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D Sneiders, D P V Lambrichts, H A Swank, C F J M Blanken-Peeters, S W Nienhuijs, M J P M Govaert, M F Gerhards, A G M Hoofwijk, R J I Bosker, J D W van der Bilt, B H M Heijnen, H O Ten Cate Hoedemaker, G J Kleinrensink, J F Lange, W A Bemelman
AIM: Laparoscopic peritoneal lavage has increasingly been investigated as a promising alternative to sigmoidectomy for perforated diverticulitis with purulent peritonitis. Most studies only reported outcomes up to 12 months. Therefore, the objective of this study was to evaluate long-term outcomes of patients treated with laparoscopic lavage. METHODS: Between 2008 and 2010, 38 patients treated with laparoscopic lavage for perforated diverticulitis in ten Dutch teaching hospitals were included...
February 16, 2019: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
Lisa Van de Wijer, Deborah N Mchaile, Quirijn de Mast, Blandina T Mmbaga, Nanda N J Rommelse, Ashanti Duinmaijer, André J A M van der Ven, Arnt F A Schellekens, Grace D Kinabo
BACKGROUND: Efavirenz is commonly prescribed for children with HIV infection, yet little is known about risks of neuropsychiatric side-effects. We aimed to compare competence (social involvement, activities, and school performance) and psychopathology (internalising and externalising problems), cognitive performance (intelligence and working memory), and adherence in Tanzanian children on an efavirenz-based versus a non-efavirenz-based regimen. METHODS: In this multicentre, cross-sectional, observational study, we included consecutive children (aged 6-12 years) with HIV infection, on combination antiretroviral therapy (cART) for at least 6 months, and with viral loads of less than 1000 copies per mL from HIV care clinics of three primary health facilities and three referral hospitals in Moshi, Kilimanjaro, Tanzania...
February 12, 2019: Lancet HIV
Joanna Moraczewska, Katarzyna Robaszkiewicz, Małgorzata Śliwinska, Marta Czajkowska, Thu Ly, Alla Kostyukova, Han Wen, Wenjun Zheng
Tropomyosin binds along actin filaments and regulates myosin binding to control muscle contraction. Tropomodulin binds to the pointed end of a filament and regulates actin dynamics, which maintains the length of a thin filament. To define the structural determinants of these tropomyosin functions, we examined the effects of two congenital myopathy mutations, A4V and R91C, in the tropomyosin gene, TPM3, which encodes the tropomyosin isoform, Tpm3.12. Tpm3.12 is specific for slow-twitch muscle fibers. Mutation A4V is located in the tropomodulin-binding, N-terminal region of Tpm3...
February 15, 2019: FEBS Journal
Rachel M Arends, Erni J Nelwan, Ratna Soediro, Reinout van Crevel, Bachti Alisjahbana, Herdiman T Pohan, A Katinka L von Borries, Aart H Schene, André J A M van der Ven, Arnt F A Schellekens
HIV, hepatitis B and C, and syphilis share common transmission routes of which primarily unsafe sexual contact and injecting drug use are important. Impulsivity is a major factor contributing to this transmission risk behavior; however comprehensive studies within female, prison, and Asian populations are scarce. This cross-sectional study aims to delineate the contributions of different aspects of impulsivity to risk behavior, among female inmates living in a prison in Jakarta (N = 214). The relationships between various aspects of impulsivity, risk behaviors and seropositivity were tested using analyses of variance and logistic regression analyses...
2019: PloS One
Ilse van Beusekom, Ferishta Bakhshi-Raiez, Marike van der Schaaf, Wim B Busschers, Nicolette F de Keizer, Dave A Dongelmans
OBJECTIVES: To describe the types and prevalence of chronic conditions in an ICU population and a population-based control group during the year before ICU admission and to quantify the risk of developing new chronic conditions in ICU patients compared with the control group. DESIGN: We conducted a retrospective cohort study, combining a national health insurance claims database and a national quality registry for ICUs. Claims data in the timeframe 2012-2014 were combined with clinical data of patients who had been admitted to an ICU during 2013...
March 2019: Critical Care Medicine
Zohra Layegh, Jill Ruwaard, Renske C F Hebing, Merel J L' Ami, Wilfred van der Weele, Mike T Nurmohamed, Charlotte Krieckaert, Gertjan Wolbink
OBJECTIVES: To evaluate the transition from reference infliximab Remicade to biosimilar Remsima in patients with rheumatoid arthritis (RA) or psoriatic arthritis (PsA). METHODS: Patients were informed through a letter about the transition to a biosimilar and were subsequently contacted for possible additional questions and whether they agreed upon the transition. Once agreed, Remsima was administered at the same dosage and interval as previous treatment with Remicade...
February 14, 2019: International Journal of Rheumatic Diseases
Thomas R F van Steenbergen, Ingrid C M van der Geest, Dennis Janssen, Maroeska M Rovers, Jurgen J Fütterer
BACKGROUND: Intraoperative cone-beam CT (CBCT) offers the advantage of navigation on the current anatomical situation and the possibility to take a control scan. We assessed the feasibility of using intraoperative CBCT for navigated intralesional curettage. METHODS: Nine benign bone tumor patients were studied. Feasibility was assessed by describing the workflow and indications for navigation, scoring CBCT image quality and registration accuracy, and measuring scan and navigation set-up times...
February 14, 2019: International Journal of Medical Robotics + Computer Assisted Surgery: MRCAS
Marloes Witjes, P Edwin Vorstius Kruijff, Bernadette J J M Haase-Kromwijk, Johannes G van der Hoeven, Nichon E Jansen, Wilson F Abdo
BACKGROUND: The aim of this nationwide observational study is to identify modifiable factors in communication about organ donation that influence family consent rates. METHODS: Thirty-two intensivists specialized in organ donation systematically evaluated all consecutive organ donation requests with physicians in the Netherlands between January 2013 and June 2016, using a standardized questionnaire. RESULTS: Out of 2528 consecutive donation requests, 2095 (83%) were evaluated with physicians...
February 14, 2019: Neurocritical Care
Frank D Verbraak, Michael D Abramoff, Gonny C F Bausch, Caroline Klaver, Giel Nijpels, Reinier O Schlingemann, Amber A van der Heijden
OBJECTIVE: To determine the diagnostic accuracy in a real-world primary care setting of a deep learning-enhanced device for automated detection of diabetic retinopathy (DR). RESEARCH DESIGN AND METHODS: Retinal images of people with type 2 diabetes visiting a primary care screening program were graded by a hybrid deep learning-enhanced device (IDx-DR-EU-2.1; IDx, Amsterdam, the Netherlands), and its classification of retinopathy (vision-threatening [vt]DR, more than mild [mtm]DR, and mild or more [mom]DR) was compared with a reference standard...
February 14, 2019: Diabetes Care
Veerle A B van den Bogaard, Peter van Luijk, Yoran M Hummel, Peter van der Meer, E Schuit, Liselotte M Boerman, Saskia W M C Maass, Jan F Nauta, Lars C Steggink, Jourik A Gietema, Geertruida H de Bock, Annette J Berendsen, Wilma G J M Smit, Nanna M Sijtsema, Roel G J Kierkels, Johannes A Langendijk, Anne P G Crijns, John H Maduro
PURPOSE: The main purpose of this study was to test the hypothesis that incidental cardiac irradiation is associated with changes in cardiac function in breast cancer (BC) survivors treated with radiotherapy (RT). METHODS AND MATERIALS: We conducted a cross-sectional study consisting of 109 BC survivors treated with RT between 2005 and 2011. The endpoint was cardiac function, assessed by echocardiography. Systolic function was assessed with the left ventricle ejection fraction (LVEF) (n=107) and the global longitudinal strain (GLS) of the left ventricle (LV) (n=52)...
February 11, 2019: International Journal of Radiation Oncology, Biology, Physics
Antonius M H P van den Besselaar, Charmane F Abdoel, Claudia J J van Rijn, Felix J M van der Meer, Christa M Cobbaert
Background In the Netherlands, each new lot of test strips for the CoaguChek XS is validated by a group of collaborating centers. The purpose of this study was to assess the accuracy of the international normalized ratio (INR) measured with consecutive test strip lots and the suitability of frozen plasma pools for accuracy evaluation. Methods Each year, a particular lot of CoaguChek XS test strips is used as reference lot. The reference lots have been validated with the International Standard for thromboplastin rTF/09, yielding a mathematical relationship (R1) between reference lot INR and International Standard INR...
February 14, 2019: Clinical Chemistry and Laboratory Medicine: CCLM
Vera Atema, Marieke van Leeuwen, Jacobien M Kieffer, Hester S A Oldenburg, Marc van Beurden, Miranda A Gerritsma, Marianne A Kuenen, Peter W Plaisier, Alexander M F Lopes Cardozo, Yvonne E A van Riet, Gijsbert Heuff, Herman Rijna, Suzan van der Meij, Eva M Noorda, Gert-Jan Timmers, Bart C Vrouenraets, Matthé Bollen, Henk van der Veen, Nina Bijker, Myra S Hunter, Neil K Aaronson
PURPOSE: We evaluated the effect of Internet-based cognitive behavioral therapy (iCBT), with or without therapist support, on the perceived impact of hot flushes and night sweats (HF/NS) and overall levels of menopausal symptoms (primary outcomes), sleep quality, HF/NS frequency, sexual functioning, psychological distress, and health-related quality of life in breast cancer survivors with treatment-induced menopausal symptoms. PATIENTS AND METHODS: We randomly assigned 254 breast cancer survivors to a therapist-guided or a self-managed iCBT group or to a waiting list control group...
February 14, 2019: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
Jeannette C Bleeker, Irene L Kok, Sacha Ferdinandusse, W Ludo van der Pol, Inge Cuppen, Annet M Bosch, Mirjam Langeveld, Terry G J Derks, Monique Williams, Maaike de Vries, Margot F Mulder, Estela Rubio Gozalbo, Monique G M de Sain- van der Velden, Alexander J Rennings, Peter J C I Schielen, Eugenie Dekkers, Riekelt H Houtkooper, Hans R Waterham, Mia L Pras-Raves, Ronald J A Wanders, Peter M van Hasselt, Marja Schoenmakers, Frits A Wijburg, Gepke Visser
BACKGROUND: Most infants with very-long-chain acyl-CoA dehydrogenase deficiency (VLCADD) identified by newborn screening (NBS) are asymptomatic at the time of diagnosis and remain asymptomatic. If this outcome is due to prompt diagnosis and initiation of therapy, or because of identification of individuals with biochemical abnormalities who will never develop symptoms, is unclear. METHODS: A 10 year longitudinal national cohort study of genetically confirmed VLCADD patients born before and after introduction of NBS...
February 13, 2019: Journal of Inherited Metabolic Disease
Lianne de Haan, Sarah J van der Lely, Anne-Loes K Warps, Quincy Hofsink, Pim B Olthof, Mark J de Keijzer, Daniël A Lionarons, Lionel Mendes-Dias, Bote G Bruinsma, Korkut Uygun, Hartmut Jaeschke, Geoffrey C Farrell, Narci Teoh, Rowan F van Golen, Tiangang Li, Michal Heger
Background: Liver regeneration following partial hepatectomy (PHx) is a complicated process involving multiple organs and several types of signaling networks. The bile acid-activated metabolic pathways occupy an auxiliary yet important chapter in the entire biochemical story. PHx is characterized by rapid but transient bile acid overload in the liver, which constitutes the first wave of proliferative signaling in the remnant hepatocytes. Bile acids trigger hepatocyte proliferation through activation of several nuclear receptors...
May 28, 2018: Journal of Clinical and Translational Research
Sander C J Verfaillie, Tessa Timmers, Rosalinde E R Slot, Chris W J van der Weijden, Linda M P Wesselman, Niels D Prins, Sietske A M Sikkes, Maqsood Yaqub, Annemiek Dols, Adriaan A Lammertsma, Philip Scheltens, Rik Ossenkoppele, Bart N M van Berckel, Wiesje M van der Flier
Objective: Subjective cognitive decline (SCD) is associated with an increased risk of Alzheimer's Disease (AD). Early disease processes, such as amyloid-β aggregation measured with quantitative PET, may help to explain the phenotype of SCD. The aim of this study was to investigate whether quantitative amyloid-β load is associated with both self- and informant-reported cognitive complaints and memory deficit awareness in individuals with SCD. Methods: We included 106 SCD patients (mean ± SD age: 64 ± 8, 45%F) with 90 min dynamic [18 F]florbetapir PET scans...
2019: Frontiers in Aging Neuroscience
Hamdi Mbarek, Margot P van de Weijer, Mathijs D van der Zee, Hill F Ip, Jeffrey J Beck, Abdel Abdellaoui, Erik A Ehli, Gareth E Davies, Bart M L Baselmans, Michel G Nivard, Meike Bartels, Eco J de Geus, Dorret I Boomsma
The tendency to conceive spontaneous dizygotic (DZ) twins is a complex trait with important contributions from both environmental factors and genetic disposition. In earlier work, we identified the first two genes as maternal susceptibility loci for DZ twinning. The aim of this study was to identify genetic variants influencing multiple births and to genetically correlate the findings across a broad range of traits. We performed a genome-wide association study (GWAS) in 8962 participants with Caucasian ancestry from UK Biobank who reported being part of a multiple birth, and 409,591 singleton controls...
February 13, 2019: European Journal of Human Genetics: EJHG
Juliane Fagotti, Adriano D S Targa, Lais S Rodrigues, Ana Carolina D Noseda, Flávia W C Dorieux, Franciele F Scarante, Jessica L Ilkiw, Fernando M Louzada, Namrata R Chowdhury, Daan R van der Veen, Benita Middleton, Jeroen L A Pennings, Jonathan R Swann, Debra J Skene, Marcelo M S Lima
Parkinson's disease (PD) is a chronic disorder that presents a range of premotor signs, such as sleep disturbances and cognitive decline, which are key non-motor features of the disease. Increasing evidence of a possible association between sleep disruption and the neurodegenerative process suggests that sleep impairment could produce a detectable metabolic signature on the disease. In order to integrate neurocognitive and metabolic parameters, we performed untargeted and targeted metabolic profiling of the rotenone PD model in a chronic sleep restriction (SR) (6 h/day for 21 days) condition...
February 13, 2019: Scientific Reports
Gitte Berkers, Peter van Mourik, Annelotte M Vonk, Evelien Kruisselbrink, Johanna F Dekkers, Karin M de Winter-de Groot, Hubertus G M Arets, Rozemarijn E P Marck-van der Wilt, Jasper S Dijkema, Maaike M Vanderschuren, Roderick H J Houwen, Harry G M Heijerman, Eduard A van de Graaf, Sjoerd G Elias, Christof J Majoor, Gerard H Koppelman, Jolt Roukema, Marleen Bakker, Hettie M Janssens, Renske van der Meer, Robert G J Vries, Hans C Clevers, Hugo R de Jonge, Jeffrey M Beekman, Cornelis K van der Ent
In vitro drug tests using patient-derived stem cell cultures offer opportunities to individually select efficacious treatments. Here, we provide a study that demonstrates that in vitro drug responses in rectal organoids from individual patients with cystic fibrosis (CF) correlate with changes in two in vivo therapeutic endpoints. We measured individual in vitro efficaciousness using a functional assay in rectum-derived organoids based on forskolin-induced swelling and studied the correlation with in vivo effects...
February 12, 2019: Cell Reports
Thomas F Rice, Dimitri A Diavatopoulos, Gaby P Smits, Pieter van Gageldonk, Guy Berbers, Fiona van der Klis, George Vamvakas, Beverly Donaldson, Marielle Bouqueau, Beth Holder, Beate Kampmann
The maternal Tdap (tetanus, diphtheria and acellular pertussis) vaccination program in the UK has successfully reduced cases of pertussis in young infants. In addition to prevention of pertussis cases, it is also important to investigate persistence of maternal antibody during infancy and possible interference of maternal antibodies with infant responses to vaccines. We recruited mother-infant pairs from vaccinated and unvaccinated pregnancies and measured concentrations of IgG against pertussis toxin (PTx), filamentous hemagglutinin (FHA), pertactin (Prn), diphtheria toxin (DTx), tetanus toxoid (TTx) Haemophilus influenzae type b (Hib) and Streptococcus pneumoniae in mothers and infants at birth, and in infants at 7 weeks and at 5 months...
February 13, 2019: Clinical and Experimental Immunology
Diederik E van der Feen, Rolf M F Berger, Beatrijs Bartelds
Cellular senescence is recognized as a crucial contributor to the pathobiology of various degenerative and cardiovascular diseases, like idiopathic pulmonary fibrosis and atherosclerosis. We describe the potential link between cellular senescence and the degenerative character of neointimal pulmonary vascular disease in pulmonary arterial hypertension (PAH). Senescence markers have been described in remodeled pulmonary arteries, triggers that induce senescence also induce PAH, pathways known to be disturbed in PAH, such as TGFβ/BMP and TNFα, are also causally associated to senescence and interventions that target a senescence phenotype, also target pulmonary vascular remodeling in vivo...
February 13, 2019: American Journal of Respiratory Cell and Molecular Biology
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