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Eye infections

Pradeep S Salve, Praveen Chokhandre, Dhananjay W Bansod
Study assesses the effects of solid-waste loading on workers, the resultant development of occupational morbidities, and economic burden of these morbidities. A cross-sectional survey was conducted with 360 municipal workers from six of 24 municipal wards in Mumbai. The nearest neighborhood method of Propensity Score Matching (PSM) examined the impact of waste-loading on the development of morbidities and to identify the risk factors - multiple logistic regression analysis was performed. The prevalence of musculoskeletal disorders (MSDs), injury, eye and skin infections found significantly higher for waste-loaders compared to comparison group...
February 17, 2019: Archives of Environmental & Occupational Health
Joana Caldeira Santos, Sara Pinto, Sofia Ferreira, Catarina Maia, Sandra Alves, Vinhas da Silva
OBJECTIVE: Characterize clinical features, epidemiology and treatment of hospitalized pediatric cases of preseptal and orbital cellulitis. METHODS: Retrospective study of children/adolescents admitted to a central hospital with preseptal and orbital cellulitis between 2007 and 2017. RESULTS: A total of 122 cases were included, 80.3% with preseptal cellulitis and 19.7% with orbital cellulitis. Patients had a median age of 5 years. Sinusitis was the most common predisposing factor (40...
February 7, 2019: International Journal of Pediatric Otorhinolaryngology
Fahriye Groen-Hakan, Suzanne van de Laar, Annemiek A van der Eijk-Baltissen, Ninette Ten Dam van Loon, Joke de Boer, Aniki Rothova
PURPOSE: To assess the clinical and laboratory manifestations and vaccination status of uveitis patients positive for Rubella virus (RV) in aqueous humor and investigate its relationship to Fuchs Uveitis Syndrome (FUS). METHODS: Retrospective study of all uveitis patients, positive for RV in aqueous humor analysis (polymerase chain reaction (PCR) and/or Goldmann-Witmer coefficient (GWC)) between January 2010 and October 2016 at the ophthalmology departments in the Erasmus Medical Center (Rotterdam) and University Medical Center Utrecht...
February 13, 2019: American Journal of Ophthalmology
Varshasnata Mohanty, Yashwanth Subbannayya, Mohammed Altaf Najar, Sneha M Pinto, Sandeep Kasaragod, Hilda Karuppiah, Bhuvaragavan Sreeramulu, Kunal Kumar Singh, Sunita Dalal, Shyamjith Manikkoth, Cynthia Arunachalam, Thottethodi Subrahmanya Keshava Prasad, Krishna R Murthy
Eye disorders and resulting visual loss are major public health problems affecting millions of people worldwide. In this context, the sclera is an opaque, thick outer coat covering more than 80% of the eye, and essential in maintaining the shape of the eye and protecting the intraocular contents against infection and the external environment. Despite efforts undertaken to decipher the scleral proteome, the functional and structural picture of the sclera still remain elusive. Recently, proteomics has arisen as a powerful tool that enables identification of proteins playing a critical role in health and disease...
February 2019: Omics: a Journal of Integrative Biology
Harrison-Williams C M Lloyd, Simon Arunga, Amos Twinamasiko, Meier A Frederick, John Onyango
AIM: The aim of the study was to assess the predictors of ocular surface squamous neoplasia (OSSN) and conjunctival squamous cell carcinoma (SCC) among Ugandan patients. MATERIALS AND METHODS: Patients presenting for removal of ocular surface lesions received human immunodeficiency virus (HIV) testing, completed questionnaires about demographic, behavioral, and historical potential risk factors for conjunctival neoplasia, and had lesions examined for interpalpebral versus other locations, rough versus smooth texture, and number of feeder vessels...
July 2018: Middle East African Journal of Ophthalmology
Namrata Gangaram Adulkar, Santhi Radhakrishnan, N Vidhya, Usha Kim
OBJECTIVE: Invasive sino-orbital fungal infections in immunocompetent patients are a rare clinical entity; the diagnosis and management of which is challenging. We present a large case series of invasive sino-orbital fungal granulomas in patients without pre-existing systemic immunocomprimising condition. DESIGN: Retrospective case series. PARTICIPANTS: Twenty cases of invasive sino-orbital/naso-orbital fungal granulomas in immunocompetent individuals...
February 14, 2019: Eye
Adrienne J Showler, Joseph Kubofcik, Alessandra Ricciardi, Thomas B Nutman
Many parasitic infections have different presenting features in endemic individuals (ENDs) and immunologically naive temporary residents (TRs). Temporary residents with loiasis often display acute symptoms and hypereosinophilia, in contrast to a parasite-induced subclinical state in chronically infected ENDs. Few studies have examined differences in ENDs and TRs infected with the related filarial parasite Onchocerca volvulus . We identified 40 TRs and 36 ENDs with imported onchocerciasis at the National Institutes of Health between 1976 and 2016...
February 11, 2019: American Journal of Tropical Medicine and Hygiene
Ian L McWilliams, Jennifer L Kielczewski, Derek D C Ireland, Jacob S Sykes, Aaron P Lewkowicz, Krishnamurthy Konduru, Biying C Xu, Chi-Chao Chan, Rachel R Caspi, Mohanraj Manangeeswaran, Daniela Verthelyi
Zaire Ebola virus (ZEBOV) survivors experience visual and CNS sequelae that suggests the ZEBOV glycoprotein can mediate neurotropism. Replication-competent rVSVΔG-ZEBOV-GP vaccine candidate is generally well tolerated; however, its potential neurotropism requires careful study. Here, we show that a single inoculation of rVSVΔG-ZEBOV-GP virus in neonatal C57BL/6 mice results in transient viremia, neurological symptoms, high viral titers in eyes and brains, and death. rVSVΔG-ZEBOV-GP infects the inner layers of the retina, causing severe retinitis...
February 12, 2019: Cell Reports
Kazuhiko Umazume, Jun Suzuki, Yoshihiko Usui, Katsuhiko Maruyama, Yoshihiro Wakabayashi, Hiroshi Goto
Purpose: Bleb-related endophthalmitis (BRE) after glaucoma surgery is an infection caused by bacteria in the avascular bleb gaining access into the eye. We report the clinical features and outcome of 10 consecutive eyes with severe BRE treated at our hospital. Methods: Ten patients (10 eyes) with stage IIIb BRE after trabeculectomy diagnosed and treated at the Department of Ophthalmology, Tokyo Medical University, between April 2013 and May 2015, were studied. Patient background, type of glaucoma, interval from the first trabeculectomy, pretreatment bleb findings, causative microorganisms, surgical methods, status of posterior vitreous detachment (PVD), and postoperative visual acuity were examined...
2019: Journal of Ophthalmology
Steeve Doizi, Marie Audouin, Luca Villa, Maria Rodríguez-Monsalve Herrero, Vincent De Coninck, Etienne Xavier Keller, Olivier Traxer
PURPOSE: During endourological procedures, the eye of the urologist is exposed to hazards such as contact with body fluids and irrigation solutions as well as laser injury, and X-ray radiation absorption. The resulting potential injuries and damages to the eye have not been summarily reviewed to date. The objective was to review the different risks of exposure to the eyes of urologists during endourological procedures. METHODS: The Medline database was searched for identification of studies on hazards to the eye of the endourologist...
February 8, 2019: World Journal of Urology
Mark Hankins, Curtis Edward Margo
The sclera is an uncommon site of primary inflammation. Biopsy is infrequently employed in the evaluation of scleritis, but familiarity with its differential diagnosis is instrumental in ensuring efficient histological evaluation. This review provides a clinical overview of scleritis and describes the context in which scleral biopsy might arise. Most cases are associated with systemic autoimmune disease, but a sizeable proportion occur as an isolated disorder. Conditions mimicking autoimmune scleritis include infection and neoplasm...
February 5, 2019: Journal of Clinical Pathology
Hongmin Zhang, Susu Liu, Juan Yue, Shengtao Sun, Qixue Lv, Shoujun Jian, Yanting Xie, Lei Han, Fenfen Zhang, Yanfang Dai, Liya Wang
Bacterial keratitis is an aggressive infectious corneal disease. With the continuing rise in antibiotic resistance and a decline in the discovery of new antibiotics, new antimicrobial drugs are now required. In the present study, we determined the antibacterial activity of diacerein, an anti-inflammatory drug, against 76 Gram-positive cocci isolated from bacterial keratitis patients in vitro and anti- Staphylococcus aureus activity in mouse bacterial keratitis model in vivo. The minimum inhibitory concentrations (MICs) of diacerein were tested using the broth microdilution method in vitro...
February 4, 2019: Antimicrobial Agents and Chemotherapy
Mahdi Balali-Mood, Bamdad Riahi-Zanjani, Mahmoud Mahmoudi, Mahmood Sadeghi
BACKGROUND: Sulfur mustard (SM) is a powerful blistering chemical warfare agent that has genotoxic effects. Cells with excessive proliferation such as lymphocytes may inherit this cellular toxicity which can lead to their malfunctions in the long-term. This study was designed to evaluate the status of acquired immunity among SM poisoned veterans around three decades after exposure. METHODS: Thirty five male Iranian veterans having at least 25% disability due to SM poisoning with long-term complications in the respiratory system, skin or eyes were investigated...
February 4, 2019: Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences
Gilad Allon, Yinon Shapira, Itzchak Beiran, Eytan Z Blumenthal
PURPOSE: To describe a new technique for sealing small corneal perforations after penetrating trauma. METHODS: Corneal perforations in six eyes were sealed using a stromal cefuroxime hydration technique. This technique is identical to the current method used to seal leaking incisions upon completion of cataract surgery except for the use of cefuroxime instead of balanced salt solution. Additionally, cefuroxime was intentionally injected into the anterior chamber...
February 1, 2019: International Ophthalmology
Velusamy Nithya, Sivakumar Rathinam, Rajapandian Siva Ganesa Karthikeyan, Prajna Lalitha
Methicillin-resistant Staphylococcus aureus (MRSA) is an important cause of vision threatening ocular infections. This study aimed to determine the prevalence and antimicrobial susceptibility pattern of MRSA and their genotypic characterization in ocular infections. The study period was from January 2007 to December 2017 in Aravind Eye Hospital, Madurai. Retrospective analysis of clinical records found a total of 1306 Staphylococcus aureus in various ocular infections. Among these, 274 (21%) were found to be MRSA with an increased incidence from 9% in 2007 to 38% in 2017 (P = ...
January 29, 2019: Infection, Genetics and Evolution
Iqra Rauf, Abdul Wajid, Irshad Hussain, Safa Ather, Muhammad Asad Ali
The first objective of the present study was to evaluate if the antibodies induced by the live LaSota and killed Newcastle disease (sub-genotype VIIi) vaccines protect the chickens against exposure with pathogenic avian avulavirus-1 (AAvV-1) of chicken and/or pigeon origins. The second objective was to study the effect of vaccines on stressed birds (dexamethasone, aflatoxin, and heat stressed) with respect to antibody production and protection against pathogenic AAvV-1 challenge. Sixty-one-day-old Hubbard chickens were divided into six groups (gA-gF) with ten animals each...
January 31, 2019: Tropical Animal Health and Production
Yong-Cai Liu, Min-Li Zhou, Ke-Jia Cheng, Shui-Hong Zhou, Xue Wen, Cheng-Dong Chang
BACKGROUND: Invasive fungal rhinosinusitis (IFR) caused by Cunninghamella is very rare but has an extremely high fatality rate. There have been only seven cases of IFR caused by Cunninghamella reported in English and, of these, only three patients survived. In this article, we present another case of IFR caused by Cunninghamella , in which the patient was initially treated successfully but then deteriorated due to a relapse of leukemia 2 mo later. CASE SUMMARY: A 50-year-old woman presented with a 2-mo history of right ocular proptosis, blurred vision, rhinorrhea and nasal obstruction...
January 26, 2019: World Journal of Clinical Cases
Kundan Kumar, Fizza Askari, Mahima Sagar Sahu, Rupinder Kaur
Candida glabrata is an opportunistic human fungal pathogen that causes superficial mucosal and life-threatening bloodstream infections in individuals with a compromised immune system. Evolutionarily, it is closer to the non-pathogenic yeast Saccharomyces cerevisiae than to the most prevalent Candida bloodstream pathogen, C. albicans . C. glabrata is a haploid budding yeast that predominantly reproduces clonally. In this review, we summarize interactions of C. glabrata with the host immune, epithelial and endothelial cells, and the ingenious strategies it deploys to acquire iron and phosphate from the external environment...
January 30, 2019: Microorganisms
Jinghua Liu, Linghan Li, Xuan Li
PURPOSE: To evaluate the effectiveness of cryopreserved amniotic membrane transplantation (AMT) in corneal ulceration. METHODS: The following electronic databases were searched: PubMed, EMBASE, and Cochrane Library. We evaluated the corneal epithelium healing rate (CEHR) and vision improvement rate (VIR) after AMT in the treatment of corneal ulceration. We analyzed the differences in the CEHR and VIR between the 2 groups of infective and noninfective corneal ulcerations...
January 29, 2019: Cornea
Sarah G Fitzpatrick, Donald M Cohen, Ashley N Clark
Ulcerated lesions of the oral cavity have many underlying etiologic factors, most commonly infection, immune related, traumatic, or neoplastic. A detailed patient history is critical in assessing ulcerative oral lesions and should include a complete medical and medication history; whether an inciting or triggering trauma, condition, or medication can be identified; the length of time the lesion has been present; the frequency of episodes in recurrent cases; the presence or absence of pain; and the growth of the lesion over time...
January 31, 2019: Head and Neck Pathology
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