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JOURNAL ARTICLE
Hiroyuki Ishiyama, Hyunjin Kim, Satoshi Saito, Soichi Takeda, Misa Takegami, Yumi Yamamoto, Soichiro Abe, Shinsaku Nakazawa, Tomotaka Tanaka, Kazuo Washida, Yoshiaki Morita, Seung-Taek Oh, Hee-Jae Jung, Jay Chol Choi, Yuriko Nakaoku, Jin Nakahara, Masatoshi Koga, Kazunori Toyoda, Kisaki Amemiya, Yoshihiko Ikeda, Kinta Hatakeyama, Ikuko Mizuta, Toshiki Mizuno, Kwang-Kuk Kim, Masafumi Ihara
OBJECTIVES: Intracerebral hemorrhage (ICH) and cerebral microbleeds (CMB) in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy are more common in East Asian populations than in people of white European ancestry. We hypothesized that the ethnic difference is explained by the East Asian-specific NOTCH3 p.R75P mutation. METHODS: This retrospective observational study included 118 patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy in Japanese and Korean cohorts...
March 23, 2024: Annals of Neurology
#22
JOURNAL ARTICLE
Philipp Arndt, Christian Chahem, Michael Luchtmann, Jan-Niklas Kuschel, Daniel Behme, Malte Pfister, Jens Neumann, Michael Görtler, Marc Dörner, Marc Pawlitzki, Robin Jansen, Sven G Meuth, Stefan Vielhaber, Solveig Henneicke, Stefanie Schreiber
BACKGROUND: Sporadic cerebral small-vessel disease (CSVD), i.e., hypertensive arteriopathy (HA) and cerebral amyloid angiopathy (CAA), is the main cause of spontaneous intracerebral hemorrhage (ICH). Nevertheless, a substantial portion of ICH cases arises from non-CSVD etiologies, such as trauma, vascular malformations, and brain tumors. While studies compared HA- and CAA-related ICH, non-CSVD etiologies were excluded from these comparisons and are consequently underexamined with regard to additional factors contributing to increased bleeding risk beyond their main pathology...
2024: Frontiers in Neurology
#23
JOURNAL ARTICLE
Yi Yan, Kemeng Zhang, Wansi Zhong, Shenqiang Yan, Bing Zhang, Jianhua Cheng, Min Lou
OBJECTIVES: To explore the influence factors for futile recanalization following endovascular treatment (EVT) in patients with acute basilar artery occlusion (BAO). METHODS: Clinical data of patients with acute BAO, who underwent endovascular treatment within 24 h of onset from January 2017 to November 2022, were retrospectively analyzed. The futile recanalization was defined as modified Thrombolysis in Cerebral Infarction (mTICI)≥2b or 3 after successful reperfusion, but the modified Rankin Scale score >2 at 90d after EVT...
March 18, 2024: Zhejiang da Xue Xue Bao. Yi Xue Ban, Journal of Zhejiang University. Medical Sciences
#24
JOURNAL ARTICLE
K Kaushik, M J H Wermer, E S van Etten
BACKGROUND AND PURPOSE: Patients who underwent red blood cell (RBC) transfusion from donors who later developed multiple spontaneous intracerebral hemorrhages (ICHs) have recently been identified to have increased risk of ICH themselves. This increased risk of ICH was hypothesized to be related to iatrogenic cerebral amyloid angiopathy (iCAA) transmission. Two cases are presented who had RBC transfusion as an infant and presented with CAA at a relatively young age decades later. METHOD: Cases were identified by prospectively asking all patients at our CAA outpatient clinic (November 2023 to January 2024) about a medical history with RBC transfusion or history with a high likelihood for RBC transfusion (e...
March 18, 2024: European Journal of Neurology
#25
JOURNAL ARTICLE
Huan Zhu, Qihang Zhang, Wenjie Li, Peijiong Wang, Qian Zhang, Dong Zhang, Yan Zhang
AIM: To evaluate and compare postoperative ischemic complications to determine the risk factors for ischemic complications following revascularization surgery for Moyamoya disease (MMD). MATERIAL AND METHODS: This single-center retrospective study included 266 procedures between 2016 and 2021. Three types of revascularization approaches including direct bypass, indirect bypass, and combined bypass were performed. To identify risk factors for postoperative ischemic complications and contralateral cerebral infarction, preoperative clinical characteristics and radiographic features were examined using multivariate and ordinal logistic regression analyses...
2024: Turkish Neurosurgery
#26
REVIEW
Masaki Mogi, Yasuhito Ikegawa, Shunsuke Haga, Satoshi Hoshide, Kazuomi Kario
Hypertension, a disease whose prevalence increases with age, induces pathological conditions of ischemic vascular disorders such as cerebral infarction and myocardial infarction due to accelerated arteriosclerosis and circulatory insufficiency of small arteries and sometimes causes hemorrhagic conditions such as cerebral hemorrhage and ruptured aortic aneurysm. On the other hand, as it is said that aging starts with the blood vessels, impaired blood flow associated with vascular aging is the basis for the development of many pathological conditions, and ischemic changes in target organs associated with vascular disorders result in tissue dysfunction and degeneration, inducing organ hypofunction and dysfunction...
March 15, 2024: Hypertension Research: Official Journal of the Japanese Society of Hypertension
#27
JOURNAL ARTICLE
Jan Leppert, Jan Küchler, Andreas Wagner, Niclas Hinselmann, Claudia Ditz
BACKGROUND: Volatile sedation is still used with caution in patients with acute brain injury because of safety concerns. We analyzed the effects of sevoflurane sedation on systemic and cerebral parameters measured by multimodal neuromonitoring in patients after aneurysmal subarachnoid hemorrhage (aSAH) with normal baseline intracranial pressure (ICP). METHODS: In this prospective observational study, we analyzed a 12-h period before and after the switch from intravenous to volatile sedation with sevoflurane using the Sedaconda Anesthetic Conserving Device with a target Richmond Agitation Sedation Scale score of - 5 to - 4...
March 14, 2024: Neurocritical Care
#28
JOURNAL ARTICLE
Daniel Strunk, Peter Bauer, Kathy Keyvani, Rolf R Diehl, Roland Veltkamp, Peter Berlit, Sven G Meuth, Lars Timmermann, Jan Claudius Schwitalla, Markus Kraemer
BACKGROUND: Moyamoya disease (MMD) is a rare disorder causing ischemic and hemorrhagic juvenile stroke. It is associated with the founder susceptibility variant p.R4810K in the RNF213 gene in East Asia. Our aim was to enhance understanding of MMD in so far poorly characterized Southeast Asians and exploring differences with Caucasian Europeans. METHODS: By retrospective analysis of medical records and systematic database search on PubMed for all published cases, we identified Southeast Asian patients with MMD...
March 13, 2024: Journal of Neurology
#29
JOURNAL ARTICLE
Lei Jiang, Jinjie Tian, Chao Guo, Yi Zhang, Ming Qian, Xuejian Wang, Zhifeng Wang, Yang Chen
OBJECTIVE: To compare neuronavigation-assisted intracerebral hematoma puncture and drainage with neuroendoscopic hematoma removal for treatment of hypertensive cerebral hemorrhage. METHOD: Ninety-one patients with hypertensive cerebral hemorrhage admitted to our neurosurgery department from June 2022 to May 2023 were selected: 47 patients who underwent endoscopic hematoma removal with the aid of neuronavigation in observation Group A and 44 who underwent intracerebral hematoma puncture and drainage in control Group B...
March 12, 2024: BMC Surgery
#30
JOURNAL ARTICLE
Luis Prats-Sanchez, Pol Camps-Renom, Philip S Nash, Duncan Wilson, Gareth Ambler, Jonathan G Best, Marina Guasch-Jiménez, Anna Ramos-Pachón, Alejandro Martinez-Domeño, Álvaro Lambea-Gil, Garbiñe Ezcurra Díaz, Daniel Guisado-Alonso, Houwei Du, Rustam Al-Shahi Salman, Hans Rolf Jäger, Gregory Y Lip, Hakan Ay, Simon Jung, Natan M Bornstein, Thomas Gattringer, Sebastian Eppinger, Dianne H van Dam-Nolen, Masatoshi Koga, Kazunori Toyoda, Felix Fluri, Thanh G Phan, Velandai K Srikanth, Ji Hoe Heo, Hee-Joon Bae, Peter J Kelly, Toshio Imaizumi, Julie Staals, Sebastian Köhler, Yusuke Yakushiji, Dilek Necioglu Orken, Eric E Smith, Joanna M Wardlaw, Francesca M Chappell, Stephen D Makin, Jean-Louis Mas, David Calvet, Régis Bordet, Christopher P Chen, Roland Veltkamp, Nagaendran Kandiah, Robert J Simister, Frank-Erik De Leeuw, Stefan T Engelter, Nils Peters, Yannie O Soo, Annaelle Zietz, Jeroen Hendrikse, Werner H Mess, David J Werring, Joan Marti-Fabregas
BACKGROUND AND OBJECTIVES: The association between statin use and the risk of intracranial hemorrhage (ICrH) following ischemic stroke (IS) or transient ischemic attack (TIA) in patients with cerebral microbleeds (CMBs) remains uncertain. This study investigated the risk of recurrent IS and ICrH in patients receiving statins based on the presence of CMBs. METHODS: We conducted a pooled analysis of individual patient data from the Microbleeds International Collaborative Network, comprising 32 hospital-based prospective studies fulfilling the following criteria: adult patients with IS or TIA, availability of appropriate baseline MRI for CMB quantification and distribution, registration of statin use after the index stroke, and collection of stroke event data during a follow-up period of ≥3 months...
April 9, 2024: Neurology
#31
Junya Tatezuki, Sujong Pak, Fukutaro Ohgaki, Yasunori Takemoto, Yasuhiko Mochimatsu
Hemorrhagic changes in a dural arteriovenous fistula are typically associated with cortical venous reflux and occur as intracerebral or subarachnoid hemorrhages. A convexity dural arteriovenous fistula (DAVF) usually flows directly into the cortical veins and exhibits cortical venous reflux. Herein, we report a rare case of a convexity DAVF without cortical venous reflux presenting with a pure acute subdural hematoma. A 19-year-old man complaining of headache without any history of head injury was diagnosed with a left acute subdural hematoma on magnetic resonance imaging (MRI) and referred to our hospital...
2024: NMC Case Report Journal
#32
JOURNAL ARTICLE
Xiao-Gang Wang, Ya-Bin Lu, Qian Li
Intracerebral hemorrhage (ICH) is the most common subtype of stroke with high disability and high mortality rates. Due to the hypertension with arteriosclerosis, hemopathy and cerebrovascular amyloidosis, the influx of blood from ruptured vessels into the brain destroys the cerebral parenchyma and results in dysfunction of central nervous system because of hematoma compression and a series of toxic metabolites. The cerebral parenchyma consists of gray and white matter. The white matter consists of myelinated axons and oligodendrocytes, whereas the gray matter consists of neuronal cell bodies and dendrites...
February 25, 2024: Sheng Li Xue Bao: [Acta Physiologica Sinica]
#33
JOURNAL ARTICLE
Li-Na Yang, Yi Sun, Yu-Zhu Wang, Jing Wang, Yi-Sha Qi, Shan-Shan Mu, Yun-Peng Liu, Zi-Qing Zhang, Zi-Mo Chen, Xiao-Jie Wang, Wu-Xiang Xie, Chang-Wei Wei, Yang Wang, An-Shi Wu
BACKGROUND: Endovascular thrombectomy (EVT) is a standard treatment for acute ischemic stroke (AIS) with large vessel occlusion. Hypertension and increased blood pressure variability within the first 24 h after successful reperfusion are related to a higher risk of symptomatic intracerebral hemorrhage and higher mortality. AIS patients might suffer from ischemia-reperfusion injury following reperfusion, especially within 24 h. Dexmedetomidine (DEX), a sedative commonly used in EVT, can stabilize hemodynamics by inhibiting the sympathetic nervous system and alleviate ischemia-reperfusion injury through anti-inflammatory and antioxidative properties...
March 4, 2024: Trials
#34
JOURNAL ARTICLE
Anthony Diaz, Jimin Shin, Ketan R Bulsara
BACKGROUND: Intracranial aneurysms are prevalent, particularly with advancing age. De novo aneurysms, occurring independently from the initial lesion, pose a unique challenge because of their unpredictable nature. Although risk factors such as female sex, smoking history, and hypertension have been proposed, the mechanisms underlying de novo aneurysm development remain unclear. OBSERVATIONS: A 79-year-old female developed a de novo saccular aneurysm within a year after management of a ruptured vertebral artery dissecting aneurysm...
March 4, 2024: J Neurosurg Case Lessons
#35
JOURNAL ARTICLE
Tsz Ching Lee, William Cy Leung, Chun Ho, Megan Wl Chiu, Ian Yh Leung, Yuen Kwun Wong, Roxanna K C Liu, Christopher Hf Sum, David Tw Lui, Raymond Cheung, Gilberto Ka Kit Leung, Koon Ho Chan, Kay-Cheong Teo, G K K Lau
BACKGROUND: Recent intensive LDL-C lowering trials, including FOURIER, ODYSSEY OUTCOMES, and TST trials, have mostly refuted the concern surrounding statin use, low-density lipoprotein cholesterol (LDL-C) lowering, and intracerebral hemorrhage (ICH) risk. However, the results from these trials may not be fully applied to ICH survivors, as the populations studied were mainly patients without prior ICH, in whom the inherent ICH risk is more than ten times lower than that of ICH survivors...
March 1, 2024: International Journal of Stroke: Official Journal of the International Stroke Society
#36
JOURNAL ARTICLE
Lauren R Miller, Marisa A Bickel, Stefano Tarantini, Megan E Runion, Zoe Matacchiera, Michaela L Vance, Clara Hibbs, Hannah Vaden, Domonkos Nagykaldi, Teryn Martin, Elizabeth C Bullen, Jessica Pinckard, Tamas Kiss, Eric W Howard, Andriy Yabluchanskiy, Shannon M Conley
INTRODUCTION: Cerebrovascular pathologies contribute to cognitive decline during aging, leading to vascular cognitive impairment and dementia (VCID). Levels of circulating insulin-like growth factor 1 (IGF-1), a vasoprotective hormone, decrease during aging. Decreased circulating IGF-1 in animal models leads to the development of VCID-like symptoms, but the cellular mechanisms underlying IGF-1-deficiency associated pathologies in the aged cerebrovasculature remain poorly understood. Here, we test the hypothesis that vascular smooth muscle cells (VSMCs) play an integral part in mediating the vasoprotective effects of IGF-1...
2024: Frontiers in Aging Neuroscience
#37
JOURNAL ARTICLE
Anna Gerasimenko, Cyril Mignot, Olivier Naggara, Florence Coulet, Samar Ekram, Solveig Heide, Clarisse Sorato, Maxime Mazowiecki, Laurence Perrin, Chrystelle Colas, Veronica Cusin, Frédéric Caux, Antoine Dardenne, Salima El Chehadeh, Alain Verloes, Hélène Maurey, Alexandra Afenjar, Florence Petit, Stéphane Barete, Odile Boespflug-Tanguy, Emmanuelle Bourrat, Yline Capri, Viorica Ciorna, Wallid Deb, Diane Doummar, Alexandre Perrier, Alexis Guédon, Emmanuel Houdart, Bertrand Isidor, Marie-Line Jacquemont, Camille Buffet, Sandra Mercier, Sandrine Passemard, Audrey Riquet, Lyse Ruaud, Elise Schaefer, Delphine Heron, Annouk Bisdorff, Patrick R Benusiglio
Central nervous system (CNS) dural arteriovenous fistulas (DAVF) have been reported in PTEN-related hamartoma tumor syndrome (PHTS). However, PHTS-associated DAVF remain an underexplored field of the PHTS clinical landscape. Here, we studied cases with a PTEN pathogenic variant identified between 2007 and 2020 in our laboratory (n = 58), and for whom brain imaging was available. Two patients had DAVF (2/58, 3.4%), both presenting at advanced stages: a 34-year-old man with a left lateral sinus DAVF at immediate risk of hemorrhage, and a 21-year-old woman with acute intracranial hypertension due to a torcular DAVF...
February 29, 2024: Clinical Genetics
#38
JOURNAL ARTICLE
Meng Wang, Jue Lu, Ziwei Lu, Zhong Wang, Zhuo Wang, Chao Wu
Background: Constipation is common in elderly inpatients with intracerebral hemorrhage. This study aimed to construct a model for predicting the risk of constipation in elderly inpatients with intracerebral hemorrhage and to provide reference for formulating targeted intervention measures. Methods: Elderly patients with intracerebral hemorrhage who were treated in the department of Neurosurgery of a third-class hospital in Suzhou from January 2018 to September 2023 were included. Clinical data of patients with and without constipation were compared...
February 26, 2024: Biological Research for Nursing
#39
REVIEW
Yu-Tong Liu, Chun-Yan Lei, Lian-Mei Zhong
OBJECTIVE: The purpose of this review is to identify the correlation between ICH and CSVD imaging markers under SMASH-U classification by searching and analyzing a large number of literatures in recent years, laying a theoretical foundation for future clinical research. At the same time, by collecting clinical data to evaluate patient prognosis, analyzing whether there are differences or supplements between clinical trial conclusions and previous theories, and ultimately guiding clinical diagnosis and treatment through the analysis of imaging biomarkers...
2024: Neuropsychiatric Disease and Treatment
#40
JOURNAL ARTICLE
Jinwei Li, Cong Liang, Junsun Dang, Yang Zhang, Hongmou Chen, Xianlei Yan, Quan Liu
Hypertensive Intracerebral Hemorrhage (HICH) is one of the most common types of cerebral hemorrhage with a high mortality and disability rate. Currently, preoperative non-contrast computed tomography (NCCT) scanning-guided stereotactic hematoma removal has achieved good results in treating HICH, but some patients still have poor prognoses. This study collected relevant clinical and radiomic data by retrospectively collecting and analyzing 432 patients who underwent stereotactic hematoma removal for HICH from January 2017 to December 2020 at the Liuzhou Workers Hospital...
2024: Frontiers in Surgery
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