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Lauriane Galle-Treger, Ishwarya Sankaranarayanan, Benjamin P Hurrell, Emily Howard, Richard Lo, Hadi Maazi, Gavin Lewis, Homayon Banie, Alan L Epstein, Peisheng Hu, Virender K Rehan, Frank D Gilliland, Hooman Allayee, Pejman Soroosh, Arlene H Sharpe, Omid Akbari
Metabolic syndrome is characterized by disturbances in glucose homeostasis and the development of low-grade systemic inflammation, which increase the risk to develop type 2 diabetes mellitus (T2DM). Type-2 innate lymphoid cells (ILC2s) are a recently discovered immune population secreting Th2 cytokines. While previous studies show how ILC2s can play a critical role in the regulation of metabolic homeostasis in the adipose tissue, a therapeutic target capable of modulating ILC2 activation has yet to be identified...
February 12, 2019: Nature Communications
Taoping Sun, Yanwei Zhang, Hao Huang, Xiaoqian Wang, Li Zhou, Shuzhen Li, Suli Huang, Changhui Xie, Ying Wen, Yalun Zhu, Xiaoli Hu, Liangkai Chen, Peiyun Li, Sijing Chen, Wei Yang, Wei Bao, Frank B Hu, Jinquan Cheng, Liegang Liu
Background: Epidemiologic studies on whole grains and risk of stroke have reported inconsistent results, with some suggesting a protective effect but others showing a null association. Objectives: The aim of this study was to examine whether plasma 3-(3,5-dihydroxyphenyl)-1-propanoic acid (DHPPA), a biomarker of whole-grain wheat and rye intake, is associated with risk of ischemic stroke. Methods: A hospital-based case-control study was conducted between March 2011 and May 2016...
February 1, 2019: American Journal of Clinical Nutrition
Lei Gao, Peng Li, Chelsea Hu, Tommy To, Melissa Patxot, Brigid Falvey, Patricia M Wong, Frank A J L Scheer, Chen Lin, Men-Tzung Lo, Kun Hu
Study Objectives: Sleep-wake regularity (SWR) is often disrupted in college students and mood disorders are rife at this age. Disrupted SWR can cause repetitive and long-term misalignment between environmental and behavioral cycles and the circadian system which may then have psychological and physical health consequences. We tested whether SWR was independently associated with mood and autonomic function in a healthy adult cohort. Methods: We studied 42 college students over a 3-week period using daily sleep-wake diaries and continuous electrocardiogram (ECG) recordings...
February 5, 2019: Sleep
Ting Zhang, Qi Zhao, Xuerong Xiao, Rui Yang, Dandan Hu, Xu Zhu, Frank J Gonzalez, Fei Li
Hyperlipidemia, characterized by high serum lipids, is a risk factor for cardiovascular disease. Recent studies have identified an important role for celastrol, a proteasome inhibitor isolated from Tripterygium wilfordii Hook. F., in obesity-related metabolic disorders. However, the exact influences of celastrol on lipid metabolism remains largely unknown. Celastrol inhibited the terminal differentiation of 3T3-L1 adipocytes, and decreased the levels of triglycerides in wild-type mice. Lipidomics analysis revealed that celastrol increased the metabolism of lysophosphatidylcholines (LPCs), phosphatidylcholines (PCs), sphingomyelins (SMs), and phosphatidylethanolamines (PEs)...
February 1, 2019: Journal of Proteome Research
Kaiyuan Zheng, Chuantao Zheng, Dan Yao, Lien Hu, Zidi Liu, Junhao Li, Yu Zhang, Yiding Wang, Frank K Tittel
By combining frequency division multiplexing assisted wavelength modulation spectroscopy (FDM-WMS) and off-axis integrated-cavity output spectroscopy (OA-ICOS), a near-infrared (near-IR) dual-gas sensor system was demonstrated for simultaneous chemical gas-phase detection of acetylene (C2H2) and methane (CH4). Two distributed feedback (DFB) lasers modulated at the frequency of 3 kHz and 4 kHz with an emitting wavelength of 1532 and 1653 nm were used to target two absorption lines, C2H2 at 6523.88 cm-1 and CH4 at 6046...
January 30, 2019: Analyst
Marta Guasch-Ferre, Geng Zong, Walter C Willett, Peter Zock, Anne J Wanders, Frank B Hu, Qi Sun
RATIONALE: Dietary monounsaturated fatty acids (MUFAs) can come from both plant and animal sources with divergent nutrient profiles that may potentially obscure the associations of total MUFAs with chronic diseases. OBJECTIVE: To investigate the associations of cis-MUFA intake from plant (MUFA-P) and animal (MUFA-A) sources with total and cause-specific mortality. METHODS AND RESULTS: We followed 63,412 women from the Nurses' Health Study (1990-2012) and 29,966 men from the Health Professionals Follow-Up Study (1990-2012)...
January 28, 2019: Circulation Research
Frank A J L Scheer, Sarah L Chellappa, Kun Hu, Steven A Shea
The risk for adverse cardiovascular events (e.g., myocardial infarction, sudden cardiac death) peaks in the morning, possibly due to the effects of the endogenous circadian system on cardiovascular risk factors, or the occurrence in the morning of specific triggers, such as mental stress. To assess any interacting effects on cardiovascular function of mental stress and the circadian system, 12 healthy adults underwent a 240-h protocol with all measurements and behaviors scheduled evenly across the circadian cycle...
January 16, 2019: Psychoneuroendocrinology
Yangyang Yang, Patrick Antoni, Marc Zimmer, Kohei Sekine, Florian Mulks, Long Hu, Lumin Zhang, Matthias Rudolph, Frank Rominger, A Stephen K Hashmi
While gold-mediated synergistic catalytic processes involving transmetalations with other metals are well understood, Au(I)/Au(III) cycles in these reactions are rarely reported. Herein a gold-catalyzed direct alkynylation of cyclopropenes is enabled via two operating catalytic cycles, an oxidative catalytic cycle involving an alkynyl Au(III) complex formed by oxidative addition and a silver mediated C-H activation.
January 24, 2019: Angewandte Chemie
Jiaxin Hu, Xiulong Shen, Frank Rigo, Thahza P Prakash, V Vinod Mootha, David R Corey
Fuchs' endothelial corneal dystrophy (FECD) leads to vision loss and is one of the most common inherited eye diseases. Corneal transplants are the only curative treatment available, and there is a major unmet need for treatments that are less invasive and independent of donor tissue. Most cases of FECD are associated with an expanded CUG repeat within the intronic region of TCF4 and the mutant RNA has been implicated as the cause of the disease. We previously presented preliminary data suggesting that single-stranded antisense oligonucleotides (ASOs) can inhibit CUG RNA foci in patient-derived cells and tissue...
January 24, 2019: Nucleic Acid Therapeutics
Tao Sun, Rameshwar Patil, Anna Galstyan, Dmytro Klymyshyn, Hui Ding, Alexandra Chesnokova, Webster K Cavenee, Frank B Furnari, Vladimir A Ljubimov, Ekaterina S Shatalova, Shawn Wagner, Debiao Li, Adam N Mamelak, Serguei I Bannykh, Chirag G Patil, Jeremy D Rudnick, Jethro Hu, Zachary B Grodzinski, Arthur Rekechenetskiy, Vida Falahatian, Alexander V Lyubimov, Yongmei L Chen, Lai Sum Leoh, Tracy R Daniels-Wells, Manuel L Penichet, Eggehard Holler, Alexander V Ljubimov, Keith L Black, Julia Y Ljubimova
There is an unmet need for the treatment of glioblastoma multiforme (GBM). The extracellular matrix (ECM), including laminins, in the tumor microenvironment is important for tumor invasion and progression. In a panel of 226 patient brain glioma samples, we found a clinical correlation between the expression of tumor vascular laminin-411 (α4β1γ1) with higher tumor grade and with expression of cancer stem cell (CSC) markers including Notch pathway members, CD133, Nestin, and c-Myc. Laminin-411 overexpression also correlated with higher recurrence rate and shorter survival of GBM patients...
January 18, 2019: Cancer Research
Shafqat Ahmad, M Vinayaga Moorthy, Olga V Demler, Frank B Hu, Paul M Ridker, Daniel I Chasman, Samia Mora
Importance: Higher Mediterranean diet (MED) intake has been associated with lower risk of cardiovascular disease (CVD), but limited data are available about the underlying molecular mechanisms of this inverse disease association in human populations. Objective: To better characterize the relative contribution of traditional and novel factors to the MED-related risk reduction in CVD events in a US population. Design, Setting, and Participants: Using a prospective cohort design, baseline MED intake was assessed in 25 994 initially healthy US women in the Women's Health Study who were followed up to 12 years...
December 7, 2018: JAMA network open
Yaqing Shu, Wei Qiu, Junfeng Zheng, Xiaobo Sun, Junping Yin, Xiaoli Yang, Xiaoyang Yue, Chen Chen, Zhihui Deng, Shasha Li, Yu Yang, Fuhua Peng, Zhengqi Lu, Xueqiang Hu, Frank Petersen, Xinhua Yu
BACKGROUND AND OBJECTIVE: Aetiology and pathogenesis of anti- N -methyl-D-aspartate receptor (anti-NMDAR) encephalitis, the most common autoimmune encephalitis, is largely unknown. Since an association of the disease with the human leucocyte antigen (HLA) has not been shown so far, we here investigated whether anti-NMDAR encephalitis is associated with the HLA locus. METHODS: HLA loci of 61 patients with anti-NMDAR encephalitis and 571 healthy controls from the Chinese Han population were genotyped and analysed for this study...
January 13, 2019: Journal of Neurology, Neurosurgery, and Psychiatry
Canan Beate Schüller, Jens Kuhn, Frank Jessen, Xiaochen Hu
BACKGROUND: Delay discounting (DD) describes the phenomenon of devaluing future rewards in favor of immediate rewards. Increased DD is a key behavioral marker of addiction, and has been suggested as a target for interventions to alleviate addiction symptoms (e.g., preference for immediate drug use over larger-and-later rewards, and relapses) in patients with substance use disorders (SUD). OBJECTIVES: Performed a meta-analysis on neuroimaging results of DD regarding specific contrasts in healthy participants...
January 11, 2019: American Journal of Drug and Alcohol Abuse
Tao Huang, Tiange Wang, Yoriko Heianza, Yan Zheng, Dianjianyi Sun, Jae H Kang, Louis R Pasquale, Eric B Rimm, JoAnn E Manson, Frank B Hu, Lu Qi
Background: A growing amount of data suggests that n-3 (ω-3) polyunsaturated fatty acid (PUFA) intake may modify the genetic association with weight change. Objectives: We aimed to prospectively test interactions of habitual consumption of n-3 PUFAs or fish, the major food source, with overall genetic susceptibility on long-term weight change. Design: Gene-diet interactions were examined in 11,330 women from the Nurses' Health Study (NHS), 6773 men from the Health Professionals Follow-Up Study (HPFS), and 6254 women from the Women's Health Initiative (WHI)...
January 9, 2019: American Journal of Clinical Nutrition
Qi Zhao, Fang Liu, Yan Cheng, Xue-Rong Xiao, Dan-Dan Hu, Ying-Mei Tang, Wei-Min Bao, Jin-Hui Yang, Tao Jiang, Jia-Peng Hu, Frank Gonzalez, Fei Li
Celastrol, derived from the roots of the Tripterygium Wilfordi, shows a striking effect on obesity. In the present study, the role of celastrol in cholestasis was investigated using metabolomics and transcriptomics. Celastrol treatment significantly alleviated cholestatic liver injury in mice induced by α-naphthyl isothiocyanate (ANIT) and thioacetamide (TAA). Celastrol was found to activate sirtuin 1 (SIRT1), increase farnesoid X receptor (FXR) signaling and inhibit nuclear factor-kappa B and P53 signaling...
January 7, 2019: Molecular & Cellular Proteomics: MCP
Yang Hu, Frank B Hu, Qi Sun
New England Journal of Medicine, Volume 379, Issue 26, Page 2572-2575, December 2018.
December 27, 2018: New England Journal of Medicine
Sarah E Reese, Cheng-Jian Xu, Herman T den Dekker, Mi Kyeong Lee, Sinjini Sikdar, Carlos Ruiz-Arenas, Simon K Merid, Faisal I Rezwan, Christian M Page, Vilhelmina Ullemar, Phillip E Melton, Sam S Oh, Ivana V Yang, Kimberley Burrows, Cilla Söderhäll, Dereje D Jima, Lu Gao, Ryan Arathimos, Leanne K Küpers, Matthias Wielscher, Peter Rzehak, Jari Lahti, Catherine Laprise, Anne-Marie Madore, James Ward, Brian D Bennett, Tianyuan Wang, Douglas A Bell, Judith M Vonk, Siri E Håberg, Shanshan Zhao, Robert Karlsson, Elysia Hollams, Donglei Hu, Adam J Richards, Anna Bergström, Gemma C Sharp, Janine F Felix, Mariona Bustamante, Olena Gruzieva, Rachel L Maguire, Frank Gilliland, Nour Baïz, Ellen A Nohr, Eva Corpeleijn, Sylvain Sebert, Wilfried Karmaus, Veit Grote, Eero Kajantie, Maria C Magnus, Anne K Örtqvist, Celeste Eng, Andrew H Liu, Inger Kull, Vincent W V Jaddoe, Jordi Sunyer, Juha Kere, Cathrine Hoyo, Isabella Annesi-Maesano, Syed Hasan Arshad, Berthold Koletzko, Bert Brunekreef, Elisabeth B Binder, Katri Räikkönen, Eva Reischl, John W Holloway, Marjo-Riitta Jarvelin, Harold Snieder, Nabila Kazmi, Carrie V Breton, Susan K Murphy, Göran Pershagen, Josep Maria Anto, Caroline L Relton, David A Schwartz, Esteban G Burchard, Rae-Chi Huang, Wenche Nystad, Catarina Almqvist, A John Henderson, Erik Melén, Liesbeth Duijts, Gerard H Koppelman, Stephanie J London
BACKGROUND: Epigenetic mechanisms, including methylation, may contribute to childhood asthma. Identifying DNA methylation profiles in asthma may inform disease pathogenesis. OBJECTIVE: To identify differential DNA methylation in newborns and children related to childhood asthma. METHODS: Within the Pregnancy And Childhood Epigenetics (PACE) consortium, we performed epigenome-wide meta-analyses of school-age asthma in relation to CpG methylation (Illumina450K) in blood measured either in newborns, in prospective analyses, or cross-sectionally, in school-age children...
December 20, 2018: Journal of Allergy and Clinical Immunology
Jihye Kim, Andrey Ziyatdinov, Vincent Laville, Frank B Hu, Eric Rimm, Peter Kraft, Hugues Aschard
With growing human genetic and epidemiologic data, there has been increased interest for the study of gene-by-environment (G-E) interaction effects. Still, major questions remain on how to test jointly a large number of interactions between multiple SNPs and multiple exposures. In this study, we first compared the relative performance of four fixed effect joint analysis approaches using simulated data, (1) omnibus test, (2) multi-exposure and genetic risk score (GRS) test, (3) multi-SNP and environmental risk score (ERS) test, and (4) GRS-ERS test, considering up to 10 exposures and 300 SNPs...
December 21, 2018: Genetics
Frank B Hu
No abstract text is available yet for this article.
December 20, 2018: Nature Reviews. Cardiology
Shafqat Ahmad, Samia Mora, Paul M Ridker, Frank B Hu, Daniel I Chasman
Objective- Higher triglyceride (TG) is a risk factor for incident type 2 diabetes mellitus (T2DM), but paradoxically, genetic susceptibility for higher TG has been associated with lower T2DM risk. There is also evidence that the genetic association may be modified by baseline TG. Whether such associations can be replicated and the interaction is selective for certain TG-rich lipoprotein particles remains to be explored. Approach and Results- Cox regression involving TG, TG-rich lipoprotein particles, and genetic determinants of TG was performed among 15 813 participants with baseline fasting status in the WGHS (Women's Genome Health Study), including 1453 T2DM incident cases during a mean 18...
November 29, 2018: Arteriosclerosis, Thrombosis, and Vascular Biology
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