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javad parvizi

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https://read.qxmd.com/read/30775431/a-trans-atlantic-perspective-on-stagnation-in-clinical-translation-of-antimicrobial-strategies-for-the-control-of-biomaterial-implant-associated-infection
#1
REVIEW
Henk J Busscher, Volker Alt, Henny C van der Mei, Paul H Fagette, Werner Zimmerli, T Fintan Moriarty, Javad Parvizi, Gerhard Schmidmaier, Michael J Raschke, Thorsten Gehrke, Roger Bayston, Larry M Baddour, Lynn C Winterton, Rabih O Darouiche, David W Grainger
Current regulatory requirements impede clinical translation and market introduction of many new antimicrobial combination implants and devices, causing unnecessary patient suffering, doctor frustration, and costs to healthcare payers. Regulatory requirements of antimicrobial combination implants and devices should be thoroughly revisited and their approval allowed based on enrichment of benefit demonstrations from high-risk patient groups and populations or device components to facilitate their clinical translation...
February 11, 2019: ACS Biomaterials Science & Engineering
https://read.qxmd.com/read/30765229/longer-operative-time-results-in-a-higher-rate-of-subsequent-periprosthetic-joint-infection-in-patients-undergoing-primary-joint-arthroplasty
#2
Qiaojie Wang, Karan Goswami, Noam Shohat, Arash Aalirezaie, Jorge Manrique, Javad Parvizi
BACKGROUND: Whether prolonged operative time is an independent risk factor for subsequent surgical site infection (SSI) and periprosthetic joint infection (PJI) following total joint arthroplasty (TJA) remains a clinically significant and underexplored issue. The aim of this study is to investigate the association between operative time and the risk of subsequent SSI and PJI in patients undergoing primary TJA. METHODS: We retrospectively reviewed 17,342 primary unilateral total knee arthroplasty and total hip arthroplasty performed at a single institution between 2005 and 2016, with a minimum follow-up of 1 year...
January 18, 2019: Journal of Arthroplasty
https://read.qxmd.com/read/30755376/hip-dysplasia-compromises-the-outcome-of-femoroacetabular-impingement-surgery
#3
Hamed Vahedi, Arash Aalirezaie, Gabriella Rolo, Javad Parvizi
BACKGROUND: The optimal treatment for patients with symptomatic hip dysplasia presenting with labral tear is unknown. Although femoroacetabular osteoplasty (FAO) has excellent outcome for most femoroacetabular impingement patients, the presence of concomitant hip dysplasia has been implicated as an adverse prognostic factor. This study evaluated the outcome of FAO in a group of dysplastic hips and compared the outcome to a cohort of patients without dysplasia. METHODS: Seventy-three patients (38 males, 35 females) with hip dysplasia who underwent FAO between 2007 and 2015 were identified...
January 18, 2019: Journal of Arthroplasty
https://read.qxmd.com/read/30647934/ptosis-of-the-hip-a-new-radiographic-finding-in-patients-undergoing-femoroacetabular-osteoplasty
#4
Ryan Sutton, Ibrahim Azboy, Camilo Restrepo, Javad Parvizi
Ptosis is a newly described phenomenon appearing on AP radiographs of patients undergoing femoroacetabular osteoplasty (FAO), and refers to a reverse break down in Shenton's Line. Thorough characterization of this phenomenon is needed to better understand the hip morphology and pathologic ramifications. Our goal was to define the radiographic hip parameters accompanying a break down in Shenton's Line and to determine how these values compare with standard values in normal hips. Using two independent readers, we retrospectively reviewed the medical records and preoperative supine radiographs of 630 patients (1260 hips) who underwent FAO by a single surgeon between 2003 and 2016...
December 2018: Journal of Hip Preservation Surgery
https://read.qxmd.com/read/30647931/the-low-volume-acetabulum-dysplasia-in-disguise
#5
Hamed Vahedi, Abtin Alvand, Seyed Morteza Kazemi, Ibrahim Azboy, Javad Parvizi
Although there are well described radiological criteria for diagnosing DDH, our experience has highlighted that a new sub-category of hips exists in which the classic radiographic characteristics for DDH may be normal but the coverage of the femoral head is compromised. The purpose of this study was to validate a simple radiographic measurement method for calculating the depth of the acetabulum in order to detect individuals with 'low-volume' acetabuli and under-covered femoral heads. We identified 24 patients who were suspected of having low-volume acetabuli and compared their radiographs with those of 150 patients with non-dysplastic hips...
December 2018: Journal of Hip Preservation Surgery
https://read.qxmd.com/read/30637303/increased-risk-of-heterotopic-ossification-following-revision-hip-arthroplasty-for-periprosthetic-joint-infection
#6
Jorge Manrique, Pouya Alijanipour, Snir Heller, Michael Dove, Javad Parvizi
Background: To investigate whether surgery for Periprosthetic Joint Infection (PJI) of the hip, the number of procedures and their duration contribute to risk of Heterotopic Ossification formation. Methods: 56 patients with hip PJI undergoing one-stage (10) or two-stage (46) exchange arthroplasty were matched to 112 patients undergoing revision arthroplasty for aseptic failure based on age, gender, body mass index (BMI), surgical approach (all direct lateral) and date of surgery (2006-2013)...
November 2018: Archives of Bone and Joint Surgery
https://read.qxmd.com/read/30609439/results-of-a-phase-ii-study-to-determine-the-efficacy-and-safety-of-genetically-engineered-allogeneic-human-chondrocytes-expressing-tgf-%C3%AE-1
#7
Bumsup Lee, Javad Parvizi, Dale Bramlet, David W Romness, Ali Guermazi, Moon Noh, Nipun Sodhi, Anton Khlopas, Michael A Mont
Genetically engineered chondrocytes virally transduced with a transforming growth factor (TGF)- β 1 (TG-C [TissueGene-C]) expression vector have been shown to have potential benefits in the nonoperative management of knee osteoarthritis. Previous literature has reported on safe dosages of TG-C. Therefore, the purpose of this study was to evaluate the Phase II results and a 24-month efficacy of this injectable mixture compared with placebo in patients with Kellgren-Lawrence (K-L) grade III knee osteoarthritis...
January 4, 2019: Journal of Knee Surgery
https://read.qxmd.com/read/30586103/meta-analysis-of-comparative-trials-evaluating-a-single-use-closed-incision-negative-pressure-therapy-system
#8
Devinder P Singh, Allen Gabriel, Javad Parvizi, Michael J Gardner, Ralph D'Agostino
BACKGROUND: Surgical site infections (SSIs) pose a significant surgical complication. Application of closed-incision negative-pressure therapy (ciNPT) has been associated with reduced SSI rates in published literature. This meta-analysis examines the effect of ciNPT use over closed incisions in reducing SSIs versus traditional dressings. METHODS: A systematic literature search using PubMed, The Cochrane Library, OVID, EMBASE, ScienceDirect, and QUOSA was performed focusing on publications between January 1, 2005, and April 30, 2018...
January 2019: Plastic and Reconstructive Surgery
https://read.qxmd.com/read/30569004/vascular-injury-and-orthopaedics
#9
EDITORIAL
Javad Parvizi
No abstract text is available yet for this article.
December 2018: Arthroplasty Today
https://read.qxmd.com/read/30551780/comparative-study-of-cultures-and-next-generation-sequencing-in-the-diagnosis-of-shoulder-prosthetic-joint-infections
#10
Surena Namdari, Thema Nicholson, Joseph Abboud, Mark Lazarus, Matthew L Ramsey, Gerald Williams, Javad Parvizi
BACKGROUND: Serum and synovial markers used to diagnose lower extremity prosthetic joint infection (PJI) have performed poorly for shoulder PJI. As a result, diagnosis is commonly reliant on the accuracy of positive or negative cultures. Next-generation sequencing (NGS) can sequence an entire bacterial genome. This study was conducted to determine the correlation between NGS and routine cultures in revision shoulder arthroplasty. METHODS: All patients undergoing revision shoulder arthroplasty were prospectively enrolled...
January 2019: Journal of Shoulder and Elbow Surgery
https://read.qxmd.com/read/30533595/culture-negative-periprosthetic-joint-infection-an-update-on-what-to-expect
#11
Timothy L Tan, Michael M Kheir, Noam Shohat, Dean D Tan, Matthew Kheir, Chilung Chen, Javad Parvizi
Background: Culture-negative periprosthetic joint infection (PJI) is a challenging condition to treat. The most appropriate management of culture-negative PJI is not known, and there is immense variability in the treatment outcome of this condition. The purpose of this study was to elucidate the characteristics, outcomes, and risk factors for failure of treatment of culture-negative PJI. Methods: A retrospective review of 219 patients (138 hips and 81 knees) who had undergone surgery for the treatment of culture-negative PJI was performed utilizing a prospectively collected institutional PJI database...
September 25, 2018: JB & JS open access
https://read.qxmd.com/read/30516629/routine-diagnostic-tests-for-periprosthetic-joint-infection-demonstrate-a-high-false-negative-rate-and-are-influenced-by-the-infecting-organism
#12
Michael M Kheir, Timothy L Tan, Noam Shohat, Carol Foltz, Javad Parvizi
BACKGROUND: Current guidelines recommend serum erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) as the first-line testing for evaluation of suspected periprosthetic joint infection, in addition to synovial white blood-cell (WBC) count and polymorphonuclear percentage. However, the sensitivity and other diagnostic measures of these tests using a standardized definition of periprosthetic joint infection and the influence of organisms on these inflammatory markers remain inadequately investigated...
December 5, 2018: Journal of Bone and Joint Surgery. American Volume
https://read.qxmd.com/read/30444756/acetabular-labral-tears-are-common-in-asymptomatic-contralateral-hips-with-femoroacetabular-impingement
#13
Hamed Vahedi, Arash Aalirezaie, Ibrahim Azboy, Tanine Daryoush, Alisina Shahi, Javad Parvizi
BACKGROUND: The number of patients undergoing hip arthroscopy for labral tears has increased, but labral tears are sometimes seen in asymptomatic patients with femoroacetabular impingement (FAI). The frequency of this finding, however, has not been well characterized nor is the proportion of patients with previously asymptomatic labral tears who may later become symptomatic. QUESTIONS/PURPOSES: The purpose of this study was to determine (1) the prevalence of labral tears and other intraarticular pathology in the asymptomatic contralateral hip of patients undergoing surgery for symptomatic FAI; (2) the likelihood that the asymptomatic hip had become symptomatic at latest followup; and (3) any association between MRI findings and age, sex, and body mass index (BMI) in both symptomatic and asymptomatic sides...
November 5, 2018: Clinical Orthopaedics and related Research
https://read.qxmd.com/read/30361126/a-meta-analysis-comparing-the-direct-anterior-with-other-approaches-in-primary-total-hip-arthroplasty
#14
Fatih Kucukdurmaz, Mohamed Sukeik, Javad Parvizi
BACKGROUND: Proponents of the direct anterior approach (DAA) for THAs suggest earlier recovery with no increased complications whereas opponents suggest higher complication rates. METHODS: We conducted a meta-analysis of randomized controlled trials (RCTs) to compare the outcomes of the DAA versus other surgical approaches in primary THAs. RESULTS: We identified 18 RCTs suitable for detailed extraction of the data. The RCTs included a total of 1661 patients with a mean age of 62 years (range 55-69)...
October 22, 2018: Surgeon: Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland
https://read.qxmd.com/read/30348579/general-assembly-prevention-surgical-site-preparation-proceedings-of-international-consensus-on-orthopedic-infections
#15
Gerald J Akins, Maria Tibau Alberdi, Andrew Beswick, John David Blaha, Joshua Bingham, James Cashman, Antonia Chen, Alexus M Cooper, Gilberto Lara Cotacio, Toni Fraguas, Anil Gambhir, Kirill Gromov, Ernesto Guerra, Gary Hooper, Anton Khlopas, David Kieser, Ianiv Klaber, Richard Kyte, Brett Levine, Michael A Mont, Vasileios Nikolaou, Jorge Nuñez, Soeren Overgaard, Javad Parvizi, Arjun Saxena, Gustavo Sayago, Hossain Shahcheraghi, Nipun Sodhi, Lucian Bogdan Solomon, Yolandi Starczak, Timothy L Tan, Majd Tarabichi, Rafael Tibau Olivan, Petri Virolainen, Michael Wyatt
No abstract text is available yet for this article.
October 19, 2018: Journal of Arthroplasty
https://read.qxmd.com/read/30348578/hip-and-knee-section-treatment-prosthesis-factors-proceedings-of-international-consensus-on-orthopedic-infections
#16
Guillem Bori, Michael Kelly, Daniel Kendoff, Mitchell R Klement, Rafael Llopis, Laurens Manning, Javad Parvizi, Michael J Petrie, Amir Sandifort, Nemandra A Sandiford, Ian Stockley
No abstract text is available yet for this article.
October 19, 2018: Journal of Arthroplasty
https://read.qxmd.com/read/30348569/general-assembly-prevention-blood-conservation-proceedings-of-international-consensus-on-orthopedic-infections
#17
Mandus Akonjom, Andrew Battenberg, David Beverland, Jae-Hyuck Choi, Yale Fillingham, Nicola Gallagher, Seung Beom Han, Woo Young Jang, William Jiranek, Jorge Manrique, Kalin Mihov, Robert Molloy, Michael A Mont, Sumon Nandi, Javad Parvizi, Trisha N Peel, Luis Pulido, Martin Sarungi, Nipun Sodhi, Maria Tibau Alberdi, Rafael Tibau Olivan, David Wallace, Xisheng Weng, Henry Wynn-Jones, Seng Jin Yeo
No abstract text is available yet for this article.
October 19, 2018: Journal of Arthroplasty
https://read.qxmd.com/read/30348567/general-assembly-prevention-antiseptic-irrigation-solution-proceedings-of-international-consensus-on-orthopedic-infections
#18
Ashley Blom, JeoungEun Cho, Andrew Fleischman, Karan Goswami, Constantinos Ketonis, Setor Kunustor, Gabriel Makar, Daniel G Meeker, Rhidian Morgan-Jones, Silvestre Ortega-Peña, Javad Parvizi, Mark Smeltzer, Jeffrey B Stambough, Kenneth Urish, Giorgio P Tonelo Zilotto
No abstract text is available yet for this article.
October 19, 2018: Journal of Arthroplasty
https://read.qxmd.com/read/30348566/hip-and-knee-section-diagnosis-algorithm-proceedings-of-international-consensus-on-orthopedic-infections
#19
Mahmoud Abdel Karim, John Andrawis, Francisco Bengoa, Carlos Bracho, Riccardo Compagnoni, Michael Cross, Jonathan Danoff, Craig J Della Valle, Pedro Foguet, Toni Fraguas, Thorsten Gehrke, Karan Goswami, Ernesto Guerra, Yong-Chan Ha, Ianiv Klaber, Georgios Komnos, Paul Lachiewicz, Christian Lausmann, Brett Levine, Andrea Leyton-Mange, Benjamin A McArthur, Rene Mihalič, Jeroen Neyt, Jorge Nuñez, Carl Nunziato, Javad Parvizi, Carsten Perka, Marie-Jacque Reisener, Cesar H Rocha, Daniel Schweitzer, Faiz Shivji, Noam Shohat, Rafael J Sierra, Linda Suleiman, Timothy L Tan, Julia Vasquez, Derek Ward, Matthias Wolf, Akos Zahar
No abstract text is available yet for this article.
October 19, 2018: Journal of Arthroplasty
https://read.qxmd.com/read/30348557/hip-and-knee-section-outcomes-proceedings-of-international-consensus-on-orthopedic-infections
#20
William P Abblitt, Tiziana Ascione, Stefano Bini, Guillem Bori, Adam C Brekke, Antonia F Chen, Paul M Courtney, Craig J Della Valle, Claudio Diaz-Ledezma, Ayman Ebied, Yale J Fillingham, Thorsten Gehrke, Karan Goswami, George Grammatopoulos, Sameh Marei, Ali Oliashirazi, Javad Parvizi, Gregory Poljowski, Kordo Saeed, Adam J Schwartz, John Segreti, Noam Shohat, Bryan D Springer, Linda I Suleiman, Lee K Swiderek, Timothy L Tan, Chun Hoi Yan, Yi Rong Zeng
No abstract text is available yet for this article.
October 19, 2018: Journal of Arthroplasty
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