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Methionine And Histamine

Gabriele Valora, Gabriella Munzi, Raffaele P Bonomo
Ternary copper(II) complexes with 1,10‑phenanthroline and the aminoacids l‑arginine, l‑aspartic acid, l‑histidine, l‑glutamic acid, l‑glutamine, l‑leucine, l‑lysine, l‑methionine, l‑phenylalanine, l‑tryptophan, l‑tyrosine, l‑valine, were studied in aqueous solution by means of UV-Vis-NIR spectrophotometry, EPR spectroscopy either at room or at low temperatures, and Square Wave Voltammetry. From the experimental data it is possible to conclude that most of these ternary complexes show a pseudo-octahedral geometry with a CuN3 O in plane chromophore and two oxygen atoms coming from water molecules perpendicularly bound to the equatorial plane...
November 3, 2018: Journal of Inorganic Biochemistry
Daniel Röth, Abby J Chiang, Weidong Hu, Gabriel B Gugiu, Christina N Morra, James Versalovic, Markus Kalkum
Colonization of the gut by certain probiotic Lactobacillus reuteri strains has been associated with reduced risk of inflammatory diseases and colorectal cancer. Previous studies pointed to a functional link between immunomodulation, histamine production, and folate metabolism, the central 1-carbon pathway for the transfer of methyl groups. Using mass spectrometry and NMR spectroscopy, we analyzed folate metabolites of L. reuteri strain 6475 and discovered that the bacterium produces a 2-carbon-transporting folate in the form of 5,10-ethenyl-tetrahydrofolyl polyglutamate...
November 19, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
Keiichi Hiramoto, Yurika Yamate, Daijiro Sugiyama, Kazunari Matsuda, Yasutaka Iizuka, Tomohiko Yamaguchi
Photoaging can be induced by long-term ultraviolet (UV)A eye irradiation, but an ameliorating method for such photoaging is not known. In this study, we examined the effects of tranexamic acid (trans-4-aminomethylcyclohexanecarboxylic acid) on photoaging of the skin induced by UVA eye irradiation. We used the C57BL/6 j female mice and locally exposed their eyes to UVA at a dose of 110 kJ/m2 using an FL20SBLB-A lamp multiple times a week for one year. The plasma urocortin 2, β-endorphin, methionine enkephalin (OGF), and histamine content, as well as the expression of the corticotropin-releasing hormone receptor (CRHR) type 2, μ-opioid receptor, opioid growth factor receptor (OGFR), T-bet, and GATA3 increased in the mice subjected to UVA eye irradiation...
November 2018: Biomedicine & Pharmacotherapy
Yoshio Muguruma, Haruhito Tsutsui, Takumi Noda, Hiroyasu Akatsu, Koichi Inoue
Confirmed biomarkers of postmortem cerebrospinal fluid (pCSF) are used to differentiate between Alzheimer's disease (AD) patients and healthy seniors with high diagnostic accuracy. However, the extent to which the performance of specific metabolic profiling facilitates reliable estimations of the concentrations of the different pCSF biomarkers and their ratios remains unclear. The interpretation of the lower levels of molecules of metabolic profiling and their concentration ratios in pCSF related to brain disorders could facilitate an unchallenging detection of peripheral biomarkers of AD stages and other dementia types...
August 1, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
Robert Root-Bernstein, Miah Turke, Udaya K Tiruttani Subhramanyam, Beth Churchill, Joerg Labahn
Extensive evidence demonstrates functional interactions between the adrenergic and opioid systems in a diversity of tissues and organs. While some effects are due to receptor and second messenger cross-talk, recent research has revealed an extracellular, allosteric opioid binding site on adrenergic receptors that enhances adrenergic activity and its duration. The present research addresses whether opioid receptors may have an equivalent extracellular, allosteric adrenergic binding site that has similar enhancing effects on opioid binding...
January 17, 2018: International Journal of Molecular Sciences
Chiara Ciaccio, Lorenzo Tognaccini, Theo Battista, Manuela Cervelli, Barry D Howes, Roberto Santucci, Massimo Coletta, Paolo Mariottini, Giulietta Smulevich, Laura Fiorucci
The spectroscopic and functional properties of the single Met80Ala and double Tyr67His/Met80Ala mutants of human cytochrome c have been investigated in their ferric and ferrous forms, and in the presence of different ligands, in order to clarify the reciprocal effect of these two residues in regulating the access of exogenous molecules into the heme pocket. In the ferric state, both mutants display an aquo high spin and a low spin species. The latter corresponds to an OH- ligand in Met80Ala but to a His in the double mutant...
April 2017: Journal of Inorganic Biochemistry
Abolfazl Heidari, Chanakan Tongsook, Reza Najafipour, Luciana Musante, Nasim Vasli, Masoud Garshasbi, Hao Hu, Kirti Mittal, Amy J M McNaughton, Kumudesh Sritharan, Melissa Hudson, Henning Stehr, Saeid Talebi, Mohammad Moradi, Hossein Darvish, Muhammad Arshad Rafiq, Hossein Mozhdehipanah, Ali Rashidinejad, Shahram Samiei, Mohsen Ghadami, Christian Windpassinger, Gabriele Gillessen-Kaesbach, Andreas Tzschach, Iltaf Ahmed, Anna Mikhailov, D James Stavropoulos, Melissa T Carter, Soraya Keshavarz, Muhammad Ayub, Hossein Najmabadi, Xudong Liu, Hans Hilger Ropers, Peter Macheroux, John B Vincent
Histamine (HA) acts as a neurotransmitter in the brain, which participates in the regulation of many biological processes including inflammation, gastric acid secretion and neuromodulation. The enzyme histamine N-methyltransferase (HNMT) inactivates HA by transferring a methyl group from S-adenosyl-l-methionine to HA, and is the only well-known pathway for termination of neurotransmission actions of HA in mammalian central nervous system. We performed autozygosity mapping followed by targeted exome sequencing and identified two homozygous HNMT alterations, p...
October 15, 2015: Human Molecular Genetics
E T Oliver, P M Sterba, S S Saini
Chronic spontaneous urticaria (CSU) significantly impacts the quality of life of those affected through symptoms of pruritus and recurrent skin lesions. In active CSU disease, reduced IgE-mediated basophil histamine release (HR) and basopenia are observed. We sought to examine the relationship between interval changes in basophil measures and shifts in patient-reported disease impairment. Simultaneous symptom and basophil evaluations were completed at two sequential study visits, and interval changes in measures were compared between visits for each subject (n = 38)...
May 2015: Allergy
Jerome Sarris, George I Papakostas, Ottavio Vitolo, Maurizio Fava, David Mischoulon
OBJECTIVE: To assess the antidepressant efficacy of S-adenosyl methionine (SAMe), a naturally occurring methyl donor, versus the selective serotonin reuptake inhibitor (SSRI) escitalopram and a placebo control; and to determine whether serum histamine or carnitine levels modified treatment response. METHODS: We examined a subsample (n=144) from one site of a two-site study of adults with diagnosed Major Depressive Disorder (MDD), recruited from 4/13/05 to 12/22/09, who consented to the additional blood draw for serum histamine and carnitine levels...
August 2014: Journal of Affective Disorders
Melvin George, Muthukumar Rajaram, Elangovan Shanmugam
Obesity has become a growing pandemic of alarming proportions in the developed and developing countries over the last few decades. The most perturbing fact regarding obesity is the increased predisposition for coronary artery disease, congestive heart failure and sudden cardiac death. The modest efficacy of current anti-obesity agents such as orlistat and the increasing withdrawals of several anti-obesity agents such as sibutramine, rimonabant have led to huge gaps in the pharmacotherapy of obesity. Lorcaserin and Phentermine-topiramate combination (phen-top) are two drugs approved by US FDA in 2012...
January 2014: Journal of Cardiovascular Pharmacology and Therapeutics
Elżbieta Jankowska, Marta Błaszak, Teresa Kowalik-Jankowska
A potentiometric, spectroscopic (UV-visible, CD and EPR) and electrospray ionization mass spectrometric (ESI-MS) study of Cu(II) binding to the neurokinin A with point mutation (S5A) (ANKA), His-Lys-Thr-Asp-Ala(5)-Phe-Val-Gly-Leu-Met-NH2 and its N-acethyl derivative (Ac-ANKA), Ac-His-Lys-Thr-Asp-Ala(5)-Phe-Val-Gly-Leu-Met-NH2 were carried out. For the ANKA and Ac-ANKA the additional deprotonation was not observed. It suggests that for the tachykinin peptides with C-terminal sequence of neurokinin A for the additional deprotonation the presence of the serine residue is necessary...
April 2013: Journal of Inorganic Biochemistry
Robert E Berry, Dhanasekaran Muthu, Tatiana K Shokhireva, Sarah A Garrett, Hongjun Zhang, F Ann Walker
The first amino acid of mature native nitrophorin 2 is aspartic acid, and when expressed in E. coli, the wild-type gene of the mature protein retains the methionine-0, which is produced by translation of the start codon. This form of NP2, (M0)NP2, has been found to have different properties from its D1A mutant, for which the Met0 is cleaved by the methionine aminopeptidase of E. coli (R. E. Berry, T. K. Shokhireva, I. Filippov, M. N. Shokhirev, H. Zhang, F. A. Walker, Biochemistry 2007, 46, 6830). Native N-terminus nitrophorin 2 ((ΔM0)NP2) has been prepared by employing periplasmic expression of NP2 in E...
September 2012: Chemistry & Biodiversity
Wei-Wei Hu, Qi Fang, Zheng-Hao Xu, Hai-Jing Yan, Ping He, Kai Zhong, Yan-Ying Fan, Ying Yang, Xiang-Nan Zhang, Chun-Yang Zhang, Hiroshi Ohtsu, Tian-Le Xu, Zhong Chen
AIM: To investigate the effect of chronic H1-antihistamine treatment on seizure susceptibility after drug withdrawal in nonepileptic rats and to further study its relation to glutamine synthetase (GS), which is the key enzyme for glutamate metabolism and gamma aminobutyric acid (GABA) synthesis. METHODS: After drug withdrawal from a 2-week treatment with diphenhydramine or pyrilamine, seizure susceptibility was determined by amygdaloid kindling or pentylenetetrazol model; meanwhile, the GS expression or activity was analyzed...
August 2012: CNS Neuroscience & Therapeutics
Maria Sundvik, Pertti Panula
Histamine is an essential factor in the ascending arousal system (AAS) during motivated behaviors. Histamine and hypocretin/orexin (hcrt) are proposed to be responsible for different aspects of arousal and wakefulness, histamine mainly for cognitive and motivated behaviors. In this study we visualized the entire histaminergic neuron population in adult male and female zebrafish brain and quantified the histaminergic neuron numbers. There were 40-45 histaminergic neurons in both male and female zebrafish brain...
December 1, 2012: Journal of Comparative Neurology
Taehyun Roh, Min Young Kwak, Eun Hwa Kwak, Dong Hyun Kim, Eun Young Han, Jung Yun Bae, Du Yeon Bang, Duck Soo Lim, Il Young Ahn, Dong Eun Jang, Seong Kwang Lim, Sun Dong Yoo, Seung Jun Kwack, Kiu Lea Park, Young Ju Lee, Kyu-Bong Kim, Jaewon Lee, Hyung Sik Kim, Byung Mu Lee
This study was designed to investigate the molecular mechanism underlying the chemopreventive effects of methionine on benzo[a]pyrene (B[a]P)-DNA adducts formation in HepG2 cells. Methionine significantly inhibited B[a]P-DNA adduct formation in HepG2 cells. Methionine significantly decreased the cellular uptake of [(3)H] B[a]P, but increased the cellular discharge of [(3)H] B[a]P from HepG2 cells into the media. B[a]P significantly lowered total cellular glutathione (GSH) level, but co-cultured with B[a]P and methionine, gradually attenuated intracellular GSH levels in a concentration-dependent manner, which was markedly higher at 20-500μM methionine...
February 5, 2012: Toxicology Letters
M Concepción Gimeno, Helen Goitia, Antonio Laguna, M Elvira Luque, M Dolores Villacampa, Catarina Sepúlveda, Margarida Meireles
Several bioconjugates of ferrocene with biological compounds such as aminoacid esters and related species have been prepared by reaction of chlorocarbonyl ferrocene with the corresponding amino acid ester (histidine methyl ester, tryptophan methyl ester, methionine methyl ester and lysine ethyl ester) or histamine or prolinamide in the presence of NEt(3). The reaction of the tryptophan or prolinamide ferrocene conjugates with [Au(acac)(PR(3))] (acac=acetylacetonate) results in the substitution of the proton of the cyclic NH groups by the fragment AuPR(3)(+) affording the complexes [Au(FcCO-tryptophan-OMe)(PR(3))] or [Au(FcCO-prolinamide)(PR(3))] (Fc=ferrocenyl group)...
November 2011: Journal of Inorganic Biochemistry
Divya Vohora, Razia Khanam, Shanthi N Pal, K K Pillai
Methionine-sulfoximine (MSO), a convulsant is known to increase the activity of histamine N-methyl transferase. The effect of a selective H3 receptor agonist R- (alpha) methylhistamine (RAMH) and antagonist (thioperamide, THP) and some antiepileptic drugs (gabapentin and sodium valproate) have been evaluated on MSO-induced convulsions in mice. The effect of THP was also evaluated in combination with these antiepileptic drugs. Sodium valproate (300 mg/kg, po) and gabapentin (400 mg/kg, po) offered protection against MSO-induced convulsions as evidenced by a significant prolongation of latency to abnormal dorsoflexion and complete protection against mortality within 6 h of administration...
August 2010: Indian Journal of Experimental Biology
E Galindo, M F Bader, D Aunis
Abstract In the present study we investigated the regulation of Chromogranin A (CGA) and Chromogranin B (CGB) biosynthesis in bovine chromaffin cells maintained in primary culture. Cellular proteins were labelled with [(35)S]methionine and the incorporated radioactivity was used as an index of the synthesis rate. The radioactivity incorporated into CGA was determined by immunoprecipitation, and that into CGB was quantified by a dot immunobinding assay using specific antibodies. Incubation of cells with carbamylcholine, nigh K(+) or histamine, three potent stimulators of catecholamine secretion in chromaffin cells, increased the rate of CGA and CGB synthesis...
December 1, 1991: Journal of Neuroendocrinology
Dino Bullinger, Richard Fux, Graeme Nicholson, Stefan Plontke, Claus Belka, Stefan Laufer, Christoph H Gleiter, Bernd Kammerer
The physiological response of the human body to several diseases can be reflected by the metabolite pattern in biological fluids. Cancer, like other diseases accompanied by metabolic disorders, causes characteristic effects on cell turnover rate, activity of modifying enzymes, and RNA/DNA modifications. This results in an altered excretion of modified nucleosides and biochemically related compounds. In the course of our metabolic profiling project, we screened 24-h urine of patients suffering from lung, rectal, or head and neck cancer for previously unknown ribosylated metabolites...
October 2008: Journal of the American Society for Mass Spectrometry
M Q Zhang, H Timmerman
Recent physiological and pharmacological studies have indicated the potential importance of tryptase, the major protein component in mast cells, in inflammatory diseases (especially asthma). Being released at inflammatory sites after the activation of mast cells, tryptase is capable of causing bronchohyperresponsiveness and infiltration of eosinophils, neutrophils, etc. in animal airways. The mechanisms by which tryptase causes bronchoconstriction involve probably the potentiation of other chemical mediators such as histamine, production of bradykinin via the hydrolysis of kininogen, and cleavage of the bronchodilating peptides VIP (vasoactive intestinal peptide) and PHM (peptide histidine-methionine)...
1997: Mediators of Inflammation
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