keyword
https://read.qxmd.com/read/38366602/plasma-metabolites-of-a-healthy-lifestyle-in-relation-to-mortality-and-longevity-four-prospective-us-cohort-studies
#21
JOURNAL ARTICLE
Anne-Julie Tessier, Fenglei Wang, Liming Liang, Clemens Wittenbecher, Danielle E Haslam, A Heather Eliassen, Deirdre K Tobias, Jun Li, Oana A Zeleznik, Alberto Ascherio, Qi Sun, Meir J Stampfer, Francine Grodstein, Kathryn M Rexrode, JoAnn E Manson, Raji Balasubramanian, Clary B Clish, Miguel A Martínez-González, Jorge E Chavarro, Frank B Hu, Marta Guasch-Ferré
BACKGROUND: A healthy lifestyle is associated with a lower premature mortality risk and with longer life expectancy. However, the metabolic pathways of a healthy lifestyle and how they relate to mortality and longevity are unclear. We aimed to identify and replicate a healthy lifestyle metabolomic signature and examine how it is related to total and cause-specific mortality risk and longevity. METHODS: In four large cohorts with 13,056 individuals and 28-year follow-up, we assessed five healthy lifestyle factors, used liquid chromatography mass spectrometry to profile plasma metabolites, and ascertained deaths with death certificates...
February 8, 2024: Med
https://read.qxmd.com/read/38364143/improved-measurement-of-cp-violation-parameters-in-b_-s-0-%C3%A2-j-%C3%AF-k-k-decays-in-the-vicinity-of-the-%C3%AF-1020-resonance
#22
JOURNAL ARTICLE
R Aaij, A S W Abdelmotteleb, C Abellan Beteta, F Abudinén, T Ackernley, B Adeva, M Adinolfi, P Adlarson, H Afsharnia, C Agapopoulou, C A Aidala, Z Ajaltouni, S Akar, K Akiba, P Albicocco, J Albrecht, F Alessio, M Alexander, A Alfonso Albero, Z Aliouche, P Alvarez Cartelle, R Amalric, S Amato, J L Amey, Y Amhis, L An, L Anderlini, M Andersson, A Andreianov, P Andreola, M Andreotti, D Andreou, D Ao, F Archilli, A Artamonov, M Artuso, E Aslanides, M Atzeni, B Audurier, D Bacher, I Bachiller Perea, S Bachmann, M Bachmayer, J J Back, A Bailly-Reyre, P Baladron Rodriguez, V Balagura, W Baldini, J Baptista de Souza Leite, M Barbetti, I R Barbosa, R J Barlow, S Barsuk, W Barter, M Bartolini, F Baryshnikov, J M Basels, G Bassi, B Batsukh, A Battig, A Bay, A Beck, M Becker, F Bedeschi, I B Bediaga, A Beiter, S Belin, V Bellee, K Belous, I Belov, I Belyaev, G Benane, G Bencivenni, E Ben-Haim, A Berezhnoy, R Bernet, S Bernet Andres, D Berninghoff, H C Bernstein, C Bertella, A Bertolin, C Betancourt, F Betti, J Bex, Ia Bezshyiko, J Bhom, L Bian, M S Bieker, N V Biesuz, P Billoir, A Biolchini, M Birch, F C R Bishop, A Bitadze, A Bizzeti, M P Blago, T Blake, F Blanc, J E Blank, S Blusk, D Bobulska, V Bocharnikov, J A Boelhauve, O Boente Garcia, T Boettcher, A Bohare, A Boldyrev, C S Bolognani, R Bolzonella, N Bondar, F Borgato, S Borghi, M Borsato, J T Borsuk, S A Bouchiba, T J V Bowcock, A Boyer, C Bozzi, M J Bradley, S Braun, A Brea Rodriguez, N Breer, J Brodzicka, A Brossa Gonzalo, J Brown, D Brundu, A Buonaura, L Buonincontri, A T Burke, C Burr, A Bursche, A Butkevich, J S Butter, J Buytaert, W Byczynski, S Cadeddu, H Cai, R Calabrese, L Calefice, S Cali, M Calvi, M Calvo Gomez, J Cambon Bouzas, P Campana, D H Campora Perez, A F Campoverde Quezada, S Capelli, L Capriotti, A Carbone, L Carcedo Salgado, R Cardinale, A Cardini, P Carniti, L Carus, A Casais Vidal, R Caspary, G Casse, M Cattaneo, G Cavallero, V Cavallini, S Celani, J Cerasoli, D Cervenkov, A J Chadwick, I Chahrour, M G Chapman, M Charles, Ph Charpentier, C A Chavez Barajas, M Chefdeville, C Chen, S Chen, A Chernov, S Chernyshenko, V Chobanova, S Cholak, M Chrzaszcz, A Chubykin, V Chulikov, P Ciambrone, M F Cicala, X Cid Vidal, G Ciezarek, P Cifra, P E L Clarke, M Clemencic, H V Cliff, J Closier, J L Cobbledick, C Cocha Toapaxi, V Coco, J Cogan, E Cogneras, L Cojocariu, P Collins, T Colombo, A Comerma-Montells, L Congedo, A Contu, N Cooke, I Corredoira, A Correia, G Corti, J J Cottee Meldrum, B Couturier, D C Craik, M Cruz Torres, R Currie, C L Da Silva, S Dadabaev, L Dai, X Dai, E Dall'Occo, J Dalseno, C D'Ambrosio, J Daniel, A Danilina, P d'Argent, A Davidson, J E Davies, A Davis, O De Aguiar Francisco, J de Boer, K De Bruyn, S De Capua, M De Cian, U De Freitas Carneiro Da Graca, E De Lucia, J M De Miranda, L De Paula, M De Serio, D De Simone, P De Simone, F De Vellis, J A de Vries, C T Dean, F Debernardis, D Decamp, V Dedu, L Del Buono, B Delaney, H-P Dembinski, V Denysenko, O Deschamps, F Dettori, B Dey, P Di Nezza, I Diachkov, S Didenko, S Ding, V Dobishuk, A D Docheva, A Dolmatov, C Dong, A M Donohoe, F Dordei, A C Dos Reis, L Douglas, A G Downes, W Duan, P Duda, M W Dudek, L Dufour, V Duk, P Durante, M M Duras, J M Durham, D Dutta, A Dziurda, A Dzyuba, S Easo, E Eckstein, U Egede, A Egorychev, V Egorychev, C Eirea Orro, S Eisenhardt, E Ejopu, S Ek-In, L Eklund, M Elashri, J Ellbracht, S Ely, A Ene, E Epple, S Escher, J Eschle, S Esen, T Evans, F Fabiano, L N Falcao, Y Fan, B Fang, L Fantini, M Faria, K Farmer, S Farry, D Fazzini, L Felkowski, M Feng, M Feo, M Fernandez Gomez, A D Fernez, F Ferrari, L Ferreira Lopes, F Ferreira Rodrigues, S Ferreres Sole, M Ferrillo, M Ferro-Luzzi, S Filippov, R A Fini, M Fiorini, M Firlej, K M Fischer, D S Fitzgerald, C Fitzpatrick, T Fiutowski, F Fleuret, M Fontana, F Fontanelli, L F Foreman, R Forty, D Foulds-Holt, M Franco Sevilla, M Frank, E Franzoso, G Frau, C Frei, D A Friday, L Frontini, J Fu, Q Fuehring, Y Fujii, T Fulghesu, E Gabriel, G Galati, M D Galati, A Gallas Torreira, D Galli, S Gambetta, M Gandelman, P Gandini, H Gao, R Gao, Y Gao, Y Gao, M Garau, L M Garcia Martin, P Garcia Moreno, J García Pardiñas, B Garcia Plana, F A Garcia Rosales, L Garrido, C Gaspar, R E Geertsema, L L Gerken, E Gersabeck, M Gersabeck, T Gershon, L Giambastiani, F I Giasemis, V Gibson, H K Giemza, A L Gilman, M Giovannetti, A Gioventù, P Gironella Gironell, C Giugliano, M A Giza, K Gizdov, E L Gkougkousis, F C Glaser, V V Gligorov, C Göbel, E Golobardes, D Golubkov, A Golutvin, A Gomes, S Gomez Fernandez, F Goncalves Abrantes, M Goncerz, G Gong, J A Gooding, I V Gorelov, C Gotti, J P Grabowski, L A Granado Cardoso, E Graugés, E Graverini, L Grazette, G Graziani, A T Grecu, L M Greeven, N A Grieser, L Grillo, S Gromov, C Gu, M Guarise, M Guittiere, V Guliaeva, P A Günther, A K Guseinov, E Gushchin, Y Guz, T Gys, T Hadavizadeh, C Hadjivasiliou, G Haefeli, C Haen, J Haimberger, S C Haines, M Hajheidari, T Halewood-Leagas, M M Halvorsen, P M Hamilton, J Hammerich, Q Han, X Han, S Hansmann-Menzemer, L Hao, N Harnew, T Harrison, M Hartmann, C Hasse, M Hatch, J He, K Heijhoff, F Hemmer, C Henderson, R D L Henderson, A M Hennequin, K Hennessy, L Henry, J Herd, J Heuel, A Hicheur, D Hill, M Hilton, S E Hollitt, J Horswill, R Hou, Y Hou, N Howarth, J Hu, J Hu, W Hu, X Hu, W Huang, X Huang, W Hulsbergen, R J Hunter, M Hushchyn, D Hutchcroft, P Ibis, M Idzik, D Ilin, P Ilten, A Inglessi, A Iniukhin, A Ishteev, K Ivshin, R Jacobsson, H Jage, S J Jaimes Elles, S Jakobsen, E Jans, B K Jashal, A Jawahery, V Jevtic, E Jiang, X Jiang, Y Jiang, Y J Jiang, M John, D Johnson, C R Jones, T P Jones, S Joshi, B Jost, N Jurik, I Juszczak, D Kaminaris, S Kandybei, Y Kang, M Karacson, D Karpenkov, M Karpov, A M Kauniskangas, J W Kautz, F Keizer, D M Keller, M Kenzie, T Ketel, B Khanji, A Kharisova, S Kholodenko, G Khreich, T Kirn, V S Kirsebom, O Kitouni, S Klaver, N Kleijne, K Klimaszewski, M R Kmiec, S Koliiev, L Kolk, A Konoplyannikov, P Kopciewicz, R Kopecna, P Koppenburg, M Korolev, I Kostiuk, O Kot, S Kotriakhova, A Kozachuk, P Kravchenko, L Kravchuk, M Kreps, S Kretzschmar, P Krokovny, W Krupa, W Krzemien, J Kubat, S Kubis, W Kucewicz, M Kucharczyk, V Kudryavtsev, E Kulikova, A Kupsc, B K Kutsenko, D Lacarrere, G Lafferty, A Lai, A Lampis, D Lancierini, C Landesa Gomez, J J Lane, R Lane, C Langenbruch, J Langer, O Lantwin, T Latham, F Lazzari, C Lazzeroni, R Le Gac, S H Lee, R Lefèvre, A Leflat, S Legotin, O Leroy, T Lesiak, B Leverington, A Li, H Li, K Li, L Li, P Li, P-R Li, S Li, T Li, T Li, Y Li, Z Li, Z Lian, X Liang, C Lin, T Lin, R Lindner, V Lisovskyi, R Litvinov, G Liu, H Liu, K Liu, Q Liu, S Liu, Y Liu, Y Liu, A Lobo Salvia, A Loi, J Lomba Castro, T Long, I Longstaff, J H Lopes, A Lopez Huertas, S López Soliño, G H Lovell, Y Lu, C Lucarelli, D Lucchesi, S Luchuk, M Lucio Martinez, V Lukashenko, Y Luo, A Lupato, E Luppi, K Lynch, X-R Lyu, R Ma, S Maccolini, F Machefert, F Maciuc, I Mackay, L R Madhan Mohan, M M Madurai, A Maevskiy, D Magdalinski, D Maisuzenko, M W Majewski, J J Malczewski, S Malde, B Malecki, L Malentacca, A Malinin, T Maltsev, G Manca, G Mancinelli, C Mancuso, R Manera Escalero, D Manuzzi, C A Manzari, D Marangotto, J F Marchand, U Marconi, S Mariani, C Marin Benito, J Marks, A M Marshall, P J Marshall, G Martelli, G Martellotti, L Martinazzoli, M Martinelli, D Martinez Santos, F Martinez Vidal, A Massafferri, M Materok, R Matev, A Mathad, V Matiunin, C Matteuzzi, K R Mattioli, A Mauri, E Maurice, J Mauricio, M Mazurek, M McCann, L Mcconnell, T H McGrath, N T McHugh, A McNab, R McNulty, B Meadows, G Meier, D Melnychuk, M Merk, A Merli, L Meyer Garcia, D Miao, H Miao, M Mikhasenko, D A Milanes, M-N Minard, A Minotti, E Minucci, T Miralles, S E Mitchell, B Mitreska, D S Mitzel, A Modak, A Mödden, R A Mohammed, R D Moise, S Mokhnenko, T Mombächer, M Monk, I A Monroy, S Monteil, A Morcillo Gomez, G Morello, M J Morello, M P Morgenthaler, J Moron, A B Morris, A G Morris, R Mountain, H Mu, Z M Mu, E Muhammad, F Muheim, M Mulder, K Müller, F Mũnoz-Rojas, R Murta, P Naik, T Nakada, R Nandakumar, T Nanut, I Nasteva, M Needham, N Neri, S Neubert, N Neufeld, P Neustroev, R Newcombe, J Nicolini, D Nicotra, E M Niel, N Nikitin, P Nogga, N S Nolte, C Normand, J Novoa Fernandez, G Nowak, C Nunez, H N Nur, A Oblakowska-Mucha, V Obraztsov, T Oeser, S Okamura, R Oldeman, F Oliva, M Olocco, C J G Onderwater, R H O'Neil, J M Otalora Goicochea, T Ovsiannikova, P Owen, A Oyanguren, O Ozcelik, K O Padeken, B Pagare, P R Pais, T Pajero, A Palano, M Palutan, G Panshin, L Paolucci, A Papanestis, M Pappagallo, L L Pappalardo, C Pappenheimer, C Parkes, B Passalacqua, G Passaleva, D Passaro, A Pastore, M Patel, J Patoc, C Patrignani, C J Pawley, A Pellegrino, M Pepe Altarelli, S Perazzini, D Pereima, A Pereiro Castro, P Perret, A Perro, K Petridis, A Petrolini, S Petrucci, H Pham, A Philippov, L Pica, M Piccini, B Pietrzyk, G Pietrzyk, D Pinci, F Pisani, M Pizzichemi, V Placinta, M Plo Casasus, F Polci, M Poli Lener, A Poluektov, N Polukhina, I Polyakov, E Polycarpo, S Ponce, D Popov, S Poslavskii, K Prasanth, L Promberger, C Prouve, V Pugatch, V Puill, G Punzi, H R Qi, W Qian, N Qin, S Qu, R Quagliani, B Rachwal, J H Rademacker, M Rama, M Ramírez García, M Ramos Pernas, M S Rangel, F Ratnikov, G Raven, M Rebollo De Miguel, F Redi, J Reich, F Reiss, Z Ren, P K Resmi, R Ribatti, G R Ricart, D Riccardi, S Ricciardi, K Richardson, M Richardson-Slipper, K Rinnert, P Robbe, G Robertson, E Rodrigues, E Rodriguez Fernandez, J A Rodriguez Lopez, E Rodriguez Rodriguez, A Rogovskiy, D L Rolf, A Rollings, P Roloff, V Romanovskiy, M Romero Lamas, A Romero Vidal, G Romolini, F Ronchetti, M Rotondo, M S Rudolph, T Ruf, R A Ruiz Fernandez, J Ruiz Vidal, A Ryzhikov, J Ryzka, J J Saborido Silva, N Sagidova, N Sahoo, B Saitta, M Salomoni, C Sanchez Gras, I Sanderswood, R Santacesaria, C Santamarina Rios, M Santimaria, L Santoro, E Santovetti, D Saranin, G Sarpis, M Sarpis, A Sarti, C Satriano, A Satta, M Saur, D Savrina, H Sazak, L G Scantlebury Smead, A Scarabotto, S Schael, S Scherl, A M Schertz, M Schiller, H Schindler, M Schmelling, B Schmidt, S Schmitt, O Schneider, A Schopper, N Schulte, S Schulte, M H Schune, R Schwemmer, G Schwering, B Sciascia, A Sciuccati, S Sellam, A Semennikov, M Senghi Soares, A Sergi, N Serra, L Sestini, A Seuthe, Y Shang, D M Shangase, M Shapkin, I Shchemerov, L Shchutska, T Shears, L Shekhtman, Z Shen, S Sheng, V Shevchenko, B Shi, E B Shields, Y Shimizu, E Shmanin, R Shorkin, J D Shupperd, B G Siddi, R Silva Coutinho, G Simi, S Simone, M Singla, N Skidmore, R Skuza, T Skwarnicki, M W Slater, J C Smallwood, J G Smeaton, E Smith, K Smith, M Smith, A Snoch, L Soares Lavra, M D Sokoloff, F J P Soler, A Solomin, A Solovev, I Solovyev, R Song, Y Song, Y Song, Y S Song, F L Souza De Almeida, B Souza De Paula, E Spadaro Norella, E Spedicato, J G Speer, E Spiridenkov, P Spradlin, V Sriskaran, F Stagni, M Stahl, S Stahl, S Stanislaus, E N Stein, O Steinkamp, O Stenyakin, H Stevens, D Strekalina, Y Su, F Suljik, J Sun, L Sun, Y Sun, P N Swallow, K Swientek, F Swystun, A Szabelski, T Szumlak, M Szymanski, Y Tan, S Taneja, M D Tat, A Terentev, F Teubert, E Thomas, D J D Thompson, H Tilquin, V Tisserand, S T'Jampens, M Tobin, L Tomassetti, G Tonani, X Tong, D Torres Machado, L Toscano, D Y Tou, C Trippl, G Tuci, N Tuning, A Ukleja, D J Unverzagt, E Ursov, A Usachov, A Ustyuzhanin, U Uwer, V Vagnoni, A Valassi, G Valenti, N Valls Canudas, M Van Dijk, H Van Hecke, E van Herwijnen, C B Van Hulse, R Van Laak, M van Veghel, R Vazquez Gomez, P Vazquez Regueiro, C Vázquez Sierra, S Vecchi, J J Velthuis, M Veltri, A Venkateswaran, M Vesterinen, D Vieira, M Vieites Diaz, X Vilasis-Cardona, E Vilella Figueras, A Villa, P Vincent, F C Volle, D Vom Bruch, V Vorobyev, N Voropaev, K Vos, C Vrahas, J Walsh, E J Walton, G Wan, C Wang, G Wang, J Wang, J Wang, J Wang, J Wang, M Wang, N W Wang, R Wang, X Wang, Y Wang, Z Wang, Z Wang, Z Wang, J A Ward, N K Watson, D Websdale, Y Wei, B D C Westhenry, D J White, M Whitehead, A R Wiederhold, D Wiedner, G Wilkinson, M K Wilkinson, I Williams, M Williams, M R J Williams, R Williams, F F Wilson, W Wislicki, M Witek, L Witola, C P Wong, G Wormser, S A Wotton, H Wu, J Wu, Y Wu, K Wyllie, S Xian, Z Xiang, Y Xie, A Xu, J Xu, L Xu, L Xu, M Xu, Z Xu, Z Xu, Z Xu, D Yang, S Yang, X Yang, Y Yang, Z Yang, Z Yang, V Yeroshenko, H Yeung, H Yin, C Y Yu, J Yu, X Yuan, E Zaffaroni, M Zavertyaev, M Zdybal, M Zeng, C Zhang, D Zhang, J Zhang, L Zhang, S Zhang, S Zhang, Y Zhang, Y Zhang, Y Zhao, A Zharkova, A Zhelezov, Y Zheng, T Zhou, X Zhou, Y Zhou, V Zhovkovska, L Z Zhu, X Zhu, X Zhu, Z Zhu, V Zhukov, J Zhuo, Q Zou, S Zucchelli, D Zuliani, G Zunica
The decay-time-dependent CP asymmetry in B_{s}^{0}→J/ψ(→μ^{+}μ^{-})K^{+}K^{-} decays is measured using proton-proton collision data, corresponding to an integrated luminosity of 6  fb^{-1}, collected with the LHCb detector at a center-of-mass energy of 13 TeV. Using a sample of approximately 349 000 B_{s}^{0} signal decays with an invariant K^{+}K^{-} mass in the vicinity of the ϕ(1020) resonance, the CP-violating phase ϕ_{s} is measured, along with the difference in decay widths of the light and heavy mass eigenstates of the B_{s}^{0}-B[over ¯]_{s}^{0} system, ΔΓ_{s}, and the difference of the average B_{s}^{0} and B^{0} meson decay widths, Γ_{s}-Γ_{d}...
February 2, 2024: Physical Review Letters
https://read.qxmd.com/read/38361531/formation-of-electron-traps-in-semiconducting-polymers-via-a-slow-triple-encounter-between-trap-precursor-particles
#23
JOURNAL ARTICLE
Mohammad Sedghi, Camilla Vael, Wei-Hsu Hu, Michael Bauer, Daniele Padula, Alessandro Landi, Mirko Lukovic, Matthias Diethelm, Gert-Jan Wetzelaer, Paul W M Blom, Frank Nüesch, Roland Hany
Already in 2012, Blom et al. reported (Nature Materials 2012, 11 , 882) in semiconducting polymers on a general electron-trap density of ≈3 × 1017 cm-3 , centered at an energy of ≈3.6 eV below vacuum. It was suggested that traps have an extrinsic origin, with the water-oxygen complex [2(H2 O)-O2 ] as a possible candidate, based on its electron affinity. However, further evidence is lacking and the origin of universal electron traps remained elusive. Here, in polymer diodes, the temperature-dependence of reversible electron traps is investigated that develop under bias stress slowly over minutes to a density of 2 × 1017 cm-3 , centered at an energy of 3...
2024: Science and Technology of Advanced Materials
https://read.qxmd.com/read/38359294/adaptive-nonequilibrium-design-of-actin-based-metamaterials-fundamental-and-practical-limits-of-control
#24
JOURNAL ARTICLE
Shriram Chennakesavalu, Sreekanth K Manikandan, Frank Hu, Grant M Rotskoff
The adaptive and surprising emergent properties of biological materials self-assembled in far-from-equilibrium environments serve as an inspiration for efforts to design nanomaterials. In particular, controlling the conditions of self-assembly can modulate material properties, but there is no systematic understanding of either how to parameterize external control or how controllable a given material can be. Here, we demonstrate that branched actin networks can be encoded with metamaterial properties by dynamically controlling the applied force under which they grow and that the protocols can be selected using multi-task reinforcement learning...
February 20, 2024: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/38335297/functional-epas1-hif2a-missense-variant-is-associated-with-hematocrit-in-andean-highlanders
#25
JOURNAL ARTICLE
Elijah S Lawrence, Wanjun Gu, Ryan J Bohlender, Cecilia Anza-Ramirez, Amy M Cole, James J Yu, Hao Hu, Erica C Heinrich, Katie A O'Brien, Carlos A Vasquez, Quinn T Cowan, Patrick T Bruck, Kysha Mercader, Mona Alotaibi, Tao Long, James E Hall, Esteban A Moya, Marco A Bauk, Jennifer J Reeves, Mitchell C Kong, Rany M Salem, Gustavo Vizcardo-Galindo, Jose-Luis Macarlupu, Rómulo Figueroa-Mujíca, Daniela Bermudez, Noemi Corante, Eduardo Gaio, Keolu P Fox, Veikko Salomaa, Aki S Havulinna, Andrew J Murray, Atul Malhotra, Frank L Powel, Mohit Jain, Alexis C Komor, Gianpiero L Cavalleri, Chad D Huff, Francisco C Villafuerte, Tatum S Simonson
Hypoxia-inducible factor pathway genes are linked to adaptation in both human and nonhuman highland species. EPAS1 , a notable target of hypoxia adaptation, is associated with relatively lower hemoglobin concentration in Tibetans. We provide evidence for an association between an adaptive EPAS1 variant (rs570553380) and the same phenotype of relatively low hematocrit in Andean highlanders. This Andean-specific missense variant is present at a modest frequency in Andeans and absent in other human populations and vertebrate species except the coelacanth...
February 9, 2024: Science Advances
https://read.qxmd.com/read/38331888/shear-margins-in-upper-half-of-northeast-greenland-ice-stream-were-established-two-millennia-ago
#26
JOURNAL ARTICLE
Daniela Jansen, Steven Franke, Catherine C Bauer, Tobias Binder, Dorthe Dahl-Jensen, Jan Eichler, Olaf Eisen, Yuanbang Hu, Johanna Kerch, Maria-Gema Llorens, Heinrich Miller, Niklas Neckel, John Paden, Tamara de Riese, Till Sachau, Nicolas Stoll, Ilka Weikusat, Frank Wilhelms, Yu Zhang, Paul D Bons
Only a few localised ice streams drain most of the ice from the Greenland Ice Sheet. Thus, understanding ice stream behaviour and its temporal variability is crucially important to predict future sea-level change. The interior trunk of the 700 km-long North-East Greenland Ice Stream (NEGIS) is remarkable due to the lack of any clear bedrock channel to explain its presence. Here, we present a 3-dimensional analysis of the folding and advection of its stratigraphic horizons, which shows that the localised flow and shear margins in the upper NEGIS were fully developed only ca 2000 years ago...
February 8, 2024: Nature Communications
https://read.qxmd.com/read/38331538/pelagic-sargassum-in-the-gulf-of-mexico-driven-by-ocean-currents-and-eddies
#27
JOURNAL ARTICLE
Yingjun Zhang, Chuanmin Hu, Dennis J McGillicuddy, Brian B Barnes, Yonggang Liu, Vassiliki H Kourafalou, Shuai Zhang, Frank J Hernandez
Pelagic Sargassum in the Gulf of Mexico (GoM) plays an important role in ocean biology and ecology, yet our knowledge of its origins and transport pathways is limited. Here, using satellite observations of Sargassum areal density and ocean surface currents between 2000 and 2023, we show that large amounts of Sargassum in the GoM can either originate from the northwestern GoM or be a result of physical transport from the northwestern Caribbean Sea, both with specific transport pathways. Sargassum of the northwestern GoM can be transported to the eastern GoM by ocean currents and eddies, eventually entering the Sargasso Sea...
February 2024: Harmful Algae
https://read.qxmd.com/read/38325187/detection-of-moderate-hepatic-steatosis-on-contrast-enhanced-dual-source-dual-energy-ct-role-and-accuracy-of-virtual-non-contrast-ct
#28
JOURNAL ARTICLE
Roberta Catania, Leo Jia, Maryam Haghshomar, Frank H Miller, Amir A Borhani
PURPOSE: To investigate diagnostic accuracy of virtual non contrast (VNC) images, based on dual-source dual-energy CT (dsDECT), for detection of at least moderate steatosis and to define a threshold value to make this diagnosis on VNC. METHODS: This single-institution retrospective study included patients who had multi-phasic protocol dsDECT. Regions of interests were placed in different segments of the liver and spleen on true non-contrast (TNC), VNC, and portal-venous phase (PVP) images...
March 2024: European Journal of Radiology
https://read.qxmd.com/read/38287718/type-2-diabetes-metabolomics-score-and-risk-of-progression-to-type-2-diabetes-among-women-with-a-history-of-gestational-diabetes-mellitus
#29
JOURNAL ARTICLE
Deirdre K Tobias, Rikuta Hamaya, Clary B Clish, Liming Liang, Amy Deik, Courtney Dennis, Kevin Bullock, Cuilin Zhang, Frank B Hu, JoAnn E Manson
BACKGROUND: Several metabolites are individually related to incident type 2 diabetes (T2D) risk. We prospectively evaluated a novel T2D-metabolite pattern with a risk of progression to T2D among high-risk women with a history of gestational diabetes mellitus (GDM). METHODS: The longitudinal Nurses' Health Study II cohort enroled 116,429 women in 1989 and collected blood samples from 1996 to 1999. We profiled plasma metabolites in 175 incident T2D cases and 175 age-matched controls, all with a history of GDM before the blood draw...
January 2024: Diabetes/metabolism Research and Reviews
https://read.qxmd.com/read/38277604/measurement-of-cp-violation-in-b-0-%C3%A2-%C3%AF-%C3%A2-%C3%A2-%C3%A2-k_-s-0-%C3%A2-%C3%AF-%C3%AF-decays
#30
JOURNAL ARTICLE
R Aaij, A S W Abdelmotteleb, C Abellan Beteta, F Abudinén, T Ackernley, B Adeva, M Adinolfi, P Adlarson, H Afsharnia, C Agapopoulou, C A Aidala, Z Ajaltouni, S Akar, K Akiba, P Albicocco, J Albrecht, F Alessio, M Alexander, A Alfonso Albero, Z Aliouche, P Alvarez Cartelle, R Amalric, S Amato, J L Amey, Y Amhis, L An, L Anderlini, M Andersson, A Andreianov, P Andreola, M Andreotti, D Andreou, D Ao, F Archilli, A Artamonov, M Artuso, E Aslanides, M Atzeni, B Audurier, D Bacher, I Bachiller Perea, S Bachmann, M Bachmayer, J J Back, A Bailly-Reyre, P Baladron Rodriguez, V Balagura, W Baldini, J Baptista de Souza Leite, M Barbetti, I R Barbosa, R J Barlow, S Barsuk, W Barter, M Bartolini, F Baryshnikov, J M Basels, G Bassi, B Batsukh, A Battig, A Bay, A Beck, M Becker, F Bedeschi, I B Bediaga, A Beiter, S Belin, V Bellee, K Belous, I Belov, I Belyaev, G Benane, G Bencivenni, E Ben-Haim, A Berezhnoy, R Bernet, S Bernet Andres, D Berninghoff, H C Bernstein, C Bertella, A Bertolin, C Betancourt, F Betti, J Bex, Ia Bezshyiko, J Bhom, L Bian, M S Bieker, N V Biesuz, P Billoir, A Biolchini, M Birch, F C R Bishop, A Bitadze, A Bizzeti, M P Blago, T Blake, F Blanc, J E Blank, S Blusk, D Bobulska, V Bocharnikov, J A Boelhauve, O Boente Garcia, T Boettcher, A Bohare, A Boldyrev, C S Bolognani, R Bolzonella, N Bondar, F Borgato, S Borghi, M Borsato, J T Borsuk, S A Bouchiba, T J V Bowcock, A Boyer, C Bozzi, M J Bradley, S Braun, A Brea Rodriguez, N Breer, J Brodzicka, A Brossa Gonzalo, J Brown, D Brundu, A Buonaura, L Buonincontri, A T Burke, C Burr, A Bursche, A Butkevich, J S Butter, J Buytaert, W Byczynski, S Cadeddu, H Cai, R Calabrese, L Calefice, S Cali, M Calvi, M Calvo Gomez, J Cambon Bouzas, P Campana, D H Campora Perez, A F Campoverde Quezada, S Capelli, L Capriotti, A Carbone, L Carcedo Salgado, R Cardinale, A Cardini, P Carniti, L Carus, A Casais Vidal, R Caspary, G Casse, M Cattaneo, G Cavallero, V Cavallini, S Celani, J Cerasoli, D Cervenkov, A J Chadwick, I Chahrour, M G Chapman, M Charles, Ph Charpentier, C A Chavez Barajas, M Chefdeville, C Chen, S Chen, A Chernov, S Chernyshenko, V Chobanova, S Cholak, M Chrzaszcz, A Chubykin, V Chulikov, P Ciambrone, M F Cicala, X Cid Vidal, G Ciezarek, P Cifra, P E L Clarke, M Clemencic, H V Cliff, J Closier, J L Cobbledick, C Cocha Toapaxi, V Coco, J Cogan, E Cogneras, L Cojocariu, P Collins, T Colombo, A Comerma-Montells, L Congedo, A Contu, N Cooke, I Corredoira, A Correia, G Corti, J J Cottee Meldrum, B Couturier, D C Craik, M Cruz Torres, R Currie, C L Da Silva, S Dadabaev, L Dai, X Dai, E Dall'Occo, J Dalseno, C D'Ambrosio, J Daniel, A Danilina, P d'Argent, A Davidson, J E Davies, A Davis, O De Aguiar Francisco, J de Boer, K De Bruyn, S De Capua, M De Cian, U De Freitas Carneiro Da Graca, E De Lucia, J M De Miranda, L De Paula, M De Serio, D De Simone, P De Simone, F De Vellis, J A de Vries, C T Dean, F Debernardis, D Decamp, V Dedu, L Del Buono, B Delaney, H-P Dembinski, V Denysenko, O Deschamps, F Dettori, B Dey, P Di Nezza, I Diachkov, S Didenko, S Ding, V Dobishuk, A D Docheva, A Dolmatov, C Dong, A M Donohoe, F Dordei, A C Dos Reis, L Douglas, A G Downes, W Duan, P Duda, M W Dudek, L Dufour, V Duk, P Durante, M M Duras, J M Durham, D Dutta, A Dziurda, A Dzyuba, S Easo, E Eckstein, U Egede, A Egorychev, V Egorychev, C Eirea Orro, S Eisenhardt, E Ejopu, S Ek-In, L Eklund, M Elashri, J Ellbracht, S Ely, A Ene, E Epple, S Escher, J Eschle, S Esen, T Evans, F Fabiano, L N Falcao, Y Fan, B Fang, L Fantini, M Faria, K Farmer, S Farry, D Fazzini, L Felkowski, M Feng, M Feo, M Fernandez Gomez, A D Fernez, F Ferrari, L Ferreira Lopes, F Ferreira Rodrigues, S Ferreres Sole, M Ferrillo, M Ferro-Luzzi, S Filippov, R A Fini, M Fiorini, M Firlej, K M Fischer, D S Fitzgerald, C Fitzpatrick, T Fiutowski, F Fleuret, M Fontana, F Fontanelli, L F Foreman, R Forty, D Foulds-Holt, M Franco Sevilla, M Frank, E Franzoso, G Frau, C Frei, D A Friday, L Frontini, J Fu, Q Fuehring, Y Fujii, T Fulghesu, E Gabriel, G Galati, M D Galati, A Gallas Torreira, D Galli, S Gambetta, M Gandelman, P Gandini, H Gao, R Gao, Y Gao, Y Gao, M Garau, L M Garcia Martin, P Garcia Moreno, J García Pardiñas, B Garcia Plana, F A Garcia Rosales, L Garrido, C Gaspar, R E Geertsema, L L Gerken, E Gersabeck, M Gersabeck, T Gershon, L Giambastiani, F I Giasemis, V Gibson, H K Giemza, A L Gilman, M Giovannetti, A Gioventù, P Gironella Gironell, C Giugliano, M A Giza, K Gizdov, E L Gkougkousis, F C Glaser, V V Gligorov, C Göbel, E Golobardes, D Golubkov, A Golutvin, A Gomes, S Gomez Fernandez, F Goncalves Abrantes, M Goncerz, G Gong, J A Gooding, I V Gorelov, C Gotti, J P Grabowski, L A Granado Cardoso, E Graugés, E Graverini, L Grazette, G Graziani, A T Grecu, L M Greeven, N A Grieser, L Grillo, S Gromov, C Gu, M Guarise, M Guittiere, V Guliaeva, P A Günther, A-K Guseinov, E Gushchin, Y Guz, T Gys, T Hadavizadeh, C Hadjivasiliou, G Haefeli, C Haen, J Haimberger, S C Haines, M Hajheidari, T Halewood-Leagas, M M Halvorsen, P M Hamilton, J Hammerich, Q Han, X Han, S Hansmann-Menzemer, L Hao, N Harnew, T Harrison, M Hartmann, C Hasse, M Hatch, J He, K Heijhoff, F Hemmer, C Henderson, R D L Henderson, A M Hennequin, K Hennessy, L Henry, J Herd, J Heuel, A Hicheur, D Hill, M Hilton, S E Hollitt, J Horswill, R Hou, Y Hou, N Howarth, J Hu, J Hu, W Hu, X Hu, W Huang, X Huang, W Hulsbergen, R J Hunter, M Hushchyn, D Hutchcroft, P Ibis, M Idzik, D Ilin, P Ilten, A Inglessi, A Iniukhin, A Ishteev, K Ivshin, R Jacobsson, H Jage, S J Jaimes Elles, S Jakobsen, E Jans, B K Jashal, A Jawahery, V Jevtic, E Jiang, X Jiang, Y Jiang, Y J Jiang, M John, D Johnson, C R Jones, T P Jones, S Joshi, B Jost, N Jurik, I Juszczak, D Kaminaris, S Kandybei, Y Kang, M Karacson, D Karpenkov, M Karpov, A M Kauniskangas, J W Kautz, F Keizer, D M Keller, M Kenzie, T Ketel, B Khanji, A Kharisova, S Kholodenko, G Khreich, T Kirn, V S Kirsebom, O Kitouni, S Klaver, N Kleijne, K Klimaszewski, M R Kmiec, S Koliiev, L Kolk, A Kondybayeva, A Konoplyannikov, P Kopciewicz, R Kopecna, P Koppenburg, M Korolev, I Kostiuk, O Kot, S Kotriakhova, A Kozachuk, P Kravchenko, L Kravchuk, M Kreps, S Kretzschmar, P Krokovny, W Krupa, W Krzemien, J Kubat, S Kubis, W Kucewicz, M Kucharczyk, V Kudryavtsev, E Kulikova, A Kupsc, B K Kutsenko, D Lacarrere, G Lafferty, A Lai, A Lampis, D Lancierini, C Landesa Gomez, J J Lane, R Lane, C Langenbruch, J Langer, O Lantwin, T Latham, F Lazzari, C Lazzeroni, R Le Gac, S H Lee, R Lefèvre, A Leflat, S Legotin, O Leroy, T Lesiak, B Leverington, A Li, H Li, K Li, L Li, P Li, P-R Li, S Li, T Li, T Li, Y Li, Z Li, Z Lian, X Liang, C Lin, T Lin, R Lindner, V Lisovskyi, R Litvinov, G Liu, H Liu, K Liu, Q Liu, S Liu, Y Liu, Y Liu, A Lobo Salvia, A Loi, J Lomba Castro, T Long, I Longstaff, J H Lopes, A Lopez Huertas, S López Soliño, G H Lovell, Y Lu, C Lucarelli, D Lucchesi, S Luchuk, M Lucio Martinez, V Lukashenko, Y Luo, A Lupato, E Luppi, K Lynch, X-R Lyu, R Ma, S Maccolini, F Machefert, F Maciuc, I Mackay, V Macko, L R Madhan Mohan, M M Madurai, A Maevskiy, D Magdalinski, D Maisuzenko, M W Majewski, J J Malczewski, S Malde, B Malecki, A Malinin, T Maltsev, G Manca, G Mancinelli, C Mancuso, R Manera Escalero, D Manuzzi, C A Manzari, D Marangotto, J F Marchand, U Marconi, S Mariani, C Marin Benito, J Marks, A M Marshall, P J Marshall, G Martelli, G Martellotti, L Martinazzoli, M Martinelli, D Martinez Santos, F Martinez Vidal, A Massafferri, M Materok, R Matev, A Mathad, V Matiunin, C Matteuzzi, K R Mattioli, A Mauri, E Maurice, J Mauricio, M Mazurek, M McCann, L Mcconnell, T H McGrath, N T McHugh, A McNab, R McNulty, B Meadows, G Meier, D Melnychuk, M Merk, A Merli, L Meyer Garcia, D Miao, H Miao, M Mikhasenko, D A Milanes, M Milovanovic, M-N Minard, A Minotti, E Minucci, T Miralles, S E Mitchell, B Mitreska, D S Mitzel, A Modak, A Mödden, R A Mohammed, R D Moise, S Mokhnenko, T Mombächer, M Monk, I A Monroy, S Monteil, A Morcillo Gomez, G Morello, M J Morello, M P Morgenthaler, J Moron, A B Morris, A G Morris, R Mountain, H Mu, Z M Mu, E Muhammad, F Muheim, M Mulder, K Müller, F Mũnoz-Rojas, D Murray, R Murta, P Naik, T Nakada, R Nandakumar, T Nanut, I Nasteva, M Needham, N Neri, S Neubert, N Neufeld, P Neustroev, R Newcombe, J Nicolini, D Nicotra, E M Niel, N Nikitin, P Nogga, N S Nolte, C Normand, J Novoa Fernandez, G Nowak, C Nunez, H N Nur, A Oblakowska-Mucha, V Obraztsov, T Oeser, S Okamura, R Oldeman, F Oliva, M Olocco, C J G Onderwater, R H O'Neil, J M Otalora Goicochea, T Ovsiannikova, P Owen, A Oyanguren, O Ozcelik, K O Padeken, B Pagare, P R Pais, T Pajero, A Palano, M Palutan, G Panshin, L Paolucci, A Papanestis, M Pappagallo, L L Pappalardo, C Pappenheimer, C Parkes, B Passalacqua, G Passaleva, A Pastore, M Patel, J Patoc, C Patrignani, C J Pawley, A Pellegrino, M Pepe Altarelli, S Perazzini, D Pereima, A Pereiro Castro, P Perret, A Perro, K Petridis, A Petrolini, S Petrucci, H Pham, A Philippov, L Pica, M Piccini, B Pietrzyk, G Pietrzyk, D Pinci, F Pisani, M Pizzichemi, V Placinta, M Plo Casasus, F Polci, M Poli Lener, A Poluektov, N Polukhina, I Polyakov, E Polycarpo, S Ponce, D Popov, S Poslavskii, K Prasanth, L Promberger, C Prouve, V Pugatch, V Puill, G Punzi, H R Qi, W Qian, N Qin, S Qu, R Quagliani, B Rachwal, J H Rademacker, R Rajagopalan, M Rama, M Ramírez García, M Ramos Pernas, M S Rangel, F Ratnikov, G Raven, M Rebollo De Miguel, F Redi, J Reich, F Reiss, Z Ren, P K Resmi, R Ribatti, G R Ricart, S Ricciardi, K Richardson, M Richardson-Slipper, K Rinnert, P Robbe, G Robertson, E Rodrigues, E Rodriguez Fernandez, J A Rodriguez Lopez, E Rodriguez Rodriguez, A Rogovskiy, D L Rolf, A Rollings, P Roloff, V Romanovskiy, M Romero Lamas, A Romero Vidal, F Ronchetti, M Rotondo, M S Rudolph, T Ruf, R A Ruiz Fernandez, J Ruiz Vidal, A Ryzhikov, J Ryzka, J J Saborido Silva, N Sagidova, N Sahoo, B Saitta, M Salomoni, C Sanchez Gras, I Sanderswood, R Santacesaria, C Santamarina Rios, M Santimaria, L Santoro, E Santovetti, D Saranin, G Sarpis, M Sarpis, A Sarti, C Satriano, A Satta, M Saur, D Savrina, H Sazak, L G Scantlebury Smead, A Scarabotto, S Schael, S Scherl, A M Schertz, M Schiller, H Schindler, M Schmelling, B Schmidt, S Schmitt, O Schneider, A Schopper, M Schubiger, N Schulte, S Schulte, M H Schune, R Schwemmer, G Schwering, B Sciascia, A Sciuccati, S Sellam, A Semennikov, M Senghi Soares, A Sergi, N Serra, L Sestini, A Seuthe, Y Shang, D M Shangase, M Shapkin, I Shchemerov, L Shchutska, T Shears, L Shekhtman, Z Shen, S Sheng, V Shevchenko, B Shi, E B Shields, Y Shimizu, E Shmanin, R Shorkin, J D Shupperd, B G Siddi, R Silva Coutinho, G Simi, S Simone, M Singla, N Skidmore, R Skuza, T Skwarnicki, M W Slater, J C Smallwood, J G Smeaton, E Smith, K Smith, M Smith, A Snoch, L Soares Lavra, M D Sokoloff, F J P Soler, A Solomin, A Solovev, I Solovyev, R Song, Y Song, Y Song, Y S Song, F L Souza De Almeida, B Souza De Paula, E Spadaro Norella, E Spedicato, J G Speer, E Spiridenkov, P Spradlin, V Sriskaran, F Stagni, M Stahl, S Stahl, S Stanislaus, E N Stein, O Steinkamp, O Stenyakin, H Stevens, D Strekalina, Y Su, F Suljik, J Sun, L Sun, Y Sun, P N Swallow, K Swientek, F Swystun, A Szabelski, T Szumlak, M Szymanski, Y Tan, S Taneja, M D Tat, A Terentev, F Teubert, E Thomas, D J D Thompson, H Tilquin, V Tisserand, S T'Jampens, M Tobin, L Tomassetti, G Tonani, X Tong, D Torres Machado, L Toscano, D Y Tou, C Trippl, G Tuci, N Tuning, A Ukleja, D J Unverzagt, E Ursov, A Usachov, A Ustyuzhanin, U Uwer, V Vagnoni, A Valassi, G Valenti, N Valls Canudas, M Van Dijk, H Van Hecke, E van Herwijnen, C B Van Hulse, R Van Laak, M van Veghel, R Vazquez Gomez, P Vazquez Regueiro, C Vázquez Sierra, S Vecchi, J J Velthuis, M Veltri, A Venkateswaran, M Vesterinen, D Vieira, M Vieites Diaz, X Vilasis-Cardona, E Vilella Figueras, A Villa, P Vincent, F C Volle, D Vom Bruch, V Vorobyev, N Voropaev, K Vos, C Vrahas, J Walsh, E J Walton, G Wan, C Wang, G Wang, J Wang, J Wang, J Wang, J Wang, M Wang, N W Wang, R Wang, X Wang, Y Wang, Z Wang, Z Wang, Z Wang, J A Ward, N K Watson, D Websdale, Y Wei, B D C Westhenry, D J White, M Whitehead, A R Wiederhold, D Wiedner, G Wilkinson, M K Wilkinson, I Williams, M Williams, M R J Williams, R Williams, F F Wilson, W Wislicki, M Witek, L Witola, C P Wong, G Wormser, S A Wotton, H Wu, J Wu, Y Wu, K Wyllie, S Xian, Z Xiang, Y Xie, A Xu, J Xu, L Xu, L Xu, M Xu, Z Xu, Z Xu, Z Xu, D Yang, S Yang, X Yang, Y Yang, Z Yang, Z Yang, V Yeroshenko, H Yeung, H Yin, C Y Yu, J Yu, X Yuan, E Zaffaroni, M Zavertyaev, M Zdybal, M Zeng, C Zhang, D Zhang, J Zhang, L Zhang, S Zhang, S Zhang, Y Zhang, Y Zhang, Y Zhao, A Zharkova, A Zhelezov, Y Zheng, T Zhou, X Zhou, Y Zhou, V Zhovkovska, L Z Zhu, X Zhu, X Zhu, Z Zhu, V Zhukov, J Zhuo, Q Zou, S Zucchelli, D Zuliani, G Zunica
A measurement of time-dependent CP violation in the decays of B^{0} and B[over ¯]^{0} mesons to the final states J/ψ(→μ^{+}μ^{-})K_{S}^{0}, ψ(2S)(→μ^{+}μ^{-})K_{S}^{0} and J/ψ(→e^{+}e^{-})K_{S}^{0} with K_{S}^{0}→π^{+}π^{-} is presented. The data correspond to an integrated luminosity of 6  fb^{-1} collected at a center-of-mass energy of sqrt[s]=13  TeV with the LHCb detector. The CP-violation parameters are measured to be S_{ψK_{S}^{0}}=0...
January 12, 2024: Physical Review Letters
https://read.qxmd.com/read/38272832/kinetics-controlled-perovskite-crystallization-for-high-performance-solar-cells
#31
JOURNAL ARTICLE
Jinghao Ge, Ran Chen, Yabin Ma, Yunfan Wang, Yingjie Hu, Lu Zhang, Fengzhu Li, Xiaokang Ma, Sai-Wing Tsang, Jiaxue You, Alex K Y Jen, Shengzhong Frank Liu
The power conversion efficiencies (PCEs) of perovskite solar cells have recently developed rapidly compared to crystalline silicon solar cells. To have an effective way to control the crystallization of perovskite thin films is the key for achieving good device performance. However, a paradox in perovskite crystallization is from the mismatch between nucleation and Oswald ripening. Usually, the large numbers of nucleation sites tend to weak Oswald ripening. Here, we proposed a new mechanism to promote the formation of nucleation sites by reducing surface energy from 44...
January 25, 2024: Angewandte Chemie
https://read.qxmd.com/read/38272606/association-of-glycaemic-index-and-glycaemic-load-with-type-2-diabetes-cardiovascular-disease-cancer-and-all-cause-mortality-a-meta-analysis-of-mega-cohorts-of-more-than-100%C3%A2-000-participants
#32
JOURNAL ARTICLE
David J A Jenkins, Walter C Willett, Salim Yusuf, Frank B Hu, Andrea J Glenn, Simin Liu, Andrew Mente, Victoria Miller, Shrikant I Bangdiwala, Hertzel C Gerstein, Sabina Sieri, Pietro Ferrari, Alpa V Patel, Marjorie L McCullough, Loïc Le Marchand, Neal D Freedman, Erikka Loftfield, Rashmi Sinha, Xiao-Ou Shu, Mathilde Touvier, Norie Sawada, Shoichiro Tsugane, Piet A van den Brandt, Kerem Shuval, Tauseef Ahmad Khan, Melanie Paquette, Sandhya Sahye-Pudaruth, Darshna Patel, Teenie Fei Yi Siu, Korbua Srichaikul, Cyril W C Kendall, John L Sievenpiper
BACKGROUND: There is debate over whether the glycaemic index of foods relates to chronic disease. We aimed to assess the associations between glycaemic index (GI) and glycaemic load (GL) and type 2 diabetes, cardiovascular disease, diabetes-related cancers, and all-cause mortality. METHODS: We did a meta-analysis of large cohorts (≥100 000 participants) identified from the Richard Doll Consortium. We searched the Cochrane Library, MEDLINE, PubMed, Embase, Web of Science, and Scopus for cohorts that prospectively examined associations between GI or GL and chronic disease outcomes published from database inception to Aug 4, 2023...
February 2024: Lancet Diabetes & Endocrinology
https://read.qxmd.com/read/38264362/plant-based-diets-and-the-incidence-of-cardiovascular-disease-the-million-veteran-program
#33
JOURNAL ARTICLE
Yanping Li, Dong D Wang, Xuan-Mai T Nguyen, Rebecca J Song, Yuk-Lam Ho, Frank B Hu, Walter C Willett, Peter W F Wilson, Kelly Cho, John Michael Gaziano, Luc Djousse
BACKGROUND: A healthful plant-based diet was associated with lower risks of coronary heart disease and type 2 diabetes, and a favourable profile of adiposity-associated biomarkers, while an unhealthful plant-based diet was associated with elevated risk of cardiometabolic disease in health professional populations. However, little is known about the associations between plant-based dietary patterns and risk of cardiovascular disease (CVD) in US veterans. METHODS: The study population consisted of 148 506 participants who were free of diabetes, CVD and cancer at baseline in the Veterans Affairs (VA) Million Veteran Program...
December 2023: BMJ nutrition, prevention & health
https://read.qxmd.com/read/38245716/plasma-metabolite-profile-of-legume-consumption-and-future-risk-of-type-2-diabetes-and-cardiovascular-disease
#34
JOURNAL ARTICLE
Hernando J Margara-Escudero, Indira Paz-Graniel, Jesús García-Gavilán, Miguel Ruiz-Canela, Qi Sun, Clary B Clish, Estefania Toledo, Dolores Corella, Ramón Estruch, Emilio Ros, Olga Castañer, Fernando Arós, Miquel Fiol, Marta Guasch-Ferré, José Lapetra, Cristina Razquin, Courtney Dennis, Amy Deik, Jun Li, Enrique Gómez-Gracia, Nancy Babio, Miguel A Martínez-González, Frank B Hu, Jordi Salas-Salvadó
BACKGROUND: Legume consumption has been linked to a reduced risk of type 2 diabetes (T2D) and cardiovascular disease (CVD), while the potential association between plasma metabolites associated with legume consumption and the risk of cardiometabolic diseases has never been explored. Therefore, we aimed to identify a metabolite signature of legume consumption, and subsequently investigate its potential association with the incidence of T2D and CVD. METHODS: The current cross-sectional and longitudinal analysis was conducted in 1833 PREDIMED study participants (mean age 67 years, 57...
January 20, 2024: Cardiovascular Diabetology
https://read.qxmd.com/read/38227336/consumption-of-100-fruit-juice-and-body-weight-in-children-and-adults-a-systematic-review-and-meta-analysis
#35
JOURNAL ARTICLE
Michelle Nguyen, Sarah E Jarvis, Laura Chiavaroli, Sonia Blanco Mejia, Andreea Zurbau, Tauseef A Khan, Deirdre K Tobias, Walter C Willett, Frank B Hu, Anthony J Hanley, Catherine S Birken, John L Sievenpiper, Vasanti S Malik
IMPORTANCE: Concerns have been raised that frequent consumption of 100% fruit juice may promote weight gain. Current evidence on fruit juice and weight gain has yielded mixed findings from both observational studies and clinical trials. OBJECTIVE: To synthesize the available evidence on 100% fruit juice consumption and body weight in children and adults. DATA SOURCES: MEDLINE, Embase, and Cochrane databases were searched through May 18, 2023...
March 1, 2024: JAMA Pediatrics
https://read.qxmd.com/read/38223529/a-mechanistic-biomarker-investigation-of-fialuridine-hepatotoxicity-using-the-chimeric-tk-nog-hu-liver-mouse-model-and-in-vitro-micropatterned-hepatocyte-cocultures
#36
JOURNAL ARTICLE
Amy G Aslamkhan, Laura Michna, Alexei Podtelezhnikov, Katerina Vlasakova, Hiroshi Suemizu, Yasuyuki Ohnishi, Liping Liu, Pamela Lane, Qiuwei Xu, Matthew C Kuhls, Zhibin Wang, Stephen Pacchione, Zoltan Erdos, Rodger William Tracy, Kenneth Koeplinger, Nagaraja Muniappa, John Valentine, Alema Galijatovic-Idrizbegovic, Warren E Glaab, Frank D Sistare, Jose Lebron
Fialuridine (FIAU) is a nucleoside-based drug that caused liver failure and deaths in a human clinical trial that were not predicted by nonclinical safety studies. A recent report concluded that a TK-NOG humanized liver (hu-liver) mouse model detected human-specific FIAU liver toxicity, and broader use of that model could improve drug safety testing. We further evaluated this model at similar dose levels to assess FIAU sensitivity and potential mechanistic biomarkers. Although we were unable to reproduce the marked acute liver toxicity with two separate studies (including one with a "sensitized" donor), we identified molecular biomarkers reflecting the early stages of FIAU mitochondrial toxicity, which were not seen with its stereoisomer (FIRU)...
February 2024: Toxicology Research
https://read.qxmd.com/read/38219955/scmr-expert-consensus-statement-for-cardiovascular-magnetic-resonance-of-patients-with-a-cardiac-implantable-electronic-device
#37
JOURNAL ARTICLE
Daniel Kim, Jeremy D Collins, James A White, Kate Hanneman, Daniel C Lee, Amit R Patel, Peng Hu, Harold Litt, Jonathan W Weinsaft, Rachel Davids, Kanae Mukai, Ming-Yen Ng, Julian A Luetkens, Ariel Roguin, Carlos E Rochitte, Pamela K Woodard, Charlotte Manisty, Karolina M Zareba, Lluis Mont, Frank Bogun, Daniel B Ennis, Saman Nazarian, Gregory Webster, Jadranka Stojanovska
Cardiovascular magnetic resonance (CMR) is a proven imaging modality for informing diagnosis and prognosis, guiding therapeutic decisions, and risk stratifying surgical intervention. Patients with a cardiac implantable electronic device (CIED) would be expected to derive particular benefit from CMR given high prevalence of cardiomyopathy and arrhythmia. While several guidelines have been published over the last 16 years, it is important to recognize that both the CIED and CMR technologies, as well as our knowledge in MR safety, have evolved rapidly during that period...
January 12, 2024: Journal of Cardiovascular Magnetic Resonance
https://read.qxmd.com/read/38199011/-i-don-t-have-a-telephone-to-the-fetus-clinicians-conceptions-of-fetal-patienthood-in-maternal-fetal-surgery-counseling
#38
JOURNAL ARTICLE
E Goldblatt Hyatt, Abigail Wilpers, Mert Ozan Bahtiyar, Yunzhe Hu, Daisy Leon-Martinez, Frank A Chervenak, Judith L M McCoyd
RATIONALE: Maternal fetal surgery (MFS) has developed rapidly since the 1960s and centers for fetal diagnosis and therapy (CFDT) have proliferated. As a result, CFDT clinicians have intervened with fetuses through pregnant bodies for decades, yet the patienthood status of the fetus and its implications for the pregnant person's autonomy have been relatively unexamined. OBJECTIVE: Our overall research aims were threefold: (1) to explore how clinicians train for and provide counseling for MFS; (2) to examine how clinicians assess fetal patienthood and its implications; and (3) to understand clinicians' professed needs and their recommendations for education and training for the provision of MFS counseling...
December 23, 2023: Social Science & Medicine
https://read.qxmd.com/read/38187603/human-induced-pluripotent-stem-cell-based-hepatic-modeling-of-lipid-metabolism-associated-tm6sf2-e167k-variant
#39
Lanuza Ap Faccioli, Yiyue Sun, Takashi Motomura, Zhenghao Liu, Takeshi Kurihara, Zhiping Hu, Zeliha Cetin, Jonathan Franks, Donna Stolz, Alina Ostrowska, Rodrigo M Florentino, Ira J Fox, Alejandro Soto-Gutierrez
BACKGROUND AND AIMS: TM6SF2 rs58542926 (E167K) is associated with an increase in the prevalence of Metabolic Disfunction-Associated Steatotic Liver Disease (MASLD). Despite all the investigation related to the role of this variant in lipid metabolism, conflicting results in mouse studies underscore the importance of creating a human model for understanding the TM6SF2 mechanism. Therefore, the aim of this study is to generate a reliable human in vitro model that mimic the effects of the TM6SF2 E167K mutation and can be used for future mechanism studies...
December 18, 2023: bioRxiv
https://read.qxmd.com/read/38185281/sugar-sweetened-or-artificially-sweetened-beverage-consumption-physical-activity-and-risk-of-cardiovascular-disease-in-adults-a-prospective-cohort-study
#40
JOURNAL ARTICLE
Lorena S Pacheco, Deirdre K Tobias, Yanping Li, Shilpa N Bhupathiraju, Walter C Willett, David S Ludwig, Cara B Ebbeling, Danielle E Haslam, Jean-Philippe Drouin-Chartier, Frank B Hu, Marta Guasch-Ferré
BACKGROUND: Whether physical activity could mitigate the adverse impacts of sugar-sweetened beverages (SSBs) or artificially sweetened beverages (ASBs) on incident cardiovascular disease (CVD) remains uncertain. OBJECTIVES: This study aimed to examine the independent and joint associations between SSB or ASB consumption and physical activity and risk of CVD, defined as fatal and nonfatal coronary artery disease and stroke, in adults from 2 United States-based prospective cohort studies...
January 6, 2024: American Journal of Clinical Nutrition
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