Luísa Carregosa Santos, Vinícius Queiroz Oliveira, Samuel Cota Teixeira, Thiago Macedo Lopes Correia, Leonardo Oliveira Silva Bastos Andrade, Lorena Polloni, Lucas Miranda Marques, Patrícia Bianca Clissa, Cristiani Baldo da Rocha, Eloisa Amália Vieira Ferro, Amélia Cristina Mendes de Magalhães Gusmão, Marcelo José Barbosa Silva, Sabri Saeed Sanabani, Veridiana de Melo Rodrigues Ávila, Daiana Silva Lopes
Phospholipases A2 (PLA2 s) from snake venom possess antitumor and antiangiogenic properties. In this study, we evaluated the antimetastatic and antiangiogenic effects of MjTX-II, a Lys49 PLA2 isolated from Bothrops moojeni venom, on lung cancer and endothelial cells. Using in vitro and ex vivo approaches, we demonstrated that MjTX-II reduced cell proliferation and inhibited fundamental processes for lung cancer cells (A549) growth and metastasis, such as adhesion, migration, invasion, and actin cytoskeleton decrease, without significantly interfering with non-tumorigenic lung cells (BEAS-2B)...
May 3, 2024: Toxicon: Official Journal of the International Society on Toxinology