Wancheng Lu, Zhijian Xiao, Hang Liao, Jianpeng Xie, Yihan Gao, Weichen Xiong, Qingye Zeng, Zhenhui Deng, Jiena Wu, Jinwei Chai, Xin Chen, Xueqing Xu
FS145, a protein containing a WGD motif, was previously described from the salivary transcriptome of the flea Xenopsylla cheopis. Nevertheless, its biological function and complete structure are still uncertain. Herein, FS145 was confirmed to adopt a common αββ structure with the WGD motif exposed on its surface and located right at the top of a loop composed of residues 72-81. Furthermore, FS145 dose-dependently inhibited the proliferation, adhesion, migration, and tube formation of HUVECs by not only binding to integrin αv β3 but also by subsequently inactivating the FAK/Src/MAPK pathway along with the reduction of the expression of MMP-2, MMP-9, VEGFA, bFGF, Ang2, Tie2, HIF-1α, and FAK...
January 9, 2024: International Journal of Biological Macromolecules