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Eran Ellenbogen, Shmuel Epshteyn, Shir Azrielant, Mor Pavlovski, Andrea Gat, Eli Sprecher, Ilan Goldberg
BACKGROUND: Frozen section (FS) is often performed when histopathological evaluations are urgently required for implementation of therapeutic measures. In dermatology, this method is most commonly used to evaluate excision margins of tumors. FS are also routinely employed to differentiate toxic epidermal necrolysis from staphylococcal scalded skin syndrome. However, little is currently known about the performance of FS in the diagnosis of inflammatory dermatoses. OBJECTIVES: To compare histopathological diagnoses in a series of patients with a clinical diagnosis of an inflammatory dermatosis for which FS and paraffin-section (PS) specimens were obtained on the same day...
February 2019: Israel Medical Association Journal: IMAJ
Vinh Ngo Minh, Van Bui Thi, Tro Chau Van, Trai Nguyen Ngoc, Anh Tran Ngoc, Em Dang Van, Marco Gandolfi, Francesca Satolli, Claudio Feliciani, Michael Tirant, Aleksandra Vojvodic, Torello Lotti
We conducted a prospective, cross-sectional study at Ho Chi Minh City Hospital of Dermato Venereology from January 2016 to March 2017 in 40 psoriatic arthritis (PsA) patients to evaluate the disease progression and therapeutic burden about the HLA patterns. Based upon our results, PsA with HLA-B27 (+) had a threat of severe arthritis. PsA with HLA-Cw06 (+) had a higher risk of earlier onset and shorter duration for plaque psoriasis to transform into PsA. HLA-DR7 (+) in PsA delayed the time for conversion from plaque psoriasis into PsA...
January 30, 2019: Open Access Macedonian Journal of Medical Sciences
Van Bui Thi, Vinh Ngo Minh, Anh Tran Ngoc, Quyet Tran Dang, Diep Le Ngoc, Em Dang Van, Thuong Nguyen Van, Phuong Pham Thi Minh, Hien Do Thi Thu, Nghi Dinh Huu, My Le Huyen, Khang Tran Hau, Marco Gandolfi, Francesca Satolli, Claudio Feliciani, Michael Tirant, Aleksandra Vojvodic, Torello Lotti
AIM: To access the effectiveness, safety and tolerance of methotrexate (MTX) in psoriatic arthritis (PsA) treatment. METHODS: We recruit 37 patients, admitted at HCMC Hospital of Dermato-Venereology from 1/2016 to 3/2017, with MTX dosage ranging from 10 mg to 15 mg per week. RESULTS: Skin lesion response after 12 weeks improved PASI 50: 40.5%, PASI 75: 24.3%. Disease activity score decreased after 12 weeks with ∆DAS28 = -1.43 + 0.79, 37...
January 30, 2019: Open Access Macedonian Journal of Medical Sciences
Tro Chau Van, Khuong Ho Thi Ngoc, Thuong Nguyen Van, Khang Tran Hau, Marco Gandolfi, Francesca Satolli, Claudio Feliciani, Michael Tirant, Aleksandra Vojvodic, Torello Lotti
AIM: Evaluate the resistance of dermatophytes to systemic antifungal drugs in the Vietnamese population. METHODS: We enrolled 101 patients with cutaneous dermatophytosis at the Dermato-Venereology hospital in HCMC from August 2016 to March 2017. All the specimens were subjected to direct examination (10% KOH mount) and culture on Sabouraud dextrose agar. In vitro antifungal sensitivity testing was done on species isolated from a culture with broth microdilution method...
January 30, 2019: Open Access Macedonian Journal of Medical Sciences
Thuong Nguyen Van, Michael Tirant, Phuong Pham Thi Minh, Francesca Satolli, Claudio Feliciani, Aleksandra Vojvodic, Torello Lotti
BACKGROUND: The World Health Academy of Dermatology, the Vitiligo Research Foundation, the Military Medical Academy of Belgrade Serbia, the University of Parma-Italy and the University of Rome Guglielmo Marconi, Rome-Italy have successfully joined Vietnamese Dermatology Community in the ambitious project of positionìng Vietnam in the Dermatologic Olympus. AIM: The aim of our special issue is to present some pearls of the Vietnamese Dermatology devoted to the description of the national and hopefully international declining of traditional therapies...
January 30, 2019: Open Access Macedonian Journal of Medical Sciences
Pauline Bouschon, Julie Waton, Bruno Pereira, Jean Luc Schmutz, Marie-Christine Ferrier le Bouëdec, Michel D'Incan
BACKGROUND: Methylisothiazolinone (MI) is a preservative responsible for an epidemic of allergic contact dermatitis (ACD). Few studies have been published on the prognosis of patients with MI-induced ACD. OBJECTIVES: To evaluate relapses of MI-induced ACD and difficulties in avoiding MI in patients who had received avoidance advice. METHODS: Retrospective study of patients with ACD to MI diagnosed in two specialized dermato-allergology units between 2010 and 2015...
January 17, 2019: Contact Dermatitis
Mariane Martins Araújo Stefani, Patricia Sammarco Rosa, Mauricio Barcelos Costa, Antônio Pedro Mendes Schetinni, Igor Manhães, Maria Araci Andrade Pontes, Patricia Costa, Luciana Raquel Vincenzi Fachin, Ida Maria Foschiani Dias Batista, Marcos Virmond, Emília Pereira, Maria Lucia Fernandes Penna, Gerson Oliveira Penna
There is evidence that in southern US, leprosy is a zoonosis infecting wild Dasypus novemcinctus armadillos but the extent of this finding is unknown. This ecological study investigated leprosy in rural communities and in wild armadillos from the Brazilian Amazon. The study area was the Mamiá Lake of Coari municipality, Amazonas State, Northern region, a hyper endemic leprosy area where residents live on subsistence farming, fishing and armadillo hunting and its meat intake are frequent. The leprosy survey was conducted in sixteen communities by a visiting team of specialists...
2019: PloS One
Georgi Tchernev, Ivanka Temelkova
BACKGROUND: Simultaneous occurrence of multiple primary melanomas is a rare, however possible phenomenon, and it is believed that older, male, white, Atypical Mole Syndrome carriers (sporadic and familial) are part of the possible risk factors for its occurrence. In these patients, it is possible to observe involutional changes or (partial/complete) regression of melanocytic lesions, which are likely to be caused by the generation of a spontaneous immune reaction against specific tumour antigens...
November 25, 2018: Open Access Macedonian Journal of Medical Sciences
Maria do Livramento Saraiva Lucoveis, Mônica Antar Gamba, Maria Angela Boccara de Paula, Ana Beatriz Pinto da Silva Morita
OBJECTIVE: To classify the level of risk for foot ulcers in people with diabetes mellitus and identify their main predictive risk factors. METHOD: Exploratory, descriptive study, in which patients were assessed in a municipal ambulatory of São Paulo through nursing consultation, following the guidelines of the International Consensus on the Diabetic Foot. Data were descriptively analyzed. RESULTS: The analyzed population was composed of 50 longevous and retired people, with household income of up to two minimum wages, with dermato-neurofunctional risk factors and unfavorable clinical indicators, and 66% had Risk 1; 16% Risk 2; 6% Risk 3 and 12% Risk 4...
November 2018: Revista Brasileira de Enfermagem
Emel Bulbul Baskan, Asli Akin Belli
BACKGROUND: Scarring is an undesirable and severe complication of acne resulting in loss of self-esteem in young people. Although microneedle fractional radiofrequency (MFR) system has emerged as a good option to treat acne scars in recent years, it was examined in a few studies which were commonly from Asian countries. AIMS: We sought to evaluate the efficacy of MFR in Turkish patients with facial acne scars. METHODS: Nine patients with atrophic facial acne scars treated with MFR device were included in the study...
November 11, 2018: Journal of Cosmetic Dermatology
L Kandolf Sekulovic, J Guo, S Agarwala, A Hauschild, G McArthur, G Cinat, A Wainstein, C Caglevic, P Lorigan, H Gogas, M Alvarez, R Duncombe, C Lebbe, K Peris, P Rutkowski, A Stratigos, A-M Forsea, L De La Cruz Merino, M Kukushkina, R Dummer, C Hoeller, C Gorry, L Bastholt, D Herceg, B Neyns, R Vieira, P Arenberger, M Bylaite-Bucinskiene, N Babovic, M Banjin, K Putnik, V Todorovic, K Kirov, J Ocvirk, A Zhukavets, A Ymeri, I Stojkovski, C Garbe
According to data from recent studies from Europe, a large percentage of patients have restricted access to innovative medicines for metastatic melanoma. Melanoma World Society and European Association of Dermato-oncology conducted a Web-based survey on access to first-line recommended treatments for metastatic melanoma by current guidelines (National Comprehensive Center Network, European Society for Medical Oncology [ESMO] and European Organization for Research and Treatment of Cancer/European Association of Dermato-oncology/European dermatology Forum) among melanoma experts from 27 European countries, USA, China, Australia, Argentina, Brazil, Chile and Mexico from September 1st, 2017 to July 1st, 2018...
November 2018: European Journal of Cancer
T Weberschock, S Grunewald, F Ochsendorf
In dermato-oncological treatment there are many gonadotoxic interventions. Alkylating and hormonally active substances as well as gonadal irradiation, in particular, are known to have a fertilization-limiting effect in men. Since 2017 certified skin cancer centers in Germany therefore have the task to implement counselling on preservation of fertility. This is supported by the S2k guidelines on preservation of fertility in oncological treatment. Because recommendation of the various interventions from the dermato-oncological guidelines are dependent on the stage, the authors advocate at least the question "Is the desire to have children of interest to you?" when patients reach the appropriate stage...
December 2018: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
Georgi Tchernev, Ilia Lozev, Ivanka Temelkova, Svetoslav Chernin, Irina Yungareva
BACKGROUND: Skin, nervous tissue, dopamine and melanoma share a common neuroectodermal origin. Hence, processes that modulate nervous tissue formation, patient mental status, motor regulation of individuals, and skin cancerogenesis are inextricably linked. Psycho-neuro-endocrine oncology (or dermato-oncology), i.e. P.N.E.O., is a new model or trend in medicine and science presented for the first time in the world literature by us, that aims to examine the relationship between the mental state, the hormones and the malignant transformation...
August 20, 2018: Open Access Macedonian Journal of Medical Sciences
Martina Zacher, Markus V Heppt, Titus J Brinker, Kinan M Hayani, Michael J Flaig, Carola Berking
Sarcomas are a heterogeneous group of mesenchymal tumors which can affect bone and soft tissue. Leiomyosarcoma (LMS) is a rare subtype localized to the skin or subcutaneous tissue. Due to the heterogeneity of sarcomas, reviews and guidelines with an in-depth focus specifically on primary LMS of the skin are sparse. This article is intended to provide an up to date and systematic overview on diagnosis, treatment, and surveillance of this rare entity to provide a framework for decision making and management for dermato-oncologists...
August 23, 2018: Medical Oncology
Ketty Peris, Mauro Alaibac, Giuseppe Argenziano, Alessandro Di Stefani, Maria C Fargnoli, Pasquale Frascione, Giulio Gualdi, Caterina Longo, Elvira Moscarella, Luigi Naldi, Giovanni Pellacani, Nicola Pimpinelli, Pietro Quaglino, Marzia Salgarello, Pietro Sollena, Vincenzo Valentini, Iris Zalaudek, Pier G Calzavara Pinton
No abstract text is available yet for this article.
June 11, 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
Maurício Barcelos Costa, Emerith Mayra Hungria, Aline Araújo Freitas, Ana Lúcia O M Sousa, Juliano Jampietro, Fernando A Soares, Mariane M A Stefani
Leprosy is a complex chronic, infectious dermato-neurological disease that affects the skin and peripheral nerves especially during immuno-inflammatory episodes known as type 1/T1R and type 2/T2R reactions. This study investigated the in situ expression of CD25+Foxp3+ Treg cells and TGF-β1, IFN-γ, IL-17 in leprosy T1R and T2R. Tregs were evaluated in 114 skin biopsies from 74 leprosy patients: 56 T1R (28-paired reaction-free/reactional biopsies, 28 unpaired T1R), 18 T2R (12 paired reaction-free/reactional biopsies, 6 unpaired T2R)...
2018: PloS One
Haudrey Assier, Florence Tetart, Martine Avenel-Audran, Annick Barbaud, Marie-Christine Ferrier-le Bouëdec, Françoise Giordano-Labadie, Brigitte Milpied, Emmanuelle Amsler, Evelyne Collet, Pascal Girardin, Angèle Soria, Julie Waton, François Truchetet, Jean-Luc Bourrain, Gwendeline Gener, Claire Bernier, Nadia Raison-Peyron
BACKGROUND: Eyelids are frequent sites of contact dermatitis. No prospective study focused on eyelid allergic contact dermatitis (EACD) has yet been published, and this topic has never been studied in French patients. OBJECTIVES: To prospectively evaluate the usefulness of an eyelid series in French patients patch tested because of EACD, and to describe these patients. METHODS: We prospectively analysed standardized data for all patients referred to our departments between September 2014 and August 2016 for patch testing for suspected EACD as the main reason...
June 8, 2018: Contact Dermatitis
Matthias Augustin, Christine Blome, Andrea Forschner, Ralf Gutzmer, Axel Hauschild, Lucie Heinzerling, Elisabeth Livingstone, Carmen Loquai, Dirk Schadendorf, Jochen Utikal, Tobias Wagner, Sophia Wilden, Katharina C Kähler
Malignant melanoma is potentially life-threatening but in most cases curable if detected early. Willingness to pay (WTP) is a preference-based construct that reflects burden of disease by assessment of the monetary value for a hypothetical cure from disease. Since WTP (directly as total amount of money) has not been assessed so far in patients with low risk melanoma, it was interesting to gain insights in this patient population and then, in a second step, compare it directly with the WTP of their treating dermato-oncologists...
2018: PloS One
Ralph M Trüeb
Traditionally, syndromes have been named after the physician who originally identified the condition. These are referred to as eponymous syndromes. Nevertheless, the term eponym is to be regarded in a broader sense, since - by definition - an eponym is a person, place, or thing after whom or which something is named. Accordingly, some eponymous syndromes do not refer to the physician who originally reported the condition, but alternatively to the indicator patient, a geographic location, or a historical, literary, or mythological context...
April 2018: Skin Appendage Disorders
Andrea D Maderal, Paul Lee Salisbury, Joseph L Jorizzo
Desquamative gingivitis is a clinical finding with several potential etiologies. Among the most common are oral lichen planus, cicatricial pemphigoid, and pemphigus vulgaris, though various other differential diagnoses exist. The presence of desquamative gingivitis often results in poor oral hygiene, which can have downstream consequences, including periodontitis and tooth loss. Though certain mucosal findings may be suggestive of a particular diagnosis, a thorough history, physical examination, and appropriate dermato- and immunopathologic assessment is necessary for narrowing this broad differential diagnosis...
May 2018: Journal of the American Academy of Dermatology
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