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Chinese herbal medicines

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https://read.qxmd.com/read/30772482/inhibitory-asic2-mediated-calcineurin-nfat-against-colorectal-cancer-by-triterpenoids-extracted-from-rhus-chinensis-mill
#1
Gang Wang, Yu-Zhu Wang, Yang Yu, Jun-Jie Wang
ETHNOPHARMACOLOGICAL RELEVANCE: Studies have shown that the etiology and pathogenesis of colorectal cancer are closely related to the tumor microenvironment, and the cancer tissue is still in the state of "energy deficit" and has to promote energy generation through high glycolysis. Rhus chinensis Mill is a Chinese herbal medicine used to treat various types of solid tumors in China. Colorectal cancer (CRC) is a heterogeneous disease group caused by abnormal changes in glucose metabolism resulted in lactic acid production, which remodels acidosis...
February 14, 2019: Journal of Ethnopharmacology
https://read.qxmd.com/read/30768873/traditional-chinese-medicine-enhances-growth-immune-response-and-resistance-to-streptococcus-agalactiae-in-nile-tilapia
#2
Emmanuel Delwin Abarike, Jichang Jian, Jufen Tang, Jia Cai, Huang Yu, Lihua Chen
Herbal supplements are suitable for improving fish health and combating diseases in fish culture. However, the mechanism of action of many herbal mixtures remains unclear. This study was conducted to evaluate the effects of traditional Chinese medicine (TCM; a mix of Astragalus membranaceus, Angelica sinensis, and Crataegus hupehensis at a ratio of 1:1:1 on a weight basis) on growth, immune response, and disease resistance in Nile tilapia Oreochromis niloticus. Experimental fish (mean ± SE weight = 57 ± 1 g) were divided into two groups: a control group and a TCM (10 g/kg) group...
February 15, 2019: Journal of Aquatic Animal Health
https://read.qxmd.com/read/30760647/shaoyao-gancao-tang-sg-tang-a-formulated-chinese-medicine-reduces-aggregation-and-exerts-neuroprotection-in-spinocerebellar-ataxia-type-17-sca17-cell-and-mouse-models
#3
Chiung-Mei Chen, Wan-Ling Chen, Chen-Ting Hung, Te-Hsien Lin, Ming-Chung Lee, I-Cheng Chen, Chih-Hsin Lin, Chih-Ying Chao, Yih-Ru Wu, Kuo-Hsuan Chang, Hsiu Mei Hsieh-Li, Guey-Jen Lee-Chen
Spinocerebellar ataxia (SCA) type 17 is an autosomal dominant ataxia caused by expanded polyglutamine (polyQ) tract in the TATA-box binding protein (TBP). Substantial studies have shown involvement of compromised mitochondria biogenesis regulator peroxisome proliferator-activated receptor gamma-coactivator 1 alpha (PGC-1α), nuclear factor erythroid 2-related factor 2 (NRF2), nuclear factor-Y subunit A (NFYA), and their downstream target genes in the pathogenesis of polyQ-expansion diseases. The extracts of Paeonia lactiflora ( P...
February 13, 2019: Aging
https://read.qxmd.com/read/30759600/heavy-metal-pollution-and-potential-health-risks-of-commercially-available-chinese-herbal-medicines
#4
Zhongzhen Wang, Hongbin Wang, Haijuan Wang, Qinchun Li, Yang Li
A survey was conducted to investigate the pollution and health risks of copper (Cu), cadmium (Cd), lead (Pb), arsenic (As), mercury (Hg) and zinc (Zn) in 60 Chinese herbal medicines (CHMs) collected from a market in Kunming City, Yunnan Province, China. Furthermore, eight CHMs (Cyathulae radix, Drynariae rhizoma, Peucedani radix, Homalomenae rhizoma, Dryopteris setosa, Polygonati rhizoma, Lilii bulbus, and Linderae radix) containing high Cd concentrations were selected to further analyse their Cd chemical forms...
February 25, 2019: Science of the Total Environment
https://read.qxmd.com/read/30758715/natural-cac-chemopreventive-agents-from-ilex-rotunda-thunb
#5
Yueqing Han, Lin Zhang, Wei Li, Xinran Liu, Jiao Xiao, Gang Chen, Ning Li
Colitis-associated cancer (CAC) is one of the most serious complications of inflammatory bowel disease. The pathogenesis of CAC is complicated and so far elusive, and the anti-inflammatory effect does not assure CAC preventive activity, making it difficult to discover CAC preventive drugs. In this study, we report the CAC preventive effect of the ethyl acetate (EIR) of Ilex rotunda Thunb., a traditional Chinese herbal medicine being clinically used to treat intestinal disease. We also report the results of screening for CAC preventive agents from EIR via a nuclear factor-kappa B (NF-κB) translocation model in Caco2 cells, since activated NF-κB can be used by tumor cells at the early stage of tumorigenesis...
February 13, 2019: Journal of Natural Medicines
https://read.qxmd.com/read/30754654/mori-ramulus-chin-ph-the-dried-twigs-of-morus-alba-l-part-1-discovery-of-two-novel-coumarin-glycosides-from-the-anti-hyperuricemic-ethanol-extract
#6
Jianbiao Yao, Houhong He, Jin Xue, Jianfang Wang, Huihui Jin, Jian Wu, Jiangning Hu, Ruwei Wang, Kenny Kuchta
In Traditional Chinese Medicine (TCM), Mori ramulus (Chin.Ph.)-the dried twigs of Morus alba L.-is extensively used as an antirheumatic agent and also finds additional use in asthma therapy. As a pathological high xanthine oxidase (XO, EC 1.1.3.22) activity is strongly correlated to hyperuricemy and gout, standard anti-hyperuremic therapy typically involves XO inhibitors like allopurinol, which often cause adverse effects by inhibiting other enzymes involved in purine metabolism. Mori ramulus may therefore be a promissing source for the development of new antirheumatic therapeutics with less side effects...
February 11, 2019: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/30744676/combination-of-acupuncture-and-chinese-herbal-formula-for-elderly-adults-with-mild-cognitive-impairment-protocol-for-a-randomized-controlled-trial
#7
Yueqi Chen, Wenjing Zhang, Huangan Wu, Lixing Lao, Jian Xu, Shifen Xu
BACKGROUND: Mild cognitive impairment (MCI) is known as a transitional status between normal cognitive function and Alzheimer's disease (AD). Acupuncture and Chinese herbal medicines (CHMs) are considered to be beneficial to patients with cognitive impairment. However, it is still unknown whether the combination of the two therapies could optimize the therapeutic effect for MCI. This trial is aimed to evaluate the therapeutic effects of acupuncture and the herbal formula Yishen Granule (YSG) for elderly patients with MCI...
February 11, 2019: Trials
https://read.qxmd.com/read/30742832/incidence-and-etiology-of-drug-induced-liver-injury-in-mainland-china
#8
Tao Shen, Yingxia Liu, Jia Shang, Qing Xie, Jun Li, Ming Yan, Jianming Xu, Junqi Niu, Jiajun Liu, Paul B Watkins, Guruprasad P Aithal, Raúl J Andrade, Xiaoguang Dou, Lvfeng Yao, Fangfang Lv, Qi Wang, Yongguo Li, Xinmin Zhou, Yuexin Zhang, Peilan Zong, Bin Wan, Zhengsheng Zou, Dongliang Yang, Yuqiang Nie, Dongliang Li, Yuya Wang, Xi'an Han, Hui Zhuang, Yimin Mao, Chengwei Chen
BACKGROUND & AIMS: We performed a nationwide, retrospective study to determine the incidence and causes of drug-induced liver injury (DILI) in mainland China. METHODS: We collected data on a total of 25,927 confirmed DILI cases, hospitalized from 2012 through 2014 at 308 medical centers in mainland China. We collected demographic, medical history, treatment, laboratory, disease severity, and mortality data from all patients. Investigators at each site were asked to complete causality assessments for each case whose diagnosis at discharge was DILI (n=29,478) according to the Roussel Uclaf Causality Assessment Method...
February 8, 2019: Gastroenterology
https://read.qxmd.com/read/30738116/total-flavonoid-aglycones-extract-in-radix-scutellariae-induces-cross-regulation-between-autophagy-and-apoptosis-in-pancreatic-cancer-cells
#9
Jiazhe Liu, Hongcheng Wang, Jianfa Wang, Qimeng Chang, Zhiqiu Hu, Xiaodong Shen, Jinfeng Feng, Ziping Zhang, Xubo Wu
ETHNOPHARMACOLOGICAL RELEVANCE: Radix Scutellariae (RS), the dried root of Scutellariae baicalensisGeorgi, known as a herbal medicine in several Asian countries including China, has been widely used to treat inflammation, hypertension, cardiovascular disease as well as cancer. The total flavonoid aglycone extracted (TFAE) was extracted by ethyl acetate and this extraction methodology was optimized and obtained the protection of Chinese patents. AIM OF THE STUDY: To investigate the underlying mechanism of the chemotherapeutic effects of TFAE in inducing autophagy and apoptosis in pancreatic cancer cells in vitro and in vivo...
February 6, 2019: Journal of Ethnopharmacology
https://read.qxmd.com/read/30736072/metabolism-of-scoparone-in-experimental-animals-and-humans
#10
Risto O Juvonen, Filip Novák, Eleni Emmanouilidou, Seppo Auriola, Juri Timonen, Aki T Heikkinen, Jenni Küblbeck, Moshe Finel, Hannu Raunio
Scoparone, a major constituent of the Chinese herbal medicine Yin Chen Hao, expresses beneficial effects in experimental models of various diseases. The intrinsic doses and effects of scoparone are dependent on its metabolism, both in humans and animals. We evaluated in detail the metabolism of scoparone in human, mouse, rat, pig, dog, and rabbit liver microsomes in vitro and in humans in vivo . Oxidation of scoparone to isoscopoletin via 6-O-demethylation was the major metabolic pathway in liver microsomes from humans, mouse, rat, pig and dog, whereas 7-O-demethylation to scopoletin was the main reaction in rabbit...
February 8, 2019: Planta Medica
https://read.qxmd.com/read/30734858/a-high-throughput-metabolomics-approach-for-the-comprehensive-differentiation-of-four-pulsatilla-adans-herbs-combined-with-a-nontargeted-bidirectional-screen-for-rapid-identification-of-triterpenoid-saponins
#11
Wendan Zhang, Honghong Jiang, Jianxi Yang, Gengshen Song, Di Wen, Wenqiao Liu, Miaomiao Jin, Qiao Wang, Yingfeng Du, Qian Sun, Liang Cao, Huijun Xu
Pulsatilla Adans (PSA) herbs (Ranunculaceae) have been widely used in traditional medicine in China and other countries. However, the authentication and quality control of PSA herbs have always been a challenging task due to their similar morphological characteristics and the diversity of the multiple components that exist in the complicated matrix. Herein, a novel integrated strategy combining UHPLC/Q-Orbitrap-MS techniques with chemometrics analysis is proposed for the discrimination of PSA materials. We developed a comprehensive method integrating a nontargeted bidirectionally screened (NTBDS) MS data set and a targeted extraction peak area analysis for the characterization of triterpenoid saponins of PSA from different species...
February 8, 2019: Analytical and Bioanalytical Chemistry
https://read.qxmd.com/read/30732199/the-efficacy-of-the-traditional-chinese-medicine-jia-wei-niu-bang-zi-granule-combined-with-methotrexate-in-treating-active-rheumatoid-arthritis-a-multicenter-randomized-double-blinded-controlled-clinical-trial
#12
Yi-Ru Wang, Li Liu, Xiao-Yun Wang, Qiong Wang, Min Yao, Xue-Jun Cui, Jian-Chun Mao, Jian Liu, Xiao-Hua Gu, Yong-Li Chen, Xiang Yu, Qi Shi, Qian-Qian Liang, Yong-Jun Wang
BACKGROUND: Rheumatoid arthritis (RA) is a chronic systemic and autoimmune inflammatory disease ending with the destruction of joints. Current therapies can relieve RA symptoms, but some also bring severe adverse events. Therefore, an effective and safe therapeutic strategy remains to be created to benefit patients with RA by large. Jia Wei Niu Bang Zi granule (NBZG) consisting of RA-fighting Chinese herbals has been used in Longhua Hospital in the last several decades. NBZG has potential therapeutic effect on RA, which should be evaluated by larger sample clinical trial...
February 2019: Medicine (Baltimore)
https://read.qxmd.com/read/30732144/herbal-medicine-zhengan-xifeng-decoction-for-essential-hypertension-protocol-for-a-systematic-review-and-meta-analysis
#13
Yonglian Huang, Yanhong Chen, Hairong Cai, Dongjie Chen, Xiaoming He, Zhixiong Li, Xiaojing Cai, Xiaohong Peng, Yaxiu Huang, Shaoping Li, Qifeng Cao, Ping Wang, Bojun Chen
BACKGROUND: Essential hypertension is one of the most common chronic diseases worldwide, as well as a leading risk factor for cardiocerebrovascular diseases. Zhengan Xifeng Decoction (ZGXFD) has been widely used to treat essential hypertension, but there is no systematic review by assessing efficacy and safety of ZGXFD on essential hypertension. Therefore, we aim to perform systematic review and meta-analysis to evaluate the efficacy and safety of ZGXFD in the treatment of essential hypertension...
February 2019: Medicine (Baltimore)
https://read.qxmd.com/read/30723517/a-randomized-controlled-clinical-trial-of-combining-therapy-with-traditional-chinese-medicine-based-psychotherapy-and-chinese-herbal-medicine-for-menopausal-women-with-moderate-to-serious-mood-disorder
#14
Yuyan Zeng, Xuchun Huang, Changqian Chen, Guangning Nie, Xiaojing Cao, Jiju Wang, Xiaoyun Wang
Objective: To comparatively examine the effectiveness and safety of the combination therapy of traditional Chinese medicine formula Bushen-Shugan granule and psychotherapy (BSSG-P) and Chinese herbal medicine Bushen-Shugan granule (BSSG) alone in the treatment of moderate to serious mood disorder in menopausal women. Methods: In our previous clinical studies, BSSG-P had been proved to be superior to BSSG, psychological treatment, and placebo in improving mild mood disorder in menopausal women...
2019: Evidence-based Complementary and Alternative Medicine: ECAM
https://read.qxmd.com/read/30723515/do-different-species-of-sargassum-in-haizao-yuhu-decoction-cause-different-effects-in-a-rat-goiter-model
#15
Dianna Liu, Feng Chen, Xue Yu, Linlin Xiu, Haiyan Liu, Shaohong Chen, Jie Gao, Chen Zhang, Na Li, Cheng He, Gansheng Zhong
Sargassum species combined with Glycyrrhiza uralensis is a famous herbal pair in traditional Chinese medicine, as one of the so-called "eighteen antagonistic medicaments." In the Chinese Pharmacopoeia, two different species of Sargassum , Sargassum pallidum and Sargassum fusiforme , are recorded but they are not clearly differentiated in clinical use. In this study, we aimed to determine whether the two species of Sargassum could result in different effects when combined with G. uralensis in Haizao Yuhu Decoction (HYD), which is used for treating thyroid-related diseases, especially goiter...
2019: Evidence-based Complementary and Alternative Medicine: ECAM
https://read.qxmd.com/read/30723409/protective-effects-of-18%C3%AE-glycyrrhetinic-acid-on-monocrotaline-induced-pulmonary-arterial-hypertension-in-rats
#16
Min Zhang, Zhi Chang, Fang Zhao, Peng Zhang, Yin-Ju Hao, Lin Yan, Ning Liu, Jun-Li Wang, Lei Bo, Ping Ma, Wei Zhou, Xuan Ma, Qing-Bin Xu, Ru Zhou
Pulmonary arterial hypertension (PAH) is a destructive and rare disorder characterized by a progressive increase in pulmonary artery pressure and vasoconstriction, ultimately leading to right ventricular failure and death. 18β-Glycyrrhetinic acid (18β-GA) is an active ingredient in the commonly used Chinese herbal medicine radix glycyrrhizae, and it possesses antioxidant, anti-inflammatory, anti-tumor, and other pharmacological properties. This study aimed to determine whether 18β-GA has protective effects against monocrotaline (MCT)-induced PAH and whether it is associated with oxidative stress...
2019: Frontiers in Pharmacology
https://read.qxmd.com/read/30721331/association-of-use-of-chinese-herbal-medicines-and-the-risk-of-fracture-in-patients-with-osteoporosis-a-population-based-cohort-study
#17
W-J Chen, H Livneh, M-H Hsieh, C-C Yeh, M-H Yeh, M-C Lu, J-T Chien, T-Y Tsai
After utilizing a large population-based claims database and the application of propensity score match approach to reduce the confounding effects, we found that the use of Chinese herbal medicines (CHMs) was related to the lower risk of sequent osteoporotic fracture by 27% among the individuals with osteoporosis. The predominant effect was observed in those receiving CHMs for more than two years. INTRODUCTION: Osteoporosis (OS) is a highly disabling condition that can lead to fragility fracture, thus posing greater burdens of functional limitations for the affected individuals...
February 5, 2019: Osteoporosis International
https://read.qxmd.com/read/30719373/stability-of-alkaloids-during-drying-process-and-their-effect-on-anticoagulating-activity-of-uncariae-ramulus-cum-uncis
#18
Lu Zou, Fengyu Lu, Bing Lin, Ying Zhou, Tingting Liu, Yue Sun
The drying process of Uncariae Ramulus Cum Uncis (URCU), a kind of traditional Chinese medicine, was studied in a scale dryer in laboratory at 65°C. It was observed that the alkaloids content of URCU firstly showed a tendency of increasing and then decreasing after reaching the peak at the 570th minute in the process of constant temperature drying. Moreover, the coagulation time of rabbit determined by test tubes has been adopted to study the effect imposed by the content of alkaloids on the anticoagulating activity of URCU...
2019: Journal of Analytical Methods in Chemistry
https://read.qxmd.com/read/30719123/chinese-herbal-medicine-wenxia-changfu-formula-reverses-cell-adhesion-mediated-drug-resistance-via-the-integrin-%C3%AE-1-pi3k-akt-pathway-in-lung-cancer
#19
YaNan Zhang, ZhiChun Wu, HuaYun Yu, HuaXin Wang, Guowei Liu, ShiJun Wang, XuMing Ji
In the treatment of lung cancer, the multidrug resistance to chemotherapeutic drugs is one of the reasons of low rates for cure and treatment failure, the combination of chemotherapeutic drugs and traditional Chinese medicine can increase the sensitivity of chemotherapy and reduce its adverse effects. Our previous study has proved that Chinese herbal medicine (CHM) Wenxia Changfu Formula (WCF for short) effectively enhances chemotherapeutic efficacy in lung cancer treatment and reverses multidrug resistance in lung cancer cells in vitro ...
2019: Journal of Cancer
https://read.qxmd.com/read/30719055/investigation-on-advanced-non-small-cell-lung-cancer-among-elderly-patients-treated-with-chinese-herbal-medicine-versus-chemotherapy-a-pooled-analysis-of-individual-data
#20
Lingling Sun, Wan Sze Yim, Paul Fahey, Shutang Wang, Xiaoshu Zhu, Jing Qiao, Hezheng Lai, Lizhu Lin
Purpose: Many patients with advanced non-small-cell lung cancer (NSCLC) seek help from Chinese herbal medicine (CHM). The purpose of this study was to investigate the survival between CHM and chemotherapy (CT) treatment of patients aged ≥60 years with advanced Epidermal Growth Factor Receptor (EGFR) wild type NSCLC and Karnofsky Performance Status (KPS) ≥ 60. Methods: We extracted individual data of all eligible patients from 1 randomized control trial and 2 cohort studies and performed a pooled analysis...
2019: Evidence-based Complementary and Alternative Medicine: ECAM
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