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https://read.qxmd.com/read/30763720/aromatic-constituents-from-ganoderma-lucidum-and-their-neuroprotective-and-anti-inflammatory-activities
#1
Shuang-Yang Lu, Xing-Rong Peng, Jin-Run Dong, Hui Yan, Qing-Hua Kong, Qiang-Qiang Shi, Da-Shan Li, Lin Zhou, Zhong-Rong Li, Ming-Hua Qiu
Five new aromatic compounds, designed as lucidumins A-D (1-4) and lucidimine E (9), along with seven known aromatic compounds (5-8, 10-12) were isolated from Ganoderma lucidum. Their structures were determined by spectroscopic method. Bioactive evaluation showed that compounds 2-4 and 6-10 displayed remarkable neuroprotective activities against corticosterone-induced PC12 cell damage, with the cell viability ranging from 69.99% to 126.00%; and compounds 1-4, 9 and 10 exhibited significant anti-inflammatory activities against LPS-induced nitric oxide (NO) production in RAW264...
February 11, 2019: Fitoterapia
https://read.qxmd.com/read/30756217/an-h-ferritin-from-the-hydrothermal-vent-shrimp-rimicaris-exoculata-and-its-potential-role-in-iron-metabolism
#2
Xiao-Li Liu, Sen Ye, Hua-Wei Li, Bo Lu, Yan-Qin Yu, Yu-Peng Fan, Wei-Jun Yang, Jin-Shu Yang
Rimicaris exoculata (Decapoda: Bresiliidae) is one of the dominant species among hydrothermal vent communities along the Mid-Atlantic Ridge. This shrimp can tolerate high concentrations of heavy metals such as iron, but the mechanisms used for detoxification and utilization of excess metals remain largely unknown. Ferritin is a major iron storage protein in most living organisms. The central heavy subunit of ferritin (H-ferritin) possesses ferroxidase activity and converts iron from Fe2+ to Fe3+ , the non-toxic form used for storage...
February 12, 2019: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://read.qxmd.com/read/30746900/integrated-bioinformatics-analysis-of-key-genes-involved-in-progress-of-colon-cancer
#3
Haojie Yang, Jiong Wu, Jingjing Zhang, Zhigang Yang, Wei Jin, Ying Li, Lei Jin, Lu Yin, Hua Liu, Zhenyi Wang
BACKGROUND: Colon cancer is one of most malignant cancers around worldwide. Nearly 20% patients were diagnosed at colon cancer with metastasis. However, the lack of understanding regarding its pathogenesis brings difficulties to study it. METHODS: In this study, we acquired high-sequence data from GEO dataset, and performed integrated bioinformatic analysis including differently expressed genes, gene ontology and Kyoto Encyclopedia of Genes and Genomes pathways analysis, protein-protein analysis, survival analysis to analyze the development of colon cancer...
February 11, 2019: Molecular Genetics & Genomic Medicine
https://read.qxmd.com/read/30745360/melanocortin-type-4-receptor-mediated-inhibition-of-a-type-k-current-enhances-sensory-neuronal-excitability-and-mechanical-pain-sensitivity-in-rats
#4
Yuan Zhang, Dongsheng Jiang, Hua Li, Yufang Sun, Xinghong Jiang, Shan Gong, Zhiyuan Qian, Jin Tao
Alpha-melanocyte-stimulating hormone (α-MSH) has been shown to be involved in nociception, but the underlying molecular mechanisms remain largely unknown. In this study, we report that α-MSH suppresses the transient outward A-type K+ current ( I A ) in trigeminal ganglion (TG) neurons and thereby modulates neuronal excitability and peripheral pain sensitivity in rats. Exposing small-diameter TG neurons to α-MSH concentration-dependently decreased I A This α-MSH-induced I A decrease was depended on the melanocortin type 4 receptor (MC4R) and associated with a hyperpolarizing shift in the voltage dependence of A-type K+ channel inactivation...
February 11, 2019: Journal of Biological Chemistry
https://read.qxmd.com/read/30744804/single-crystalline-nanosheets-of-hybrid-perovskite-fabricated-by-a-vapor-solution-sequential-deposition-route
#5
Boya Zhao, Jie Liu, Zhi-Hua Li, Yao-Xuan Chen, Qian-Qing Ge, Yaqing Feng, Jin-Song Hu
Organic-inorganic hybrid perovskite single crystals have attracted much attention due to their superior optoelectronic properties. Herein, we report a facile vapor-solution sequential route to prepare single-crystalline nanosheets of hybrid lead triiodide perovskite. It is found that this two-step deposition is able to fabricate sizeable high-quality single-crystalline nanosheets with no need of delicate control of crystallization conditions such as concentration or temperature for normal single crystal growth...
June 1, 2019: Journal of Nanoscience and Nanotechnology
https://read.qxmd.com/read/30743857/alcohol-ethoxylates-significantly-synergize-pesticides-than-alkylphenol-ethoxylates-considering-bioactivity-against-three-pests-and-joint-toxicity-to-daphnia-magna
#6
Bei-Xing Li, Xiu-Yu Pang, Peng Zhang, Jin Lin, Xiao-Xu Li, Yang Liu, Hua Li, Feng Liu, Wei Mu
Seeking alternatives for alkylphenol ethoxylates (APEOs) have been a heavily researched topic in the surfactant industry and agricultural systems. In this study, the combined effects of different ethoxylates and pesticides on the bioactivity against three pests and toxicological risks to Daphnia magna were investigated. Results showed that alcohol ethoxylates (AEOs) had higher synergistic effects on the bioactivity of pesticides against Spodoptera exigua, Agrotis ipsilon and Aphis citricola than did APEOs. In terms of the joint toxicity of the ethoxylates and pesticides to D...
December 10, 2018: Science of the Total Environment
https://read.qxmd.com/read/30742740/association-between-remote-diffusion-weighted-imaging-lesions-and-cerebral-small-vessel-disease-in-primary-intracerebral-hemorrhage
#7
Xu-Hua Xu, Xiang-Hua Ye, Jia-Wen Li, Jin-Song Cai, Ting Gao, Wen-Ji Zhang, Guo-Hua Zhao, Lu-Sha Tong, Feng Gao
BACKGROUND AND PURPOSE: The aim of this study was to examine the association among remote diffusion-weighted imaging lesions (R-DWILs), imaging markers of cerebral small vessel disease (cSVD), and total cSVD burden in patients with primary intracerebral hemorrhage (ICH). METHODS: Three hundred and forty-four consecutive primary ICH patients were enrolled prospectively. R-DWILs on magnetic resonance imaging (MRI), as well as four imaging markers of cSVD, including cerebral microbleeds (CMBs), white matter hyperintensities (WMHs), lacunes, and enlarged perivascular spaces (EPVS) were rated with validated scales...
February 11, 2019: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://read.qxmd.com/read/30741830/presence-of-serum-antinuclear-antibodies-correlating-unfavorable-overall-survival-in-patients-with-chronic-lymphocytic-leukemia
#8
Qian Sun, Li Wang, Hua-Yuan Zhu, Yi Miao, Wei Wu, Jin-Hua Liang, Lei Cao, Yi Xia, Jia-Zhu Wu, Yan Wang, Rong Wang, Lei Fan, Wei Xu, Jian-Yong Li
BACKGROUND: Serum antinuclear antibodies (ANAs) are positive in some patients with chronic lymphocytic leukemia (CLL), but the prognostic value of ANAs remains unknown. The aim of this study was to evaluate the role of ANAs as a prognostic factor in CLL. METHODS: This study retrospectively analyzed clinical data from 216 newly diagnosed CLL subjects with ANAs test from 2007 to 2017. Multivariate Cox regression analyses were used to screen the independent prognostic factors related to time to first treatment (TTFT), progression free survival (PFS) and overall survival (OS)...
February 6, 2019: Chinese Medical Journal
https://read.qxmd.com/read/30740916/comparison-of-outcome-and-toxicity-of-postoperative-intensity-modulated-radiation-therapy-with-two-dimensional-radiotherapy-in-patients-with-soft-tissue-sarcoma-of-extremities-and-trunk
#9
Jianyang Wang, Yongwen Song, Xinfan Liu, Jing Jin, Weihu Wang, Zihao Yu, Yueping Liu, Ning Li, Hui Fang, Hua Ren, Yuan Tang, Yu Tang, Bo Chen, Ningning Lu, Shunan Qi, Shulian Wang, Yexiong Li
BACKGROUND: To compare the survival outcomes and late toxicities of postoperative intensity-modulated radiation therapy (IMRT) with two-dimensional radiotherapy (2D-RT) for patients with soft tissue sarcoma (STS) of extremities and trunk. METHODS: 274 consecutive patients with nonmetastatic STS of extremities and trunk treated with postoperative IMRT (n = 187) and 2D-RT (n = 87) were analyzed. Survival was calculated by using Kaplan-Meier method. Independent prognostic factors were identified using Cox stepwise regression analysis for variables with a P-value <0...
February 10, 2019: Cancer Medicine
https://read.qxmd.com/read/30738479/-evaluation-of-the-cutoff-of-anti-hcv-antibody-enzyme-linked-immunosorbent-assay-in-7-blood-station-laboratories
#10
Zheng-Min Liu, Rui Wang, Li-Qin Huang, Jing-Hui Hu, Le Chang, Wei Zhen, Peng Wang, Fang Wang, Chao Wei, Shao-Wen Zhu, Jin-Feng Zeng, Yan-Hua Shi, Wei Zheng, Lu-Nan Wang, Hong-Wei Ge
OBJECTIVE: To evaluate the necessity and suitability of the anti-HCV ELISA teot gray zone setted up by 7 blood station laboratories. METHODS: 7 blood station laboratories were coded as 1, 2, 3, 4, 5, 6 and 7 respectively; 8 kinds of ELISA reagents were coded as A, B, C, D, E, F, G and H respectively. 1 or 2 of 8 ELISA reagents produced by different manufactories were used to detect the anti-HCV in specimens of same group by 7 blood station laboratories; the Westen blot was used to detect the specimens with difference of detected results so as to difine the serological status of specimens...
February 2019: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://read.qxmd.com/read/30737149/osspl18-controls-grain-weight-and-grain-number-in-rice
#11
Hua Yuan, Peng Qin, Li Hu, Shijie Zhan, Shifu Wang, Peng Gao, Jing Li, Mengya Jin, Zhengyan Xu, Qiang Gao, Anping Du, Bin Tu, Weilan Chen, Bingtian Ma, Yuping Wang, Shigui Li
Grain weight and grain number are two important traits directly determining grain yield in rice. To date, a lot of genes related to grain weight and grain number have been identified; however, the regulatory mechanism underlying these genes remains largely unknown. In this study, we studied the biological function of OsSPL18 during grain and panicle development in rice. Knockout (KO) mutants of OsSPL18 exhibited reduced grain width and thickness, panicle length and grain number, but increased tiller number...
January 23, 2019: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://read.qxmd.com/read/30735305/pyridinic-n-protected-synthesis-of-3d-nitrogen-doped-porous-carbon-with-increased-mesoporous-defects-for-oxygen-reduction
#12
Jin Luo, Kangjun Wang, Xing Hua, Wang Wang, Jun Li, Shiming Zhang, Shengli Chen
Nitrogen (N)-doped carbons are potential nonprecious metal catalysts to replace Pt for the oxygen reduction reaction (ORR). Pyridinic-N-C is believed to be the most active N group for catalyzing ORR. In this work, using zinc phthalocyanine as a precursor effectively overcomes the serious loss of pyridinic-N, which is commonly regarded as the biggest obstacle to catalytic performance enhancement upon adopting a second pyrolysis process, for the preparation of a 3D porous N-doped carbon framework (NDCF). The results show only ≈14% loss in pyridinic-N proportion in the Zn-containing sample during the second pyrolysis process...
February 8, 2019: Small
https://read.qxmd.com/read/30734515/optimized-culturing-conditions-for-an-algicidal-bacterium-pseudoalteromonas-sp-sp48-on-harmful-algal-blooms-caused-by-alexandrium-tamarense
#13
Yi-Hua Lyu, Yue-Xia Zhou, Yi Li, Jin Zhou, Yi-Xiao Xu
Bacteria play an important role in preventing algal blooms and reducing their harm to the environment. To improve the algicidal activity of Pseudoalteromonas SP48 which had an inhibition effect on dinoflagellate Alexandrium tamarense, its growth medium and fermentation conditions were optimized for this bacterium. In this study, we used two steps to establish the optimum conditions. First, the proper proportion of medium was selected based on an orthogonal design. Then, the fermentation conditions were further optimized through uniform design in an enlarged 5L bioreactor...
February 7, 2019: MicrobiologyOpen
https://read.qxmd.com/read/30734248/invasive-fungal-disease-is-associated-with-chronic-graft-versus-host-disease-after-allogeneic-hematopoietic-stem-cell-transplant-a-single-center-retrospective-study
#14
Hua Jin, Zhiping Fan, Fen Huang, Yanyan Chai, Li Xuan, Ren Lin, Na Xu, Jieyu Ye, Jing Sun, Qifa Liu
BACKGROUND: Invasive fungal disease (IFD) and graft-versus-host disease (GVHD) are major causes of morbidity and mortality after allogeneic hematopoietic stem cell transplantation (allo-HSCT). However, the impacts of IFD on chronic GVHD remain unknown. METHODS: We conducted a retrospective study of 510 patients with hematologic malignancy undergoing allo-HSCT to explore the effects of IFD on chronic GVHD. RESULTS: The 2-year cumulative incidences of overall (limited and extensive) and extensive chronic GVHD post-transplantation were higher in patients with IFD compared with those without IFD (69...
February 7, 2019: Infection
https://read.qxmd.com/read/30724266/altered-corneal-nerves-in-chinese-thyroid-associated-ophthalmopathy-patients-observed-by-in-vivo-confocal-microscopy
#15
Lian-Qun Wu, Pei Mou, Zi-Yu Chen, Jin-Wei Cheng, Qi-Hua Le, Ji-Ping Cai, Rui-Li Wei
BACKGROUND Thyroid-associated ophthalmopathy (TAO) is a common endocrine autoimmune disease. The present study explored corneal nerve changes in TAO patients. MATERIAL AND METHODS Thirty-eight Chinese TAO patients and 20 healthy individuals were included in the study. Central corneal subbasal nerve density and morphology were evaluated with in vivo laser scanning confocal microscopy and quantified using automated CCmetrics software. RESULTS The values of the central corneal subbasal nerve plexus parameters of both active and inactive TAO patients were significantly decreased compared with those of controls, including corneal nerve fiber density (CNFD) (P<0...
February 6, 2019: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://read.qxmd.com/read/30720126/comparison-of-adipose%C3%A2-and-bone-marrow%C3%A2-derived-stem-cells-in-protecting-against-ox%C3%A2-ldl%C3%A2-induced-inflammation-in-m1%C3%A2-macrophage%C3%A2-derived-foam-cells
#16
Jian-Zhong Li, Tian-Hui Cao, Jin-Cheng Han, Hui Qu, Shuang-Quan Jiang, Bao-Dong Xie, Xiao-Long Yan, Hua Wu, Xiang-Lan Liu, Fan Zhang, Xiao-Ping Leng, Kai Kang, Shu-Lin Jiang
Adipose‑derived stem cells (ADSCs) and bone marrow‑derived stem cells (BMSCs) are considered to be prospective sources of mesenchymal stromal cells (MSCs), that can be used in cell therapy for atherosclerosis. The present study investigated whether ADSCs co‑cultured with M1 foam macrophages via treatment with oxidized low‑density lipoprotein (ox‑LDL) would lead to similar or improved anti‑inflammatory effects compared with BMSCs. ADSCs, peripheral blood monocytes, BMSCs and ox‑LDL were isolated from ten coronary heart disease (CHD) patients...
February 1, 2019: Molecular Medicine Reports
https://read.qxmd.com/read/30720115/mir%C3%A2-155-mediates-inflammatory-injury-of-hippocampal-neuronal-cells-via-the-activation-of-microglia
#17
Xiao-Hua Sun, Ming-Fen Song, Hai-Dong Song, Yu-Wen Wang, Ming-Jin Luo, Li-Ming Yin
MicroRNA (miR)‑155 has a crucial role in various cellular functions, including differentiation of hematopoietic cells, immunization, inflammation and cardiovascular diseases. The present study aimed to investigate the roles and mechanisms of miR‑155 in treatment‑resistant depression (TRD). A Cell Counting Kit‑8 assay and flow cytometry were performed to assess the cell viability and apoptosis of microglial cells, respectively. Western blotting and reverse transcription‑quantitative polymerase chain reaction assays were used to evaluate the associated protein and mRNA expression, respectively...
January 31, 2019: Molecular Medicine Reports
https://read.qxmd.com/read/30719157/the-survival-benefit-of-palliative-gastrectomy-and-or-metastasectomy-in-gastric-cancer-patients-with-synchronous-metastasis-a-population-based-study-using-propensity-score-matching-and-coarsened-exact-matching
#18
Lu-Ping Yang, Zi-Xian Wang, Ming-Ming He, Ying Jin, Chao Ren, Zhi-Qiang Wang, Feng-Hua Wang, Yu-Hong Li, Feng Wang, Rui-Hua Xu
Introduction: Palliative surgeries were controversial for asymptomatic metastatic gastric cancer (mGC) patients. This study was aimed to evaluate survival benefit of palliative surgeries to gastric and/or metastatic tumors in mGC patients based on U.S population. Materials and Methods: A total of 8345 gastric cancer patients diagnosed with synchronous distal metastasis between 2004 to 2013 from the Surveillance, Epidemiology, and End Results Program (SEER) database were divided into four groups according to surgery strategies: surgeries to both primary and metastatic tumors (SPM), gastrectomy only (GO), metastasectomy only (MO) and no surgery performed (NS)...
2019: Journal of Cancer
https://read.qxmd.com/read/30718121/what-is-the-optimal-neuropsychological-test-battery-for-schizophrenia-in-china
#19
Chuan Shi, Lan Kang, Shuqiao Yao, Yibin Ma, Tao Li, Ying Liang, Zhang Cheng, Yifeng Xu, Jianguo Shi, Xiufeng Xu, Congpei Zhang, Donald R Franklin, Robert K Heaton, Hua Jin, Xin Yu
BACKGROUND: The MATRICS consensus cognitive battery (MCCB) has been widely used to evaluate cognitive deficits in schizophrenia (SCZ), however, no study has formally examined the validity of the MCCB in Chinese SCZ. This study compared Chinese SCZ patients with healthy Chinese controls on the MCCB and some additional neurocognitive tests to determine if the Chinese MCCB is an optimal battery to assess the cognitive deficits in Chinese SCZ patients. METHOD: The study enrolled and examined 230 patients met DSM-IV criteria for SCZ and 656 healthy controls matched for gender, age and education...
February 1, 2019: Schizophrenia Research
https://read.qxmd.com/read/30717766/pck1-negatively-regulates-cell-cycle-progression-and-hepatoma-cell-proliferation-via-the-ampk-p27-kip1-axis
#20
Lin Tuo, Jin Xiang, Xuanming Pan, Jieli Hu, Hua Tang, Li Liang, Jie Xia, Yuan Hu, Wenlu Zhang, Ailong Huang, Kai Wang, Ni Tang
BACKGROUND: Altered glucose metabolism endows tumor cells with metabolic flexibility for biosynthesis requirements. Phosphoenolpyruvate carboxykinase 1 (PCK1), a key enzyme in the gluconeogenesis pathway, is downregulated in hepatocellular carcinoma (HCC) and predicts poor prognosis. Overexpression of PCK1 has been shown to suppress liver tumor growth, but the underlying mechanism remains unclear. METHODS: mRNA and protein expression patterns of PCK1, AMPK, pAMPK, and the CDK/Rb/E2F pathway were determined using qRT-PCR and western blotting...
February 4, 2019: Journal of Experimental & Clinical Cancer Research: CR
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