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Pulmonary Embolism AND Thromboelastography

Ramona Nicolau-Raducu, Thiago Beduschi, Rodrigo Vianna, Christian Diez, Mahmoud Sleem, Singh Bhavnha, Georgia Vasileiou, Yehuda Raveh
Detrimental consequences of hypofibrinolysis, also known as fibrinolytic shutdown (FS), have recently arisen, and its significance in liver transplantation remains unknown. To fill this gap, this retrospective study included 166 adults who received transplants between 2016 and 2018 for whom baseline thromboelastography was available. Based on percent (%) clot lysis 30 minutes after maximal amplitude, patients were stratified into 3 fibrinolysis phenotypes: FS, physiologic fibrinolysis, and hyperfibrinolysis...
December 7, 2018: Liver Transplantation
J A Loughran, T L Kitchen, S Sindhakar, M Ashraf, M Awad, E J Kealaher
Amniotic fluid embolism is a rare but often catastrophic emergency. The non-specific clinical features and lack of diagnostic tests make it a diagnosis of exclusion. Point-of-care visco-elastometric testing is being increasingly used during obstetric haemorrhage. We present a case of amniotic fluid embolism, diagnosed and managed using rotational thromboelastography. During a precipitous labour, a 21-year-old multiparous woman became pale, distressed and disorientated. The fetus was delivered using forceps...
September 11, 2018: International Journal of Obstetric Anesthesia
Zixia Wu, Zhiyong Liu, Wei Zhang, Wenzheng Zhang, En Mu
OBJECTIVE: To explore the correlation between thromboelastography (TEG) parameters and the risk of venous thromboembolism (VTE) and bleeding in patients receiving anticoagulant therapy in surgical intensive care unit (SICU). METHODS: 205 patients received low molecular weight heparin (LMWH) anticoagulant therapy admitted to SICU of Tianjin Hospital from December 2016 to December 2017 were consecutively enrolled. TEG detection was performed in all patients at 1 day after anticoagulation therapy, and coagulation reaction time (R value), blood clot generation time (K value), blood clot generation rate (α angle) and maximum width value (MA value) were recorded...
July 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
Jieqiong Song, Lizhen Xuan, Wei Wu, Yaxing Shen, Lijie Tan, Ming Zhong
BACKGROUND: The methodology of thromboprophylaxis post minimally invasive esophagectomy (MIE) is unclear. Thus, we compared the efficacy and safety of fondaparinux and nadroparin on the prophylaxis of venous thromboembolism (VTE) after MIE. MATERIALS AND METHODS: We conducted a randomized, double-blind, treatment-controlled study. Consecutive patients undergoing MIE randomly received a single dose of either nadroparin 2850 AxaIU (Group H) or fondaparinux 2.5 mg (Group F) daily...
June 2018: Thrombosis Research
Samin Rezania, Michael A Puskarich, Daniela N Petrusca, Evandro M Neto-Neves, Matthew T Rondina, Jeffrey A Kline
Changes in systemic redox balance can alter platelet activation and aggregation. Acute pulmonary embolism (PE) is a systematic inflammatory disease associated with mechanical shear stress, increased thrombin, catecholamines, serotonin and hemolysis, which cumulatively can hyperactivate platelets and accelerate their turnover. We tested the hypothesis that platelets from patients with moderately severe PE will show hyperstimulation and a pre-apoptotic phenotype associated with microparticles (MPs) in plasma...
July 2017: Thrombosis Research
Fabiana Tartamella, Michele C Vassallo, Giorgio Berlot, Paolo Grassi, Filippo Testa
Deep venous thromboembolism and pulmonary embolism are still underdiagnosed in the ICU. Thromboelastography (TEG) has shown considerable variability in sensitivity and specificity as a predictor of venous thromboembolism (VTE). We designed a prospective double-blind observational study to predict the risk of VTE using TEG in a cohort of critically ill patients. Seventy-two hours after admission in the ICU and consequent prophylaxis with low-molecular-weight heparin, we performed compressive color-Doppler ultrasound and diagnosed deep venous thrombosis...
October 2016: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
William B Stubblefield, Nathan J Alves, Matthew T Rondina, Jeffrey A Kline
BACKGROUND: We examine the clinical significance and biomarkers of tissue plasminogen activator (tPA)-catalyzed clot lysis time (CLT) in patients with intermediate-risk pulmonary embolism (PE). METHODS: Platelet-poor, citrated plasma was obtained from patients with PE. Healthy age- and sex-matched patients served as disease-negative controls. Fibrinogen, α2-antiplasmin, plasminogen, thrombin activatable fibrinolysis inhibitor (TAFI), plasminogen activator Inhibitor 1 (PAI-1), thrombin time and D-dimer were quantified...
2016: PloS One
Walid Mohamed Emara, Khaled K Moez, Abeer H Elkhouly
BACKGROUND: This study was performed to test the effectiveness of topical tranexamic acid (TXA) in reducing blood loss in pelvic hemiarthoplasty surgeries compared with intravenous TXA, regarding the incidence of thromboembolic complications (deep vein thrombosis [DVT], pulmonary embolism (PE) and cerebrovascular stroke [CVS]). PATIENTS AND METHODS: After obtaining institutional ethical approval 60 patients divided into three groups. Group A: Received intravenous TXA Group B: Received topical TXA Group C: Control group (placebo saline)...
January 2014: Anesthesia, Essays and Researches
Jamie J Coleman, Ben L Zarzaur, Chad W Katona, Zachary J Plummer, Laura S Johnson, Alison Fecher, Jamie M O'Rear, David V Feliciano, Grace S Rozycki
BACKGROUND: Recent studies using thromboelastography indicate that patients are at risk for hypercoagulability early after injury. Pulmonary embolism (PE) is also well known to cause significant morbidity and mortality after injury and can occur within 72 hours of admission (early PE). Despite this risk, prophylactic anticoagulation is often delayed in patients with certain injuries due to concerns about bleeding. STUDY DESIGN: This was a retrospective study of injured patients with a PE from 2007 to 2013 at 3 level I trauma centers...
April 2015: Journal of the American College of Surgeons
Alexander Hincker, Justin Feit, Robert N Sladen, Gebhard Wagener
INTRODUCTION: Thromboembolic complications contribute substantially to perioperative morbidity and mortality. Routine laboratory tests do not detect patients with acquired or congenital hypercoagulability who may be at increased risk of perioperative thromboembolism. Rotational thromboelastometry (ROTEM) is a digitized modification of conventional thromboelastography that is stable and technically easy to use. We designed a prospective observational study to evaluate whether preoperative ROTEM can identify patients at increased risk for postoperative thromboembolic complications after major non-cardiac surgery...
2014: Critical Care: the Official Journal of the Critical Care Forum
R Goggs, D L Chan, L Benigni, C Hirst, L Kellett-Gregory, V L Fuentes
OBJECTIVES: To evaluate the feasibility of CT pulmonary angiography for identification of naturally occurring pulmonary thromboembolism in dogs using predefined diagnostic criteria and to assess the ability of echocardiography, cardiac troponins, D-dimers and kaolin-activated thromboelastography to predict the presence of pulmonary thromboembolism in dogs. METHODS: Twelve dogs with immune-mediated haemolytic anaemia and evidence of respiratory distress were prospectively evaluated...
April 2014: Journal of Small Animal Practice
Mark L Ryan, Chad M Thorson, David R King, Robert M Van Haren, Ronald J Manning, David M Andrews, Alan S Livingstone, Kenneth G Proctor
BACKGROUND: Central venous catheters (CVCs) increase the risk of venous thromboembolism. We have previously demonstrated that pulmonary artery catheters are associated with a hypercoagulable state in an animal model and in patients. The purpose of this study is to determine whether the insertion of a CVC is associated with a similar response. METHODS: HASH(0x560fd9c952d0) ANIMAL: 7F femoral artery catheters were placed in healthy anesthetized swine (N = 16)...
August 2012: Journal of Trauma and Acute Care Surgery
T Sakai, T Matsusaki, F Dai, K A Tanaka, J B Donaldson, I A Hilmi, J Wallis Marsh, R M Planinsic, A Humar
BACKGROUND: Intraoperative pulmonary thromboembolism (PTE) is an often overlooked cause of mortality during adult liver transplantation (LT) with diagnostic challenge. The goals of this study were to investigate the incidence, clinical presentation, and outcome of PTE and to identify risk factors or diagnostic predictors for PTE. METHODS: Four hundred and ninety-five consecutive, isolated, deceased donor LTs performed in an institution for a 3 yr period (2004-6) were analysed...
March 2012: British Journal of Anaesthesia
Heidi New, Christopher G Byers
Pulmonary thromboembolism (PTE) has been associated with many diseases. Clot formation is a consequence of hypercoagulability, blood stasis, and damage to the endothelium of blood vessels, a set of changes known as the Virchow triad. Diagnosing PTE may be difficult because common clinical signs, including tachypnea, dyspnea, and hypoxemia, are not pathognomonic for the disease. The initial workup for PTE should include arterial blood gas analysis and thoracic radiography. If there is a strong clinical suspicion for PTE, further tests are indicated, such as D-dimer measurement, thromboelastography, and advanced imaging...
September 2011: Compendium: Continuing Education for Veterinarians
Dhruv Singhal, Emmanuil Smorodinsky, Lifei Guo
Microvascular reconstructive surgery has seen a revival with the introduction of muscle-sparing perforator flaps. Recognition of potential ethnic differences in coagulation profiles would be important to a microvascular surgeon. Based on clinical observations, we hypothesize that Asian patients have a less thrombogenic coagulation profile than Caucasians. An extensive retrospective review was performed. The annual incidence of venous thromboembolism in the United States is generally accepted to range from 70 to 120 events per 100,000 people versus 16 to 17 events per 100,000 persons in Asia...
January 2011: Journal of Reconstructive Microsurgery
Lesley De Pietri, Roberto Montalti, Bruno Begliomini, Giulia Scaglioni, Giorgia Marconi, Alexia Reggiani, Fabrizio Di Benedetto, Stefano Aiello, Alberto Pasetto, Gianluca Rompianesi, Giorgio E Gerunda
BACKGROUND AND OBJECTIVE: Despite clinical and laboratory evidence of perioperative hypercoagulability, alterations in haemostasis after potentially haemorrhagic oncologic surgery are difficult to predict. This study aims to evaluate the entity, the extent and the duration of perioperative coagulative alterations following pancreas and liver oncologic surgery, by the use of both routine tests and thromboelastogram (TEG). METHODS: Fifty-six patients undergoing liver (n = 38) and pancreatic (n = 18) surgery were studied...
July 2010: European Journal of Anaesthesiology
Robert Goggs, Livia Benigni, Virginia Luis Fuentes, Daniel L Chan
OBJECTIVE: To review the pathophysiology, clinical signs, diagnosis, and treatment of pulmonary thromboembolism (PTE) in small animals. DATA SOURCES: Human and veterinary clinical studies, reviews, texts, and recent research in canine and feline PTE diagnosis and thromboembolic therapeutics. HUMAN DATA SYNTHESIS: In humans, clinical probability assessment and point-of-care D-dimer-based algorithms are widely used. Computed tomography pulmonary angiography is the gold standard for PTE diagnosis in humans...
February 2009: Journal of Veterinary Emergency and Critical Care
Myung S Park, Wenjun Z Martini, Michael A Dubick, Jose Salinas, Saulius Butenas, Bijan S Kheirabadi, Anthony E Pusateri, Jeffrey A Vos, Charles H Guymon, Steven E Wolf, Kenneth G Mann, John B Holcomb
OBJECTIVES: To investigate the hemostatic status of critically ill, nonbleeding trauma patients. We hypothesized that a hypercoagulable state exists in patients early after severe injury and that the pattern of clotting and fibrinolysis are similar between burned and nonburn trauma patients. MATERIALS: Patients admitted to the surgical or burn intensive care unit within 24 hours after injury were enrolled. Blood samples were drawn on days 0 through 7. Laboratory tests included prothrombin time (PT), activated partial thromboplastin time (aPTT), levels of activated factor XI, D-dimer, protein C percent activity, antithrombin III percent activity, and thromboelastography (TEG)...
August 2009: Journal of Trauma
Arturo Prado, Patricio Andrades, Stefan Danilla, Francisco Parada
OBJECTIVE: The purpose of this study was to prospectively investigate coagulation during suction-assisted lipoplasty (SAL) and to compare it to other plastic surgery where no SAL was used, with the aid of a computerised thromboelastograph coagulation analyser (TEG). METHODS: A prospective cohort study enrolled 50 pure SAL patients and 50 patients presenting for other aesthetic plastic surgery operations, without the need of liposuction. TEG evaluates in real time the competency of the blood clot in samples that are studied under a low shear environment resembling venous flow...
November 2009: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
Kenta Okamura, Itsuo Nakagawa, Shozo Hidaka, Yasunori Okada, Takashi Kubo, Takahiro Kato
BACKGROUND: A large number of studies have examined the incidence of thromboembolic complications after orthopedic surgery of the lower extremity. We investigated the perioperative changes of coagulability following total knee arthroplasty (TKA) or total hip arthroplasty (THA) using thromboelastography (TEG), which could comprehensively assess the coagulation and fibrinolytic system. METHODS: Thirty patients scheduled for TKA (n= 10), THA (n= 10) and other lower extremity orthopedic surgery (control, n= 10) were studied...
June 2007: Masui. the Japanese Journal of Anesthesiology
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