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https://read.qxmd.com/read/30781677/kidney-involvement-in-patients-with-type-1-autoimmune-pancreatitis
#1
Miroslav Vujasinovic, Raffaella Maria Pozzi Mucelli, Roberto Valente, Caroline Sophie Verbeke, Stephan L Haas, J-Matthias Löhr
INTRODUCTION: Autoimmune pancreatitis (AIP) type 1 is a special form of chronic pancreatitis with a strong lymphocytic infiltration as the pathological hallmark and other organ involvement (OOI). IgG4-related kidney disease (IgG4-RKD) was first reported as an extrapancreatic manifestation of AIP in 2004. The aim of the present study was to determine the frequency and clinical impact of kidney lesions observed in patients with AIP type 1. METHODS: We performed a single-centre retrospective study on a prospectively collected cohort of patients with a histologically proven or highly probable diagnosis of AIP according to the International Consensus Diagnostic Criteria (ICDC) classification...
February 18, 2019: Journal of Clinical Medicine
https://read.qxmd.com/read/30778739/deep-learning-and-radiomics-the-utility-of-google-tensorflow%C3%A2-inception-in-classifying-clear-cell-renal-cell-carcinoma-and-oncocytoma-on-multiphasic-ct
#2
Heidi Coy, Kevin Hsieh, Willie Wu, Mahesh B Nagarajan, Jonathan R Young, Michael L Douek, Matthew S Brown, Fabien Scalzo, Steven S Raman
PURPOSE: Currently, all solid enhancing renal masses without microscopic fat are considered malignant until proven otherwise and there is substantial overlap in the imaging findings of benign and malignant renal masses, particularly between clear cell RCC (ccRCC) and benign oncocytoma (ONC). Radiomics has attracted increased attention for its utility in pre-operative work-up on routine clinical images. Radiomics based approaches have converted medical images into mineable data and identified prognostic imaging signatures that machine learning algorithms can use to construct predictive models by learning the decision boundaries of the underlying data distribution...
February 18, 2019: Abdominal Radiology
https://read.qxmd.com/read/30777562/predictable-and-unusual-adverse-effects-of-immunosuppression-in-pediatric-liver-transplant-patients
#3
Hakan Öztürk, Neslihan Ekşi Bozbulut, Sinan Sarı, Ödül Eğritaş Gürkan, Hakan Sözen, Ali Sapmaz, Aydın Dalgıç, Buket Dalgıç
OBJECTIVES: Our aim was to determine potentially adverse effects of immunosuppressive protocols after liver transplantation in children. MATERIALS AND METHODS: The medical records of 60 children who underwent liver transplant retrospectively analyzed. Corticosteroid, tacrolimus, and mycophenolate mofetil were the primary immunosuppressive agents used in our center. RESULTS: The mean age of children was 6.1 years, ranging from 3 months to 17 years (34 boys, 26 girls)...
January 2019: Experimental and Clinical Transplantation
https://read.qxmd.com/read/30774098/diagnosis-and-treatment-of-c3-glomerulopathy-in-a-center-of-expertise
#4
J J E Koopman, Y K O Teng, C J F Boon, L P van den Heuvel, T J Rabelink, C van Kooten, A P J de Vries
C3 glomerulopathy is a rare renal disease that has been distinguished as a renal disease for about 10 years. It is caused by an excessive activation of the alternative complement pathway in the circulation, which leads to deposition of complement factor C3 in glomeruli. It is diagnosed based on clinical presentation, histological patterns in a kidney biopsy and tests of the complement pathways. It can closely resemble immune complexmediated glomerulonephritis and postinfectious glomerulonephritis. Renal failure develops in up to half of all patients within 10 years after presentation...
January 2019: Netherlands Journal of Medicine
https://read.qxmd.com/read/30770735/alterations-in-tissue-microrna-after-heat-stress-in-the-conscious-rat-potential-biomarkers-of-organ-specific-injury
#5
Matthew G Permenter, Bonna C McDyre, Danielle L Ippolito, Jonathan D Stallings
BACKGROUND: Heat illness remains a significant cause of morbidity in susceptible populations. Recent research elucidating the cellular mechanism of heat stress leading to heat illness may provide information to develop better therapeutic interventions, risk assessment strategies, and early biomarkers of organ damage. microRNA (miRNA) are promising candidates for therapeutic targets and biomarkers for a variety of clinical conditions since there is the potential for high specificity for individual tissues and unique cellular functions...
February 15, 2019: BMC Genomics
https://read.qxmd.com/read/30768833/modelling-graft-loss-in-patients-with-donor-specific-antibody-at-baseline-using-the-birmingham-mayo-birmay-predictor-implications-for-clinical-trials
#6
A Bentall, B H Smith, M Gonzales, K Bonner, W D Park, L D Cornell, P G Dean, C A Schinstock, R Borrows, C Lefaucheur, A Loupy, M D Stegall
Predicting which renal allografts will fail and the likely cause of failure is important in clinical trial design to either enrich patient populations to be or as surrogate efficacy endpoints for trials aimed at improving long-term graft survival. This study tests our previously Birmingham-Mayo model (termed the BirMay Predictor) developed in a low-risk kidney transplant population in order to predict the outcome of patients with DSA at the time of transplantation and identify new factors to improve graft loss prediction in DSA+ patients...
February 15, 2019: American Journal of Transplantation
https://read.qxmd.com/read/30768761/implementing-reverse-phase-protein-array-profiling-as-a-sensitive-method-for-the-early-pre-clinical-detection-of-off-target-toxicities-associated-with-sunitinib-malate
#7
Alice C O'Farrell, Ian S Miller, Rhys Evans, Marina Alamanou, Maurice Cary, Girish Mallya Udupi, Adam Lafferty, Naser Monsefi, Mattia Cermona, Jochen Hm Prehn, Henk M Verheul, William M Gallagher, Mathias Gehrmann, Annette T Byrne
The tyrosine kinase inhibitor (TKI) sunitinib is a multi-targeted agent approved across multiple cancer indications. Nevertheless, since approval, data has emerged to describe a worrisome side effect profile including hypertension, hand-foot syndrome, fatigue, diarrhoea, mucositis, proteinuria and (rarely) congestive heart failure. It has been hypothesised that the observed multi-parameter toxicity profile is related to 'on-target' kinase inhibition in 'off-target' tissues. Herein, to interrogate off-target effects in pre-clinical studies, a reverse phase protein array (RPPA) approach was employed...
February 15, 2019: Proteomics. Clinical Applications
https://read.qxmd.com/read/30768730/acute-kidney-injury-model-established-by-systemic-glutathione-depletion-in-mice
#8
Akiko Matsubara, Shingo Oda, Ru Jia, Tsuyoshi Yokoi
Glutathione (GSH) is one of the most extensively studied tripeptides. The roles for GSH in redox signaling, detoxification of xenobiotics and antioxidant defense have been investigated. A drug-induced rhabdomyolysis mouse model was recently established in L-buthionine-(S,R)-sulfoximine (BSO; a GSH synthesis inhibitor)-treated normal mice by co-administration of antibacterial drug and statin. In these models, mild kidney injury was observed in the BSO only-treated mice. Therefore, in this study, we studied kidney injury in the GSH-depleted mouse...
February 15, 2019: Journal of Applied Toxicology: JAT
https://read.qxmd.com/read/30767589/multifocal-synchronous-upper-urinary-tract-carcinosarcoma-sarcomatoid-carcinoma-with-rhabdomyoblastic-differentiation
#9
Kosuke Takemura, Toru Motoi, Akiko Tonooka, Nobuaki Funata, Yasukazu Nakanishi, Madoka Kataoka, Masaya Ito, Kazumasa Sakamoto, Hiroaki Suzuki, Ken-Ichi Tobisu, Fumitaka Koga
Carcinosarcoma of the upper urinary tract is very rare. In this article, we report a case of upper urinary tract carcinosarcoma with rhabdomyoblastic differentiation showing distinct transition between the epithelial and mesenchymal components confirmed by morphology and immunohistochemistry. An 81-year-old female underwent radical nephroureterectomy under the diagnosis of left ureteral urothelial carcinoma (UC). Multiple invasive tumors showed combined histology with UC and rhabdomyosarcomatous elements (pT2-ureter and pT3-renal pelvis, pN0, u-lt0, ly0, v0, RM0)...
February 15, 2019: International Journal of Surgical Pathology
https://read.qxmd.com/read/30767375/evaluation-of-biomarkers-of-kidney-injury-following-4-succinylated-gelatin-and-6-hydroxyethyl-starch-130-0-4-administration-in-a-canine-hemorrhagic-shock-model
#10
Corrin J Boyd, Melissa A Claus, Anthea L Raisis, Rachel Cianciolo, Erika Bosio, Giselle Hosgood, Mary Nabity, Trevor Mori, Anne Barden, Claire R Sharp, Lisa Smart
OBJECTIVE: To investigate the association between synthetic colloids and biomarkers of acute kidney injury (AKI) in dogs with hemorrhagic shock. DESIGN: Experimental interventional study. SETTING: University. ANIMALS: Twenty-four healthy ex-racing Greyhounds. INTERVENTIONS: Anesthetized Greyhounds subjected to hemorrhage for 60 min were resuscitated with 20 mL/kg of fresh whole blood (FWB), 6% hydroxyethyl starch (HES) 130/0...
February 14, 2019: Journal of Veterinary Emergency and Critical Care
https://read.qxmd.com/read/30766848/pressurized-intraperitoneal-aerosol-chemotherapy-procedure-for-nonresectable-peritoneal-carcinomatosis-first-indian-study
#11
S P Somashekhar, K R Ashwin, C Rohit Kumar, Amit Rauthan, Sushmita H Rakshit
Background: Peritoneal carcinomatosis (PC) is a common evolution of abdominal cancers and is associated with poor prognosis. A few selected patients have option of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy, but majority who are not eligible for curative approach can undergo pressurized intraperitoneal aerosol chemotherapy (PIPAC). It is an emerging field of research with major therapeutic potential. It is a safe and innovative approach, which enhances the effect of chemotherapy without major toxicity...
January 2019: South Asian Journal of Cancer
https://read.qxmd.com/read/30765434/occurrence-of-diabetic-nephropathy-after-renal-transplantation-despite-intensive-glycemic-control-an-observational-cohort-study
#12
Maarten Coemans, Elisabet Van Loon, Evelyne Lerut, Pieter Gillard, Ben Sprangers, Aleksandar Senev, Marie-Paule Emonds, Jan Van Keer, Jasper Callemeyn, Liesbeth Daniëls, Jeroen Sichien, Geert Verbeke, Dirk Kuypers, Chantal Mathieu, Maarten Naesens
OBJECTIVE: The kinetics and risk factors of diabetic nephropathy after kidney transplantation remain unclear. This study investigated the posttransplant occurrence of diabetic nephropathy and the contribution of posttransplant glycemic control. RESEARCH DESIGN AND METHODS: We performed a single-center prospective cohort study of 953 renal allograft recipients and 3,458 protocol-specified renal allograft biopsy specimens up to 5 years after transplantation. The effects of pretransplant diabetes and glycemic control (glycated hemoglobin levels) on the posttransplant histology were studied...
February 14, 2019: Diabetes Care
https://read.qxmd.com/read/30764798/complete-biopsy-proven-resolution-of-deposits-in-recurrent-proliferative-glomerulonephritis-with-monoclonal-igg-deposits-pgnmigd-following-rituximab-treatment-in-renal-allograft
#13
Jon Von Visger, Clarissa Cassol, Uday Nori, Gerardo Franco-Ahumada, Tibor Nadasdy, Anjali A Satoskar
BACKGROUND: Proliferative glomerulonephritis with monoclonal IgG deposits (PGNMIGD) is a disease entity classified under the group of "Monoclonal gammopathy-related kidney diseases", and can recur after transplant. Clinical remission of proteinuria in patients with PGNMIGD has been previously shown following anti-B cell and/or anti-plasma cell therapies. Our case is the first to show complete histologic resolution of the glomerular monoclonal IgG kappa deposits in a case of recurrent PGNMIGD in renal allograft after rituximab and steroid treatment...
February 14, 2019: BMC Nephrology
https://read.qxmd.com/read/30762651/volume-computed-tomography-perfusion-imaging-evaluation-of-the-significance-in-oncologic-follow-up-of-metastasizing-renal-cell-carcinoma-in-the-early-period-of-targeted-therapy-preliminary-results
#14
Aida Vehabovic-Delic, Marija Balic, Christopher Rossmann, Thomas Bauernhofer, Hannes A Deutschmann, Helmut Schoellnast
INTRODUCTION: The aim of this study was to assess the significance of volume computed tomography perfusion imaging of metastasizing renal cell carcinoma (mRCC) in the early period after the initiation of targeted therapy. METHODS: Blood flow (BF), blood volume, and clearance (CL) were calculated in 10 patients with histologically verified mRCC before and 1 month after initiation of targeted therapy using compartmental analysis algorithms. In addition, the longest diameter of tumor was measured for both time points and compared...
February 11, 2019: Journal of Computer Assisted Tomography
https://read.qxmd.com/read/30758870/hereditary-xanthinuria-in-a-goat
#15
Krystal J Vail, Nicole M Tate, Tasha Likavec, Katie M Minor, Philippa M Gibbons, Raquel R Rech, Eva Furrow
A 2-year-old mixed breed goat was presented for a 1-day history of anorexia and 1 week of weight loss. Serum biochemistry disclosed severe azotemia. Abdominal ultrasound examination showed decreased renal corticomedullary distinction, poor visualization of the renal pelves, and dilated ureters. On necropsy, the kidneys were small, the pelves were dilated, and the medulla was partially effaced by variably sized yellow nephroliths. Histologically, cortical and medullary tubules were distended by yellow-brown, multilayered crystals...
February 13, 2019: Journal of Veterinary Internal Medicine
https://read.qxmd.com/read/30747865/re-the-probability-of-aggressive-versus-indolent-histology-based-on-renal-tumor-size
#16
M Pilar Laguna
No abstract text is available yet for this article.
February 8, 2019: Journal of Urology
https://read.qxmd.com/read/30747837/the-impact-of-early-clinical-and-subclinical-t-cell-mediated-rejection-after-kidney-transplantation
#17
William Hoffman, Rajil Mehta, Dana R Jorgensen, Puneet Sood, Parmjeet Randhawa, Christine M Wu, Chetan Puttarajappa, Nirav A Shah, Amit D Tevar, Sundaram Hariharan
BACKGROUND: We investigated the effect of Clinical and Subclinical T Cell Mediated Rejection (C-TCMR and SC-TCMR) on allograft histology, function and progression. METHODS: Adult kidney recipients with 2 protocol biopsies were divided into: No-TCMR (No-TCMR) on biopsies (n=104), SC-TCMR (n=56), and C-TCMR (n=32) in at least 1 biopsy. Chronicity (ci+ct+cg+cv) scores, renal function, and the burden of renal disease measured by AUC (serum creatinine mg*month/dl) were compared...
February 4, 2019: Transplantation
https://read.qxmd.com/read/30746839/indications-and-results-of-diagnostic-biopsy-in-pediatric-renal-tumors-a-retrospective-analysis-of-317-patients-with-critical-review-of-siop-guidelines
#18
Yvan de la Monneraye, J Michon, H Pacquement, I Aerts, Daniel Orbach, F Doz, F Bourdeaut, S Sarnacki, P Philippe-Chomette, G Audry, A Coulomb, P Fréneaux, J Klijanienko, D Berrebi, J-M Zucker, G Schleiermacher, H J Brisse
OBJECTIVES: According to the Renal Tumor Study Group (RTSG) of the International Society of Paediatric Oncology (SIOP), diagnostic biopsy of renal tumors prior to neoadjuvant chemotherapy is not mandatory unless the presentation is atypical for a Wilms tumor (WT). This study addresses the relevance of this strategy as well as the accuracy and safety of image-guided needle biopsy. METHODS: Clinical, radiological, and pathological data from 317 children (141 males/176 females, mean age: 4 years, range, 0-17...
February 12, 2019: Pediatric Blood & Cancer
https://read.qxmd.com/read/30746369/incidence-risk-factors-and-outcome-of-bk-polyomavirus-infection-after-kidney-transplantation
#19
Evaldo Favi, Carmelo Puliatti, Rajesh Sivaprakasam, Mariano Ferraresso, Federico Ambrogi, Serena Delbue, Federico Gervasi, Ilaria Salzillo, Nicholas Raison, Roberto Cacciola
BACKGROUND: Polyomavirus-associated nephropathy is a leading cause of kidney allograft failure. Therapeutic options are limited and prompt reduction of the net state of immunosuppression represents the mainstay of treatment. More recent application of aggressive screening and management protocols for BK-virus infection after renal transplantation has shown encouraging results. Nevertheless, long-term outcome for patients with BK-viremia and nephropathy remains obscure. Risk factors for BK-virus infection are also unclear...
February 6, 2019: World Journal of Clinical Cases
https://read.qxmd.com/read/30746132/renal-toxicities-associated-with-pembrolizumab
#20
Hassan Izzedine, Alexis Mathian, Stephane Champiat, Cécile Picard, Christine Mateus, Emilie Routier, Andrea Varga, David Malka, Alexandra Leary, Judith Michels, Jean-Marie Michot, Aurélien Marabelle, Olivier Lambotte, Zahir Amoura, Jean-Charles Soria, Sihem Kaaki, Nathalie Quellard, Jean-Michel Goujon, Isabelle Brocheriou
Objective: Expanded clinical experience with patients treated by pembrolizumab has accumulated. However, renal toxicities associated with this anti-programmed cell death 1 agent are poorly described because kidney histology is rarely sought. As a nephrology referral centre, we aimed to describe the clinic-biological and histopathological characteristics of pembrolizumab-related nephropathy and its response to treatment. Methods: We conducted a monocentric large case series study, including all pembrolizumab-treated cancer patients presenting a renal toxicity addressed to our centre from 2015 to 2017...
February 2019: Clinical Kidney Journal
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