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Altitude And Coagulation

Debashree Das, Suryanarayan Biswal, Kalpana Kumari Barhwal, Pushpender Bhardwaj, Ashish Kumar, Sunil Kumar Hota, Om Prakash Chaurasia, Bhuvnesh Kumar
BACKGROUND: The prevalence of procoagulant state under prolonged hypoxic exposures and the complications and lack of specificity associated with use of existing anti-thrombotic agents have necessitated the search for safer and natural therapeutics. Codonopsis, a widely studied medicinal herb, has been reported to decrease whole blood viscosity but the bioactive ingredients involved, and their mechanism of action therein however remain to be investigated. PURPOSE: The present study aimed at evaluating the efficacy of C...
March 27, 2019: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
Xi Du, Rong Zhang, Shengliang Ye, Fengjuan Liu, Peng Jiang, Xiaochuan Yu, Jin Xu, Li Ma, Haijun Cao, Yuanzhen Shen, Fangzhao Lin, Zongkui Wang, Changqing Li
For individuals migrating to or residing permanently in high-altitude regions, environmental hypobaric hypoxia is a primary challenge that induces several physiological or pathological responses. It is well documented that human beings adapt to hypobaric hypoxia via some protective mechanisms, such as erythropoiesis and overproduction of hemoglobin; however, little is known on the alterations of plasma proteome profiles in accommodation to high-altitude hypobaric hypoxia. In the present study, we investigated differential plasma proteomes of high altitude natives and lowland normal controls by a TMT-based proteomic approach...
April 3, 2019: Journal of Proteome Research
Teryn R Roberts, John A Jones, Jae-Hyek Choi, Kyle N Sieck, George T Harea, Daniel S Wendorff, Brendan M Beely, Vitali Karaliou, Andrew P Cap, Michael R Davis, Leopoldo C Cancio, Valerie G Sams, Andriy I Batchinsky
BACKGROUND: Coagulation monitoring capabilities during transport are limited. Thromboelastography (TEG) is a whole-blood clotting test measuring clot formation, stabilization and fibrinolysis; and is traditionally performed in a laboratory. We evaluated a new point-of-care TEG analyzer, TEG 6s (Haemonetics; Braintree, MA), in a large animal model of combat-relevant trauma managed with extracorporeal life support (ECLS) during ground and high-altitude aeromedical evacuation. The objective was to compare TEG 6s used during transport vs...
February 7, 2019: Journal of Trauma and Acute Care Surgery
Tianbo Jin, Linhao Zhu, Mei Bai, Xue He, Li Wang, Dongya Yuan, Shanqu Li, Yongjun He
AIM: High-altitude pulmonary edema (HAPE), as a multifactorial disease, is caused by stress failure and involves both environmental and genetic factors. Study shows that IL-1 receptors can selectively decrease the oxygen arterial hypertension and influence the blood coagulation. So we evaluated whether genetic polymorphisms in IL1R1 and 1L1R2 genes are associated with the risk of HAPE in Chinese Han population. METHODS: Ten susceptible SNPs in the IL1R1 and IL1R2 genes were genotyped among 265 HAPE cases and 303 controls using the Agena MassARRAY platform...
January 22, 2019: Molecular Genetics & Genomic Medicine
Rong Zhang, Xiaochuan Yu, Yuanzhen Shen, Chunhui Yang, Fengjuan Liu, Shengliang Ye, Xi Du, Li Ma, Haijun Cao, Zongkui Wang, Changqing Li
OBJECTIVE: To explore the correlations between RBCs indexes and the basic coagulation parameters, and provide data for further studies on high altitude-induced thrombotic disease. METHODS: A total of eligible 433 volunteers were divided into different groups according to HGB concentration and HCT, respectively. PT, APTT, TT and Fbg were measured by clotting assays. HGB content, HCT and PLT count were assessed by automated hematology analyzer. RESULTS: APTT and PT were significantly higher in group 4 (high HGB or HCT groups) (p < 0...
December 2019: Hematology (Amsterdam, Netherlands)
Zongkui Wang, Fengjuan Liu, Shengliang Ye, Peng Jiang, Xiaochuan Yu, Jin Xu, Xi Du, Li Ma, Haijun Cao, Chuang Yuan, Yuanzhen Shen, Fangzhao Lin, Rong Zhang, Changqing Li
High-altitude polycythemia (HAPC) is one of the classic chronic mountain sicknesses and has been a serious public health problem in high-altitude regions. Despite numerous studies on HAPC via genomics or transcriptomics approaches, the pathogenesis of HAPC is still unclear. Here, we performed a TMT- based comparative quantitative proteomics analysis to reveal the changes of plasma proteomics profiles between HAPC subjects and healthy controls. Of identified 818 proteins, 7 and 12 proteins were up-regulated and down-accumulated, respectively, compared HAPC patients with healthy controls...
December 31, 2018: Journal of Proteomics
Liang Bai, Baoning Liu, Changmian Ji, Sihai Zhao, Siyu Liu, Rong Wang, Weirong Wang, Pu Yao, Xuming Li, Xiaojun Fu, Haiyan Yu, Min Liu, Fengming Han, Ning Guan, Hui Liu, Dongyuan Liu, Yuanqing Tao, Zhongdong Wang, Shunsheng Yan, Greg Florant, Michael T Butcher, Jifeng Zhang, Hongkun Zheng, Jianglin Fan, Enqi Liu
The Himalayan marmot (Marmota himalayana) is a hibernating mammal that inhabits the high-elevation regions of the Himalayan mountains. Here we present a draft genome of the Himalayan marmot, with a total assembly length of 2.47 Gb. Phylogenetic analyses showed that the Himalayan marmot diverged from the Mongolian marmot approximately 1.98 million years ago. Transcriptional changes during hibernation included genes responsible for fatty acid metabolism in liver and genes involved in complement and coagulation cascades and stem cell pluripotency pathways in brain...
December 5, 2018: IScience
Prabhash Kumar Jha, Anita Sahu, Amit Prabhakar, Tarun Tyagi, Tathagata Chatterjee, Prathima Arvind, Jiny Nair, Neha Gupta, Babita Kumari, Velu Nair, Nitin Bajaj, Jayashree Shanker, Manish Sharma, Bhuvnesh Kumar, Mohammad Zahid Ashraf
Venous thromboembolism (VTE), a multi-factorial disease, is the third most common cardiovascular disease. Established genetic and acquired risk factors are responsible for the onset of VTE. High altitude (HA) also poses as an additional risk factor, predisposing individuals to VTE; however, its molecular mechanism remains elusive. This study aimed to identify genes/pathways associated with the pathophysiology of deep vein thrombosis (DVT) at HA. Gene expression profiling of DVT patients, who developed the disease, either at sea level or at HA-DVT locations, resulted in differential expression of 378 and 875 genes, respectively...
July 2018: Thrombosis and Haemostasis
Cécile H Kicken, Marisa Ninivaggi, Joke Konings, Martijn Moorlag, Dana Huskens, Jasper A Remijn, Saartje Bloemen, Marcus D Lancé, Bas De Laat
INTRODUCTION:  Epidemiological studies suggest that hypobaric hypoxia at high altitude poses a risk for developing venous thromboembolism. The cause of this observed hypercoagulability remains unclear. Therefore, this study aimed to investigate the effect of hypobaric hypoxia at 3,883 m above sea level on thrombin generation and platelet activation. METHODS:  After complying with medical ethical procedures, 18 participants were recruited, of whom 1 had to leave the study prematurely due to mild acute mountain sickness...
May 2018: Thrombosis and Haemostasis
Alistair S Rocke, Gordon G Paterson, Matthew T Barber, Alexander I R Jackson, Shona Main, Calum Stannett, Martin F Schnopp, J Kenneth Baillie, Elizabeth H Horne, Carl Moores, Paul Harrison, Alastair F Nimmo, A A Roger Thompson
Interaction between hypoxia and coagulation is important given the increased risk of thrombotic diseases in chronically hypoxic patients who reside at sea level and in residents at high altitude. Hypoxia alters the proteome of platelets favouring a prothrombotic phenotype, but studies of activation and consumption of specific coagulation factors in hypoxic humans have yielded conflicting results. We tested blood from 63 healthy lowland volunteers acclimatizing to high altitude (5,200 m) using thromboelastometry and assays of platelet function to examine the effects of hypoxia on haemostasis...
January 2018: Thrombosis and Haemostasis
Dong-Ping Ye, Shun-Li Zhang, Quan-Hong Xu, Lin-Jie Wei
Hypoxia leads to increased red blood cells and blood viscosity at high altitude while moderate trauma increases coagulation in blood. Under the above-mentioned conditions, venous sinus thrombosis is more likely to occur. A patient suffering bilateral acetabular fractures together with the gradual disturbance of consciousness was admitted to our hospital. Though computed tomography arteriogram (CTA) of the brain displayed normal blood vessels; bilateral thalamus and brainstem infarction were found on head computed tomography (CT) and Galen vein thrombosis on cerebral computed tomography venography (CTV)...
October 2017: Chinese Journal of Traumatology
Zongkui Wang, Hua Liu, Miaomiao Dou, Xi Du, Jijun Hu, Na Su, Ya Wang, Rong Zhang, Changqing Li
OBJECTIVE: According to the international guidelines, fresh frozen plasma (FFP) is unanimously used to treat coagulation disorders. The quality of FFP is critical for the clinical transfusion. Till now, few studies have integratedly evaluated the differences of FFP from blood donors at between high altitude (HA) and low altitude (LA). Besides, there were no special quality standards for HA FFP in China. MATERIALS AND METHODS: Up to 41 HA (Lhasa, 3700 m) and 46 LA (Chengdu, 500 m) blood donors were included in our study to estimate the differences of FFP from HA and LA blood donors...
2017: PloS One
Gayatri Padhy, Anamika Gangwar, Manish Sharma, Kalpana Bhargava, Niroj Kumar Sethy
Padhy, Gayatri, Anamika Gangwar, Manish Sharma, Kalpana Bhargava, and Niroj Kumar Sethy. Plasma proteomics of Ladakhi natives reveal functional regulation between renin-angiotensin system and eNOS-cGMP pathway. High Alt Med Biol. 18:27-36, 2017.-Humans have been living in high altitudes for more than 25,000 years but the molecular pathways promoting survival and performance in these extreme environments are not well elucidated. In an attempt to understand human adaptation to high altitudes, we used two-dimensional gel electrophoresis combined with MALDI-TOF/TOF to identify plasma proteins and associated pathways of ethnic Ladakhi natives residing at 3520 m...
March 2017: High Altitude Medicine & Biology
Shizheng Wu, Guisheng Hao, Shukun Zhang, Dongmei Jiang, Tana Wuren, Junming Luo
The aim of the present study was to examine cerebral vasoconstriction in patients with chronic high altitude disease [cerebrovascular reactivity (CVR)], and to evaluate differences in alterations of brain vascular contractile reactivity of chronic mountain sickness (CMS) patients and healthy controls. Alterations of endothelin (ET) and its receptor, as well as endothelial nitric oxide synthase (eNOS) levels in the plasma were examined to determine the cerebral reservation capacities in CMS patients. Transcranial Doppler ultrasound and carbon dioxide analysis methods were used to detect the CVR variances...
September 2016: Molecular Medicine Reports
Daoliang Lan, Xianrong Xiong, Cai Huang, Tserang Donko Mipam, Jian Li
BACKGROUND: Yaks (Bos grunniens) are endemic species that can adapt well to thin air, cold temperatures, and high altitude. These species can survive in harsh plateau environments and are major source of animal production for local residents, being an important breed in the Qinghai-Tibet Plateau. However, compared with ordinary cattle that live in the plains, yaks generally have lower fertility. Investigating the basic physiological molecular features of yak ovary and identifying the biological events underlying the differences between the ovaries of yak and plain cattle is necessary to understand the specificity of yak reproduction...
2016: PloS One
Marc Schaber, Veronika Leichtfried, Dietmar Fries, Maria Wille, Hannes Gatterer, Martin Faulhaber, Philipp Würtinger, Wolfgang Schobersberger
INTRODUCTION: The aim of the present study was to investigate whether a 12-hour exposure in a normobaric hypoxic chamber would induce changes in the hemostatic system and a procoagulant state in volunteers suffering from acute mountain sickness (AMS) and healthy controls. MATERIALS AND METHODS: 37 healthy participants were passively exposed to 12.6% FiO2 (simulated altitude hypoxia of 4,500 m). AMS development was investigated by the Lake Louise Score (LLS). Prothrombin time, activated partial thromboplastin time, fibrinogen, and platelet count were measured and specific methods (i...
2015: BioMed Research International
S-W Xie, C Liu, Y-X Gao, Y Chen, C-H Jiang, L Chen, Y-Q Gao
OBJECTIVE: This study was aimed to investigate the prevalence rate and clinical characteristics of high altitude deterioration (HADT), which would provide a scientific basis for the diagnosis and prevention of HADT. SUBJECTS AND METHODS: A total of 175 subjects, who had migrated to a high altitude (4516 m) for more than 1 year, were investigated. A questionnaire survey based on the symptoms of HADT was conducted, and 117 subjects were determined to have HADT according to the diagnostic criteria of HADT...
September 2015: European Review for Medical and Pharmacological Sciences
K Brosh, I Strassman, M Seelenfreund
IMPORTANCE: It is well known that altitude ascent with intravitreal gas can cause expansion of gas and intraocular pressure (IOP) elevation. According to Boyle's law, the gas bubble will not expand unless a higher altitude than the gas insertion site has been reached. We report four cases in which intravitreal gas was injected at an altitude of 790 m (Jerusalem). All four cases developed high IOP even though they did not reach a higher altitude in their post-operative period. OBSERVATIONS: A report of four patients following vitrectomy with 12% mixture of perfluoropropane and air are presented...
July 2014: Eye
A B Makeshova, M O Éralieva, A A Levina, Iu I Mamukova, A R Raimzhanov
Conditions of hypoxic hypoxia at 3200 m height exert significant positive changes in hemopoiesis, normalizing erythropoiesis and coagulation system. Hypoxic climate therapy can be regarded as an additional efficient method to the pathogenetic treatment for patient with unpainful aplastic anemia and idiopathic thrombocytopenic purpura. It should be emphasized that patients must be out of immunosuppressive therapy when getting high altitude stationary.
July 2013: Voenno-medit︠s︡inskiĭ Zhurnal
Tarun Tyagi, Shadab Ahmad, Neha Gupta, Anita Sahu, Yasmin Ahmad, Velu Nair, Tathagat Chatterjee, Nitin Bajaj, Shantanu Sengupta, Lilly Ganju, Shashi Bala Singh, Mohammad Z Ashraf
Oxygen-compromised environments, such as high altitude, air travel, and sports, and pathological conditions, such as solid tumors, have been suggested to be prothrombotic. Despite the indispensable role of platelets in thrombus formation, the studies linking hypoxia, platelet reactivity, and thrombus formation are limited. In the present study, platelet proteome/reactivity was analyzed to elucidate the acute hypoxia-induced prothrombotic phenotype. Rats exposed to acute simulated hypoxia (282 torr/8% oxygen) demonstrated a decreased bleeding propensity and increased platelet reactivity...
February 20, 2014: Blood
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