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JOURNAL ARTICLE
Jobran M Moshi, Monique Ummelen, Frank Smedts, Frans C S Ramaekers, Anton H N Hopman
Methylation and hydroxymethylation of cytosine moieties in CpG islands of specific genes are epigenetic processes shown to be involved in the development of cervical (pre)neoplastic lesions. We studied global (hydroxy)methylation during the subsequent steps in the carcinogenic process of the uterine cervix by using immunohistochemical protocols for the detection of 5-methylcytosine (5-mC) and 5-hydroxymethylcytosine (5-hmC) in paraffin-embedded tissues of the normal epithelia and (pre)malignant lesions. This approach allowed obtaining spatially resolved information of (epi)genetic alterations for individual cell populations in morphologically heterogeneous tissue samples...
2024: PloS One
#2
JOURNAL ARTICLE
Xuemei Wang, Yuan Ma, Jing Ru, Lin Fan, Rao Peng, Xinzhen Du, Xiaoquan Lu
Pharmaceuticals and personal care products (PPCPs) have a significant impact on the environment and human health, due to their sometimes toxic and carcinogenic characteristics. Therefore, an innovative chemosensor was constructed for ultrasensitive determination of two typical PCCPs (hydroquinone (HQ) and catechol (CC)) in several minutes. The homemade chemosensor (UiO-67@GO/MWCNTs) consisted of MOF(UiO-67), graphene oxide (GO), and multi-walled carbon nanotubes (MWCNTs) composites; it was a networked, structurally sparse, porosity-rich, homogeneous octahedral composite, and had ultra-high electrical conductivity, which provided lots of active adsorption sites, promote charge transfer, and enrich lots of molecules to be measured in a few minutes...
April 18, 2024: Mikrochimica Acta
#3
JOURNAL ARTICLE
Liangliang Qing, Qingchao Li, Yongjin Yang, Wenbo Xu, Yanan Wang, Rongxing Li, Chengyu You, Zhilong Dong
The expression pattern of MUC1-C in tumors is closely linked to tumor progression; however, its specific mechanism remains unclear. The expression of MUC1-C in cancer and adjacent normal tissues was detected using immunohistochemistry and Western blot. The IC50 of cells to gemcitabine was determined using the CCK8 assay. The effects of hypoxia and MUC1-C on the behavioral and metabolic characteristics of bladder cancer cells were investigated. Gene expression was assessed through Western blot and polymerase chain reaction...
April 18, 2024: Molecular Carcinogenesis
#4
JOURNAL ARTICLE
Longxue Ma, Junning Ma, Yuanyuan Tian, Xu Li, Bowen Tai, Fuguo Xing
Aflatoxins (AFs), highly carcinogenic natural products, are produced by the secondary metabolism of fungi such as Aspergillus flavus . Essential for the fungi to respond to environmental changes and aflatoxin synthesis, the pheromone mitogen-activated protein kinase (MAPK) is a potential regulator of aflatoxin biosynthesis. However, the mechanism by which pheromone MAPK regulates aflatoxin biosynthesis is not clear. Here, we showed Gal83, a new target of Fus3, and identified the pheromone Fus3-MAPK signaling pathway as a regulator of the Snf1/AMPK energy-sensing pathway modulating aflatoxins synthesis substrates...
April 18, 2024: Journal of Agricultural and Food Chemistry
#5
JOURNAL ARTICLE
Xuan Liu, Jay R Turner, Christopher R Oxford, Jacob McNeill, Brenna Walsh, Emmie Le Roy, Crystal L Weagle, Emily Stone, Haihui Zhu, Wenyu Liu, Zilin Wei, Nicole P Hyslop, Jason Giacomo, Ann M Dillner, Abdus Salam, Al-Amin Hossen, Zubayer Islam, Ihab Abboud, Clement Akoshile, Omar Amador-Muñoz, Nguyen Xuan Anh, Araya Asfaw, Rajasekhar Balasubramanian, Rachel Ying-Wen Chang, Craig Coburn, Sagnik Dey, David J Diner, Jinlu Dong, Tareq Farrah, Paterne Gahungu, Rebecca M Garland, Michel Grutter de la Mora, Sina Hasheminassab, Juanette John, Jhoon Kim, Jong Sung Kim, Kristy Langerman, Pei-Chen Lee, Puji Lestari, Yang Liu, Tesfaye Mamo, Mathieu Martins, Olga L Mayol-Bracero, Mogesh Naidoo, Sang Seo Park, Yoav Schechner, Robyn Schofield, Sachchida N Tripathi, Eli Windwer, Ming-Tsang Wu, Qiang Zhang, Michael Brauer, Yinon Rudich, Randall V Martin
Global ground-level measurements of elements in ambient particulate matter (PM) can provide valuable information to understand the distribution of dust and trace elements, assess health impacts, and investigate emission sources. We use X-ray fluorescence spectroscopy to characterize the elemental composition of PM samples collected from 27 globally distributed sites in the Surface PARTiculate mAtter Network (SPARTAN) over 2019-2023. Consistent protocols are applied to collect all samples and analyze them at one central laboratory, which facilitates comparison across different sites...
April 12, 2024: ACS EST Air
#6
JOURNAL ARTICLE
Xiaoqing Zhang, Huanhuan Liu, Xin Li, Zhaowei Zhang, Zhihua Chen, Dajun Ren, Shuqin Zhang
Heavy metals pollution is a notable threat to environment and human health. This study evaluated the potential ecological and health risks of heavy metals (Cu, Cr, Cd, Pb, Zn, Ni, and As) and their accumulation in a peanut-soil system based on 34 soil and peanut kernel paired samples across China. Soil As and Cd posed the greatest pollution risk with 47.1% and 17.6% of soil samples exceeding the risk screen levels, respectively, with 26.5% and 20.6% of the soil sites at relatively strong potential ecological risk level, respectively, and with the geo-accumulation levels at several soil sites in the uncontaminated to moderately contaminated categories...
April 15, 2024: Environmental Research
#7
REVIEW
Yuxiao Zhang, Frimpong Alex Justice, Jingning Tang, Isaac Oyeyemi Olayode, Sampson Kofi Kyei, Prince Owusu-Ansah, Philip Kwabena Agyeman, Jamshid Valiev Fayzullayevich, Gangfeng Tan
Road dust-associated contaminants (RD-AC) are gradually becoming a much thornier problem, as their monotonous correlations render them carcinogenic, mutagenic, and teratogenic. While many studies have examined the harmful effects of road dust on both humans and the environment, few studies have considered the co-exposure risk and gradient outcomes given the spatial extent of RD-AC. In this spirit, this paper presents in-depth elucidation into the baffling complexities induced by both major and emerging contaminants of road dust through a panorama-to-profile up-to-date review of diverse studies unified by the goal of advancing innovative methods to mitigate these contaminants...
April 15, 2024: Environmental Pollution
#8
JOURNAL ARTICLE
Chukwu Fidelis Opia, Ibe Francis Chizoruo
The research determined the anthropogenic source and risk evaluation of total petroleum hydrocarbons of some ground water sources within Orji auto repair workshops, Owerri, Imo State, Nigeria. The concentrations of total petroleum hydrocarbons in different groundwater samples within this vicinity were determined by selecting samples from five sampling locations using the liquid-liquid extraction process and gas chromatography fitted with a flame ionization detector. The concentrations of TPHs were determined with C15 (Pentadecane) and C30 (Triaconate) having the highest total concentrations in all sample locations of 29...
March 2024: Environmental analysis, health and toxicology
#9
JOURNAL ARTICLE
Patrick Hinton, Paul J Villeneuve, Elisabeth Galarneau, Kristian Larsen, Deyong Wen, Jun Meng, Verica Savic-Jovcic, Junhua Zhang, Will D King
PURPOSE: Polycyclic aromatic hydrocarbons (PAHs) represent a class of ubiquitous pollutants recognized as established human carcinogens and endocrine-disrupting chemicals. PAHs have seldom been modeled at the population-level in epidemiological studies. Fluoranthene is a prevalent PAH in urban settings and correlates with the occurrence of other PAHs. The purpose of this study was to evaluate associations between long-term residential exposure to ambient PAHs and breast cancer risk, both pre- and post-menopausal, in Canada...
April 17, 2024: Cancer Causes & Control: CCC
#10
JOURNAL ARTICLE
Arpamas Vachiraarunwong, Min Gi, Tohru Kiyono, Shugo Suzuki, Masaki Fujioka, Guiyu Qiu, Runjie Guo, Tomoki Yamamoto, Anna Kakehashi, Masayuki Shiota, Hideki Wanibuchi
Arsenic is highly toxic to the human bladder. In the present study, we established a human bladder epithelial cell line that closely mimics normal human bladder epithelial cells by immortalizing primary uroplakin 1B-positive human bladder epithelial cells with human telomerase reverse transcriptase (HBladEC-T). The uroplakin 1B-positive human bladder epithelial cell line was then used to evaluate the toxicity of seven arsenicals (iAsV , iAsIII , MMAV , MMAIII , DMAV , DMAIII , and DMMTAV ). The cellular uptake and metabolism of each arsenical was different...
April 17, 2024: Archives of Toxicology
#11
REVIEW
Hanyun Liang, Xin Zheng, Xiao Zhang, Yan Zhang, Jie Zheng
Chromatin remodeling is a critical step in the DNA damage response, and the ATP-dependent chromatin remodelers are a group of epigenetic regulators that alter nucleosome assembly and regulate transcription factor accessibility to DNA, preventing genomic instability and tumorigenesis caused by DNA damage. The SWI/SNF chromatin remodeling complex is one of them, and mutations in the gene encoding the SWI/SNF subunit are frequently found in digestive tumors. We review the most recent literature on the role of SWI/SNF complexes in digestive tumorigenesis, with different SWI/SNF subunits playing different roles...
April 17, 2024: Medical Oncology
#12
JOURNAL ARTICLE
Lian Chen, Zi-Hang Zou, Pei-Zhen Zhang, Yu-Han Wang, Zhen-Jiang Wang, Sen Lin, Cui-Ming Tang, Guo-Qing Luo, Jian-Wu Zhong, Zhi-Yi Li, Yuan Wang
Taking a city in Guangdong Province as the research area, the concentration and spatial distribution characteristics of heavy metals in the surface soil were studied to clarify the situation of soil heavy metal pollution and priority control factors, providing basic data for the prevention and control of soil heavy metal pollution in the city. The content characteristics of heavy metals in 221 soil samples in the city were analyzed, and the potential health risk assessment and source analysis were carried out through the Monte Carlo model, the potential health risk assessment (HRA) model, and the PMF receptor model...
May 8, 2024: Huan Jing Ke Xue= Huanjing Kexue
#13
JOURNAL ARTICLE
Gang-Li Sun, Li-Ping Wu, Bo Xu, Yu-Zong Gao, Xue-Yan Zhao, Ya-Qin Ji, Wen Yang
Atmospheric polycyclic aromatic hydrocarbons (PAHs) and their derivatives are a global problem that influences the environment and threatens human health. To investigate the characteristics, sources, and health risk assessment of PM2.5 -bound PAHs and their derivatives, PM2.5 were collected at an urban site in Zibo from November 5 to December 26, 2020, and the concentrations of 16 conventional PAHs, nine NPAHs, and five OPAHs in PM2.5 were analyzed using gas chromatography-mass spectrometry. Source apportionment of PAHs and their derivatives was conducted using diagnostic ratios and a PMF model, and the health risks of PAHs and their derivatives to adult men and women were evaluated using the source-dependent incremental lifetime cancer risk (ILCR) model...
May 8, 2024: Huan Jing Ke Xue= Huanjing Kexue
#14
JOURNAL ARTICLE
Jie Tao, Hui-Jiao Yan, Yi-Fei Xu, Hai-Tao Jing
A total of 18 metal elements in ambient PM2.5 in Zhengzhou were continuously determined using an online heavy metal observation instrument in January and April, 2021, and the changes in element concentrations were analyzed. Metal elements were traced via enrichment factors, positive matrix factorization (PMF), and a characteristic radar chart. The US EPA health risk assessment model was used to assess the health risks of heavy metals, and the backward trajectory method and the concentration-weighted trajectory (CWT) method were used to evaluate the potential source regions of health risks...
May 8, 2024: Huan Jing Ke Xue= Huanjing Kexue
#15
JOURNAL ARTICLE
Rocio Castillo-Sanchez, Alejandra Garcia-Hernandez, Pablo Torres-Alamilla, Pedro Cortes-Reynosa, Fernando Candanedo-Gonzales, Eduardo Perez Salazar
Breast cancer is the most frequent neoplasia in developed countries and the leading cause of death in women worldwide. Epithelial-to-mesenchymal transition (EMT) is a cellular process through which epithelial cells decrease or lose their epithelial characteristics and gain mesenchymal properties. EMT mediates tumor progression, because tumor cells acquire the capacity to execute the multiple steps of invasion and metastasis. Benzo[a]pyrene (B[a]P) is an environmental organic pollutant generated during the burning of fossil fuels, wood, and other organic materials...
April 17, 2024: Molecular Carcinogenesis
#16
JOURNAL ARTICLE
Shaoting Zhang, Liangying Zhang, Dan Zhang, Yue Guo, Yisha Gao, Zongying Jiang, Shujing Li, Anbu Liu, Xu Cao, Jinhai Tian, Sien Zhao, Yuanyuan Yu, Wei Yang, Ru Bai, Ling Huang, Hongli Yan, Hui Zhao, Jianmin Sun
Gastrointestinal stromal tumors (GISTs) are predominately induced by KIT mutants. In this study, we found that four and a half LIM domains 2 (FHL2) was highly expressed in GISTs and KIT signaling dramatically increased FHL2 transcription while FHL2 inhibited KIT transcription. In addition, our results showed that FHL2 associated with KIT and increased the ubiquitination of both wild-type KIT and primary KIT mutants in GISTs, leading to decreased expression and activation of KIT although primary KIT mutants were less inhibited by FHL2 than wild-type KIT...
April 17, 2024: Molecular Carcinogenesis
#17
JOURNAL ARTICLE
Shouhui Yang, Wei Tang, Azadeh Azizian, Jochen Gaedcke, Yuuki Ohara, Helen Cawley, Nader Hanna, B Michael Ghadimi, Trisha Lal, Subrata Sen, Chad J Creighton, Jianjun Gao, Nagireddy Putluri, Stefan Ambs, S Perwez Hussain
Inflammation and aberrant cellular metabolism are widely recognized as hallmarks of cancer. In pancreatic ductal adenocarcinoma (PDAC), inflammatory signaling and metabolic reprogramming are tightly interwoven, playing pivotal roles in the pathogenesis and progression of the disease. However, the regulatory functions of inflammatory mediators in metabolic reprogramming in pancreatic cancer have not been fully explored. Earlier, we demonstrated that pro-inflammatory mediator macrophage migration inhibitory factor (MIF) enhances disease progression by inhibiting its downstream transcriptional factor nuclear receptor subfamily 3 group C member 2 (NR3C2)...
April 17, 2024: Carcinogenesis
#18
JOURNAL ARTICLE
Shibiru Damana, Abiyot Kelecha Geletu, Ibrahim Umer Keru
BACKGROUND: Khat ( Catha edulis Forsk ) is a stimulant plant grown in East Africa and the Arabian Peninsula. Heavy metal pollution has been a global concern due to its acute and chronic health effects and the major route of exposure is the consumption of contaminated foods. In this study, the determination and health risk assessment of heavy metals (Mn, Cu, Zn, Ni, Cr, Cd, and Pb) in khat and its support soil samples was carried out. MATERIALS AND METHODS: Khat and its support soil were analyzed for the levels of 7 toxic heavy metals by Atomic Absorption Spectrophotometer...
2024: Environmental Health Insights
#19
REVIEW
Yadolah Fakhri, Zahra Esfandiari, Fereshteh Mehri, Vahid Ranaei, Zahra Pilevar
The papers were searched in databases including PubMed, Scopus, Web of science, Embase, Science Direct until 21 September 2023 and meta-analysis of concentration of PTEs in honey was performed using random effects model based on country subgroups. The non-carcinogenic risk and carcinogenic risk were calculated by Target Hazard Quotient (THQ) and Cancer Risk (CR), respectively. The sort of PTEs in honey based on pooled concentration was Cu (1.10E + 02 µg/kg) > Ni (1.80E + 01 µg/kg) > Pb (2...
April 16, 2024: International Journal of Environmental Health Research
#20
JOURNAL ARTICLE
Annibale Biggeri, Giorgia Stoppa, Laura Facciolo, Giuliano Fin, Silvia Mancini, Valerio Manno, Giada Minelli, Federica Zamagni, Michela Zamboni, Dolores Catelan, Lauro Bucchi
BACKGROUND: Per- and polyfluoroalkyl substances (PFAS) are associated with many adverse health conditions. Among the main effects is carcinogenicity in humans, which deserves to be further clarified. An evident association has been reported for kidney cancer and testicular cancer. In 2013, a large episode of surface, ground and drinking water contamination with PFAS was uncovered in three provinces of the Veneto Region (northern Italy) involving 30 municipalities and a population of about 150,000...
April 16, 2024: Environmental Health
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