Hailiang Bai, Xiafen Bai, Xingxia Hao, Jiake Chai, Hongjie Duan
Post-burn hypermetabolism remains an important clinical problem. During this phase, there is a significant loss of diaphragmatic proteins. Better understanding of respiratory muscle dynamics and potential mechanisms affecting respiratory muscle function is necessary for the development of effective therapeutic approaches. Male wistar rats were subjected to 50% total body surface area (TBSA) burns and sham injuries, and respiratory muscle function was assessed with 0, 1, 4, 7, and 14 d post-injury, including Pulmonary function, blood gas analysis, transdiaphragmatic pressure, diaphragm ultrasonography, isolated diaphragm contractility, and fatigue index...
January 20, 2024: Journal of Burn Care & Research: Official Publication of the American Burn Association