keyword
https://read.qxmd.com/read/38307440/respiratory-activity-during-seizures-induced-by-pentylenetetrazole
#21
JOURNAL ARTICLE
Hanna L Umezu, Paloma G Bittencourt-Silva, Flávio A G Mourão, Fabrício A Moreira, Márcio Flávio D Moraes, Victor R Santos, Glauber S F da Silva
This study investigated the respiratory activity in adult Wistar rats across different behavioral seizure severity induced by pentylenetetrazole (PTZ). Animals underwent surgery for electrodes implantation, allowing simultaneous EEG and diaphragm EMG (DIAEMG) recordings and the respiratory frequency and DIAEMG amplitude were measured. Seizures were acutely induced through PTZ injection and classified based on a pre-established score, with absence-like seizures (spike wave discharge (SWD) events on EEG) representing the lowest score...
January 31, 2024: Respiratory Physiology & Neurobiology
https://read.qxmd.com/read/38293643/prognostic-value-of-diaphragmatic-ultrasound-in-patients-admitted-for-covid-19-pneumonia
#22
JOURNAL ARTICLE
Javier Lázaro Sierra, Miranda Doz Arcas, Paloma Clavería Marco, M Teresa Rosell Abos, Miguel Angel Santolaria López, Laura Pérez Gimenez, Teresa Lanzuela Benedicto, Marcos Zuil Martin, Ana Boldova Loscertales, Sandra García Saez, Ana Huertas Puyuelo, David Nieto Sánchez, José Angel Carretero García
INTRODUCTION: COVID-19 pneumonia results in an impairment of the diaphragmatic musculature that influences the development of respiratory failure during the patient's hospitalization. Diaphragmatic ultrasound is a useful, non-invasive, and accessible tool for measuring the function of this muscle. OBJECTIVE: Assessing the morphological and functional ultrasound status of the diaphragm in patients admitted within the first 24 h for COVID-related pneumonia and its association with hospital morbidity and mortality (NCT05805579)...
2024: Open Respir Arch
https://read.qxmd.com/read/38290603/rapid-review-of-ventilator-induced-diaphragm-dysfunction
#23
REVIEW
Huimin Wu, Bobby Chasteen
Ventilator-induced diaphragm dysfunction is gaining increased recognition. Evidence of diaphragm weakness can manifest within 12 h to a few days after the initiation of mechanical ventilation. Various noninvasive and invasive methods have been developed to assess diaphragm function. The implementation of diaphragm-protective ventilation strategies is crucial for preventing diaphragm injuries. Furthermore, diaphragm neurostimulation emerges as a promising and novel treatment option. In this rapid review, our objective is to discuss the current understanding of ventilator-induced diaphragm dysfunction, diagnostic approaches, and updates on strategies for prevention and management...
March 2024: Respiratory Medicine
https://read.qxmd.com/read/38288323/symptoms-arising-from-the-diaphragm-muscle-function-and-dysfunction
#24
REVIEW
Bruno Bordoni, Rohini Kotha, Allan R Escher
There can be many reasons that damage the function of the diaphragm, either transiently or permanently, involving one hemilate or both muscle portions. The diaphragm is associated only with breathing, but many other functions are related to it. The patient is not always aware of the presence of diaphragmatic dysfunction, and it is not always immediate to identify non-respiratory diaphragmatic symptoms. Pseudoanginal pain, night sweats, difficulty memorizing, or muscular and visceral problems of the pelvic floor are just some of the disorders linked to reduced diaphragmatic contractility...
January 2024: Curēus
https://read.qxmd.com/read/38256653/perioperative-diaphragm-dysfunction
#25
REVIEW
Jinge Hu, Ruijuan Guo, Huili Li, Hong Wen, Yun Wang
Diaphragm Dysfunction (DD) is a respiratory disorder with multiple causes. Although both unilateral and bilateral DD could ultimately lead to respiratory failure, the former is more common. Increasing research has recently delved into perioperative diaphragm protection. It has been established that DD promotes atelectasis development by affecting lung and chest wall mechanics. Diaphragm function must be specifically assessed for clinicians to optimally select an anesthetic approach, prepare for adequate monitoring, and implement the perioperative plan...
January 17, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38255175/increased-frequency-of-giant-miniature-end-plate-potentials-at-the-neuromuscular-junction-in-diabetic-rats
#26
JOURNAL ARTICLE
Julián Elías Martínez-Sánchez, Yolitzy Cárdenas, Xóchitl Trujillo, Mónica Ríos-Silva, M Irene Díaz-Reval, Jaime Alberto Bricio-Barrios, Jesús Muñiz, Julio Alcaraz-Siqueiros, Miguel Huerta
There is a need for research addressing the functional characteristics of the motor end-plate in diabetes to identify mechanisms contributing to neuromuscular dysfunction. Here, we investigated the effect of diabetes on spontaneous acetylcholine release in the rat neuromuscular junction. We studied two randomized groups of male Wistar rats (n = 7 per group, 350 ± 50 g, 12-16 weeks of age): one with streptozotocin-induced experimental diabetes, and a healthy control group without diabetes. After 8 weeks of monitoring after diabetes induction, rats in both groups were anesthetized with pentobarbital...
December 27, 2023: Biomedicines
https://read.qxmd.com/read/38249924/the-molecular-mechanism-of-sepsis-induced-diaphragm-dysfunction
#27
JOURNAL ARTICLE
Xiaosa Yuan, Fangsu Xue, Yunchi Yu, Xiaowen Cao, Yimin Han, Fei Wang, Lou Zhong
BACKGROUND: No effective drugs for the treatment of sepsis-induced diaphragm dysfunction are currently available. Therefore, it is particularly important to clarify the molecular regulatory mechanism of this condition and subsequently implement effective treatment and prevention of sepsis-induced diaphragm dysfunction. METHODS: A mouse model of diaphragm dysfunction was established via injection of lipopolysaccharide (LPS). An RNA-sequencing (RNA-seq) technique was used to detect the differentially expressed genes (DEGs) in the diaphragms of mice...
December 30, 2023: Journal of Thoracic Disease
https://read.qxmd.com/read/38245850/respiratory-muscle-contraction-characteristics-and-potential-mechanisms-in-severely-burned-rats
#28
JOURNAL ARTICLE
Hailiang Bai, Xiafen Bai, Xingxia Hao, Jiake Chai, Hongjie Duan
Post-burn hypermetabolism remains an important clinical problem. During this phase, there is a significant loss of diaphragmatic proteins. Better understanding of respiratory muscle dynamics and potential mechanisms affecting respiratory muscle function is necessary for the development of effective therapeutic approaches. Male wistar rats were subjected to 50% total body surface area (TBSA) burns and sham injuries, and respiratory muscle function was assessed with 0, 1, 4, 7, and 14 d post-injury, including Pulmonary function, blood gas analysis, transdiaphragmatic pressure, diaphragm ultrasonography, isolated diaphragm contractility, and fatigue index...
January 20, 2024: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://read.qxmd.com/read/38230846/effect-of-post-extubation-inspiratory-muscle-training-on-diaphragmatic-function-in-mechanically-ventilated-patients-a-randomized-controlled-trial
#29
JOURNAL ARTICLE
Reyhan Kaygusuz Benli, Ufuk Yurdalan, Barış Yılmaz, Nalan Adıgüzel
BACKGROUND: Diaphragmatic dysfunction is a common problem in patients who have been mechanically ventilated. OBJECTIVES: The study aimed to evaluate the effectiveness of inspiratory muscle training (IMT) on diaphragm muscle thickness and function in mechanically ventilated patients. MATERIAL AND METHODS: A single-blind trial was conducted. Twenty patients were randomly assigned to either the conventional physiotherapy (CP) group or to the IMT group for 5 days following extubation...
January 17, 2024: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://read.qxmd.com/read/38218756/relationship-between-motor-dysfunction-the-respiratory-muscles-and-pulmonary-function-in-stroke-patients-with-hemiplegia-a-retrospective-study
#30
JOURNAL ARTICLE
Meng Li, Ying Huang, HaiYun Chen, ShuoShuo Wang, Ying Zhou, Ying Zhang
BACKGROUND: The interaction between motor dysfunction and respiratory functions in stroke patients with hemiplegia are not fully understood, particularly with regard to the relationship between changes in trunk control, balance, and daily activities, and changes in respiratory muscle strength and pulmonary volume. Investigating this relationship will facilitate the optimization of stroke rehabilitation strategies. METHODS: Clinical history data were collected from 134 patients to analyze the relationship between motor function scales scores and spirometric data...
January 13, 2024: BMC Geriatrics
https://read.qxmd.com/read/38214045/outcomes-in-critically-ill-patients-after-diaphragmatic-stimulation-on-ventilator-induced-diaphragmatic-dysfunction-a-systematic-review
#31
JOURNAL ARTICLE
Alessandro Panelli, Julius J Grunow, Michael A VERFUß, Hermann G Bartels, Zarina Brass, Stefan J Schaller
INTRODUCTION: Mechanical ventilation (MV) is a lifesaving procedure for critically ill patients. Diaphragm activation and stimulation may counteract side effects, such as ventilator-induced diaphragm dysfunction (VIDD). The effects of stimulation on diaphragm atrophy and patient outcomes are reported in this systematic review. EVIDENCE ACQUISITION: Studies investigating diaphragmatic stimulation versus standard of care in critically ill patients and evaluating clinical outcomes were extracted from a Medline database last on January 23, 2023, after registration in Prospero (CRD42021259353)...
December 2023: European Journal of Physical and Rehabilitation Medicine
https://read.qxmd.com/read/38194712/the-effect-of-respiratory-muscle-training-on-respiratory-muscle-strength-diaphragm-thickness-mobility-and-exercise-capacity-in-patients-with-systemic-lupus-erythematosus-and-associated-shrinking-lung-syndrome
#32
JOURNAL ARTICLE
Fulden Sari, Deran Oskay, Abdurrahman Tufan
Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder that can impact any organ in the body. The pathophysiology of shrinking lung syndrome (SLS), a rare pulmonary complication of SLE, remains unknown. The objective of the current case series was to investigate the effects of inspiratory muscle training (IMT) on diaphragm thickness/mobility, respiratory muscle strength, peripheral muscle thickness/strength, and functional exercise capacity in patients with SLE and associated SLS. Three patients with SLE were included in the case series...
January 9, 2024: Lupus
https://read.qxmd.com/read/38189895/replacement-of-fluoroscopy-by-ultrasonography-in-the-evaluation-of-hemidiaphragm-function-an-exploratory-prospective-study
#33
JOURNAL ARTICLE
Søren Helbo Skaarup, Peter Juhl-Olsen, Anne Sofie Grundahl, Brian Bridal Løgstrup
INTRODUCTION: Dysfunction of the diaphragm may ultimately lead to respiratory insufficiency and compromise patient outcome. Evaluation of diaphragm function is cumbersome. Fluoroscopy has been the gold standard to measure diaphragmatic excursion. Ultrasonography can visualize diaphragm excursion and holds many advantages such as no radiation exposure, increased portability and accessibility. However, correlation between fluoroscopy and ultrasonography has never been studied. We aimed to compare fluoroscopic and ultrasound measures of diaphragm excursion to determine if ultrasonography can replace fluoroscopy...
January 8, 2024: The ultrasound journal
https://read.qxmd.com/read/38181283/effects-of-diaphragm-electrical-stimulation-in-treating-respiratory-dysfunction-on-mechanical-ventilation-after-intracerebral-hemorrhage-a-single-center-retrospective-study
#34
JOURNAL ARTICLE
Yan Wu, Suqin Wang, Jing Zhang, Yan Wang, Jiaojiao Zhong, Yuhai Wang
Intracerebral hemorrhage (ICH) is a major cause of death and disability worldwide. The benefits of electrical stimulation in the treatment of respiratory dysfunction in patients on mechanical ventilation is unknown. Nevertheless, there is a dearth of evidence-based medical research concerning its clinical efficacy. From January 2019 to January 2023, every enrolled patients experienced respiratory dysfunction after ICH while being supported by mechanical ventilation. A total of 205 eligible patients were enrolled and then allocated into 2 groups: control group and observation group...
January 5, 2024: Medicine (Baltimore)
https://read.qxmd.com/read/38157829/is-there-a-synergistic-relationship-between-diaphragm-and-pelvic-floor-muscles-in-pregnant-women
#35
JOURNAL ARTICLE
Sinem Çiçek, Özge Çeliker Tosun, Manolya Parlas, Dilek Bilgiç, Onur Yavuz, Sefa Kurt, Melda Başer Seçer, Gökhan Tosun, Mehmet Özer, Alper İleri
OBJECTIVE: The aim of this study is to examine whether there is a synergistic relationship between the diaphragm and pelvic floor muscles (PFM) in pregnant women. MATERIAL AND METHODS: Our study was carried out as a cross-sectional study in primigravid pregnants in the second and third trimesters. Superficial electromyography (EMG), 2D/3D ultrasonography (USG), pulmonary function test (PFT), PERFECT, maximum expiratory pressure (MEP) and inspiratory pressure (MIP) measurements were used to evaluate pelvic floor and diaphragm muscle functions during pregnancy...
December 23, 2023: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://read.qxmd.com/read/38109016/phrenic-nerve-stimulation-to-prevent-diaphragmatic-dysfunction-and-ventilator-induced-lung-injury
#36
REVIEW
Alessandro Panelli, Michael A Verfuß, Martin Dres, Laurent Brochard, Stefan J Schaller
Side effects of mechanical ventilation, such as ventilator-induced diaphragmatic dysfunction (VIDD) and ventilator-induced lung injury (VILI), occur frequently in critically ill patients. Phrenic nerve stimulation (PNS) has been a valuable tool for diagnosing VIDD by assessing respiratory muscle strength in response to magnetic PNS. The detection of pathophysiologically reduced respiratory muscle strength is correlated with weaning failure, longer mechanical ventilation time, and mortality. Non-invasive electromagnetic PNS designed for diagnostic use is a reference technique that allows clinicians to measure transdiaphragm pressure as a surrogate parameter for diaphragm strength and functionality...
December 18, 2023: Intensive Care Medicine Experimental
https://read.qxmd.com/read/38097957/cellular-senescence-contributes-to-mechanical-ventilation-induced-diaphragm-dysfunction-by-upregulating-p53-signalling-pathways
#37
JOURNAL ARTICLE
Weimin Shen, Ye Jiang, Ying Xu, Xiaoli Qian, Jianwei Jia, Yuejia Ding, Yuhan He, Qing Pan, Jinyang Zhuang, Huiqing Ge, Peifeng Xu
BACKGROUND: Mechanical ventilation can cause acute atrophy and injury in the diaphragm, which are related to adverse clinical results. However, the underlying mechanisms of ventilation-induced diaphragm dysfunction (VIDD) have not been well elucidated. The current study aimed to explore the role of cellular senescence in VIDD. METHODS: A total of twelve New Zealand rabbits were randomly divided into 2 groups: (1) spontaneously breathing anaesthetized animals (the CON group) and (2) mechanically ventilated animals (for 48 h) in V-ACV mode (the MV group)...
December 14, 2023: BMC Pulmonary Medicine
https://read.qxmd.com/read/38085880/setting-positive-end-expiratory-pressure-role-in-diaphragm-protective-ventilation
#38
REVIEW
Myrte Wennen, Wout Claassen, Leo Heunks
PURPOSE OF REVIEW: With mechanical ventilation, positive end-expiratory pressure (PEEP) is applied to improve oxygenation and lung homogeneity. However, PEEP setting has been hypothesized to contribute to critical illness associated diaphragm dysfunction via several mechanisms. Here, we discuss the impact of PEEP on diaphragm function, activity and geometry. RECENT FINDINGS: PEEP affects diaphragm geometry: it induces a caudal movement of the diaphragm dome and shortening of the zone of apposition...
February 1, 2024: Current Opinion in Critical Care
https://read.qxmd.com/read/38074128/case-report-severe-respiratory-failure-caused-by-licorice
#39
Hiroaki Taniguchi, Takero Terayama, Nobuaki Kiriu, Hiroshi Kato, Soichiro Seno, Yasumasa Sekine, Yoshihiro Tanaka, Tetsuro Kiyozumi
Licorice, one of the most commonly used herbs, can cause hypokalemia, metabolic alkalosis, and apparent mineralocorticoid excess, also known as pseudoaldosteronism. Herein, we present a case of diaphragmatic dysfunction caused by licorice administration. An 80-year-old woman who had been taking dietary supplements and following a restricted diet for approximately 6 months was brought to the emergency department with impaired consciousness. Chronic respiratory acidosis was observed, and hypertension and hypokalemia became more prominent during hospitalization...
2023: Frontiers in Pharmacology
https://read.qxmd.com/read/38071289/comparison-of-breathing-pattern-and-diaphragmatic-motion-in-patients-with-unilateral-cervical-radiculopathy-and-asymptomatic-group
#40
JOURNAL ARTICLE
Raziyeh Yousefiyan, Amin Kordi Yoosefinejad, Reza Jalli, Iman Rezaei
BACKGROUND: The associations between neck pain and respiratory dysfunction were clarified in patients with neck pain. There is dearth of evidence on pulmonary dysfunction and diaphragmatic excursion in patients with unilateral cervical radiculopathy (CR). The purpose of this study was to compare the breathing pattern and diaphragmatic excursion in patients with unilateral CR with those in an asymptomatic group. METHODS: Twenty-five patients with unilateral CR and 25 asymptomatic individuals aged between 30 and 55 participated in this study...
December 9, 2023: BMC Pulmonary Medicine
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