Theresia A Mikolasch, Peter M George, Jagdeep Sahota, Thomas Nancarrow, Shaney L Barratt, Felix A Woodhead, Vasilis Kouranos, Victoria S A Cope, Andrew W Creamer, Silan Fidan, Balaji Ganeshan, Luke Hoy, John A Mackintosh, Robert Shortman, Anna Duckworth, Janet Fallon, Helen Garthwaite, Melissa Heightman, Huzaifa I Adamali, Sarah Lines, Thida Win, Rebecca Wollerton, Elisabetta A Renzoni, Matthew Steward, Athol U Wells, Michael Gibbons, Ashley M Groves, Bibek Gooptu, Chris J Scotton, Joanna C Porter
BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a progressive, fatal disorder with a variable disease trajectory. The aim of this study was to assess the potential of neutrophil-to-lymphocyte ratio (NLR) to predict outcomes in IPF. METHODS: We adopted a two-stage discovery (n = 71) and validation (n = 134) design using patients from the UCL partners (UCLp) cohort. We then combined discovery and validation cohorts and included an additional 794 people with IPF, using real-life data from 5 other UK centers, to give a combined cohort of 999 patients...
January 2023: EClinicalMedicine