Jiarui Ding, John J Garber, Amiko Uchida, Ariel Lefkovith, Grace T Carter, Praveen Vimalathas, Lauren Canha, Michael Dougan, Kyle Staller, Joseph Yarze, Toni M Delorey, Orit Rozenblatt-Rosen, Orr Ashenberg, Daniel B Graham, Jacques Deguine, Aviv Regev, Ramnik J Xavier
Coordinated cell interactions within the esophagus maintain homeostasis, and disruption can lead to eosinophilic esophagitis (EoE), a chronic inflammatory disease with poorly understood pathogenesis. We profile 421,312 individual cells from the esophageal mucosa of 7 healthy and 15 EoE participants, revealing 60 cell subsets and functional alterations in cell states, compositions, and interactions that highlight previously unclear features of EoE. Active disease displays enrichment of ALOX15+ macrophages, PRDM16+ dendritic cells expressing the EoE risk gene ATP10A, and cycling mast cells, with concomitant reduction of TH 17 cells...
April 18, 2024: Nature Communications