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Right isomerism

Chao Ma, Huida Guan, Zhengcai Ju, Shuping Li, Gang Deng, Yunpeng Zhang, Qiyan Lin, Xuemei Cheng, Li Yang, Zhengtao Wang, Changhong Wang
Notoginsenoside Fc (NGFc), a protopanaxadiol-type saponin, shows multi-pharmacological activities. Chemical stability evaluation plays a crucial role in drug development. In this study, the forced degradation behavior of NGFc was investigated under hydrolytic and oxidative conditions. A specific ultra-high performance liquid chromatography with quadrupole time-of-flight mass spectrometry was developed for the separation, identification, and characterization of the degradation products of NGFc. Fifty potential degradation products were formed via deglycosylation, dehydration, hydration, isomerization, side-chain cleaving, oxidation, and superoxidation...
February 15, 2019: Journal of Separation Science
Lakshmi Murli, M S Ranjit, Prashant Shah
Unroofed coronary sinus, an unusual form of interatrial communication, is a rare cardiac anomaly. It is not a true defect of the atrial septum. It is described as a partial (focal or fenestrated) or complete absence of the roof of the coronary sinus, resulting in a communication between the coronary sinus and left atrium. It is presumably the least common variety of defects associated with interatrial shunting. Such defects are often difficult to diagnose and may even be overlooked during surgery for complex congenital heart disease...
January 2019: Annals of Pediatric Cardiology
Tatiana Kondakova, John E Cronan
One key to the success of Pseudomonas spp. is their ability to reside in the hostile environments. Pseudomonas spp. possess a cis-trans isomerase (Cti) an enzyme that converts the cis-unsaturated fatty acids of the membrane lipids to their trans-isomers to rigidify the membrane and thereby resist stresses. Whereas the posttranslational Cti regulation has been previously reported, transcriptional cti regulation remains to be studied in more details. Here, we have studied cti transcriptional regulation in the solvent-tolerant strain P...
January 31, 2019: Environmental Microbiology
Vinesh Appadurai, Jennifer Thoreau, Theresa Malpas, Mugur Nicolae
BACKGROUND: An improvement in life expectancy in patients suffering from adult congenital heart disease (ACHD) has corresponded with a rise in heart failure incidence within this group. An area that has not been addressed in ACHD heart failure guidelines has been the use of combined inhibition of angiotensin receptor-neprolysin pathways. This case series sought to demonstrate tolerability and 6-month outcome measures of sacubitril/valsartan use in ACHD patients with a severely impaired systemic ventricle...
December 17, 2018: Heart, Lung & Circulation
An Peng, Yingjian Ye, Wei Feng, Jiaqi Zhang, Yu Wang, Jiabao Yin
Left atrial isomerism (LAI) is a rare type of heterotaxy syndrome1 . The most common anomalies of the fetuses with LAI are the absence of the hepatic segment of the inferior vena cava (IVC), the interrupted suprarenal IVC segment with enlarged azygos or hemiazygos vein continuation, and the azygos vein passing posterior of the aorta and running up to join the superior vena cava (SVC)2 . This article is protected by copyright. All rights reserved.
December 24, 2018: Ultrasound in Obstetrics & Gynecology
Sara Fernández-Castillejo, Alba Macià, Maria-José Motilva, Úrsula Catalán, Rosa Solà
SCOPE: The antithrombotic effects of resveratrol (RV) and its derivatives remain unknown. The objective is to evaluate the modulatory effects of RV, its glucoside form, piceid, and its biological metabolites (RV-3-O-β-D-Glucuronide,RV-4'-O-D-Glucuronide,and RV-3-O-Sulfate) on tissue factor (TF). Moreover, the endothelial metabolism of RV is assessed. METHODS AND RESULTS: Human aortic endothelial cells (HAECs) were incubated with trans-piceid, trans-RV or their biological metabolites and stimulated with tumour necrosis factor-α (TNF-α)...
December 20, 2018: Molecular Nutrition & Food Research
Hannah Lively-Endicott, Diego A Lara
Background: Heterotaxy is a condition of abnormal lateralization of organs across the body's left-right axis, causing multiple congenital malformations. The anatomic manifestations of heterotaxy syndrome generally follow one of two patterns, referred to as right atrial isomerism (with two similar right atria and duplication of right-sided features of multiple organs) and left atrial isomerism (with two similar left atria and duplication of left-sided features of multiple organs). Cardiac surgical intervention for patients with heterotaxy syndrome depends on ventricular physiology and circulatory balance...
2018: Ochsner Journal
Alexander Alabugin
Photoactive molecules enable much of modern biology and biochemistry - a vast library of fluorescent chromophores is used to track and label cellular structures and macromolecules. However, photochemistry is better-known to the synthetic or physical organic chemist as a "light switch" that turns on unusual excited-state reactivity, isomerization, or dynamic adjustment of structure. This review details a rapidly growing approach to bio-photochemistry that uses low-energy near-IR wavelengths not only for imaging, but for close spatial control over chemical switching events in biosystems...
December 7, 2018: Photochemistry and Photobiology
Roan A S Vasdev, Lachlan F Gaudin, Dan Preston, Jackmil P Jogy, Gregory I Giles, James D Crowley
New bis- quinoline ( L q ) and bis- isoquinoline-based ( L iq ) ligands have been synthesized, along with their respective homoleptic [Pd2 ( L q or L iq )4 ]4+ cages ( C q and C iq ). The ligands and cages were characterized by 1 H, 13 C and diffusion ordered (DOSY) NMR spectroscopies, high resolution electrospray ionization mass spectrometry (HR-ESIMS) and in the case of the bis -quinoline cage, X-ray crystallography. The crystal structure of the C q architecture showed that the [Pd2 ( L q )4 ]4+ cage formed a twisted meso isomer where the [Pd( quinoline )4 ]2+ units at either end of the cage architecture adopt the opposite twists (left and right handed)...
2018: Frontiers in Chemistry
Mads P Sulbaek Andersen, Theis I Sølling, Lene Løffler Andersen, Aleksandra Volkova, Dvien Hovanessian, Connor Britzman, Ole John Nielsen, Timothy J Wallington
The chemical mechanisms of the OH radical, Cl-atom and O3 initiated oxidation of (Z)-CF3CH[double bond, length as m-dash]CHCl were studied at 296 ± 1 K in 10-700 Torr air of N2/O2 diluent. Cl atoms add to the [double bond splayed left]C[double bond, length as m-dash]C[double bond splayed right] double bond: 12 ± 5% to the terminal carbon and 85 ± 5% to the central carbon. In 700 Torr of air the products are CF3CHClCHO, HCOCl, CF3COCl, CF3CHO, (E)-CF3CH[double bond, length as m-dash]CHCl, CF3C(O)CHCl2, and CF3CHClCOCl...
November 14, 2018: Physical Chemistry Chemical Physics: PCCP
Patricia Garcia-Canadilla, Hector Dejea, Anne Bonnin, Vedrana Balicevic, Sven Loncaric, Chong Zhang, Constantine Butakoff, Jazmin Aguado-Sierra, Mariano Vázquez, Laurence H Jackson, Daniel J Stuckey, Cristoph Rau, Marco Stampanoni, Bart Bijnens, Andrew C Cook
BACKGROUND: In the era of increasingly successful corrective interventions in patients with congenital heart disease (CHD), global and regional myocardial remodeling are emerging as important sources of long-term morbidity/mortality. Changes in organization of the myocardium in CHD, and in its mechanical properties, conduction, and blood supply, result in altered myocardial function both before and after surgery. To gain a better understanding and develop appropriate and individualized treatment strategies, the microscopic organization of cardiomyocytes, and their integration at a macroscopic level, needs to be completely understood...
October 2018: Circulation. Cardiovascular Imaging
Han-Gook Cho, Lester Andrews
The insertion products of laser-ablated Pb atom reactions with ethane and mono-, di-, tri-, and tetrahalomethanes in excess argon were prepared and identified from their matrix infrared spectra on the basis of DFT computed frequencies and observed isotopic shifts. Unlike the lighter elements in group 14, the heaviest member lead exists primarily in the oxidation state 2+ using 6p orbitals in reaction products due to relativistic contraction of the 6s orbital. The C-Pb-X (X = H, F, Cl) bond is close to a right angle, indicating that Pb contributes mostly p-character to the C-Pb and Pb-X bonds...
November 15, 2018: Journal of Physical Chemistry. A
Frederic R Lyimo, Pedro Pallangyo, Naizihijwa Majani, Theophylly L Mushi, Sulende Kubhoja
BACKGROUND: Congenital cardiac defects are not rare among neonates. Prompt assessment for life-threatening anomalies is essential for rapid management decisions and positive outcomes. Extracardiac anomalies can occur in congenital heart defects, and their presence increases morbidity and mortality in these neonates. CASE PRESENTATION: We report a case of a 31- month-old infant black girl in Tanzania who presented with an on-and-off history of difficulty in breathing, easy fatigability, facial and lower-limb swelling, recurrent respiratory tract infections, and failure to thrive...
October 24, 2018: Journal of Medical Case Reports
Fatima Ali, Sonia Qureshi, Muneer Amanullah, Mehnaz Atiq
Objective: Total anomalous pulmonary venous return is an uncommon cyanotic congenital heart defect. Echocardiography is the initial diagnostic tool. Complimentary non-invasive modalities like cardiac computerized tomographic angiography and cardiac magnetic resonance imaging have replaced the need for cardiac catheterization in difficult cases. This study aimed to determine the accuracy of echocardiography in diagnosing total anomalous pulmonary venous return, and to determine the factors that may decrease its sensitivity...
September 2018: Pakistan Journal of Medical Sciences Quarterly
Takushi Fujimoto, Kenji Inaba, Hiroshi Kadokura
Formation of a disulfide bond is a critical step in the folding of numerous secretory and membrane proteins and catalyzed in vivo. A variety of mechanisms and protein structures have evolved to catalyze oxidative protein folding. Those enzymes that directly interact with a folding protein to accelerate its oxidative folding are mostly thiol-disulfide oxidoreductases that belong to the thioredoxin superfamily. The enzymes of this class often use a CXXC active-site motif embedded in their thioredoxin-like fold to promote formation, isomerization, and reduction of a disulfide bond in their target proteins...
October 19, 2018: Protein Science: a Publication of the Protein Society
Xing Qiao, Lu Yang, Qun Gao, Shu Yang, Zhaojie Li, Jie Xu, Changhu Xue
BACKGROUND: In this paper, the changes in free astaxanthin (F-AST) and astaxanthin esters (AST-E) in L. vannamei during iced storage and frozen storage were investigated. The liquid chromatography-atmospheric pressure chemical ionization-tandem mass spectrometry (LC-APCI-MS/MS) method was used to quantify molecular species of AST-E in shrimp during storage. RESULTS: Based on the analysis of auto-oxidation products, apo-12-astaxanthinal and apo-13-astaxanthinone DHA ester were identified as the major oxidation products of F-AST and AST-E in L...
October 14, 2018: Journal of the Science of Food and Agriculture
Rana S Al-Zahrani, Samaher H Alharbi, Rawan M A Tuwaijri, Bayan T Alzomaili, Alaa Althubaiti, Talat Mesud Yelbuz
Background/Aim: Transposition of the great arteries (TGA) is traditionally classified as a "conotruncal heart defect", implying that TGA evolves from abnormal development of the outflow tract (OFT) of the embryonic heart. However, recently published genetic data suggest that TGA may be linked to laterality gene defects rather than OFT gene defects. The aim of our study was to clarify whether there is any statistically significant link between TGA and clinically diagnosed laterality defects (heterotaxy)...
September 2018: Annals of Pediatric Cardiology
Martin Audet, Raymond C Stevens
The first crystal structure of a G Protein-Coupled Receptor (GPCR) was that of the bovine rhodopsin, solved in 2000, and is a light receptor within retina rode cells that enables vision by transducing a conformational signal from the light-induced isomerization of retinal covalently bound to the receptor. More than seven years after this initial discovery and following more than twenty years of technological developments in GPCR expression, stabilization, and crystallography, the high-resolution structure of the adrenaline binding β2 -adrenergic receptor, a ligand diffusible receptor, was discovered...
September 21, 2018: Protein Science: a Publication of the Protein Society
Onder Albayram, Peter Angeli, Elizabeth Bernstein, Sean Baxley, Ziang Gao, Kun Ping Lu, Xiao Zhen Zhou
Tau is a microtubule-associated protein heavily implicated in neurodegenerative diseases collectively known as tauopathies, including Alzheimer's disease and chronic traumatic encephalopathy. Phosphorylation of tau at Thr231 allows for the isomerization of phosphorylated tau (p-tau) into distinct cis and trans conformations. Cis, but not trans, p-tau is detectable not only in Alzheimer's disease and chronic traumatic encephalopathy, but also right after traumatic brain injury depending on injury severity and frequency both in humans and animal models...
2018: Journal of Alzheimer's Disease and Parkinsonism
Paula Mapelli-Brahm, Charles Desmarchelier, Marielle Margier, Emmanuelle Reboul, Antonio J Meléndez Martínez, Patrick Borel
SCOPE: Absorption mechanisms of phytoene (PT) and phytofluene (PTF) are poorly known. The main objectives of the study are to measure their micellization and intestinal cell uptake efficiencies and to compare them to those of commonly consumed carotenoids. Other objectives are to assess the involvement of protein(s) in their cellular uptake and whether they compete with other carotenoids for micellization and cellular uptake. METHODS AND RESULTS: Tomato-extract-purified PT and PTF, mainly present as cis-isomers, are much better incorporated in synthetic mixed micelles than pure all-trans lycopene...
September 7, 2018: Molecular Nutrition & Food Research
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