Katharina Schimmel, Stevan D Stojanović, Cheng-Kai Huang, Mira Jung, Martin H Meyer, Ke Xiao, Lea Grote-Levi, Christian Bär, Angelika Pfanne, Saskia Mitzka, Annette Just, Robert Geffers, Katharina Bock, Franziska Kenneweg, Felix Kleemiß, Christine S Falk, Jan Fiedler, Thomas Thum
BACKGROUND: Myocardial fibrosis is a hallmark of the failing heart, contributing to the most common causes of deaths worldwide. Several microRNAs (miRNAs, miRs) controlling cardiac fibrosis were identified in recent years; however, a more global approach to identify miRNAs involved in fibrosis is missing. METHODS AND RESULTS: Functional miRNA mimic library screens were applied in human cardiac fibroblasts (HCFs) to identify annotated miRNAs inducing proliferation...
October 27, 2020: Journal of Molecular and Cellular Cardiology