Emerald Butko, Martin Distel, Claire Pouget, Bart Weijts, Isao Kobayashi, Kevin Ng, Christian Mosimann, Fabienne E Poulain, Adam McPherson, Chih-Wen Ni, David L Stachura, Natasha Del Cid, Raquel Espín-Palazón, Nathan D Lawson, Richard Dorsky, Wilson K Clements, David Traver
The adult blood system is established by hematopoietic stem cells (HSCs), which arise during development from an endothelial-to-hematopoietic transition of cells comprising the floor of the dorsal aorta. Expression of aortic runx1 has served as an early marker of HSC commitment in the zebrafish embryo, but recent studies have suggested that HSC specification begins during the convergence of posterior lateral plate mesoderm (PLM), well before aorta formation and runx1 transcription. Further understanding of the earliest stages of HSC specification necessitates an earlier marker of hemogenic endothelium...
March 15, 2015: Development