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https://read.qxmd.com/read/30697991/scaffolding-adapter-protein-gab1-impairs-bfgf-induced-bio-activity-via-affecting-pi3k-akt-pathway
#1
J C Zhang, W X Li, L Wu, X Liu, L Zhang
The role of Grb2-associated binder 1 (Gab1) in bFGF-activated PI3K-AKT pathway of endothelial cells remains largely unknown. To elucidate this role, a set of studies with siRNA knockdown of Gab1 was performed. Knockdown of Gab1 using siRNA was performed in fused endothelial cell line EA.hy926 and the low level of Gab1 was confirmed with quantitative R-T PCR and Western blotting. Effects of Gab1 down-regulation were examined on several aspects: bFGF-induced AKT phosphorylation, proliferation, migration and vessel tubing formation of EA...
January 30, 2019: Journal of Biological Regulators and Homeostatic Agents
https://read.qxmd.com/read/30673277/novel-cellularly-active-inhibitor-regresses-ddah1-induced-prostate-tumor-growth-by-restraining-tumor-angiogenesis-through-targeting-ddah1-adma-nos-pathway
#2
Karthik Reddy Kami Reddy, Chandrashekhar Dasari, Shalini Vandavasi, Sirisha Natani, Bhukya Supriya, Surender Singh Jadav, Sai Ram N, Jerald Mahesh Kumar, Ramesh Ummanni
Dimethylarginine dimethylaminohydrolase1 (DDAH1) inhibitors are important therapeutics by virtue of their ability to control nitric oxide (NO) production by elevating asymmetric dimethylarginine (ADMA) levels. In a screening campaign, we identified that DD1E5 (3-amino-6-tert-butyl-N-(1,3-thiazol-2-yl)-4-(trifluoromethyl)thieno[2,3-b]pyridine-2- carboxamide) inhibits the DDAH1 activity both in vitro and in cultured cells. Mechanistic studies found that DD1E5 is a competitive inhibitor (dissociation constant (Ki) of 2...
January 23, 2019: ACS Combinatorial Science
https://read.qxmd.com/read/30650184/effect-of-induction-therapy-with-lenalidomide-doxorubicin-and-dexamethasone-on-bone-remodeling-and-angiogenesis-in-newly-diagnosed-multiple-myeloma
#3
Evangelos Terpos, Eirini Katodritou, Argiris Symeonidis, Flora Zagouri, Antonis Gerofotis, Georgia Christopoulou, Maria Gavriatopoulou, Dimitrios Christoulas, Ioannis Ntanasis-Stathopoulos, Alexandra Kourakli, Pavlina Konstantinidou, Efstathios Kastritis, Meletios A Dimopoulos
There is limited data regarding the efficacy and safety of lenalidomide, adriamycin and dexamethasone (RAD) combination on newly diagnosed multiple myeloma (NDMM) patients. There is also scarce information about the effect of lenalidomide on bone metabolism and angiogenesis in NDMM. Thus, we conducted a Phase 2 study to evaluate the efficacy and safety of RAD regimen as induction in transplant-eligible NDMM patients and we studied the effects on bone metabolism and angiogenesis. A total of 45 patients were enrolled...
January 16, 2019: International Journal of Cancer. Journal International du Cancer
https://read.qxmd.com/read/30642153/autophagy-is-a-potential-target-for-enhancing-the-anti-angiogenic-effect-of-mebendazole-in-endothelial-cells
#4
So Jung Sung, Hyun-Kyung Kim, Yong-Kil Hong, Young Ae Joe
Mebendazole (MBZ), a microtubule depolymerizing drug commonly used for the treatment of helminthic infections, has recently been noted as a repositioning candidate for angiogenesis inhibition and cancer therapy. However, the definite anti-angiogenic mechanism of MBZ remains unclear. In this study, we explored the inhibitory mechanism of MBZ in endothelial cells (ECs) and developed a novel strategy to improve its anti-angiogenic therapy. Treatment of ECs with MBZ led to inhibition of EC proliferation in a dose-dependent manner in several culture conditions in the presence of vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF) or FBS, without selectivity of growth factors, although MBZ is known to inhibit VEGF receptor 2 kinase...
January 31, 2019: Biomolecules & Therapeutics
https://read.qxmd.com/read/30632632/inhibition-of-angiogenesis-and-tumor-growth-by-a-novel-1-4-naphthoquinone-derivative
#5
Hiroko Murota, Tomohiro Shinya, Arisa Nishiuchi, Mariko Sakanaka, Ken-Ichi Toda, Tokutaro Ogata, Noboru Hayama, Tetsutaro Kimachi, Satoru Takahashi
Hit, Lead & Candidate Discovery Antiangiogenesis therapy is a promising way for treatment of solid cancers, and many angiogenesis inhibitors that target vascular endothelial growth factor (VEGF) or its receptors have been developed. We explored novel antiangiogenic compounds other than anti-VEGF drugs by screening our synthetic compound library and found that 6-thiophen-3-yl-2-methoxy-1,4-naphthoquinone (6-TMNQ) had potential as a novel angiogenesis inhibitor. This paper describes the effects of 6-TMNQ on angiogenesis and tumor growth in vitro and in vivo...
January 11, 2019: Drug Development Research
https://read.qxmd.com/read/30597545/changes-in-characteristics-of-periodontal-ligament-stem-cells-in-spheroid-culture
#6
Kengo Iwasaki, Mizuki Nagata, Keiko Akazawa, Tetsuro Watabe, Ikuo Morita
OBJECTIVES: The periodontal ligament (PDL) has important roles in maintaining homeostasis, wound healing, and regeneration of periodontal tissues by supplying stem/progenitor cells. Periodontal ligament stem cells (PDLSCs) have mesenchymal stem cell (MSC)-like characteristics and can be isolated from periodontal tissues. The aim of this study was to examine the effect of three-dimensional spheroid culture on the characteristics of PDLSCs. MATERIAL AND METHODS: Periodontal ligament stem cells were isolated and cultured from healthy teeth, and PDLSC spheroids were formed by pellet culture in polypropylene tubes...
December 30, 2018: Journal of Periodontal Research
https://read.qxmd.com/read/30597174/epo-protects-mesenchymal-stem-cells-from-hyperglycaemic-injury-via-activation-of-the-akt-foxo3a-pathway
#7
Jinjin Cui, Xiaohong Liu, Zhuoqi Zhang, Yongli Xuan, Xinxin Liu, Fengyun Zhang
INTRODUCTION: Mesenchymal stem cell (MSC)-based therapies have demonstrated positive outcomes for treating cardiovascular disease. However, the proliferative ability of MSCs decreases during chronic exposure to hyperglycaemia; their ability to contribute to endogenous injury repair is thus reduced. Erythropoietin (EPO) was recently reported to protect against hyperglycaemia-related injury in various cells and may be a good candidate for enhancing MSC functions under hyperglycaemic conditions...
December 28, 2018: Life Sciences
https://read.qxmd.com/read/30556154/improvement-in-infected-wound-healing-in-type-1-diabetic-rat-by-the-synergistic-effect-of-photobiomodulation-therapy-and-conditioned-medium
#8
Mohammadjavad Fridoni, Reza Kouhkheil, Mohammad-Amin Abdollhifar, Abdollah Amini, Mahdi Ghatrehsamani, Seyed Kamran Ghoreishi, Sufan Chien, Sahar Bayat, Mohammad Bayat
We investigated the effects of photobiomodulation therapy (PBMT) and conditioned medium (CM) of human bone marrow mesenchymal stem cells (hBM-MSC) individually and/or in combination on the stereological parameters and the expression of basic fibroblast growth factor (bFGF), hypoxia-inducible factor (HIF-1α), and stromal cell-derived factor-1α (SDF-1α) in a wound model infected with methicillin-resistant Staphylococcus aureus (MRSA) in diabetic rats. CM was provided by culturing hBM-MSCs. Type 1 diabetes mellitus (T1DM) was induced in 72 rats, divided into four groups, harboring 18 rats each: group 1 served as a control group, group 2 received PBMT, group 3 received CM, and group 4 received CM + PBMT...
December 16, 2018: Journal of Cellular Biochemistry
https://read.qxmd.com/read/30532986/steroid-receptor-coactivator-1-regulates-glioma-angiogenesis-through-polyomavirus-enhancer-activator-3-signaling
#9
Yi Zhang, Wei Shi
Steroid receptor coactivator 1 (SRC-1) is a transcriptional coactivator for steroid receptors and other transcription factors. SRC-1 has been shown to play an important role in the progression of breast cancer and prostate cancer. However, its role in glioma progression remains unknown. Here, in this study, we reported that SRC-1 is upregulated in the vessels of human glioma and exerts important regulatory functions. Specifically, SRC-1 expression significantly enhanced bFGF-mediated angiogenesis in vivo. Downregulating of SRC-1 expression suppressed endothelial cell migration and tube formation in vitro and upregulated the expression of pro-angiogenic factors including VEGF and MMP-9 in glioma cells...
December 11, 2018: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://read.qxmd.com/read/30469488/loss-of-myeloid-specific-tgf-%C3%AE-signaling-decreases-cthrc1-to-downregulate-bfgf-and-the-development-of-h1993-induced-osteolytic-bone-lesions
#10
Sourik S Ganguly, Paul G Daft, Jingchen Cao, Xiangqi Meng, Zhendong A Zhong, Alexandra Vander Ark, Austin Meadows, Zach Madaj, Bart Williams, Xiaohong Li
The role of myeloid cell-specific TGF-β signaling in non-small-cell lung cancer (NSCLC)-induced osteolytic bone lesion development is unknown. We used a genetically engineered mouse model, Tgfbr2LysMCre knockout (KO), which has a loss of TGF-β signaling specifically in myeloid lineage cells, and we found that the area of H1993 cell-induced osteolytic bone lesions was decreased in Tgfbr2LysMCre KO mice, relative to the area in control littermates. The bone lesion areas were correlated with tumor cell proliferation, angiogenesis, and osteoclastogenesis in the microenvironment...
November 22, 2018: Cancers
https://read.qxmd.com/read/30444717/lymph-angiogenesis-contribute-to-sex-differences-in-lung-cancer-through-eralpha-signalling
#11
Charline Dubois, Natacha Rocks, Silvia Blacher, Irina Primac, Anne Gallez, Melissa García-Caballero, Céline Gérard, Laurent Brouchet, Agnes Noel, Francoise Lenfant, Didier Cataldo, Christel Péqueux
Estrogen signalling pathways are emerging targets for lung cancer therapy. Unravelling the contribution of estrogens in lung cancer development is a pre-requisite to support the development of sex-based treatments and to identify patients who could potentially benefit from anti-estrogen treatments. In this study, we highlight the contribution of lymphatic and blood endothelia in the sex-dependent modulation of lung cancer. The orthotopic graft of syngeneic lung cancer cells into immunocompetent mice showed that lung tumours grew faster in female mice than in males...
November 1, 2018: Endocrine-related Cancer
https://read.qxmd.com/read/30416190/first-in-man-clinical-pilot-study-showing-the-safety-and-efficacy-of-intramuscular-injection-of-basic-fibroblast-growth-factor-with-atelocollagen-solution-for-critical-limb-ischemia
#12
Kazunori Ono, Kenji Yanishi, Makoto Ariyoshi, Satoshi Kaimoto, Motoki Uchihashi, Keisuke Shoji, Satoaki Matoba
BACKGROUND: Therapeutic angiogenesis with basic fibroblast growth factor (bFGF) with atelocollagen was confirmed in a study using a limb ischemia mouse model. Because the number of elderly patients with critical limb ischemia (CLI) is increasing, particularly that caused by arteriosclerosis obliterans (ASO), the development of less invasive angiogenesis therapies desired. Methods and Results: This first-in-man clinical study was designed to assess the safety and efficacy of i.m. injection of bFGF with atelocollagen...
November 9, 2018: Circulation Journal: Official Journal of the Japanese Circulation Society
https://read.qxmd.com/read/30335902/microrna-34a-promotes-cmecs-apoptosis-and-upregulate-inflammatory-cytokines-thus-worsening-cmecs-damage-and-inhibiting-angiogenesis-by-negatively-targeting-the-notch-signaling-pathway
#13
Jia Li, Jin Gong, Xiaobing Li, Li Shen, Yewei Xie, Rufang Zhang
OBJECTIVE: Recently, microRNA-34a (miR-34a) has been reported to lead to secretion of proinflammatory cytokine in endothelial cells, whereas whether miR-34a plays a protective role in damaged cardiac microvascular endothelial cells (CMECs) remains to be determined. Herein, the purpose of this study is to explore the effect of miR-34a in mediating Notch signaling pathway in apoptosis and angiogenesis of damaged CMECs. METHODS: The primary mice CMECs were isolated, cultivated, and identified before establishment of damaged CMEC model by incubation with homocysteine (HCY) for 24 hours...
October 18, 2018: Journal of Cellular Biochemistry
https://read.qxmd.com/read/30323846/angiogenesis-after-administration-of-basic-fibroblast-growth-factor-induces-proliferation-and-differentiation-of-mesenchymal-stem-cells-in-elastic-perichondrium-in-an-in-vivo-model-mini-review-of-three-sequential-republication-abridged-reports
#14
REVIEW
Toru Miyanaga, Yoshimichi Ueda, Aiko Miyanaga, Mikio Yagishita, Naoko Hama
To date, studies on mesenchymal tissue stem cells (MSCs) in the perichondrium have focused on in vitro analysis, and the dynamics of cartilage regeneration from the perichondrium in vivo remain largely unknown. We have attempted to apply cell and tissue engineering methodology for ear reconstruction using cultured chondrocytes. We hypothesized that by inducing angiogenesis with basic fibroblast growth factor (bFGF), MSCs or cartilage precursor cells would proliferate and differentiate into cartilage in vivo and that the regenerated cartilage would maintain its morphology over an extended period...
2018: Cellular & Molecular Biology Letters
https://read.qxmd.com/read/30323681/lncrna-loc100132354-promotes-angiogenesis-through-vegfa-vegfr2-signaling-pathway-in-lung-adenocarcinoma
#15
Yumin Wang, Fan Zhang, Junjun Wang, Lijuan Hu, Feng Jiang, Jian Chen, Jie Chen, Liangxing Wang
Purpose: This study aimed to study the biological function and the molecular mechanisms associated with the promotion of angiogenesis by lncRNA LOC100132354 in lung adenocarcinoma (LAD). Patients and methods: The mRNA expression levels of 100 pairs of LAD and normal tissue samples of LOC100132354, vascular endothelial growth factor A (VEGFA), VEGF receptor-2 (VEGFR2), basic fibroblast growth factor (bFGF), and thrombospondin-1 (TSP-1) were analyzed by qPCR. LOC100132354 was knockdown and overexpressed in SPCA-1 and A549 cell lines to analyze the protein and mRNA expression levels of VEGFA, VEGFR2, bFGF, TSP-1, and changes in protein expression levels of Ras, P-A-Raf, P-B-Raf, P-C-Raf, P-Mekl/2, and P-Erk1/2...
2018: Cancer Management and Research
https://read.qxmd.com/read/30263873/human-adipose-derived-stem-cell-conditioned-media-and-exosomes-containing-malat1-promote-human-dermal-fibroblast-migration-and-ischemic-wound-healing
#16
Denise R Cooper, Chunyan Wang, Rehka Patel, Andrea Trujillo, Niketa A Patel, Jamie Prather, Lisa J Gould, Mack H Wu
Objective: Chronically ill patients heal recalcitrant ulcerative wounds more slowly. Human adipose-derived stem cells (hADSCs) play an important role in tissue regeneration and exosomes secreted by hADSC contribute to their paracrine signaling. In addition to cytokines, lipids and growth factors, hADSC secrete mRNA, miRNA, and long noncoding (lnc) RNA into exosomes. In this study we examined the role of lncRNA MALAT1 (metastasis-associated lung adenocarcinoma transcript 1), an abundant lncRNA in exosomes from conditioned media (CM), on cell migration and ischemic wound healing...
September 1, 2018: Advances in Wound Care
https://read.qxmd.com/read/30246884/sulodexide-inhibits-angiogenesis-via-decreasing-dll4-and-notch1-expression-in-mouse-proepicardial-explant-cultures
#17
Justyna Niderla-Bielińska, Krzysztof Bartkowiak, Bogdan Ciszek, Ewa Jankowska-Steifer, Alicja Krejner, Anna Ratajska
Sulodexide (SDX) is a mixed drug containing low-molecular-weight heparin sulfate and dermatan sulfate. It exerts mild anticoagulant action but can also affect leukocytes, macrophages, and cell-cell adhesion and may interact with growth factors although its direct influence on endothelial cells is not well described. Clinically, SDX is used for the treatment of cardiovascular diseases, where it exerts anti-inflammatory and endothelial protective effects. The aim of this study was to determine the influence of SDX on tubule formation and angiogenesis-related proteins' mRNA expression in endothelial cell line C166 and mouse proepicardial explants...
September 24, 2018: Fundamental & Clinical Pharmacology
https://read.qxmd.com/read/30219518/endothelium-specific-cyp2j2-overexpression-improves-cardiac-dysfunction-by-promoting-angiogenesis-via-jagged1-notch1-signaling
#18
REVIEW
Qinshuo Zhao, Jingqiu Huang, Dong Wang, Liang Chen, Dating Sun, Chunxia Zhao
BACKGROUND: Myocardial infarction (MI) contributes to the development of cardiac remodeling and heart failure. Insufficient post-MI myocardial angiogenesis has been identified as a non-negligible event which precipitates heart failure progression. Previous studies reported that cytochrome P450 epoxygenase and its metabolites exerted beneficial effects on cardiovascular diseases. However, the role of cytochrome P450 2J2 (CYP2J2) in post-MI heart failure is incompletely understood. METHODS AND RESULTS: First, western blot and real-time PCR analyses showed that CYP2J2 expression increased clearly in patients with acute MI and old MI, compared to control...
October 2018: Journal of Molecular and Cellular Cardiology
https://read.qxmd.com/read/30197125/1-methoxycarbony-%C3%AE-carboline-from-picrasma-quassioides-exerts-anti-angiogenic-properties-in-huvecs-in-vitro-and-zebrafish-embryos-in-vivo
#19
Qing-Hua Lin, Wei Qu, Jian Xu, Feng Feng, Ming-Fang He
Angiogenesis is a crucial process in the development of inflammatory diseases, including cancer, psoriasis and rheumatoid arthritis. Recently, several alkaloids from Picrasma quassioides had been screened for angiogenic activity in the zebrafish model, and the results indicated that 1-methoxycarbony-β-carboline (MCC) could effectively inhibit blood vessel formation. In this study, we further confirmed that MCC can inhibit, in a concentration-dependent manner, the viability, migration, invasion, and tube formation of human umbilical vein endothelial cells (HUVECs) in vitro, as well as the regenerative vascular outgrowth of zebrafish caudal fin in vivo...
August 2018: Chinese Journal of Natural Medicines
https://read.qxmd.com/read/30196288/discovery-and-characterization-of-a-high-affinity-small-peptide-ligand-h1-targeting-fgfr2iiic-for-skin-wound-healing
#20
Ying Zhao, Qiang Wang, Yuan Jin, Yadan Li, Changjun Nie, Peipei Huang, Zhixin Li, Bihui Zhang, Zijian Su, An Hong, Xiaojia Chen
BACKGROUND/AIMS: How to aid recovery from severe skin injuries, such as burns, chronic or radiation ulcers, and trauma, is a critical clinical problem. Current treatment methods remain limited, and the discovery of ideal wound-healing therapeutics has been a focus of research. Functional recombinant proteins such as basic fibroblast growth factor (bFGF) and epidermal growth factor (EGF) have been developed for skin repair, however, some disadvantages in their use remain. This study reports the discovery of a novel small peptide targeting fibroblast growth factor receptor 2 IIIc (FGFR2IIIc) as a potential candidate for skin wound healing...
2018: Cellular Physiology and Biochemistry
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