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placental allografts

Joshua Luck, Timo Rodi, Alexander Geierlehner, Afshin Mosahebi
Outcomes following standard wound care (SWC) for diabetic foot ulcers (DFUs) remain suboptimal. Supplementing SWC with tissue engineered allogeneic cellular wound therapies represents an emerging treatment strategy. This review aimed to evaluate the efficacy and safety of allogeneic skin substitutes and human placental membrane allografts in the management of DFUs. Ovid MEDLINE and Embase databases were searched from inception to October 2017. Any randomized controlled trial (RCT) with an allogeneic skin substitute or placental membrane allograft intervention group was included...
January 20, 2019: International Journal of Lower Extremity Wounds
Kyle W Sundblad, Elisabet K Tassis
Surgical tendon repairs of the lower extremity are frequently associated with post-operative (post-op) risks that result in poor patient outcomes. Initially, increased pain levels may contribute to extended post-op rehabilitation while the development of tissue adhesions and fibrosis limit long-term functionality through reduced range of motion. Several surgical methods describing incorporation of various augmentative graft materials in tendon repair exist. However, reports demonstrating technique and both short- and long-term patient outcomes are lacking...
December 2018: Medicine (Baltimore)
A Inkeri Lokki, Jenni K Heikkinen-Eloranta, Hannele Laivuori
Pregnancy is an immunological challenge to the mother. The fetal tissues including the placenta must be protected from activation of the maternal immune system. On the other hand, the placental tissue sheds into the maternal circulation and must be adequately identified and phagocytized by the maternal immune system. During a healthy pregnancy, numerous immunosuppressive processes take place that allow the allograft fetus to thrive under exposure to humoral and cellular components of the maternal immune system...
2018: Frontiers in Immunology
Eric L Johnson, Alla Danilkovitch
A large necrotic nasal wound with interdomal subcutaneous tissue loss and the exposed greater alar cartilage was managed conservatively with a placental allograft. This approach is an alternative to the complex staged surgical reconstructive procedures for poor surgical candidates, patients unwilling to undergo facial surgeries, or autologous nasal graft failures.
November 2018: Clinical Case Reports
Markus Abeln, Iris Albers, Ulrike Peters-Bernard, Kerstin Flächsig-Schulz, Elina Kats, Andreas Kispert, Stephen Tomlinson, Rita Gerardy-Schahn, Anja Münster-Kühnel, Birgit Weinhold
The negatively charged sugar sialic acid (Sia) occupies the outermost position in the bulk of cell surface glycans. Lack of sialylated glycans due to genetic ablation of the Sia activating enzyme CMP-sialic acid synthase (CMAS) resulted in embryonic lethality around day 9.5 post coitum (E9.5) in mice. Developmental failure was caused by complement activation on trophoblasts in Cmas-/- implants accompanied by infiltration of maternal neutrophils at the fetal-maternal interface, intrauterine growth restriction, impaired placental development and a thickened Reichert's membrane...
November 1, 2018: Journal of Clinical Investigation
Jenn D Bullard, Jennifer Lei, Jeremy J Lim, Michelle Massee, Anna M Fallon, Thomas J Koob
Chronic wounds are a significant health care problem with serious implications for quality of life because they do not properly heal and often require therapeutic intervention. Amniotic membrane allografts have been successfully used as a biologic therapy to promote soft tissue healing; however, the umbilical cord, another placental-derived tissue, has also recently garnered interest because of its unique composition but similar placental tissue origin. The aim of this study was to characterize PURION® PLUS Processed dehydrated human umbilical cord (dHUC) and evaluate the biological properties of this tissue that contribute to healing...
September 10, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
Mukta S Sane, Neha Misra, Nathan M Quintanar, Christopher D Jones, Soumyajit Banerjee Mustafi
AIM: Placental allografts used for tissue regeneration differ in membrane compositions and processing techniques. A uniquely folded dehydrated binate amniotic membrane (DBAM) was biochemically characterized to evaluate its potential role in wound healing. METHODS: Histology, Luminex-based immunoassay and standard in vitro cell biology techniques were employed. RESULTS: Histological staining confirmed that the DBAM was chorion free with epithelial cell layer of the respective amnion membranes facing outward...
September 2018: Regenerative Medicine
Douglas J Pacaccio, Shawn M Cazzell, Gabriel J Halperin, Maria A Kasper, Joel M Neutel, Brian D O'Carroll, Alexander M Reyzelman
OBJECTIVE: To evaluate the safety and efficacy of a chorioamniotic allograft, used as a wound cover for chronic foot ulcers, in patients with diabetes. METHODS: A multicentre, prospective, postmarket study where eligible patients received up to 11 weekly wound cover applications. Computerised planimetry was used to calculate the diabetic foot ulcer (DFU) area each week. The primary endpoint of the study was wound closure assessment. Secondary endpoints included DFU recurrence and morbidity...
July 1, 2018: Journal of Wound Care
Megan B Barnet, Prunella Blinman, Wendy Cooper, Michael J Boyer, Steven Kao, Christopher C Goodnow
Cancer cells seem to exploit mechanisms that evolve as part of physiological tolerance, which is a complementary and often beneficial form of defense. The study of physiological systems of tolerance can therefore provide insights into the development of a state of host tolerance of cancer, and how to break it. Analysis of these models has the potential to improve our understanding of existing immunological therapeutic targets, and help to identify future targets and rational therapeutic combinations. The treatment of cancer with immune checkpoint inhibitors aims to reverse the progression to tolerance of cancer, and achieve an immunogenic, rather than tolerogenic, homeostasis...
August 2018: BioEssays: News and Reviews in Molecular, Cellular and Developmental Biology
Joel Ang, Chih-Kang David Liou, Harry P Schneider
Placental membrane grafts have long been used in the realms of wound care and ophthalmology to assist in the healing cascade. Recently, surgeons have started to implant placental membrane grafts in a wide variety of foot and ankle surgeries to take advantage of their many touted benefits. The application of placental membrane grafts for cases of lower extremity tendinopathy is detailed in this article.
July 2018: Clinics in Podiatric Medicine and Surgery
Gian Carlo Di Renzo, Valentina Tosto, Irene Giardina
The time of birth is a critical determinant of perinatal and long-term outcomes. Preterm birth is still the first cause of infant mortality and morbidity; unfortunately, rates of preterm birth remain high in both high- and low-resource countries, ranging from 5% to 18%. Preterm parturition is a syndrome, which can be induced by various factors such as infection, cervical pathology, uterine overdistension, progesterone deficiency, vascular alterations (utero-placental ischemia, decidual hemorrhage), maternal and fetal stress, allograft reaction, allergic phenomena, and probably other several unknown factors...
October 2018: Best Practice & Research. Clinical Obstetrics & Gynaecology
Christopher M Dress, Elisabet K Tassis
Dupuytren's disease (DD) is a rare connective tissue disorder resulting in progressive fibrosis and thickening of the palmar fascia, and contracture of the fingers due to excessive collagen deposition. Staged surgical interventions are reserved for severe cases, yet worsening of fibrosis and contracture of fingers post-surgery, has been reported to have a recurrence rate as high as 85%. Here, the authors report on use of viable cryopreserved placental membrane (vCPM) allograft as an adjunct to open fasciectomy...
March 2018: Journal of Surgical Case Reports
Sarah Grace George, Anil Kumar Kanakamedala, Jaideep Mahendra, Nashra Kareem, Little Mahendra, Jeethu John Jerry
AIM: The aim of the present study was to compare the treatment of gingival recession defects using a coronally-advanced flap procedure with or without placental membrane. METHODS: Sixty teeth in 15 patients with single and multiple Miller's class I and II gingival recession defects bilaterally in the anterior and premolar region of the maxilla and mandible were divided into two groups. In group I (control), 30 recession defects were treated with coronally-advanced flap alone using Zucchelli's technique...
August 2018: Journal of Investigative and Clinical Dentistry
Katherine Leavey, Samantha L Wilson, Shannon A Bainbridge, Wendy P Robinson, Brian J Cox
Background: Preeclampsia (PE) is a heterogeneous, hypertensive disorder of pregnancy, with no robust biomarkers or effective treatments. We hypothesized that this heterogeneity is due to the existence of multiple subtypes of PE and, in support of this hypothesis, we recently identified five clusters of placentas within a large gene expression microarray dataset ( N  = 330), of which four (clusters 1, 2, 3, and 5) contained a substantial number of PE samples. However, while transcriptional analysis of placentas can subtype patients, we propose that the addition of epigenetic information could discern gene regulatory mechanisms behind the distinct PE pathologies, as well as identify clinically useful potential biomarkers...
2018: Clinical Epigenetics
Yuko Arita, Corinne Yeh, Theodosia Thoma, Darios Getahun, Ramkumar Menon, Morgan R Peltier
Polybrominated diphenyl ethers (PBDEs) are pollutants that may increase the risk of preterm birth. In previous studies, we found that a mixture of PBDEs altered the expression of biomarkers for preterm birth by the placenta. However, there are 209 different PBDE congeners with different tissue distributions. How these different congeners may alter the production of immunomodulators by the placenta that help to maintain the survival of the fetal allograft is unclear. Therefore, we compared the effects 5 common congeners on basal and bacteria-stimulated cytokine production by the placenta...
February 2018: Journal of Reproductive Immunology
Xingbo P Sun, Amy G Wilson, Georgina M Michael
Plantar fasciitis is one of the most common conditions encountered by a podiatric physician. Although most individuals respond well to traditional conservative and surgical remedies, a portion of patients will exhaust all available treatment options and will experience ongoing pain that can ultimately affect their quality of life. There has been an increase in scientific and clinical research surrounding the medical use of human placental membranes (HPMs) and many of these point-of-care allografts are now commercially available...
May 2018: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
Eric L Johnson, Elisabet K Tassis, Georgina M Michael, Susan G Whittinghill
RATIONALE: Occupational burn injuries can be detrimental and difficult to manage. The majority of complex cases are referred and managed at regional burn centers where access to specialized care is available. As an alternative to hospitalization with staged surgical procedures, placental products may be used for outpatient medical management of these common burn injuries, especially if access to a regional burn center is limited or restricted.Fresh amnion has been a treatment of choice in burns for more than 100 years...
December 2017: Medicine (Baltimore)
Lawrence A DiDomenico, Dennis P Orgill, Robert D Galiano, Thomas E Serena, Marissa J Carter, Jarrod P Kaufman, Nathan J Young, Charles M Zelen
BACKGROUND: In a recently published, prospective randomized controlled trial (RCT) comparing aseptically processed dehydrated human amnion/chorion allograft (dHACA) to standard of care (SOC), 85% wound closure rates were reported in the dHACA arm while only 25% of patients in the SOC arm healed. OBJECTIVE: The purpose of this retrospective crossover study is to evaluate the effectiveness of dHACA in those patients that failed to respond to the SOC treatments and who exited the original study after failing up to 12 weeks of SOC treatment...
July 26, 2017: Wounds: a Compendium of Clinical Research and Practice
Amy Johnson, Alexandra Gyurdieva, Sandeep Dhall, Yi Duan-Arnold, Alla Danilkovitch
No abstract text is available yet for this article.
November 2017: Annals of Plastic Surgery
Eli Maymon, Roberto Romero, Gaurav Bhatti, Piya Chaemsaithong, Nardhy Gomez-Lopez, Bogdan Panaitescu, Noppadol Chaiyasit, Percy Pacora, Zhong Dong, Sonia S Hassan, Offer Erez
OBJECTIVE: The objective of this study is to determine whether the amniotic fluid (AF) concentration of soluble CXCR3 and its ligands CXCL9 and CXCL10 changes in patients whose placentas show evidence of chronic chorioamnionitis or other placental lesions consistent with maternal anti-fetal rejection. METHODS: This retrospective case-control study included 425 women with (1) preterm delivery (n=92); (2) term in labor (n=68); and (3) term not in labor (n=265). Amniotic fluid CXCR3, CXCL9 and CXCL10 concentrations were determined by ELISA...
February 23, 2018: Journal of Perinatal Medicine
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