S Brushett, R Gacesa, A Vich Vila, M F Brandao Gois, S Andreu-Sánchez, J C Swarte, M A Y Klaassen, V Collij, T Sinha, L A Bolte, J Wu, M Swertz, M L A de Kroon, S A Reijneveld, C Wijmenga, R K Weersma, J Fu, H M van Loo, A Kurilshikov, A Zhernakova
The gut microbiome is involved in the bi-directional relationship of the gut - brain axis. As most studies of this relationship are small and do not account for use of psychotropic drugs (PTDs), we explored the relations of the gut microbiome with several internalizing disorders, while adjusting for PTDs and other relevant medications, in 7,656 Lifelines participants from the Northern Netherlands (5,522 controls and 491 participants with at least one internalizing disorder). Disorders included dysthymia, major depressive disorder (MDD), any depressive disorder (AnyDep: dysthymia or MDD), generalized anxiety disorder (GAD) and any anxiety disorder (AnyAnx: GAD, social phobia and panic disorder)...
December 2023: Gut Microbes