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Hendrik Naujokat, Maximilian Lipp, Yahya Açil, Henning Wieker, Falk Birkenfeld, Andre Sengebusch, Florian Böhrnsen, Jörg Wiltfang
AIM: Reconstruction of bone defects with autologous grafts has certain disadvantages. The aim of this study is to introduce a new type of living bioreactor for engineering of bone flaps and to evaluate the effect of different barrier membranes. MATERIALS & METHODS: Scaffolds loaded with bone morphogenetic proteins and bone marrow aspirate wrapped with either a collagen membrane or a periosteal flap were implanted in the greater omentum of miniature pigs. RESULTS: Both histological and radiographic evaluation showed proven bone formation and increased density after 8 and 16 weeks, with an enhanced effect of the periosteal transplant...
February 15, 2019: Regenerative Medicine
Hendrik Naujokat, Sönke Harder, Lara Yasemin Schulz, Jörg Wiltfang, Christian Flörke, Yahya Açil
PURPOSE: Successful implant therapy is based on fast, safe, and predictable osseointegration. Several surface modifications have been introduced to improve the bone-to-implant interaction. This in vivo study evaluates the impact of plasma surface conditioning on early wound healing and osseointegration. MATERIALS AND METHODS: A total of 16 dental implants with a sand-blasted and acid-etched surface were conditioned with cold atmospheric plasma prior to insertion in the frontal bone of four miniature pigs...
December 22, 2018: Journal of Cranio-maxillo-facial Surgery
L Zhang, A Gülses, N Purcz, J Weimer, J Wiltfang, Y Açil
BACKGROUND: Integrins are highly attractive targets in oncology due to their involvement in angiogenesis in a wide spectrum of cancer entities. Among several integrin inhibitors, cilengitide is suggested to be one of the most promising inhibitors. However, little is known about the cellular processes induced during cilengitide chemotherapy in head and neck squamous cell carcinoma (HNSCC). MATERIALS AND METHODS: For the current study, 3 HNSCC cell lines, SCC4, SCC15 and SCC25; and 3 primary culture cells, TU53, TU57, and TU63 were used...
January 10, 2019: Clinical & Translational Oncology
Rola El Rassi, Lokman I Meho, Acile Nahlawi, Johnny S Salameh, Ali Bazarbachi, Elie A Akl
Background: The aim of this study was to assess recent trends in medical research productivity in Arab countries. Methods: We collected bibliometric data for the world countries, Arab countries, and Arab institutions for 2007-2016, using Essential Science Indicators, Journal Citation Reports, and Web of Science database. We collected the number of published papers overall and per year, citations per paper, and number of papers published in top quartile and top 10% journals...
December 2018: Journal of Global Health
Yahya Açil, Kaspar Torz, Aydin Gülses, Henning Wieker, Mirko Gerle, Nicolai Purcz, Olga Marie Will, Jens Eduard Meyer, Jörg Wiltfang
PURPOSE: The aim of this study was to investigate the oncolytic properties of KI-21-3, a shortened fragment of LL-37, against oral squamous cell carcinoma (OSCC) in an animal model. MATERIALS AND METHODS: Twelve athymic nude mice were divided into a therapy and a control group of six animals each. In both groups, SCC-4 cells were administered extraorally into the floor of the mouth in order to create an OSCC model. In the study group, KI-21-3 was applied intravenously during the 8th and 9th weeks...
September 2018: Journal of Cranio-maxillo-facial Surgery
Mustafa Ayna, Bastian Wessing, Ralf Gutwald, Andreas Neff, Thomas Ziebart, Yahya Açil, Jörg Wiltfang, Aydin Gülses
The aim of this paper was to demonstrate the treatment outcomes following immediate functional loading concept of short implants inserted for single tooth replacement in the posterior maxilla. The study was performed on 63 patients who received short (6 mm) implants for single tooth replacement in the posterior maxilla. Forty-eight patients underwent immediate functional concept, whereas 15 of the implants were loaded 3 months after insertion. The patients were evaluated for up to 5 years after prosthesis completion...
July 17, 2018: Odontology
Juan A Lara, Alma Burciaga-Monge, Angel Chávez, Marc Revés, Rodolfo Lavilla, Monserrat Arró, Albert Boronat, Teresa Altabella, Albert Ferrer
Steryl esters (SEs) serve as a storage pool of sterols that helps to maintain proper levels of free sterols (FSs) in cell membranes throughout plant growth and development, and participates in the recycling of FSs and fatty acids released from cell membranes in aging tissues. SEs are synthesized by sterol acyltransferases, a family of enzymes that catalyze the transfer of fatty acil groups to the hydroxyl group at C-3 position of the sterol backbone. Sterol acyltransferases are categorized into acyl-CoA:sterol acyltransferases (ASAT) and phospholipid:sterol acyltransferases (PSAT) depending on whether the fatty acyl donor substrate is a long-chain acyl-CoA or a phospolipid...
2018: Frontiers in Plant Science
H Naujokat, Y Açil, A Gülses, F Birkenfeld, J Wiltfang
In 2016, we reported the world's first reconstruction of a mandibular discontinuity defect using a custom-made bone transplant that had been prefabricated in the gastrocolic omentum using tissue engineering strategies. However, the tissue of an engineered human neomandible has not been evaluated histologically until now. The current study assessed the long-term histological characteristics of biopsies of the neomandible 9months after transplantation. Histological analysis showed an increased amount of vital mineralized bone tissue after 10months, in comparison to biopsies obtained earlier...
November 2018: International Journal of Oral and Maxillofacial Surgery
Seher Basaran Acil, Leyla Dinç
AIM: To adapt the Nursing Authority and Autonomy Scale (NAAS) into Turkish the Nursing Authority and Autonomy Scale (NAAS) to Turkish and assess its psychometric properties for Turkish nurses and nurse managers. BACKGROUND: The NAAS is a tool that specifically measures nursing authority and autonomy from the perspectives of nurses and nurse managers. METHODS: The study sample consisted of 160 nurse managers and 266 staff nurses. Content validity was assessed using expert approval...
September 2018: Journal of Nursing Management
Marion Vallet, Acil Jaafar, Pierre-Yves Charles, Ivan Tack
INTRODUCTION: Estimation of volemic status can be useful in the diagnosis of some hydro-electrolytic disorders such as hyponatremia and dyskalemia. As a matter of fact, clinical examination and classical biological parameters are not discriminant enough. The aim of this study was to determine the biological parameters that are better correlated to volemic status. METHOD: Volemic status was established using extracellular fluid volume, measured by apparent distribution of inuline, in non-edematous patients and without cardiac or hepatic insufficiency...
April 2018: Néphrologie & Thérapeutique
Mirko Gerle, Tuula Peñate Medina, Aydin Gülses, Hanwen Chu, Hendrik Naujokat, Jörg Wiltfang, Yahya Açil
Human papillomavirus (HPV) infection, especially HPV-16 and HPV-18, has been increasingly associated with head and neck squamous cell carcinoma. The treatment of HPV-positive squamous cell carcinoma has a better response to both radiotherapy and chemotherapy and presents a better prognosis for the patient. Defining the underlying mechanism of the difference might help in developing future treatment options and could be an important factor in personal therapy planning. Endogenously secreted acid sphingomyelinase (ASMase) levels in the cellular stress caused by irradiation and cisplatin were investigated...
March 21, 2018: Medical Oncology
Yahya Açil, Mia Leena Arndt, Aydin Gülses, Henning Wieker, Hendrik Naujokat, Mustafa Ayna, Jörg Wiltfang
OBJECTIVE: The aim of this paper was to assess the effects of zoledronate (ZOL) and alendronate (FOS) on apoptotic behavior and gene expression of pro- and inflammatory cytokines of three cell types (human osteoblasts, human gingival fibroblasts and human osteogenic sarcoma cell lines) during a period of 4 weeks. MATERIAL AND METHODS: Cell viability and proliferation was assessed via cell proliferation test (MTT), fluorescence diacetate analysis (FDA). Expression of inflammatory cytokines was investigated by using polymerase chain reaction...
April 2018: Journal of Cranio-maxillo-facial Surgery
Tugana Akbas, Gamze Ugurluer, Meltem Acil, Taner Arpaci, Meltem Serin
BACKGROUND: To describe the role and benefits of intraoperative sonographic (US) guidance in intracavitary brachytherapy of cervical cancer. METHODS: The data of 142 patients who received tandem-based intracavitary brachytherapy for cervical cancer between January 2010 and June 2015 were retrospectively reviewed. US guidance was carried out for tandem selection and appropriate application. The complications and applicator conformity were assessed with planning CT...
January 2018: Journal of Clinical Ultrasound: JCU
Mustafa Ayna, Aydin Gülses, Yahya Acil
The study aims to document the clinical outcomes over a 7-year period of two techniques used for the rehabilitation of edentulous mandibles according to the "All-on-Four™" concept: (1) fixed complete-arch prostheses fabricated with metal-ceramic implant-supported fixed prosthesis with a titanium framework and all-ceramic crowns and (2) bar-retained implant-supported removable prosthesis with acrylic resin prosthetic teeth. The study was performed on 32 patients who received immediately loaded "All-on-Four™" fixed mandibular prostheses...
January 2018: Odontology
Utako Ishimoto, Shoko Nakamura, Yusuke Sasaki, Naoki Takahashi, Satoru Iwasa, Yoshitaka Honma, Natsuko Okita, Atsuo Takashima, Ken Kato, Tetsuya Hamaguchi, Narikazu Boku
BACKGROUND: Ovarian metastasis of gastric cancer is thought to be less sensitive to chemotherapy. METHODS: The subjects of this retrospective study were 15 gastric cancer patients with ovarian metastasis treated with first-line chemotherapy between January 1998 and April 2015. Response to chemotherapy was compared between ovarian metastasis and other measurable lesions; progression free survival(PFS), post progression survival(PPS), and overall survival(OS)were compared among the patients showing disease progression only at the ovary(group A), only at lesions other than the ovary(group B), and at both sites(group C)...
March 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Gozde Gultekin, Zeliha Kincir, Merve Kurt, Yasir Catal, Asli Acil, Aybike Aydin, Mualla Özcan, Busra N Delikkaya, Selma Kacar, Murat Emul
PURPOSE: Facial emotion recognition is a basic element in non-verbal communication. Although some researchers have shown that recognizing facial expressions may be important in the interaction between doctors and patients, there are no studies concerning facial emotion recognition in nurses. Here, we aimed to investigate facial emotion recognition ability in nurses and compare the abilities between nurses from psychiatry and other departments. METHODS: In this cross-sectional study, sixty seven nurses were divided into two groups according to their departments: psychiatry (n=31); and, other departments (n=36)...
December 1, 2016: Clinical and Investigative Medicine. Médecine Clinique et Experimentale
Olga Maria Will, Nicolai Purcz, Athena Chalaris, Carola Heneweer, Susann Boretius, Larissa Purcz, Lila Nikkola, Nureddin Ashammakhi, Holger Kalthoff, Claus-Christian Glüer, Jörg Wiltfang, Yahya Açil, Sanjay Tiwari
Despite aggressive treatment with radiation and combination chemotherapy following tumor resection, the 5-year survival rate for patients with head and neck cancer is at best only 50%. In this study, we examined the therapeutic potential of localized release of diclofenac from electrospun nanofibers generated from poly(D,L-lactide-co-glycolide) polymer. Diclofenac was chosen since anti-inflammatory agents that inhibit cyclooxygenase have shown great potential in their ability to directly inhibit tumor growth as well as suppress inflammation-mediated tumor growth...
2016: International Journal of Nanomedicine
Mohammad W Godah, Rima A Abdul Khalek, Lama Kilzar, Hiba Zeid, Acile Nahlawi, Luciane Cruz Lopes, Andrea J Darzi, Holger J Schünemann, Elie A Akl
BACKGROUND: Low- and middle-income countries adapt World Health Organization (WHO) guidelines instead of de novo development for financial, epidemiologic, sociopolitical, cultural, organizational, and other reasons. OBJECTIVE: To systematically evaluate reported processes used in the adaptation of WHO guidelines for human immunodeficiency virus (HIV) and tuberculosis (TB). METHODS: We searched three online databases/repositories: United States Agency for International Development (USAID) AIDS Support and Technical Resources - Sector One program (AIDSTAR-One) National Treatment Database; the AIDSspace Guideline Repository, and WHO Database of national HIV and TB guidelines...
December 2016: Journal of Clinical Epidemiology
Aydin Gülses, Mustafa Ayna, Hakan Güçlü, Metin Sencimen, M Nabi Basiry, Matthias Gierloff, Yahya Açil
The aim of this study was to analyze the primary stability of BoneTrust Sinus implants (BTSIs), which are intended to enable higher primary stability by their special design with reduced thread section in cases of reduced vertical bone availability, in comparison with standard BoneTrust implants (SBTIs) in vitro. A bone window 3 cm in length, 4 cm in width, and 3 cm in depth, resembling the maxillary bone window of the lateral sinus wall with 4 mm of residual bone height, was prepared at the dorsal side of freshly slaughtered bovine ribs...
September 2016: International Journal of Periodontics & Restorative Dentistry
Yahya Açil, Jan Sievers, Aydin Gülses, Mustafa Ayna, Jörg Wiltfang, Hendrik Terheyden
The aim of this study was to evaluate the correlation between resonance frequency analysis (RFA) values and the histomorphometric bone-implant contact (BIC) immediately after insertion of the implant. Additionally, it was examined to define which extent peak insertion torque (PIT) was correlated with the latter measurements. 15 Xive® S plus root from dental implants were inserted in fresh porcine frontal bones. The insertion torque was measured with the Kavo Intrasurg 300 surgical unit. RFA connector was coupled to the implants and the mean value of 20 consecutive RFA measurements was calculated via Osstell® ISQ device...
July 2017: Odontology
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