keyword
https://read.qxmd.com/read/33878834/-analysis-of-the-clinical-efficacy-and-safety-of-bronchial-thermoplasty-in-the-treatment-of-patients-with-severe-asthma-and-asthma-chronic-obstructive-pulmonary-disease-overlap
#21
JOURNAL ARTICLE
S Y Hu, F Long, L Long, W T Huang, P Fu, H B Dong, J F Gan, Z H Huang
Objective: To investigate the clinical efficacy and safety analysis of bronchial thermoplasty (BT) in the treatment of severe asthma and asthma-chronic obstructive pulmonary disease overlap. Methods: The clinical data of 49 patients with asthma-COPD overlap who received BT in the University of Chinese Academy of Sciences Shenzhen Hospital from January 2016 to December 2018 and 50 patients with severe asthma who received BT in the same period were retrospectively analyzed. Patients were divided into overlap group and asthma group, and the baseline data of two groups were recorded...
April 20, 2021: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://read.qxmd.com/read/33590820/clinical-predictors-of-nonadherence-to-positive-airway-pressure-therapy-in-children-a-retrospective-cohort-study
#22
JOURNAL ARTICLE
Henrietta Blinder, Franco Momoli, Stephen H Holland, Anna Blinder, Dhenuka Radhakrishnan, Sherri L Katz
STUDY OBJECTIVES: Despite the importance of treating sleep-disordered breathing, positive airway pressure adherence rates in children are low. Identifying readily available predictors of nonadherence would enable the development of targeted interventions and supports, but literature is limited. Our objective was to identify baseline clinical predictors of 6-month positive airway pressure therapy nonadherence in children with SDB through a retrospective cohort study. METHODS: This study evaluated children (ages 8-17 years) prescribed positive airway pressure therapy for sleep-disordered breathing between 2011 and 2017 at a single pediatric tertiary hospital...
June 1, 2021: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://read.qxmd.com/read/33199525/night-shift-work-is-associated-with-an-increased-risk-of-asthma
#23
MULTICENTER STUDY
Robert J Maidstone, James Turner, Celine Vetter, Hassan S Dashti, Richa Saxena, Frank A J L Scheer, Steven A Shea, Simon D Kyle, Deborah A Lawlor, Andrew S I Loudon, John F Blaikley, Martin K Rutter, David W Ray, Hannah Jane Durrington
INTRODUCTION: Shift work causes misalignment between internal circadian time and the external light/dark cycle and is associated with metabolic disorders and cancer. Approximately 20% of the working population in industrialised countries work permanent or rotating night shifts, exposing this large population to the risk of circadian misalignment-driven disease. Analysis of the impact of shift work on chronic inflammatory diseases is lacking. We investigated the association between shift work and asthma...
January 2021: Thorax
https://read.qxmd.com/read/32853821/psychometric-properties-of-the-asthma-symptom-index-in-patients-with-severe-asthma
#24
JOURNAL ARTICLE
Qin Shen, Robyn von Maltzahn, Linda Nelsen, Dennis Revicki
BACKGROUND: Evaluation of symptoms is essential in asthma clinical research. Daily symptom diaries require once- or twice-daily recording, making them less suited to real-world use. A modified version of the established Asthma Symptom Utility Index (ASUI) that includes symptom attributes (Asthma Symptom Index [ASI]) was developed as a less-burdensome measure of asthma symptoms. OBJECTIVE: To evaluate the ASI and replicate ASUI psychometric properties, including validity, reliability, responsiveness, and minimal clinically important difference (MCID) estimation in patients ≥12 years of age with severe asthma...
January 2021: Journal of Allergy and Clinical Immunology in Practice
https://read.qxmd.com/read/32786104/can-serum-periostin-ykl-40-and-osteopontin-levels-in-pre-school-children-with-recurrent-wheezing-predict-later-development-of-asthma
#25
JOURNAL ARTICLE
Hakan Guvenir, Betul Buyuktiryaki, Ilknur Kulhas Celik, Ersoy Civelek, Aysun Kilic Suloglu, Cagatay Karaaslan, Selcan Genc, Emine Dibek Misirlioglu, Muge Toyran, Tayfur Ginis, Can N Kocabas
BACKGROUND: Currently, there are no reliable clinical tools available for predicting asthma in pre-school-aged children with recurrent wheezing. The aim of this study was to evaluate the usefulness of serum periostin, YKL-40, and osteopontin biomarkers in wheezy pre-school-aged children for predicting the development of asthma in school ages. METHODS: The study was prospectively conducted between 2011 and 2017. The clinical features of the pre-school-aged children with recurrent wheezing and the levels of serum periostin, YKL-40, and osteopontin were measured...
January 2021: Pediatric Allergy and Immunology
https://read.qxmd.com/read/32459632/health-equity-in-the-effectiveness-of-web-based-health-interventions-for-the-self-care-of-people-with-chronic-health-conditions-systematic-review
#26
REVIEW
Sophie Turnbull, Christie Cabral, Alastair Hay, Patricia J Lucas
BACKGROUND: Web-based self-care interventions have the potential to reduce health inequalities by removing barriers to access to health care. However, there is a lack of evidence about the equalizing effects of these interventions on chronic conditions. OBJECTIVE: This study investigated the differences in the effectiveness of web-based behavioral change interventions for the self-care of high burden chronic health conditions (eg, asthma, chronic obstructive pulmonary disease [COPD], diabetes, and osteoarthritis) across socioeconomic and cultural groups...
June 5, 2020: Journal of Medical Internet Research
https://read.qxmd.com/read/32432128/increased-weekly-mean-pm-2-5-and-no-2-are-associated-with-increased-proportions-of-lower-airway-granulocytes-in-ontario-horses
#27
JOURNAL ARTICLE
Gabrielle Brankston, Amy L Greer, Quinn Marshall, Brittany Lang, Kai Moore, Douglas Hodgins, John T G Hennessey, Janet Beeler-Marfisi
Ambient pollution is associated with the development and exacerbation of human asthma, but whether air pollution exposure is associated with lower airway inflammation in horses has not been fully evaluated. The Air Quality Health Index (AQHI) is an online tool used by asthmatic Ontarians to modify their outdoor activity when ambient pollution is high. A single AQHI value, falling on a scale from 1 to 10+ , is calculated from measurements of fine particulate matter (PM2.5 ), nitrogen dioxide (NO2 ), and ozone (O3 )...
2020: Frontiers in Veterinary Science
https://read.qxmd.com/read/32293348/early-origins-of-allergy-and-asthma-aries-study-protocol-for-a-prospective-prenatal-birth-cohort-in-chile
#28
JOURNAL ARTICLE
Caroll D Hernández, Paola Casanello, Paul R Harris, José A Castro-Rodríguez, Carolina Iturriaga, Guillermo Perez-Mateluna, Marcelo Farías, Marcela Urzúa, Cherie Hernandez, Carolina Serrano, Mauricio Sandoval, Rodrigo Hoyos-Bachiloglu, Ricardo Uauy, Arturo Borzutzky
BACKGROUND: Growing evidence shows that atopic dermatitis (AD), food allergy (FA), allergic rhinitis, and asthma are largely determined during the first 1000 days (time elapsed from conception to the 2nd birthday). The ARIES birth cohort aims to determine prenatal and perinatal conditions, as well as genetic and epigenetic factors, that participate in the early setting of immune responses, and the role of these in the later determination of the risk of allergic diseases and asthma in the offspring...
April 15, 2020: BMC Pediatrics
https://read.qxmd.com/read/32188435/clinical-and-lung-function-outcomes-in-a-cohort-of-children-with-severe-asthma
#29
JOURNAL ARTICLE
Patricia de Gouveia Belinelo, Aleisha Nielsen, Bernadette Goddard, Lauren Platt, Carla Rebeca Da Silva Sena, Paul D Robinson, Bruce Whitehead, Jodi Hilton, Tanya Gulliver, Laurence Roddick, Kasey Pearce, Vanessa E Murphy, Peter G Gibson, Adam Collison, Joerg Mattes
BACKGROUND: Uncontrolled severe asthma in children is burdensome and challenging to manage. This study aims to describe outcomes in children with uncontrolled severe asthma managed in a nurse-led severe asthma clinic (SAC). METHODS: This retrospective analysis uses data collected from children referred by a paediatric respiratory specialist to a nurse-led SAC for uncontrolled severe asthma between 2014 and 2019. The pre-clinical assessments included a home visit to assess modifiable factors that could be addressed to improve control...
March 18, 2020: BMC Pulmonary Medicine
https://read.qxmd.com/read/32071133/initial-modified-pulmonary-index-score-predicts-hospital-length-of-stay-for-asthma-subjects-admitted-to-the-pediatric-intensive-care-unit
#30
JOURNAL ARTICLE
Andrew G Miller, Kaitlyn E Haynes, Rachel M Gates, Kanecia O Zimmerman, Kathleen W Bartlett, Heather S McLean, Kyle J Rehder
BACKGROUND: Scoring systems are frequently used to assess the severity of pediatric asthma exacerbations. The modified pulmonary index score (MPIS) has been found to be highly correlated with length of stay (LOS) in the pediatric intensive care unit (PICU). We sought to evaluate the use of the MPIS to predict hospital LOS for patients admitted to our PICU. METHODS: We retrospectively reviewed the medical records of pediatric asthma subjects aged 2-17 y admitted to our PICU between June 2014 and November 2017...
February 18, 2020: Respiratory Care
https://read.qxmd.com/read/32024332/asthma-predictive-index-as-a-useful-diagnostic-tool-in-preschool-children-a-cross-sectional-study-in-korea
#31
JOURNAL ARTICLE
Dong Hyeon Lee, Ji-Won Kwon, Hyung Young Kim, Ju-Hee Seo, Hyo-Bin Kim, So-Yeon Lee, Gwang-Cheon Jang, Dae-Jin Song, Woo Kyung Kim, Young-Ho Jung, Soo-Jong Hong, Jung Yeon Shim
BACKGROUND: It is challenging to diagnose asthma in preschool children. The asthma predictive index (API) has been used to predict asthma and decide whether to initiate treatment in preschool children. PURPOSE: This study aimed to investigate the association between questionnaire-based current asthma with API, pulmonary function, airway hyperreactivity (AHR), fractional expiratory nitric oxide (FeNO), and atopic sensitization in preschool children. METHODS: We performed a population-based cross-sectional study in 916 preschool children aged 4-6 years...
March 2020: Clinical and experimental pediatrics
https://read.qxmd.com/read/31690378/the-infant-and-toddler-with-wheezing
#32
JOURNAL ARTICLE
Nurcicek Padem, Rachel Glick Robison
Recurrent wheezing is common in young infants and toddlers, with 50% of all children having at least one wheezing episode in the first 6 years of life. Initial wheezing episodes in young children often are linked to respiratory infections due to viral pathogens, such as respiratory syncytial virus, human rhinovirus, human metapneumovirus, and influenza virus. Bacterial colonization of the neonatal airway also may be significant in the late development of recurrent wheeze and asthma. Wheezing in young children can be classified into specific phenotypes based on the onset and persistence of wheezing...
November 1, 2019: Allergy and Asthma Proceedings:
https://read.qxmd.com/read/31632291/modified-shuttle-test-distance-correlates-with-peak-oxygen-uptake-in-children-and-adolescents-with-severe-therapy-resistant-asthma
#33
JOURNAL ARTICLE
Daniele Schiwe, João Paulo Heinzmann-Filho, Cláudia Silva Schindel, Mailise Fátima Gheller, Natália Evangelista Campos, Paulo Márcio Pitrez, Márcio Vinícius Fagundes Donadio
Introduction: Several tests may be used to assess exercise intolerance in severe therapy-resistant asthma (STRA), including the gold standard cardiopulmonary exercise test (CPET) and the modified shuttle test (MST). Objective: To correlate the distance achieved in the MST with peak oxygen uptake (VO2 peak) and to compare the maximal heart rate (HRmax) obtained in both tests in children and adolescents with STRA. Methods: This is a cross-sectional study, with 19 children and adolescents with STRA...
2019: Frontiers in Physiology
https://read.qxmd.com/read/31463300/predicting-asthma-using-clinical-indexes
#34
REVIEW
Jose A Castro-Rodriguez, Lorena Cifuentes, Fernando D Martinez
Asthma is no longer considered a single disease, but a common label for a set of heterogeneous conditions with shared clinical symptoms but associated with different cellular and molecular mechanisms. Several wheezing phenotypes coexist at preschool age but not all preschoolers with recurrent wheezing develop asthma at school-age; and since at the present no accurate single screening test using genetic or biochemical markers has been developed to determine which preschooler with recurrent wheezing will have asthma at school age, the asthma diagnosis still needs to be based on clinical predicted models or scores...
2019: Frontiers in Pediatrics
https://read.qxmd.com/read/30623040/factors-associated-with-daily-life-physical-activity-in-patients-with-asthma
#35
JOURNAL ARTICLE
Florence Hennegrave, Olivier Le Rouzic, Stéphanie Fry, Hélène Behal, Cécile Chenivesse, Benoit Wallaert
Background and Objectives: Little is known about the consequences of asthma on daily life physical activity (DLPA ). The aim of this study was to evaluate DLPA and determine its relationship to clinical and functional parameters in patients with asthma. Methods: This was a single-center prospective study of DLPA conducted between May 2015 and June 2016 in northern France. Fifty-one adult patients with asthma and 36 healthy control subjects were enrolled. Four DLPA parameters were assessed for 5 consecutive days with a physical activity monitor: number of steps walked per day (SPD), total energy expenditure (EE, in kcal/day), EE spent in physical activity requiring ≥3 metabolic equivalents (METs), and time (min) spent in activities requiring ≥3 METs...
October 2018: Health Science Reports
https://read.qxmd.com/read/29795072/palivizumab-prophylaxis-respiratory-syncytial-virus-and-subsequent-development-of-asthma
#36
JOURNAL ARTICLE
Mahir Igde, Hilal Kabasakal, Onur Ozturk, Guner Karatekin, Canan Aygun
BACKGROUND: Respiratory syncytial virus (RSV) infection is a disease commonly encountered during childhood and it may relapse. An experience in the early childhood would induce asthma development in the future. Palivizumab has a proven efficacy for the RSV prophylaxis so it may prevent asthma. Our aim was to evaluate the possible protective effect of palivizumab on the development of asthma by using the modified Asthma Predictive Index (mAPI). METHODS: This study's data consist of 339 children between 2 to 5 years of age followed up in healthy children unit from 2008 to 2011...
June 2018: Minerva Pediatrica
https://read.qxmd.com/read/29522812/abnormal-lung-function-at-preschool-age-asthma-in-adolescence
#37
JOURNAL ARTICLE
Katariina Lajunen, Satu Kalliola, Anne Kotaniemi-Syrjänen, Seppo Sarna, L Pekka Malmberg, Anna S Pelkonen, Mika J Mäkelä
BACKGROUND: Asthma often begins early in childhood. However, the risk for persistence is challenging to evaluate. OBJECTIVE: This longitudinal study relates lung function assessed with impulse oscillometry (IOS) in preschool children to asthma in adolescence. METHODS: Lung function was measured with IOS in 255 children with asthma-like symptoms aged 4-7 years. Baseline measurements were followed by exercise challenge and bronchodilation tests...
May 2018: Annals of Allergy, Asthma & Immunology
https://read.qxmd.com/read/29331617/asthma-predictive-index-in-relation-to-respiratory-mechanics-by-impulse-oscillometry-in-recurrent-wheezers
#38
JOURNAL ARTICLE
T Arikoglu, S B Batmaz, D D Yildirim, Ö Tezol, G Bozlu, S Kuyucu
BACKGROUND: The identification of children who will have persistent asthma has become a focus of recent research. The aim of this study was to assess whether impulse oscillometry (IOS) has a diagnostic value to predict modified API (asthma predictive index) in pre-schoolers with recurrent wheezing. METHODS: Pre-school children aged 3-6 years with recurrent wheezing were enrolled. The study population was divided into two groups based on mAPI criteria. Lung function was assessed by IOS...
March 2018: Allergologia et Immunopathologia
https://read.qxmd.com/read/29122495/up-regulation-of-serum-periostin-and-squamous-cell-carcinoma-antigen-levels-in-infants-with-acute-bronchitis-due-to-respiratory-syncytial-virus
#39
JOURNAL ARTICLE
Hiroaki Nakamura, Kenichi Akashi, Masako Watanabe, Shoichiro Ohta, Junya Ono, Yoshinori Azuma, Noriko Ogasawara, Keisuke Yamamoto, Norikazu Shimizu, Hiroyuki Tsutsumi, Kenji Izuhara, Toshio Katsunuma
BACKGROUND: Periostin and squamous cell carcinoma antigen (SCCA) are involved in the pathogenesis of asthma. Acute bronchitis due to respiratory syncytial virus (RSV) infection during infancy exhibits an asthma-like pathogenesis, suggesting that it may be associated with the subsequent development of asthma. However, the mechanism by which RSV infection leads to development of asthma has not yet been fully elucidated. METHODS: Infants younger than 36 months were enrolled and classified into three groups...
April 2018: Allergology International: Official Journal of the Japanese Society of Allergology
https://read.qxmd.com/read/28895039/wheezing-in-infancy-an-overview-of-recent-literature
#40
REVIEW
Christine Muglia, John Oppenheimer
PURPOSE OF REVIEW: Wheezing in infancy is a common presentation with many potential causes. In writing this review, we sought to summarize the newest recommendations and testing available for the more common etiologies of wheezing. RECENT FINDINGS: Regarding the diagnosis of asthma, the modified asthma predictive index has recently been established as a useful predictive tool. Non-breath held multidetector CT with 3D volume rendering airway images is also a newer helpful diagnostic tool for tracheomalacia due to ease of use and its 100% positive predictive value...
September 11, 2017: Current Allergy and Asthma Reports
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