keyword
https://read.qxmd.com/read/35088833/netsolp-predicting-protein-solubility-in-escherichia-coli-using-language-models
#21
JOURNAL ARTICLE
Vineet Thumuluri, Hannah-Marie Martiny, Jose J Almagro Armenteros, Jesper Salomon, Henrik Nielsen, Alexander Rosenberg Johansen
MOTIVATION: Solubility and expression levels of proteins can be a limiting factor for large-scale studies and industrial production. By determining the solubility and expression directly from the protein sequence, the success rate of wet-lab experiments can be increased. RESULTS: In this study, we focus on predicting the solubility and usability for purification of proteins expressed in Escherichia coli directly from the sequence. Our model NetSolP is based on deep learning protein language models called transformers and we show that it achieves state-of-the-art performance and improves extrapolation across datasets...
January 27, 2022: Bioinformatics
https://read.qxmd.com/read/35014970/an-open-source-privacy-preserving-large-scale-mobile-framework-for-cardiovascular-health-monitoring-and-intervention-planning-with-an-urban-african-american-population-of-young-adults-user-centered-design-approach
#22
JOURNAL ARTICLE
Gari Clifford, Tony Nguyen, Corey Shaw, Brittney Newton, Sherilyn Francis, Mohsen Salari, Chad Evans, Camara Jones, Tabia Henry Akintobi, Herman Taylor
BACKGROUND: Cardiovascular diseases (CVDs) are the leading cause of death worldwide and are increasingly affecting younger populations, particularly African Americans in the southern United States. Access to preventive and therapeutic services, biological factors, and social determinants of health (ie, structural racism, resource limitation, residential segregation, and discriminatory practices) all combine to exacerbate health inequities and their resultant disparities in morbidity and mortality...
January 11, 2022: JMIR Formative Research
https://read.qxmd.com/read/34849581/netsolp-predicting-protein-solubility-in-e-coli-using-language-models
#23
JOURNAL ARTICLE
Vineet Thumuluri, Hannah-Marie Martiny, Jose J Almagro Armenteros, Jesper Salomon, Henrik Nielsen, Alexander R Johansen
MOTIVATION: Solubility and expression levels of proteins can be a limiting factor for large-scale studies and industrial production. By determining the solubility and expression directly from the protein sequence, the success rate of wet-lab experiments can be increased. RESULTS: In this study, we focus on predicting the solubility and usability for purification of proteins expressed in Escherichia coli directly from the sequence. Our model NetSolP is based on deep learning protein language models called transformers and we show that it achieves state-of-the-art performance and improves extrapolation across datasets...
November 27, 2021: Bioinformatics
https://read.qxmd.com/read/34845960/digital-health-what-do-we-mean-by-clinical-validation
#24
JOURNAL ARTICLE
Sachin S Shah, Andrew Gvozdanovic
No abstract text is available yet for this article.
November 30, 2021: Expert Review of Medical Devices
https://read.qxmd.com/read/34613664/making-ideas-a-reality-optimising-healthtech-innovation-in-australia
#25
JOURNAL ARTICLE
Ken Sloan
In Australia, there is a wealth of opportunity to accelerate innovation in healthtech. It is well known that Australia's healthcare system has the right ecosystem to support new ideas into reality. Surgeons together with academia play a significant role in democratising innovative solutions. However, we are learning it takes many actors and contributors to ensure the process is clearer into the future by addressing barriers, incentivising innovation and creating systemic frameworks.
November 2021: ANZ Journal of Surgery
https://read.qxmd.com/read/34508155/nettcr-2-0-enables-accurate-prediction-of-tcr-peptide-binding-by-using-paired-tcr%C3%AE-and-%C3%AE-sequence-data
#26
JOURNAL ARTICLE
Alessandro Montemurro, Viktoria Schuster, Helle Rus Povlsen, Amalie Kai Bentzen, Vanessa Jurtz, William D Chronister, Austin Crinklaw, Sine R Hadrup, Ole Winther, Bjoern Peters, Leon Eyrich Jessen, Morten Nielsen
Prediction of T-cell receptor (TCR) interactions with MHC-peptide complexes remains highly challenging. This challenge is primarily due to three dominant factors: data accuracy, data scarceness, and problem complexity. Here, we showcase that "shallow" convolutional neural network (CNN) architectures are adequate to deal with the problem complexity imposed by the length variations of TCRs. We demonstrate that current public bulk CDR3β-pMHC binding data overall is of low quality and that the development of accurate prediction models is contingent on paired α/β TCR sequence data corresponding to at least 150 distinct pairs for each investigated pMHC...
September 10, 2021: Communications Biology
https://read.qxmd.com/read/34484239/popcover-2-0-improved-selection-of-peptide-sets-with-optimal-hla-and-pathogen-diversity-coverage
#27
JOURNAL ARTICLE
Jonas Birkelund Nilsson, Alba Grifoni, Alison Tarke, Alessandro Sette, Morten Nielsen
The use of minimal peptide sets offers an appealing alternative for design of vaccines and T cell diagnostics compared to conventional whole protein approaches. T cell immunogenicity towards peptides is contingent on binding to human leukocyte antigen (HLA) molecules of the given individual. HLA is highly polymorphic, and each variant typically presents a different repertoire of peptides. This polymorphism combined with pathogen diversity challenges the rational selection of peptide sets with broad immunogenic potential and population coverage...
2021: Frontiers in Immunology
https://read.qxmd.com/read/34068215/effects-of-flavonoids-extracted-from-citrus-aurantium-on-performance-behavior-and-rumen-gene-expression-in-holstein-bulls-fed-with-high-concentrate-diets-in-pellet-form
#28
JOURNAL ARTICLE
Montserrat Paniagua, Francisco Javier Crespo, Anna Arís, Maria Devant
Flavonoid supplementation may modify the behavior and rumen inflammatory response of fattening bulls, and this could be related to the concentrate presentation (mash or pellet) form. In the present study, 150 Holstein bulls (183.0 ± 7.53 kg BW and 137 ± 1.8 d of age) were randomly allocated to one of eight pens and assigned to control (C) or (BF) ( Citrus aurantium , Bioflavex CA, HealthTech Bio Actives, Spain, 0.4 kg per ton of concentrate of Bioflavex CA, 20% naringin). Concentrate (pellet) intake was recorded daily, and BW and animal behavior fortnightly...
May 13, 2021: Animals: An Open Access Journal From MDPI
https://read.qxmd.com/read/31844838/highlights-of-2019-protein-engineering-summit-pegs-in-boston-usa-advancing-antibody-based-cancer-therapies-to-the-clinic
#29
JOURNAL ARTICLE
Hong Li, You Li, Cheng Wang, Shouye Wang, Mitchell Ho
The 15th Annual Protein Engineering Summit (PEGS) organized by Cambridge Healthtech Institute was held in Boston, USA from April 8th to 12th 2019. This report highlights the presentations in the Oncology Stream of this meeting with a focus on bispecific antibodies (BsAbs). A variety of BsAb formats with different target antigens (CD3, CTLA4, PD-1, PD-L1, EGFR, HER2, BCMA, CD19, CD20, CD38, CD123, TGFβ, PSMA, etc.) have been discussed, in which the T-cell engaging (anti-CD3) BsAb is the most studied construct to exhibit promising immunotherapeutic activities...
October 2019: Antibody Therapeutics
https://read.qxmd.com/read/30891510/functional-textile-finishing-of-type-i-collagen-isolated-from-bovine-bone-for-potential-healthtech
#30
JOURNAL ARTICLE
Cortés Melissa Paola, Amaya María Camila, Cañas Ana, Osorio Marlon, Sánchez Diego, Zuluaga Robin, Gómez Beatriz, Castro Cristina
Collagen is the most abundant fibrous protein in animal's body and is widely used for biomedical and pharmaceutical applications. The principal sources of this protein are bovine, porcine and fish skin and bones. In Colombia, bovine bones are waste from meat industry, this material have potential as an alternative source of collagen isolation. The aim of this study was to evaluate the composition and some properties of type I collagen (COL I) extracted of bovine bones of Zebu-Bos Primigenius Indicus and its use as textile finishing to modify two types of fabrics: first a taffeta weave and the second a single jersey knit, both 100% cotton...
February 2019: Heliyon
https://read.qxmd.com/read/27667383/leading-the-way-cardiology-and-the-future-of-healthtech-innovation
#31
Seema Pursnani, Raj Khandwalla, Rigved Tadwalkar
No abstract text is available yet for this article.
2016: Reviews in Cardiovascular Medicine
https://read.qxmd.com/read/23495909/cell-based-assays-for-high-throughput-screening
#32
JOURNAL ARTICLE
Frank H Büttner
The fifth international World Pharmaceutical Congress was organised by the Cambridge Healthtech Institute and contained six concurrent conferences in parallel. This report focuses on the third annual conference: 'Cell-based assays for HTS'. The major topics of this meeting were technologies for setting up screening assays, cells as biological reagents for screening campaigns, three-dimensional cell culture and the use of stem cells for drug screening. Technology-based presentations focused on the latest developments for cell-based screening, such as the open microscopy environment, a cell culture array as a kind of 'cell culture on a chip', a cellular microarray for analysing the binding behaviour of cells and aptamer technology...
September 2006: Expert Opinion on Drug Discovery
https://read.qxmd.com/read/22864478/2nd-pegs-annual-symposium-on-antibodies-for-cancer-therapy-april-30-may-1-2012-boston-usa
#33
Mitchell Ho, Ivor Royston, Alain Beck
The 2nd Annual Antibodies for Cancer Therapy symposium, organized again by Cambridge Healthtech Institute as part of the Protein Engineering Summit, was held in Boston, USA from April 30th to May 1st, 2012. Since the approval of the first cancer antibody therapeutic, rituximab, fifteen years ago, eleven have been approved for cancer therapy, although one, gemtuzumab ozogamicin, was withdrawn from the market. The first day of the symposium started with a historical review of early work for lymphomas and leukemias and the evolution from murine to human antibodies...
September 2012: MAbs
https://read.qxmd.com/read/21882939/cambridge-healthtech-institute-drug-discovery-chemistry-san-diego-ca-usa-12-14-april-2011
#34
Woody Sherman, Noeris Salam, Dora Warshaviak
No abstract text is available yet for this article.
September 2011: Future Medicinal Chemistry
https://read.qxmd.com/read/19759920/the-prexcel-q-method-for-qpcr
#35
JOURNAL ARTICLE
Jack M Gallup, Mark R Ackermann
The purpose of this manuscript is to describe a reliable approach to quantitative real-time polymerase chain reaction (qPCR) assay development and project management, which is currently embodied in the Excel 2003-based software program named "PREXCEL-Q" (P-Q) (formerly known as "FocusField2-6Gallup-qPCRSet-upTool-001," "FF2-6-001 qPCR set-up tool" or "Iowa State University Research Foundation [ISURF] project #03407"). Since its inception from 1997-2007, the program has been well-received and requested around the world and was recently unveiled by its inventor at the 2008 Cambridge Healthtech Institute's Fourth Annual qPCR Conference in San Diego, CA...
December 15, 2008: International Journal of Biomedical Science: IJBS
https://read.qxmd.com/read/19330171/drug-repositioning-summit-finding-new-routes-to-success
#36
Clara Campas
The Third Annual Drug Repositioning Summit 2008 was held at the Hyatt Harborside Hotel in Boston, Massachusetts, October 6-7, and focused on new strategies for drug repositioning. The meeting, organized by The Cambridge Healthtech Institute, brought together a panel of speakers from the industry and the academia, who discussed and proposed new routes for success in drug repositioning based on their own experience in the field. This meeting report summarizes the most relevant presentations and issues discussed...
March 2009: Drug News & Perspectives
https://read.qxmd.com/read/18988119/the-future-of-cancer-diagnostics-next-generation-molecular-technologies-cambridge-healthtech-institute-s-inaugural-conference
#37
Francis L Martin
Cambridge Health Tech Institute's first conference on 'The Future of Cancer Diagnostics: Next Generation Molecular Technologies' covered the following areas: regulatory requirements regarding the validation of new cancer diagnostics; how such validation processes might be suitably implemented from laboratory to clinical pipeline to the bedside; translational strategies, such as proteomics or methylation patterns; and novel biomarkers in oncology. Overall in this golden age of cancer research, the aims and objectives of the meeting were to explore how the implementation of new diagnostic strategies could be facilitated...
November 2008: IDrugs: the Investigational Drugs Journal
https://read.qxmd.com/read/18980535/novel-vaccines-bridging-research-development-and-production
#38
Alicia Demirjian, Ofer Levy
Vaccines are among the greatest achievements of modern medicine, leading to the eradication of naturally occurring smallpox, the near elimination of polio and the control of diseases such as rotavirus and hepatitis A and B in industrialized countries. Conventional vaccines, however, protect against a limited number of infectious diseases and, in some cases, provide incomplete protection. Effective vaccines against common infections such as HIV, hepatitis C and malaria remain an unmet medical need. These gaps, together with the threat of resurgence of eradicated diseases, contribute to the growing need for the development of new vaccines and the improvement of existing ones...
November 2008: Expert Review of Vaccines
https://read.qxmd.com/read/18465528/inhibition-of-human-proteases-from-target-identification-to-therapy-23-24-april-1998-boston-ma-usa
#39
JOURNAL ARTICLE
R A Greenwald
This two-day meeting, sponsored by the Cambridge Healthtech Institute, was attended by around 70 scientists, primarily from the pharmaceutical industry, with a small number from academia. Most of the industry representatives were from smaller companies engaged in drug development; virtually no multinational companies were represented. Four main topics were covered: target identification and pathophysiology; structural analysis and drug design; screening for proteinase inhibitors; and, clinical development. The target identification session was by far the strongest...
June 1998: IDrugs: the Investigational Drugs Journal
https://read.qxmd.com/read/18154445/new-applications-of-microarray-data-analysis-integrating-genetics-with-omics-organized-by-the-cambridge-healthtech-institute-15-17-august-2007-washington-dc-usa
#40
REVIEW
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