Read by QxMD icon Read


Akitaka Fujisaki, Takatoshi Aoki, Hidekuni Narimatsu, Chie Kuwahara, Atsushi Nozaki, Kunitaka Menuki, Akinori Sakai, Yukunori Korogi
The original version of this article, published on 03 September 2018, unfortunately contained a mistake.
February 19, 2019: European Radiology
Toshiharu Urakami, Yohei Hamada, Yusuke Oka, Tomohide Okinaka, Hiroki Yamakuchi, Hiroki Magarifuchi, Yosuke Aoki
The objective of this study was to explore the optimal dosage regimen of daptomycin and to determine the necessity and validity of a high-dose regimen from the perspectives of PK/PD parameters using Monte Carlo Simulation (MCS) and therapeutic drug monitoring (TDM) in a Japanese clinical setting. The volume of distribution (0.13 ± 0.012 L/kg) in this study was greater than that in healthy volunteers reported in Japan. The range of half-lives was between 8.9 and 34.9 h, which were gradually prolonged as creatinine clearance decreased...
February 16, 2019: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
Osamu Yoshino, Kaori Yamada-Nomoto, Kuniyuki Kano, Yosuke Ono, Mutsumi Kobayashi, Masami Ito, Satoshi Yoneda, Akitoshi Nakashima, Tomoko Shima, Takashi Onda, Yutaka Osuga, Junken Aoki, Shigeru Saito
OBJECTS: There is growing evidence that sphingosine 1-phosphate (S1P) is involved in inflammatory diseases. As endometriosis is known as an inflammatory disease, we investigated the role of S1P system in the development of endometriosis. METHODS: The expression of sphingosine kinase (SphK) 1 in endometriosis lesions was examined by immunohistochemistry. The cystic fluid of ovarian cysts/tumors were obtained to measure S1P concentrations. Endometriotic stromal cells (ESC) derived from endometrioma were used for in vitro experiments...
February 19, 2019: Reproductive Sciences
Juliane C R Fernandes, Stephanie M Acuña, Juliana I Aoki, Lucile M Floeter-Winter, Sandra M Muxel
The identification of RNAs that are not translated into proteins was an important breakthrough, defining the diversity of molecules involved in eukaryotic regulation of gene expression. These non-coding RNAs can be divided into two main classes according to their length: short non-coding RNAs, such as microRNAs (miRNAs), and long non-coding RNAs (lncRNAs). The lncRNAs in association with other molecules can coordinate several physiological processes and their dysfunction may impact in several pathologies, including cancer and infectious diseases...
February 17, 2019: Non-Coding RNA
Takahisa Mitsui, Kenichiro Aoki
Water is ubiquitous, and the surface properties of ice have been studied for some time, due to their importance. A liquidlike layer (LLL) is known to exist on ice, below the melting point. We use surface thermal fluctuation spectroscopy to study the LLL, including its thickness, for pure ice, and for ice with impurities. We find that the properties of the LLL are experimentally those of liquid water, with thickness much smaller than previous results. We also find that impurities cause the LLL to be thicker, and quite inhomogeneous, with properties depending on the dopant...
January 2019: Physical Review. E
Masaru Miyazaki, Mikiko Aoki, Kaori Koga, Makoto Hamasaki, Yoshikazu Sugiyama, Kensuke Midorikawa, Daisuke Hamatake, Michio Masaki, Yasushi Takamatsu, Akinori Iwasaki, Toshifumi Sakata, Toshitaka Nagao, Kazuki Nabeshima
Adenoid cystic carcinoma (AdCC) with high-grade transformation (AdCC-HGT) is rare, and AdCC-HGT with spindle cell component is particularly rare. The patient was a 65-year-old man with a 5 cm sized swelling of the right submandibular gland. Submandibular sialoadenectomy was performed. Histopathological findings mainly showed conventional AdCC, and minorly showed two other components: (1) the pleomorphic component, a proliferation of atypical pleomorphic epithelial cells forming solid or small clusters and accompanied by necrosis; (2) the spindle cell component, containing atypical spindle cells invading the stroma...
February 15, 2019: Auris, Nasus, Larynx
Makito Miyake, Shinji Fukui, Daisuke Gotoh, Yoshiaki Matsumura, Shoji Samma, Yoshihiro Matsumoto, Hitoshi Momose, Shunta Hori, Shuji Watanabe, Takuya Owari, Yosuke Morizawa, Yoshitaka Itami, Yasushi Nakai, Takeshi Inoue, Satoshi Anai, Kazumasa Torimoto, Katsuya Aoki, Nobumichi Tanaka, Kiyohide Fujimoto
BACKGROUND: Retroperitoneal tumors are an uncommon disease known to consist of a diverse group of benign and malignant neoplasms. Treatment of unresectable retroperitoneal lesions requires pathological diagnosis. Here, we report the utility and safety of retroperitoneoscopic biopsy for unresectable retroperitoneal lesions excluding urogenital cancers. METHODS: We analyzed 47 patients consisting of 23 (49%) and 24 (51%) cases that underwent retroperitoneoscopic tissue biopsy and open biopsy, respectively...
February 18, 2019: World Journal of Surgical Oncology
Akiko Ono, Tomohiro Suzuki, Saki Gotoh, Haruka Kono, Megumi Matsui, Daichi Aoki, Masaru Matsuda, Hirokazu Kawagishi, Makoto Ogata
An α-l-fucosidase (Pap-Alf) was purified from the pancreas of a starfish Patiria pectinifera by ammonium sulfate precipitation followed by several column chromatographies. The molecular mass of the purified enzyme was estimated to be 52.6 kDa by SDS-PAGE, although gel filtration analysis of the native enzyme suggests it exists as a homodimer in solution. The purified enzyme showed maximal activity at pH 5.0 and 70 °C. The enzyme was highly specific toward a fucosyl-monosaccharide (Fuc-α-pNP), but it also showed activity toward 2-sulfo-Fuc-α-pNP and fucosyl-α-lactosides (Fuc-α-Galβ1→4Glc-β-pNP)...
February 7, 2019: Carbohydrate Research
Nao Nishida-Aoki, Taranjit S Gujral
Cell-cell interactions are of crucial importance for tissue formation, homeostasis, regeneration processes, and immune response. Recent studies underlined contribution of cell-cell interaction in tumor microenvironment (TME) for tumor progression and metastasis. Cancer cells modify the host cells to tumor-supportive traits, and the modified host cells contribute to tumor progression by interacting with cancer cells and further modifying other normal cells. However, the complex interaction networks of cancer cells and host cells remained largely unknown...
January 22, 2019: Oncotarget
Alma Fujisawa, Risako Toki, Hideaki Miyake, Tomoko Shoji, Hiromi Doi, Hiromi Hayashi, Rina Hanabusa, Hiromi Mutsuro-Aoki, Takuya Umehara, Tadashi Ando, Hiroki Noguchi, Arnout Voet, Sam-Yong Park, Koji Tamura
This study reports the X-ray crystallographic structure of the glycyl-tRNA synthetase (GlyRS) of Nanoarchaeum equitans - a hyperthermophilic archaeal species. This is the first archaeal GlyRS crystal structure elucidated. The GlyRS comprises an N-terminal catalytic domain and a C-terminal anticodon-binding domain with a long β-sheet inserted between these domains. An unmodified transcript of the wild-type N. equitans tRNAGly was successfully glycylated using GlyRS. Substitution of the discriminator base A73 of tRNAGly with any other nucleotide caused a significant decrease in glycylation activity...
February 13, 2019: Biochemical and Biophysical Research Communications
Iori Kisu, Yu Liu, Gaowen Chen, Min Jong Song, Cherry Yin-Yi Chang, Tan Hak Koon, Kouji Banno, Daisuke Aoki
Uterus transplantation (UTx) is now a possible approach for women with absolute uterine factor infertility to deliver a child, following the first successful delivery by Brännström et al. in Sweden in September 2014. This remarkable achievement attracted major attention worldwide and caused many countries to prepare for UTx, including countries in Asia. To date, three groups have performed UTx in humans in Asia, and many others are aiming for the clinical application of UTx with accumulation of basic experimental data...
February 14, 2019: Journal of Clinical Medicine
Makoto Aoki, Toshikazu Abe, Shuichi Hagiwara, Kiyohiro Oshima
No abstract text is available yet for this article.
March 2019: Critical Care Medicine
Makoto Nakai, Yutaro Hara, Shinnosuke Yonaiyama, Hiroyuki Jin, Tomohisa Tokura, Kazunori Aoki, Hiroaki Kawashima, Yoshikazu Toyoki, Masaaki Endo
A 65-year-old man was hospitalized for gastric cancer. Abdominal computed tomography detected lower gastric cancer and invasion of the liver. Initial laboratory data showed high levels of serum AFP(2,688.6 ng/mL). He underwent distal gastrectomy with left lobectomy of the liver and cholecystectomy. Histology confirmed that the tumor consisted of 2 components: primary gastric choriocarcinoma and AFP-producing carcinoma. The pathological staging was pT4b(liver), N3aM0, Stage ⅢC. After surgery, AFP levels decreased to within the normal limits...
January 2019: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Shouta Miyatake, Yoshitaka Mizobe, Maria K Tsoumpra, Kenji Rowel Q Lim, Yuko Hara, Fazel Shabanpoor, Toshifumi Yokota, Shin'ichi Takeda, Yoshitsugu Aoki
Exon skipping using phosphorodiamidate morpholino oligomers (PMOs) is a promising treatment strategy for Duchenne muscular dystrophy (DMD). The most significant limitation of these clinically used compounds is their lack of delivery systems that target muscles; thus, cell-penetrating peptides are being developed to enhance uptake into muscles. Recently, we reported that uptake of peptide-conjugated PMOs into myofibers was mediated by scavenger receptor class A (SR-A), which binds negatively charged ligands...
January 25, 2019: Molecular Therapy. Nucleic Acids
Noriyuki Yoshida, Asuna Arai, Momoe Aoki, Miho Moriya, Kaho Sekiguchi, Takashi Shimizu
Early development in clitellate annelids is characterized by a highly stereotyped sequence of unequal, spiral cleavages. Cell 2d (i.e., the second micromere of the D quadrant) in the oligochaete Tubifex tubifex also undergoes an evolutionarily conserved sequence of cell division to produce four bilateral pairs of ectodermal teloblasts that act as embryonic stem cells. This study was conducted to characterize each of the 15 rounds of cell division that occur in the 2d cell lineage in this clitellate. After its occurrence, cell 2d undergoes three rounds of highly unequal divisions, giving off the first smaller daughter cell toward the posterior right of the larger daughter cell, the second cell toward the posterior left, and the third cell toward the anterior side of the cell; the larger daughter cell that results from the third division (i...
February 14, 2019: Journal of Morphology
Nobuhiko Okamoto, Atsushi Takata, Noriko Miyake, Naomichi Matsumoto
RASopathies including Noonan syndrome (NS), Costello syndrome, and Cardiofaciocutaneous syndrome are caused by heterozygous germline mutations in genes of the RAS/MAPK pathway that plays a role in cellular proliferation, differentiation, and survival. Novel genes associated with RASopathies are increasing in number (Aoki et al. 2016). This article is protected by copyright. All rights reserved.
February 13, 2019: Congenital Anomalies
Eri Kumaki, Keisuke Tanaka, Kohsuke Imai, Yuki Aoki-Nogami, Akira Ishiguro, Satoshi Okada, Hirokazu Kanegane, Fumihiko Ishikawa, Tomohiro Morio
Mutation in the gene encoding tRNA nucleotidyl transferase, CCA-adding 1 (TRNT1), an enzyme essential for the synthesis of the 3'-terminal CCA sequence in tRNA molecules, results in a disorder that features sideroblastic anemia, B-cell immunodeficiency, periodic fever, and developmental delay. Mutations in TRNT1 are also linked to phenotypes including retinitis pigmentosa, cataracts, and cardiomyopathy. To date, it has remained unclear how defective TRNT1 is linked to B-cell deficiency. Here we report the case of a 12-year-old boy without sideroblastic anemia who harbors novel compound heterozygous mutations in TRNT1...
February 13, 2019: International Journal of Hematology
Atsushi Saito, Takahiro Bizenjima, Takahiro Takeuchi, Eiichi Suzuki, Masahiro Sato, Kouki Yoshikawa, Yurie Kitamura, Daisuke Matsugami, Hideto Aoki, Daichi Kita, Kentaro Imamura, Daisuke Irokawa, Fumi Seshima, Sachiyo Tomita
AIM: To evaluate the use of recombinant human fibroblast growth factor (rhFGF)-2 in combination with deproteinized bovine bone mineral (DBBM) compared with rhFGF-2 alone, in the treatment of intrabony periodontal defects. MATERIALS AND METHODS: Patients with periodontitis who had received initial periodontal therapy and had intrabony defects of > 3 mm were enrolled. Sites were randomly assigned to receive 0.3% rhFGF-2+DBBM (test) or rhFGF-2 alone (control). Clinical parameters and a patient-reported outcome measure (PROM) were evaluated at baseline and at 3 and 6 months postoperatively...
February 13, 2019: Journal of Clinical Periodontology
Kageto Yamada, Ryoichi Saito, Saori Muto, Masakazu Sasaki, Hinako Murakami, Kotaro Aoki, Yoshikazu Ishii, Kazuhiro Tateda
OBJECTIVES: Campylobacter jejuni is one of the most common pathogens causing gastroenteritis. Because there is currently insufficient epidemiological information on the antimicrobial susceptibility and molecular characterization of clinical isolates of C. jejuni in Japan, we carried out antimicrobial susceptibility testing, and MLST of clinical C. jejuni isolates in Tokyo between 2000 and 2017. METHODS: Antimicrobial susceptibility to erythromycin and ciprofloxacin was tested in 430 clinical isolates of C...
February 9, 2019: Journal of Global Antimicrobial Resistance
Tomoyasu Horikawa, Shuntaro C Aoki, Mitsuaki Tsukamoto, Yukiyasu Kamitani
Achievements of near human-level performance in object recognition by deep neural networks (DNNs) have triggered a flood of comparative studies between the brain and DNNs. Using a DNN as a proxy for hierarchical visual representations, our recent study found that human brain activity patterns measured by functional magnetic resonance imaging (fMRI) can be decoded (translated) into DNN feature values given the same inputs. However, not all DNN features are equally decoded, indicating a gap between the DNN and human vision...
February 12, 2019: Scientific Data
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"