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optical coherence tomography angiogram

Andrew W Stacey, Maria Pefkianaki, Tomas Ilginis, Michael Michaelides, Phill Hykin, Andrew Webster, Anthony T Moore, Mandeep S Sagoo
BACKGROUND AND OBJECTIVE: To identify the clinical and imaging characteristics of isolated retinal astrocytic hamartomas (IRAH). PATIENTS AND METHODS: A case series of eight patients diagnosed with IRAH. RESULTS: The average age at diagnosis was 32 years (range: 9 years to 80 years). After a median follow-up time of 59 months, none of the lesions had demonstrated any change or growth. Fundus fluorescein angiogram identified hyperfluorescence in five of six imaged lesions...
February 1, 2019: Ophthalmic Surgery, Lasers & Imaging Retina
Zhirong Wang, Limei Sun, Panfeng Wang, Chonglin Chen, Aiyuan Zhang, Weiqing Wang, Xiaoyan Ding
BACKGROUND: Oculodentodigitaldysplasia (ODDD; MIM no. 164200) is a rare hereditary disorder caused by mutations in the gene GJA1.Ocular disorders included microcornea, cornea opacity and glaucoma. However, few studies described fundus findings. MATERIALS AND METHODS: Ophthalmic examination included visual acuity measurement, intraocular pressure (IOP) measurements, slit-lamp biomicroscopy, B-scan ultrasonography, Ultrasound biomicroscopy (UBM), spectral-domain optical coherence tomography (SD-OCT), ERG and retcam fluorescein angiogram...
February 15, 2019: Ophthalmic Genetics
Massimo Lorusso, Luisa Micelli Ferrari, Eleni Nikolopoulou, Tommaso Micelli Ferrari
Purpose: To describe a case of a 25-year-old man with choroidal neovascularization (CNV) secondary to traumatic choroidal rupture treated with intravitreal bevacizumab and to evaluate the vascular structure of the area near the traumatic choroidal rupture. Methods: The patient underwent complete ophthalmologic evaluation, including best-corrected visual acuity (BCVA), intraocular pressure, anterior segment and funds examination, and optical coherence tomography angiography (OCTA) at baseline and on each follow-up visit...
2019: Case Reports in Ophthalmological Medicine
Zhenhe Ma, Ning Ding, Yao Yu, Yushu Ma, Xincheng Yuan, Yi Wang, Yuqian Zhao, Jingmin Luan, Jian Liu
Optical coherence tomography (OCT) angiography is a noninvasive imaging modality that produces volumetric views of blood flow perfusion in vivo with resolution at capillary level, which has been widely adopted to monitor cerebral perfusion status after stroke in experimental settings. Accurate quantification of cerebral perfusion from OCT angiograms is important for understanding the cerebral vascular pathophysiology and assessing the treatment of ischemic stroke. Quantification of blood vessels from OCT angiography faces some problems; one is uneven backscatter (which causes some blood vessels to be very bright, some very dark), and the other is that the brightness in the same blood vessel also changes due to the difference in diameter or depth...
December 10, 2018: Applied Optics
Maged Alnawaiseh, Friederike Schubert, Peter Heiduschka, Nicole Eter
PURPOSE: To evaluate the correlation between the flow density measured by optical coherence tomography angiography and functional parameters in patients with retinitis pigmentosa. METHODS: Twenty eyes of 20 patients with retinitis pigmentosa and 21 eyes of 21 healthy subjects were prospectively included in this study. Optical coherence tomography angiography was performed using RTVue XR Avanti with AngioVue (Optovue Inc). The macula was imaged with a 6 × 6-mm scan, whereas for the optic nerve head a 4...
January 2019: Retina
Larissa Lahme, Eliane Luisa Esser, Natasa Mihailovic, Friederike Schubert, Jost Lauermann, Andreas Johnen, Nicole Eter, Thomas Duning, Maged Alnawaiseh
BACKGROUND: There is increasing evidence for the involvement of cerebrovascular factors in Alzheimer's disease (AD). OBJECTIVE: To evaluate retinal and optic nerve head perfusion in patients with AD using optical coherence tomography angiography (OCTA), and to analyze the correlations of quantitative OCTA metrics with AD pathology and vascular cerebral lesions in AD patients. METHODS: 36 eyes of 36 patients with AD (study group) and 38 eyes of 38 healthy subjects (control group) were prospectively included in this study...
2018: Journal of Alzheimer's Disease: JAD
M Dubosq, B O Patterson, R Azzaoui, T Mesnard, A De Préville, J Sobocinski
In lower limb arteries, assessment of stent apposition and/or the single opening of the diseased artery remains poor since this relies on 2D angiogram. Extrapolating experience gained with coronary arteries, optical coherence tomography (OCT) could provide 3D reconstructions of the arterial wall and the stent implanted. A modified protocol of OCT acquisition, which usually includes large amount of iodine contrast flush, is presented here in 3 patients with long and complex occlusion of the superficial femoral artery (SFA)...
November 27, 2018: Annals of Vascular Surgery
Takuya Hashimoto, Yoshiyasu Minami, Ryota Kakizaki, Teruyoshi Nemoto, Kazuhiro Fujiyoshi, Kentaro Meguro, Takao Shimohama, Taiki Tojo, Junya Ako
BACKGROUND: Tendon xanthomas are accumulations of collagen and macrophages, which contain cholesterol esters and a marker of high risk for coronary artery disease (CAD). OBJECTIVE: The aim of the article was to clarify whether the presence of Achilles tendon thickening (ATT) was associated with disease severity and plaque vulnerability in patients with CAD. METHODS: A total of 241 consecutive patients who underwent percutaneous coronary intervention and ATT assessment were analyzed...
October 29, 2018: Journal of Clinical Lipidology
Florence Coscas, Marco Lupidi, Jean François Boulet, Alexandre Sellam, Diogo Cabral, Rita Serra, Catherine Français, Eric H Souied, Gabriel Coscas
AIMS: To evaluate on optical coherence tomography angiography (OCT-A), the predictive role of different qualitative findings of choroidal neovascularisations (CNV) in assessing the status of exudative age-related macular degeneration (eAMD) and to develop a potential model to predict the CNV activity. METHODS: Retrospective review of the multimodal imaging records of patients with eAMD obtained during treatment for type 1 or type 2 CNV. The qualitative analysis of CNVs on OCT angiograms assessed the presence or absence of tiny branching vessels, loops, peripheral anastomotic arcades and choriocapillaris hypointense halo...
November 22, 2018: British Journal of Ophthalmology
Larissa Lahme, Elena Marchiori, Giuseppe Panuccio, Pieter Nelis, Friederike Schubert, Natasa Mihailovic, Giovanni Torsello, Nicole Eter, Maged Alnawaiseh
The aim of the study presented here was to evaluate retinal and optic nerve head (ONH) perfusion in patients with severe asymptomatic carotid artery stenosis (CAS) compared with healthy controls and to analyze the impact of carotid endarterectomy using optical coherence tomography angiography (OCT-A). 25 eyes of 25 patients with CAS (study group) and 25 eyes of 25 healthy controls (control group) were prospectively included in this study. OCT-A was performed using RTVue XR Avanti (Optovue, Inc, Fremont, California, USA)...
November 21, 2018: Scientific Reports
Yukun Guo, Acner Camino, Jie Wang, David Huang, Thomas S Hwang, Yali Jia
Screening and assessing diabetic retinopathy (DR) are essential for reducing morbidity associated with diabetes. Macular ischemia is known to correlate with the severity of retinopathy. Recent studies have shown that optical coherence tomography angiography (OCTA), with intrinsic contrast from blood flow motion, is well suited for quantified analysis of the avascular area, which is potentially a useful biomarker in DR. In this study, we propose the first deep learning solution to segment the avascular area in OCTA of DR...
November 1, 2018: Biomedical Optics Express
Marco Nassisi, Elmira Baghdasaryan, Tudor Tepelus, Samuel Asanad, Enrico Borrelli, Srinivas R Sadda
PURPOSE: To evaluate the topographic distribution of the choriocapillaris (CC) flow deficits in a population of healthy subjects. METHODS: Using a swept-source optical-coherence tomography angiography (SS-OCTA) device, two repeated volume 6 x 6 mm and 3 x 3 mm scans were acquired in healthy subjects at the Doheny-UCLA Eye Centers. The en-face CC angiogram was binarized and analyzed for percentage of flow deficits (FD%) using a grid of progressive, concentric rings covering a circular area with a diameter of 2...
2018: PloS One
Lu-Lu Chen, Qiong Wang, Wei-Hong Yu, You-Xin Chen
AIM: To determine acute and chronic choroidal vascular changes after vortex vein occlusion in monkeys. METHODS: One or two temporal vortex veins were occluded in 8 cynomolgus monkeys. Fluorescein angiography (FA), indocyanine green angiogram (ICGA), and enhanced-depth imaging optical coherence tomography (EDI-OCT) were performed preoperatively and at 1d, 1, 4, 8 and 12wk after occlusion. EDI-OCT images were binarized to calculate the choroid vascular index (CVI)...
2018: International Journal of Ophthalmology
Thomas M Waterbury, Marysia S Tweet, Sharonne N Hayes, Mackram F Eleid, Malcolm R Bell, Amir Lerman, Mandeep Singh, Patricia J M Best, Bradley R Lewis, Charanjit S Rihal, Bernard J Gersh, Rajiv Gulati
BACKGROUND: Risks and mechanisms of extension of conservatively managed spontaneous coronary artery dissection (SCAD) remain incompletely understood. Study objectives were to (1) evaluate mechanisms of early SCAD evolution through serial angiographic analysis, and (2) determine predictors of early SCAD progression. METHODS AND RESULTS: Retrospective registry study of patients with SCAD managed with an initial conservative strategy (n=240). Patients who experienced significant SCAD progression within 14 days, defined as clinical worsening plus new critical coronary obstruction on repeat angiography, were compared with remaining controls...
September 2018: Circulation. Cardiovascular Interventions
Maksymilian P Opolski, Mateusz Spiewak, Magdalena Marczak, Artur Debski, Paul Knaapen, Stefan P Schumacher, Adam D Staruch, Kajetan Grodecki, Zbigniew Chmielak, Hubert Lazarczyk, Krzysztof Kukula, Pawel Tyczynski, Jerzy Pregowski, Maciej Dabrowski, Jacek Kadziela, Elzbieta Florczak, Anna Skrobisz, Adam Witkowski
OBJECTIVES: This study sought to assess the presence and morphological features of coronary plaques on optical coherence tomography (OCT) as the causes of myocardial infarction with nonobstructive coronary arteries (MINOCA). BACKGROUND: Although coronary atherosclerosis has been postulated as a potential mechanism of MINOCA, the interaction between disrupted coronary plaques and myocardial injury remains unknown. METHODS: In a prospective study, consecutive patients with MI but without significant coronary stenosis (≥50%) at angiography underwent OCT and cardiac magnetic resonance (CMR) with late gadolinium-enhancement (LGE)...
October 12, 2018: JACC. Cardiovascular Imaging
Jingjiang Xu, Yuandong Li, Shaozhen Song, William Cepurna, John Morrison, Ruikang K Wang
We report the development of a 1300 nm swept-source optical coherence tomography (SS-OCT) system specifically designed to perform OCT imaging and optical microangiography (OMAG) in rat eyes in vivo and its use in evaluating the effects of intraocular pressure (IOP) elevation on ocular circulation. The swept laser is operated in single longitude mode with a 90 nm bandwidth centered at 1300 nm and 200 kHz A-line rate, providing remarkable sensitivity fall-off performance along the imaging depth, a larger field of view of 2...
September 26, 2018: Microvascular Research
Qinqin Zhang, Yingying Shi, Hao Zhou, Giovanni Gregori, Zhongdi Chu, Fang Zheng, Elie H Motulsky, Luis de Sisternes, Mary Durbin, Philip J Rosenfeld, Ruikang K Wang
Background: To estimate choriocapillaris flow deficits beyond normal intercapillary distance with swept source optical coherence tomography angiography (SS-OCTA). Methods: Subjects were enrolled and repeated SS-OCTA scans were performed using the 3 mm × 3 mm scan pattern. Blood flow was identified using the complex optical microangiography (OMAGc ) algorithm. The choriocapillaris (CC) was defined as a 20 µm slab of the flow volume beneath the outer boundary of Bruch's membrane (BM) and was compensated with the corresponding structural image for flow deficits measurement...
August 2018: Quantitative Imaging in Medicine and Surgery
Felice Cardillo Piccolino, Marco Lupidi, Carlo Cagini, Daniela Fruttini, Massimo Nicolò, Chiara Maria Eandi, Silvia Tito
Purpose: To investigate the retinal vascular response to the isometric exercise in patients with central serous chorioretinopathy (CSCR) by using optical coherence tomography angiography (OCT-A). Methods: This was a multicenter case-control study including 35 CSCR patients and 25 age-matched healthy controls. All subjects underwent macular OCT-A scans in resting conditions and during a handgrip isometric exercise. Hemodynamic data, such as systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), and ocular perfusion pressure (OPP), were recorded at baseline and during the stress test...
September 4, 2018: Investigative Ophthalmology & Visual Science
Sho Hashimoto, Akihiko Takahashi, Yukio Mizuguchi, Takeshi Yamada, Norimasa Taniguchi, Tetsuya Hata, Shunsuke Nakajima
We aimed to evaluate the impact of tissue characterization for in-stent restenosis (ISR) with optical computed tomography (OCT) during excimer laser coronary angioplasty (ELCA) in the drug-eluting stent (DES) era. The effect of ELCA for ISR according to differences in tissue characteristics is unclear. Fifty-three ISR lesions (7 bare metal stents and 46 drug-eluting stents) were treated with an ELCA catheter. After ELCA, balloon dilatation with either the scoring or non-compliant balloons was conducted. The procedure was completed by applying a drug-coated balloon...
August 22, 2018: Cardiovascular Intervention and Therapeutics
Kim Vieira Kayat, Luiz Roisman, Claudio Zett, Eduardo A Novais, Michel Eid Farah
BACKGROUND AND OBJECTIVE: To illustrate how optical coherence tomography (OCT) angiography (OCTA) can be misinterpreted if not evaluated along with structural en face OCT to analyze the signal intensity. PATIENTS AND METHODS: Patients with different macular diseases associated with suspicious flow impairment in the choriocapillaris were recruited to be imaged on the RTVue XR Avanti device (Optovue, Fremont, CA) with the Angio Retina mode. En face OCT angiograms, structural en face OCT, and corresponding OCT B-scans with flow signal overlaid were compared to evaluate the correspondence of signal strength to areas of flow reduction in the choriocapillaris...
August 1, 2018: Ophthalmic Surgery, Lasers & Imaging Retina
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