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https://read.qxmd.com/read/30900858/-preparation-of-hydrophilic-magnetic-molecularly-imprinted-resins-of-chlorogenic-acid-and-evaluation-of-its-solid-phase-extraction-performance
#1
Sheng Peng, Huan Li, Shuyun Shi
Hydrophilic, magnetic molecularly imprinted resins (MMIRs) were fabricated inside Fe3 O4 @mSiO2 pores by the one-pot copolycondensation of chlorogenic acid (CGA), resorcinol, melamine, and formaldehyde. The final porous MMIRs with larger numbers of surface recognition sites were obtained by removing mSiO2 . The successful preparation of MMIRs was confirmed using transmission electron microscopy, Fourier transform infrared spectroscopy, vibrating sample magnetometry, thermo-gravimetric analysis, and water contact angle analysis...
March 8, 2019: Se Pu, Chinese Journal of Chromatography
https://read.qxmd.com/read/30900857/-preparation-and-application-of-melamine-molecularly-imprinted-photonic-crystal-hydrogel-sensor
#2
Zhehan Liu, Xin Zhang, Axin Liang, Liquan Sun, Aiqin Luo
In this paper, molecularly imprinted photonic crystal hydrogels (MIPHs) were prepared by combining photonic crystals with molecular imprinting technology. The MIPHs were used as optical sensors for the rapid reorganization and detection of melamine in water samples. In this experiment, melamine was used as a template molecule, and the MIPHs were prepared by successive self-assembly, polymerization, and template removal. Morphological characterization by scanning electron microscopy (SEM) showed that the MIPHs possessed a highly ordered three-dimensional (3D) macroporous structure containing nanocavities...
March 8, 2019: Se Pu, Chinese Journal of Chromatography
https://read.qxmd.com/read/30900808/molecularly-imprinted-polymeric-shell-coated-monodisperse-porous-silica-microspheres-as-a-stationary-phase-for-microfluidic-boronate-affinity-chromatography
#3
ÇağılZeynep Süngü, Çiğdem Kip, Ali Tuncel
Molecular imprinting of cis-diol functionalized agents via boronate affinity interaction has been usually performed using nanoparticles as supports which can not be utilized as a stationary phase in continuous microcolumn applications. In this study, monodisperse-porous, spherical silica particles in micron-size range, with bimodal pore diameter distribution were selected as a new support for the synthesis of a molecularly imprinted boronate affinity sorbent, using a cis-diol functionalized agent as the template...
March 22, 2019: Journal of Separation Science
https://read.qxmd.com/read/30898153/genome-wide-methylation-profiling-of-beckwith-wiedemann-syndrome-patients-without-molecular-confirmation-after-routine-diagnostics
#4
I M Krzyzewska, M Alders, S M Maas, J Bliek, A Venema, P Henneman, F I Rezwan, K V D Lip, A N Mul, D J G Mackay, M M A M Mannens
Beckwith-Wiedemann syndrome (BWS) is caused due to the disturbance of imprinted genes at chromosome 11p15. The molecular confirmation of this syndrome is possible in approximately 85% of the cases, whereas in the remaining 15% of the cases, the underlying defect remains unclear. The goal of our research was to identify new epigenetic loci related to BWS. We studied a group of 25 patients clinically diagnosed with BWS but without molecular conformation after DNA diagnostics and performed a whole genome methylation analysis using the HumanMethylation450 Array (Illumina)...
March 21, 2019: Clinical Epigenetics
https://read.qxmd.com/read/30897554/direct-cell-imprint-lithography-in-superconductive-carbon-black-polymer-composites-process-optimization-characterization-and-in-vitro-toxicity-analysis
#5
Vigneswaran Narayanamurthy, Fahmi Samsuri, Al'aina Yuhainis Firus Khan, Hairul Aini Hamzah, Madia Baizura Baharom, Kumary Tv, Anil Kumar Pr, Deepa K Raj
Cell imprint lithography (CIL) or cell replica plays a vital role in the fields like biomimetic smart culture substrates, bone tissue engineering, cell guiding, cell adhesion, tissue engineering, cell microenvironment, tissue microenvironment, cell research, drug delivery, diagnostic, therapeutic and many other applications. Herein we report a new formulation of superconductive carbon black photopolymer composite and its characterization towards cell imprint lithography (CIL) process technique. In this article, demonstrated an approach of carbon nanoparticle-polymer composite (CPC) for patterning cells...
March 21, 2019: Bioinspiration & Biomimetics
https://read.qxmd.com/read/30892007/ultrasensitive-microfluidic-paper-based-electrochemical-biosensor-based-on-molecularly-imprinted-film-and-boronate-affinity-sandwich-assay-for-glycoprotein-detection
#6
Xiaolu Sun, Yannan Jian, He Wang, Shenguang Ge, Mei Yan, Jinghua Yu
In this work, we proposed a strategy that combined molecularly imprinted polymers (MIPs) and hybridization chain reaction into microfluidic paper-based analytical devices for ultrasensitive detecting target glycoprotein ovalbumin (OVA). In the fabrication, Au nanorods with large surface area and superior conductibility grew on paper cellulosic fiber as a matrix to fix a boronate-affinity sandwich assay. The composite of MIPs including 4-mercaptophenylboronic acid (MPBA) was able to capture target glycoprotein OVA...
March 20, 2019: ACS Applied Materials & Interfaces
https://read.qxmd.com/read/30889872/sensing-by-molecularly-imprinted-polymer-evaluation-of-the-binding-properties-with-different-techniques
#7
Maria Pesavento, Simone Marchetti, Letizia De Maria, Luigi Zeni, Nunzio Cennamo
The possibility of investigating the binding properties of the same molecularly imprinted polymer (MIP), most probably heterogeneous, at various concentration levels by different methods such as batch equilibration and sensing, is examined, considering two kinds of sensors, based respectively on electrochemical and surface plasmon resonance (SPR) transduction. As a proof of principle, the considered MIP was obtained by non-covalent molecular imprinting of 2-furaldehyde (2-FAL). It has been found that different concentration ranges of 2-FAL in aqueous matrices can be measured by the two sensing methods...
March 18, 2019: Sensors
https://read.qxmd.com/read/30889694/nanoporous-imprinted-polymers-nanomips-for-controlled-release-of-cancer-drug
#8
Bhagyashree A Korde, Juili S Mankar, Sumidha Phule, Reddithota J Krupadam
In this article, a new approach to directly synthesize drug molecule imbedded in the nanometer sized polymer particles is reported. Molecular imprinting is used to prepare polymers for drug specific for selectively loading of a desired drug. Computer simulations were performed to provide mechanistic insights on the binding modalities of model cancer drug, amygdalin with the polymer precursors. Controlled release of amygdalin from nanoMIPs was studied in vitro cell test and monitoring the absorbance at λem of 390 nm by fluorescence...
June 2019: Materials Science & Engineering. C, Materials for Biological Applications
https://read.qxmd.com/read/30888522/phosphorimetric-determination-of-4-nitrophenol-using-mesoporous-molecular-imprinting-polymers-containing-manganese-ii-doped-zns-quantum-dots
#9
Shiqing Luo, Yanming Miao, Junping Guo, Xiaojie Sun, Guiqin Yan
Mesoporous molecularly imprinted polymers (MIPs) containing mangnanese-doped ZnS quantum dots (Mn-ZnS QDs) were prepared for specific recognition and detection of 4-nitrophenol (4-NP). The Mn-ZnS QDs display orange room-temperature phosphorescence with excitation/emission peaks at 295/590 nm and a decay time of 2.0 ms. In the presence of 4-NP, the orange phosphorescence is strongly reduced. Phosphorescence drops linearly in the 0.1-100 μM 4-NP concentration range, and the detection limit is 60 nM. The detection limit is far lower than the maximally allowed 4-NP concentrations in surface water and drinking water as specified by the U...
March 19, 2019: Mikrochimica Acta
https://read.qxmd.com/read/30877344/rapid-detection-of-aflatoxin-b-1-by-dummy-template-molecularly-imprinted-polymer-capped-cdte-quantum-dots
#10
Pengqi Guo, Wu Yang, Hao Hu, Yitao Wang, Peng Li
A novel and sensitive fluorescent sensor was synthesized for the rapid and specific recognition of aflatoxin B1 (AFB1) by our combining molecular imprinting techniques with quantum dot technology. Molecularly imprinted polymers coated CdTe quantum dots (MIP@CdTe QDs) were prepared through the Stöber method with 5,7-dimethoxycoumarin as a dummy template. 3-Aminopropyltriethoxysilane was selected as the functional monomer, and tetraethyl orthosilicate was used as the cross-linking agent. The best molar ratio of 5,7-dimethoxycoumarin to functional monomer to cross-linker was 4:20:15...
March 15, 2019: Analytical and Bioanalytical Chemistry
https://read.qxmd.com/read/30876803/shannon-s-information-bernal-s-biopoiesis-and-bernoulli-distribution-as-pillars-for-building-a-definition-of-life
#11
Radosław W Piast, Radosław Piast
The quest for defining life has lasted since the beginning of modern science. During the last century, we have reached a lot of milestones toward the understanding of life and its molecular basis. Also, as living creatures, we have imprinted awareness about what is life and what is not. It seems like we have everything we need to formulate the definition of life. If so, why has one, that would satisfy everybody, not yet been announced? What is holding us back? Although we seem to know what life is, our understanding of its edges is still blurry...
March 12, 2019: Journal of Theoretical Biology
https://read.qxmd.com/read/30876637/organic-inorganic-nanoparticles-molecularly-imprinted-photoelectrochemical-sensor-for-%C3%AE-solanine-based-on-p-type-polymer-dots-and-n-cds-heterojunction
#12
Lebao Mao, Mengting Gao, Xiaojie Xue, Linli Yao, Wei Wen, Xiuhua Zhang, Shengfu Wang
In this study, a molecularly imprinted polymer photoelectrochemcal (MIP-PEC) sensor based on semiconducting organic polymer dots (Pdots) and inorganic CdS quantum dots (QDs) has been established for the determination of α-Solanine. Specifically, p-type Pdots (p-Pdots) and n-type CdS QDs (n-CdS) were utilized to form organic-inorganic nanoparticles p-n heterojunction to enhance signal response, and their specific energy levels (VB/CB or HOMO/LUMO) were calculated for photoelectrochemical (PEC) bioanalysis application...
June 20, 2019: Analytica Chimica Acta
https://read.qxmd.com/read/30876598/preparation-of-molecularly-imprinted-polymers-and-application-in-a-biomimetic-biotin-avidin-elisa-for-the-detection-of-bovine-serum-albumin
#13
Chen Guoning, Guo Pengqi, Wang Yan, Wang Lu, Shu Hua, Li Yunzhe, Jing Wanghui, Chang Chun, Fu Qiang
Immunoassay as a primary analytical tool is widely applied in the field of analysis. However, biological antibodies used in the routine immunoassay exhibit high cost and poor stability. Herein, in this study, a biomimetic ELISA method using molecularly imprinted polymers as a alternative to antibodies was developed. The molecularly imprinted polymers were prepared through dopamine polymerization using Fe3 O4 nanoparticles as magnetic nuclei, bovine serum albumin as a template, dopamine as a functional monomer and crosslinking agent...
June 1, 2019: Talanta
https://read.qxmd.com/read/30876553/molecularly-imprinted-polymers-coupled-to-mass-spectrometric-detection-for-metallothionein-sensing
#14
Tereza Vaneckova, Lucie Vanickova, Michaela Tvrdonova, Adam Pomorski, Artur Krężel, Tomas Vaculovic, Viktor Kanicky, Marketa Vaculovicova, Vojtech Adam
We report a facile method for detection of metallothionein (MT), a promising clinically relevant biomarker, in spiked plasma samples. This method, for the first time, integrates molecularly imprinted polymers as purification/pretreatment step with matrix assisted laser desorption/ionization time-of-flight mass spectrometric detection and with laser ablation inductively coupled plasma mass spectrometry for analysis of MTs. The prepared MT-imprinted polydopamine layer showed high binding capacity and specific recognition properties toward the template...
June 1, 2019: Talanta
https://read.qxmd.com/read/30876543/colorimetric-determination-of-total-protein-content-in-serum-based-on-the-polydopamine-protein-adsorption-competition-on-microplates
#15
Pasquale Palladino, Alvaro Brittoli, Emanuela Pascale, Maria Minunni, Simona Scarano
We report a facile, low-cost and safe analytical method for estimation of total protein content, even in complex matrix like human serum, by exploiting the competition between proteins and polydopamine (PDA) for surface binding. The surface coating has been examined by using a microplate reader taking the advantage of the PDA absorbance in the visible region, obtaining new insights into the modelling of polydopamine deposition and polymer/protein adsorption competition. This is helpful for rational development of imprinted biosensors, and potentially offering a with broad applications ranging from diagnostic tools in medicine to food analysis...
June 1, 2019: Talanta
https://read.qxmd.com/read/30871280/molecularly-imprinted-polymer-based-sensors-for-medical-applications
#16
REVIEW
Yeşeren Saylan, Semra Akgönüllü, Handan Yavuz, Serhat Ünal, Adil Denizli
Sensors have been extensively used owing to multiple advantages, including exceptional sensing performance, user-friendly operation, fast response, high sensitivity and specificity, portability, and real-time analysis. In recent years, efforts in sensor realm have expanded promptly, and it has already presented a broad range of applications in the fields of medical, pharmaceutical and environmental applications, food safety, and homeland security. In particular, molecularly imprinted polymer based sensors have created a fascinating horizon for surface modification techniques by forming specific recognition cavities for template molecules in the polymeric matrix...
March 13, 2019: Sensors
https://read.qxmd.com/read/30868507/preparation-of-molecularly-imprinted-composites-initiated-by-hemin-graphene-hybrid-nanosheets-and-its-application-in-detection-of-sulfamethoxazole
#17
Shao-Fei Guo, Xiao-Yu Chen, Peng Wang, Cheng Chen, Rui-Hua Pan, Yue-Tao Ling, Yi-Zhu Tang
Molecularly imprinted polymers (MIPs) exhibit high selectivity resulting from imprinted cavities and superior performance from functional materials, which have attracted much attention in many fields. However, the combination of MIPs film and functional materials is a great challenge. In this study, hemin/graphene hybrid nanosheets (H-GNs) were used to initiate the imprinted polymerization by catalyzing the generation of free radicals. Thus, MIPs using sulfamethoxazole as the template was directly prepared on the surface of H-GNs without any film modification...
February 2019: Current Medical Science
https://read.qxmd.com/read/30866048/preparation-of-magnetic-molecularly-imprinted-polymers-for-the-rapid-detection-of-diethylstilbestrol-in-milk-samples
#18
YuXia Huang, Tao Zhao, Jinxing He
BACKGROUND: Diethylstilbestrol (DES) residues are harmful to human health because of their potential carcinogenic properties. Therefore, it is important to develop a fast and efficient pretreatment method to prevent their harmful effects on human health and the environment. RESULTS: In this paper, two types of magnetic molecularly imprinted polymers (MMIPs) of DES were prepared by bulk polymerization and sol-gel, respectively. The synthetic materials were characterized by Fourier-transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM) and thermogravimetric analysis (TGA)...
March 13, 2019: Journal of the Science of Food and Agriculture
https://read.qxmd.com/read/30866009/assisted-reproductive-technology-and-epigenetics
#19
Anthony M DeAngelis, Anne E Martini, Carter M Owen
Assisted reproductive technology (ART) is responsible for 1.7% of births in the United States annually. Despite a large number of studies promoting the efficacy and safety of these practices, there have been reports of imprinting disorders occurring at higher frequencies in children born through ART. Driven by findings in animal studies, it has been postulated that various ART procedures employed at critical points in embryonic development may predispose the genomic imprinting process to errors. Alterations in DNA methylation patterns at imprinting control centers have been reported by some studies to occur more frequently in children with imprinting disorders conceived by ART compared with spontaneous conception, though these findings are not consistently demonstrated and controversy has surrounded the strength of these associations...
May 2018: Seminars in Reproductive Medicine
https://read.qxmd.com/read/30865607/synthesis-and-application-of-a-molecularly-imprinted-polymer-in-selective-solid-phase-extraction-of-efavirenz-from-water
#20
Sinothando P Mtolo, Precious N Mahlambi, Lawrence M Madikizela
Efavirenz is one of the antiretroviral drugs widely used to treat the human immunodeficiency virus. Antiretroviral drugs have been found to be present in surface water and wastewater. Due to complexity of environmental samples, solid-phase extraction (SPE) is used for isolation and pre-concentration of antiretroviral drugs prior to their chromatographic analysis. However, the commercially available SPE sorbents lack selectivity, which tends to prolong the analysis time. Therefore, in this study a molecularly imprinted polymer was synthesized for the specific recognition of efavirenz and then applied as the SPE sorbent for its extraction from wastewater and surface water samples...
January 2019: Water Science and Technology: a Journal of the International Association on Water Pollution Research
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