Nawal Kishore Sahu, Ritu Sharma, Kshirsagar Prasad Suhas, Jyoti Joshi, Kunal Prakash, Richa Sharma, Ramendra Pratap, Xiwen Hu, Sukhbir Kaur, Mukesh Jain, Carmine Coluccini, Paolo Coghi, Sandeep Chaudhary
Leishmaniasis is a neglected tropical disease, and there is an emerging need for the development of effective drugs to treat it. To identify novel compounds with antileishmanial properties, a novel series of functionalized spiro[indoline-3,2'-pyrrolidin]-2-one/spiro[indoline-3,3'-pyrrolizin]-2-one 23a - f , 24a - f , and 25a - g were prepared from natural-product-inspired pharmaceutically privileged bioactive sub-structures, i.e., isatins 20a - h , various substituted chalcones 21a - f , and 22a - c amino acids, via 1,3-dipolar cycloaddition reactions in MeOH at 80 °C using a microwave-assisted approach...
June 16, 2023: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry