Dadi Xie, Jinxiu Guo, Ruili Dang, Yanan Li, Qingying Si, Wenxiu Han, Shan Wang, Ning Wei, Junjun Meng, Linlin Wu
Tacrolimus (Tac) is a common immunosuppressant that used in organ transplantation. However, its therapeutic index is narrow, and it is prone to adverse side effects, along with an increased risk of toxicity, namely, cardio-, nephro-, hepato-, and neurotoxicity. Prior metabolomic investigations involving Tac-driven toxicity primarily focused on changes in individual organs. However, extensive research on multiple matrices is uncommon. Hence, in this research, the authors systemically evaluated Tac-mediated toxicity in major organs, namely, serum, brain, heart, liver, lung, kidney, and intestines, using gas chromatography-mass spectrometry (GC-MS)...
November 28, 2022: BMC Pharmacology & Toxicology