. These falls usually have a big impact on health and independence of the older adults, as well as financial impact on the health systems. Thus, many studies have developed fall detectors from several types of sensors. Previous studies related to the creation of fall detection systems models use only one dataset that usually has a small number of samples...
March 5, 2024: Sensors
https://read.qxmd.com/read/38466643/tumor-infiltrating-lymphocytes-refine-outcomes-in-triple-negative-breast-cancer-treated-with-anthracycline-free-neoadjuvant-chemotherapy
#15
JOURNAL ARTICLE
Miguel Martín, Rachel Yoder, Roberto Salgado, Maria Del Monte-Millán, Enrique L Alvarez, Isabel Echavarría, Joshua M Staley, Anne P O'Dea, Lauren E Nye, Shane R Stecklein, Coralia Bueno Muiño, Yolanda Jerez-Gilarranz, María Cebollero, Oscar Bueno, Jose Ángel Garcia-Saenz, Fernando Moreno, Uriel Bohn, Henry Gomez, Tatiana Massarrah, Qamar J Khan, Andrew K Godwin, Sara López-Tarruella, Priyanka Sharma
BACKGROUND: Stromal tumor-infiltrating lymphocytes (sTILs) are associated with pathologic complete response (pCR) and long-term outcomes for triple-negative breast cancer (TNBC) in setting of anthracycline-based chemotherapy. Impact of sTILs on refining outcomes beyond prognostic information provided by pCR in anthracycline-free neoadjuvant chemotherapy (NAC) is not known. PATIENTS & METHODS: This is pooled analysis of two studies where patients with stage I(T>1cm)-III TNBC received carboplatin(AUC 6) plus docetaxel(75mg/m2) (CbD) NAC...
March 11, 2024: Clinical Cancer Research
https://read.qxmd.com/read/38465441/correlation-of-light-and-electron-microscopic-morphometric-parameters-of-glomerular-capillaries-with-serum-creatinine-and-proteinuria
#16
JOURNAL ARTICLE
Dibyajyoti Boruah, A W Kashif, Barun Kumar Chakrabarty, Sarika Harikrishnan, Arijit Sen
Waste products in the bloodstream are filtered by the glomerular capillaries in the kidneys and excreted into the urine. When making a differential diagnosis of kidney diseases, structural assessment of glomeruli using histological, ultrastructural, and immunological studies is crucial. This study assessed the microscopic and ultrastructural morphometric parameters of glomerular capillaries and examined their correlation with serum creatinine and proteinuria. A total of 60 kidney biopsy cases received by the transmission electron microscope (TEM) laboratory for diagnosis were included in the study...
March 11, 2024: Journal of Histotechnology
https://read.qxmd.com/read/38464820/retrospective-analysis-of-discordant-results-between-histology-and-other-clinical-diagnostic-tests-on-helicobacter-pylori-infection
#17
JOURNAL ARTICLE
Xiaohua Qi, Kevin Kuan, Tony El Jabbour, Yungtai Lo, Qiang Liu, Yanan Fang
BACKGROUND: A reliable test is essential for diagnosing Helicobacter pylori ( H. pylori ) infection, and crucial for managing H. pylori -related diseases. Serving as an excellent method for detecting H. pylori infection, histologic examination is a test that clinicians heavily rely on, especially when complemented with immunohistochemistry (IHC). Additionally, other diagnostic tests for H. pylori , such as the rapid urease test (CLO test) and stool antigen test (SA), are also highly sensitive and specific...
February 16, 2024: World Journal of Gastrointestinal Endoscopy
https://read.qxmd.com/read/38461329/quality-assessment-of-malaria-microscopic-diagnosis-at-the-aristide-le-dantec-university-hospital-of-dakar-senegal-in-2020
#18
JOURNAL ARTICLE
Mamane N Garba, Awa B Dème, Khadim Diongue, Younousse Diédhiou, Amadou M Mbaye, NDèye M Dia, N'Dèye A Seck, Daba Zoumarou, Lamine Ndiaye, Mamadou S Yade, Baba Dièye, Aita Sène, Abdoulaye Tine, Mariama Touré, Nogaye Gadiaga, Awa Fall, Bassirou Ngom, Djiby Sow, Aliou Ndiaye, Astou Keita, Mame F Ndiaye, Jules F Gomis, Nana F Diop, Guète Diallo, Ibrahima M Ndiaye, Elhadj M Ba, Omar Bitèye, Cheikh Ndiaye, Fama S D Mbodji, Pape O Ndiaye, Tolla Ndiaye, Amy Gaye, Mouhamad Sy, Yaye D Ndiaye, Mame C Seck, Mouhamadou Ndiaye, Aida S Badiane, Mamadou A Diallo, Daouda Ndiaye
BACKGROUND: Following WHO guidelines, microscopy is the gold standard for malaria diagnosis in endemic countries. The Parasitology-Mycology laboratory (LPM) is the National Reference Laboratory and is currently undergoing ISO 15189 accreditation. In this context, we assessed the performance of the laboratory by confirming the reliability and the accuracy of results obtained in accordance with the requirements of the ISO 15189 standards. This study aimed to verify the method of microscopic diagnosis of malaria at the LPM, in the Aristide Le Dantec hospital (HALD) in Dakar, Senegal...
March 9, 2024: BMC Research Notes
https://read.qxmd.com/read/38459547/histological-criteria-for-selecting-patients-who-need-clonality-test-for-non-gastric-malt-lymphoma-diagnosis
#19
JOURNAL ARTICLE
Dajeong Park, Junhun Cho
The histological diagnosis of extranodal marginal zone lymphoma of the mucosa-associated lymphoid tissue (MALT lymphoma) is difficult for pathologists. Recently, digital pathology systems have been widely used to provide tools that can objectively measure lesions on slides. In this study, we measured the extent of marginal zone expansion in suspected MALT lymphoma cases and compared the results with those of a molecular clonality test. In total, 115 patients who underwent an IGH gene rearrangement test for suspected MALT lymphoma were included in this study...
March 8, 2024: Diagnostic Pathology
https://read.qxmd.com/read/38456581/dynamic-functional-connectivity-in-the-right-temporoparietal-junction-captures-variations-in-male-autistic-trait-expression
#20
JOURNAL ARTICLE
Laura Bravo Balsa, Ahmad Abu-Akel, Carmel Mevorach
Autistic individuals can experience difficulties with attention reorienting and Theory of Mind (ToM), which are closely associated with anterior and posterior subdivisions of the right temporoparietal junction. While the link between these processes remains unclear, it is likely subserved by a dynamic crosstalk between these two subdivisions. We, therefore, examined the dynamic functional connectivity (dFC) between the anterior and posterior temporoparietal junction, as a biological marker of attention and ToM, to test its contribution to the manifestation of autistic trait expression in Autism Spectrum Condition (ASC)...
March 8, 2024: Autism Research: Official Journal of the International Society for Autism Research
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