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https://read.qxmd.com/read/30721904/a-study-of-pap-smears-in-hiv-positive-and-hiv-negative-women-from-a-tertiary-care-center-in-south-india
#1
Kritika Gupta, Cheryl Sarah Philipose, Sharada Rai, John Ramapuram, Gagandeep Kaur, Hema Kini, Chaithra Gv, Deepa Adiga
OBJECTIVES: The aim of this work was to study the spectrum of epithelial abnormalities on Pap smears of HIV-positive women categorized as per the Bethesda System of Reporting Cervical Cytology, to correlate them with CD4 lymphocyte counts, and to compare them with the spectrum of abnormalities seen in a HIV-negative control group. Study Design and Methodology: The present study was a 6-year retrospective study conducted in the Department of Pathology at Kasturba Medical College, Mangalore, which included 150 Pap smears from HIV-positive and HIV-negative women, respectively...
February 5, 2019: Acta Cytologica
https://read.qxmd.com/read/30711015/detection-of-pagetoid-urothelial-intraepithelial-neoplasia-extending-to-the-vagina-by-cervical-screening-cytology-a-case-report-with-renewed-immunochemical-summary
#2
Yuki Koyanagi, Chiaki Kubo, Shigenori Nagata, Ayumi Ryu, Koji Hatano, Rieko Kano, Satoshi Tanada, Jun-Ichi Ashimura, Atsushi Idota, Shoji Kamiura, Tomoyuki Yamasaki, Shin-Ichi Nakatsuka
BACKGROUND: Pagetoid spread of urothelial carcinoma (UC) to the lower genital tract is quite a rare and diagnostically challenging condition. Pagetoid urothelial intraepithelial neoplasia extending to the vagina is difficult to diagnose, especially in remote recurrences without symptomatic or macroscopic lesions typical to Paget disease. However, its identification by cervical screening cytology is important because UC is often characterized by a long history of relapse. CASE PRESENTATION: A 68-year-old Japanese postmenopausal woman developed brown vaginal discharge after radical cystectomy for bladder cancer (high-grade UC, pT2a pN0 cM0 [Union for International Cancer Control, 8th edition]) concomitant with focal in-situ UC in the urethra...
February 2, 2019: Diagnostic Pathology
https://read.qxmd.com/read/30695899/-clinicopathological-analysis-of-cervical-basaloid-squamous-cell-carcinoma
#3
L Q Wang, Y Wang, W Jin, C Cao, Y Q Ma, X H Ding, A J Liu
Objective: To investigate the clinical and histopathological features of cervical basal squamous cell carcinoma (BSCC). Methods: A retrospective analysis of 10 cases of cervical BSCC was carried out. The clinical data and all the pathological sections were reviewed, the related immunohistochemical results were statistically analyzed, the clinicopathological features were analyzed, and then followed the prognosis. Results: (1) Clinical features: the median onset age of BSCC in cervix was 51 years old (ranged 35-69 years old), 5 of them were postmenopausal women...
January 25, 2019: Zhonghua Fu Chan Ke za Zhi
https://read.qxmd.com/read/30694917/efficacy-and-safety-of-ospemifene-in-postmenopausal-women-with-moderate-to-severe-vaginal-dryness-a-phase-3-randomized-double-blind-placebo-controlled-multicenter-trial
#4
David F Archer, Steven R Goldstein, James A Simon, Arthur S Waldbaum, Steven A Sussman, Corrado Altomare, Julie Zhu, Yuki Yoshida, Sam Schaffer, Graziella Soulban
OBJECTIVE: To evaluate the safety and efficacy of ospemifene for the treatment of moderate to severe vaginal dryness in postmenopausal women with vulvovaginal atrophy (VVA). METHODS: This 12-week, multicenter, double-blind phase 3 study randomized postmenopausal women (aged 40-80 years) with VVA and moderate to severe vaginal dryness as their most bothersome symptom to daily oral ospemifene 60 mg or placebo. Coprimary efficacy endpoints included changes from baseline to week 12 in percentages of vaginal parabasal and superficial cells, vaginal pH, and vaginal dryness severity with ospemifene versus placebo; other secondary endpoints were evaluated (weeks 4, 8, and 12)...
January 28, 2019: Menopause: the Journal of the North American Menopause Society
https://read.qxmd.com/read/30688732/diagnosis-of-primary-clear-cell-carcinoma-of-the-vagina-by-18f-fdg-pet-ct
#5
Zhanli Fu, Xueqi Chen, Xing Yang, Qian Li
A 41-year-old woman presented with irregular vaginal bleeding, and a vaginal tumor was found and proved to be a clear cell carcinoma by biopsy. An F-FDG PET/CT was performed to exclude its metastatic possibility, which showed the vaginal tumor was the only lesion with F-FDG avidity. The vaginectomy and hysterectomy were performed to resect the lesion, and primary clear cell carcinoma of the vagina was finally diagnosed.
January 25, 2019: Clinical Nuclear Medicine
https://read.qxmd.com/read/30653661/recurrence-of-endometrial-carcinoma-presenting-as-vulvar-lesions
#6
Misgav Rottenstreich, Shunit Armon, Uzi Beller, Ora Rosengarten, Fiona Vernea, Orna Reichman
Endometrial cancer is the most common gynecological malignancy in developed countries. Although this cancer generally carries a good prognosis, 10%-15% of patients will suffer recurrent disease and vulvar metastasis is extremely rare. A 60-year-old female (G3P3) was referred to the vulvo-vaginal clinic in Shaare Zedek Medical Center, Jerusalem, Israel, with a 3-month history of painful vulvar lesions that were initially treated by others for molluscum contagiosum. This article is protected by copyright. All rights reserved...
January 17, 2019: International Journal of Gynaecology and Obstetrics
https://read.qxmd.com/read/30642849/large-cell-neuroendocrine-carcinoma-of-the-uterine-cervix
#7
Amir Habeeb, Hany Habeeb
We report a case of large cell neuroendocrine carcinoma of the uterine cervix. A 33-year-old woman presented with a 4-month history of irregular vaginal bleeding and suspicious cervix. Transvaginal ultrasound showed a 3×3.8 cm cervical mass with a marked increase in the blood flow. MRI pelvis showed an exophytic tumour with left external iliac lymph node metastasis. Immunohistochemistry of the tumour cells showed strong positivity for the neuroendocrine markers synaptophysin and a very high Ki67 proliferation index...
January 14, 2019: BMJ Case Reports
https://read.qxmd.com/read/30636946/diagnostic-test-accuracy-review-of-cytology-for-squamous-intraepithelial-lesion-and-squamous-cell-carcinoma-of-uterine-cervix
#8
Jung-Soo Pyo, Guhyun Kang, Hye Kyoung Yoon, Hyun Jung Kim
Background: Even though cervico-vaginal smears have been used as a primary screening test for cervical carcinoma, the diagnostic accuracy has been controversial. The present study aimed to evaluate the diagnostic accuracy of cytology for squamous intraepithelial lesion (SIL) and squamous cell carcinoma (SqCC) of the uterine cervix through a diagnostic test accuracy (DTA) review. Methods: A DTA review was performed using 38 eligible studies that showed concordance between cytology and histology...
January 14, 2019: Journal of Korean Medical Science
https://read.qxmd.com/read/30636633/high-grade-serous-ovarian-carcinoma-with-mucinous-differentiation-report-of-a-rare-and-unique-case-suggesting-transition-from-the-set-feature-of-high-grade-serous-carcinoma-to-the-stem-feature
#9
Yuichiro Hatano, Maho Tamada, Nami Asano, Yoh Hayasaki, Hiroyuki Tomita, Ken-Ichirou Morishige, Akira Hara
BACKGROUND: High-grade serous carcinoma, a representative high-grade ovarian carcinoma, is believed to be closely associated with a TP53 mutation. Recently, this category of ovarian carcinoma has gained increasing attention owing to the recognition of morphological varieties of TP53-mutated high-grade ovarian carcinoma. Herein, we report the case of a patient with high-grade serous carcinoma with mucinous differentiation. CASE PRESENTATION: A 59-year-old postmenopausal woman was referred to the gynecologist because of abnormal vaginal bleeding...
January 12, 2019: Diagnostic Pathology
https://read.qxmd.com/read/30633138/primary-small-cell-neuroendocrine-tumor-within-a-urethral-diverticulum
#10
Katelin Sisler, Alex Knutson, Mary McLennan
BACKGROUND: Primary small cell neuroendocrine carcinoma of the urinary tract is a very rare cancer, accounting for fewer than 0.5% of urinary tract tumors. These are aggressive neoplasms with high rates of metastases. Urethral diverticula can be found in up to 6% of women. CASE: A 31-year-old woman presented with a clear vaginal discharge and an anterior vaginal wall mass that was thought to be a recurrent cyst. After surgical dissection, she was noted to have a urethral diverticulum with a solid nodule at the base...
January 8, 2019: Obstetrics and Gynecology
https://read.qxmd.com/read/30617760/hormone-replacement-therapy-in-cancer-survivors-review-of-the-literature
#11
REVIEW
Tamás Deli, Mónika Orosz, Attila Jakab
Rapid advance in oncology leads to increasing survival of oncologic patients. More and more of them live long enough to reach either the natural age of menopause or, as a side effect of their oncotherapy, experience the cessation of gonadal function, leading to premature ovarian insufficiency, with disturbing vasomotor symtoms and long-term negative cardiovascular and skeletal effects. Thus, an ever increasing number of cancer survivors search endocrinologic help in the form of hormone replacement therapy (HRT)...
January 8, 2019: Pathology Oncology Research: POR
https://read.qxmd.com/read/30616555/hpv-vaccine-in-the-treatment-of-usual-type-vulval-and-vaginal-intraepithelial-neoplasia-a-systematic-review
#12
Stacey Bryan, Cynthia Barbara, Jane Thomas, Adeola Olaitan
BACKGROUND: HPV DNA is found in almost 80% of VIN/VaIN. Current management is inadequate, with high recurrence rates. Our objective was to review the literature regarding the role of HPV vaccine in secondary prevention and treatment of VIN/VaIN. METHODS: Database searches included Ovid Medline, Embase, Web of Science, The Cochrane Library and Clinicaltrials.gov . Search terms included HPV vaccine AND therapeutic vaccine* AND VIN OR VAIN, published in English with no defined date limit...
January 7, 2019: BMC Women's Health
https://read.qxmd.com/read/30591092/comparison-of-reproductive-function-in-female-tgmisiir%C3%A2-tag-transgenic-and-wildtype-c57bl-6-mice
#13
Patricia B Hoyer, Photini F Rice, Caitlin C Howard, Jennifer W Koevary, Joceline P Dominguez Cooks, Gabrielle V Hutchens, Setsuko K Chambers, Zelieann R Craig, Denise C Connolly, Jennifer K Barton
Transgenic TgMISIIR-TAg (TAg) mice express the oncogenic virus SV40 in Mullerian epithelial cells. Female TAg micespontaneously develop epithelial ovarian carcinoma, the most common type of ovarian cancer in women. Female TAg miceare infertile, but the reason has not been determined. We therefore investigated whether female TAg mice undergo puberty,demonstrate follicular development, maintain regular cycles, and ovulate. Ovarian cancers in women commonly develop aftermenopause. The occupational chemical 4-vinylcyclohexene diepoxide (VCD) accelerates follicle degeneration in the ovariesof rats and mice, causing early ovarian failure...
December 27, 2018: Comparative Medicine
https://read.qxmd.com/read/30591091/comparison-of-reproductive-function-in-female-tgmisiir%C3%A2-tag-transgenic-and-wildtype-c57bl-6-mice
#14
Patricia B Hoyer, Photini F Rice, Caitlin C Howard, Jennifer W Koevary, Joceline P Dominguez Cooks, Gabrielle V Hutchens, Setsuko K Chambers, Zelieann R Craig, Denise C Connolly, Jennifer K Barton
Transgenic TgMISIIR-TAg (TAg) mice express the oncogenic virus SV40 in Mullerian epithelial cells. Female TAg micespontaneously develop epithelial ovarian carcinoma, the most common type of ovarian cancer in women. Female TAg miceare infertile, but the reason has not been determined. We therefore investigated whether female TAg mice undergo puberty,demonstrate follicular development, maintain regular cycles, and ovulate. Ovarian cancers in women commonly develop aftermenopause. The occupational chemical 4-vinylcyclohexene diepoxide (VCD) accelerates follicle degeneration in the ovariesof rats and mice, causing early ovarian failure...
December 27, 2018: Comparative Medicine
https://read.qxmd.com/read/30585589/-gelatinases-a-and-b-and-their-endogenous-regulators-in-the-corpus-uteri-in-squamous-cell-cervical-carcinoma
#15
O S Timoshenko, T A Gureeva, E V Kugaevskaya, L E Zavalishina, Yu Yu Andreeva, N I Solovyeva
OBJECTIVE: To investigate the expression of gelatinases A and B (matrix metalloproteinases (MMP 2 and MMP 9) and endogenous regulators of their activity, such as a tissue inhibitor of MMP - TIMP-2 and a Pro-MMP-9 activator - urokinase-type plasminogen activator (uPA) as factors of corpus uteri invasion in squamous cell cervical carcinoma (SCCC). MATERIAL AND METHODS: The surgical material obtained after hysterectomy in patients diagnosed with SCCC was examined. RT-PCR, immunohistochemistry (IHC), and enzyme-linked immunosorbent assay were used...
2018: Arkhiv Patologii
https://read.qxmd.com/read/30585018/-microcystic-elongated-and-fragmented-invasion-pattern-in-endometrial-carcinoma-the-clinicopathology-analysis
#16
X B Zhang, C L Zhao, X L Qi, Y Qin, Y Wang, D H Shen
Objective: To assess the clinical value for the clinicopathological features of microcystic elongated and fragmented (MELF) invasion in endometrial carcinoma (EEC) . Methods: The clinicopathological data of 108 cases of endometrial carcinoma with total hysterectomy, bilateral adnexectomy, and pelvic dissection were retrospectively analysis in Peking University People's Hospital from April 2015 to October 2016. Twenty-five patients with endometrial carcinoma showing MELF invasion pattern were collected. We analyzed retrospectively the association of MELF pattern invasion with clinical pathology data and prognosis of the patients, partial immunohistochemical staining was implemented...
December 25, 2018: Zhonghua Fu Chan Ke za Zhi
https://read.qxmd.com/read/30561092/human-papillomavirus-and-p16-in-squamous-cell-carcinoma-and-intraepithelial-neoplasia-of-the-vagina
#17
Hanna Kristina Bertoli, Christina Louise Rasmussen, Freja Laerke Sand, Vanna Albieri, Bodil Norrild, Freija Verdoodt, Susanne K Kjaer
We estimated the overall and type-specific prevalence of human papillomavirus (HPV) and p16 overexpression in vaginal cancer and vaginal intraepithelial neoplasia (VaIN). We conducted a systematic search of PubMed, Embase and Cochrane Library to identify studies published between 1986 and 2017 using PCR-based or Hybrid Capture 2 tests to evaluate the presence of HPV DNA and/or using any method to detect p16 overexpression in VaIN, vaginal squamous cell carcinoma (VaSCC), or other types of vaginal cancer. Applying a random effects model, we estimated the pooled prevalence of HPV and p16 overexpression along with 95% confidence intervals (CIs)...
December 18, 2018: International Journal of Cancer. Journal International du Cancer
https://read.qxmd.com/read/30550486/pathologic-prognostic-factors-in-endometrial-carcinoma-other-than-tumor-type-and-grade
#18
Naveena Singh, Lynn Hirschowitz, Richard Zaino, Isabel Alvarado-Cabrero, Maire A Duggan, Rouba Ali-Fehmi, Elizabeth Euscher, Jonathan L Hecht, Lars-Christian Horn, Olga Ioffe, Xavier Matias-Guiu, W Glenn McCluggage, Yoshiki Mikami, Jaume Ordi, Vinita Parkash, M Ruhul Quddus, Charles M Quick, Annette Staebler, Charles Zaloudek, Marisa Nucci, Anais Malpica, Esther Oliva
Although endometrial carcinoma (EC) is generally considered to have a good prognosis, over 20% of women with EC die of their disease, with a projected increase in both incidence and mortality over the next few decades. The aim of accurate prognostication is to ensure that patients receive optimal treatment and are neither overtreated nor undertreated, thereby improving patient outcomes overall. Patients with EC can be categorized into prognostic risk groups based on clinicopathologic findings. Other than tumor type and grade, groupings and recommended management algorithms may take into account age, body mass index, stage, and presence of lymphovascular space invasion...
January 2019: International Journal of Gynecological Pathology
https://read.qxmd.com/read/30546144/intestinal-type-adenocarcinoma-of-the-vagina-clinico-pathologic-features-of-a-common-tumor-with-a-rare-localization
#19
G Broggi, E Piombino, G Magro, G M Vecchio
Intestinal-type adenocarcinoma is a rare primary vaginal carcinoma and considerably more uncommon than metastatic lesions which represent the most frequent malignancy at this anatomic site. Among all malignant tumors, colorectal, breast and female genital tract carcinomas have the tendency to metastasize to the vagina. As morphologic and immunohistochemical features of intestinal-type adenocarcinoma occurring primarily in the vagina are not specific, clinical and radiologic information is crucial to exclude a metastatic lesion...
September 2018: Pathologica
https://read.qxmd.com/read/30544435/clinicopathologic-features-and-outcomes-of-primary-vaginal-adenosis-as-a-dermatologic-and-gynecologic-burden-a-retrospective-study
#20
Tiantian Han, Ying Jin, Yan Li, Yalan Bi, Lingya Pan
In the recent 20 years, primary vaginal adenosis is extremely rare and the data of clinical presentations, management, and outcome have not been studied systematically.In this retrospective study, women with vaginal adenosis between January 1997 and June 2017 were identified from the hospital's medical records. Data on patient age, history, symptoms, mass location, size, diagnosis, complications, treatment, and recurrence were analyzed by SPSS 20.0.Twenty women were histopathologically diagnosed as having vaginal adenosis (mean age, 37...
December 2018: Medicine (Baltimore)
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