keyword
https://read.qxmd.com/read/38510931/-bacillus-coagulans-tci711-supplementation-improved-nonalcoholic-fatty-liver-by-modulating-gut-microbiota-a-randomized-placebo-controlled-clinical-trial
#1
JOURNAL ARTICLE
Rong-Hong Hsieh, Yu-Ju Chien, Wen-Yi Lan, Yung-Kai Lin, Yung-Hsiang Lin, Chi-Fu Chiang, Ming-Ta Yang
BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) has become one of the major problems of chronic liver disease worldwide. It not only causes damage to the liver but also engenders chronic hepatitis and cirrhosis. Recent studies have shown that regulating Bacillus coagulans can improve NAFLD. OBJECTIVES: This trial explores whether B. coagulans TCI711 (BCT) could ameliorate NAFLD. METHODS: A total of 57 patients with NAFLD were recruited through FibroScan liver fibrosis scanner and divided into placebo ( n = 28) and BCT-supplemented groups ( n = 29)...
March 2024: Current Developments in Nutrition
https://read.qxmd.com/read/38474799/the-role-of-probiotics-in-the-prevention-of-clostridioides-difficile-infection-in-patients-with-chronic-kidney-disease
#2
REVIEW
Sylwia Dudzicz-Gojowy, Andrzej Więcek, Marcin Adamczak
In patients suffering from chronic kidney disease (CKD), substantial unfavourable alterations in the intestinal microbiota composition, i.e., dysbiosis, have been noted. The main causes of such dysbiosis among others are insufficient dietary fibre content in the diet, fluid restrictions, medications used, and physical activity limitation. One clinically important consequence of dysbiosis in CKD patients is high risk of Clostridioides difficile infection (CDI). In observational studies, it was found that CDI is more frequent in CKD patients than in the general population...
February 27, 2024: Nutrients
https://read.qxmd.com/read/38474096/therapeutic-effect-of-natural-products-and-dietary-supplements-on-aflatoxin-induced-nephropathy
#3
REVIEW
Ebenezer Ofori-Attah, Mai Hashimoto, Mayu Oki, Daisuke Kadowaki
Aflatoxins are harmful natural contaminants found in foods and are known to be hepatotoxic. However, recent studies have linked chronic consumption of aflatoxins to nephrotoxicity in both animals and humans. Here, we conducted a systematic review of active compounds, crude extracts, herbal formulations, and probiotics against aflatoxin-induced renal dysfunction, highlighting their mechanisms of action in both in vitro and in vivo studies. The natural products and dietary supplements discussed in this study alleviated aflatoxin-induced renal oxidative stress, inflammation, tissue damage, and markers of renal function, mostly in animal models...
March 1, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38461124/synbiotics-prebiotics-and-probiotics-for-people-with-chronic-kidney-disease-summary-of-a-cochrane-review
#4
JOURNAL ARTICLE
Gus Rasich, L Susan Wieland
No abstract text is available yet for this article.
February 25, 2024: Explore: the Journal of Science and Healing
https://read.qxmd.com/read/38427291/the-interplay-between-dietary-choline-and-cardiometabolic-disorders-a-review-of-current-evidence
#5
REVIEW
Natalia G Vallianou, Dimitris Kounatidis, Sotiria Psallida, Fotis Panagopoulos, Theodora Stratigou, Eleni Geladari, Irene Karampela, Dimitrios Tsilingiris, Maria Dalamaga
PURPOSE OF REVIEW: Choline is an essential nutrient for human health and cellular homeostasis as it is necessary for the synthesis of lipid cell membranes, lipoproteins, and the synthesis of the neurotransmitter acetylcholine. The aim of this review is to analyze the beneficial effects of choline and its significance in cellular metabolism and various inflammatory pathways, such as the inflammasome. We will discuss the significance of dietary choline in cardiometabolic disorders, such as non-alcoholic fatty liver disease (NAFLD), cardiovascular disease (CVD), and chronic kidney disease (CKD) as well as in cognitive function and associated neuropsychiatric disorders...
March 1, 2024: Current Nutrition Reports
https://read.qxmd.com/read/38396596/investigating-the-efficacy-of-kidney-protective-lactobacillus-mixture-containing-pet-treats-in-feline-chronic-kidney-disease-and-its-possible-mechanism
#6
JOURNAL ARTICLE
Ching-Wen Tsai, Hsiao-Wen Huang, Ya-Jane Lee, Ming-Ju Chen
Microbiota-based strategies are a novel auxiliary therapeutic and preventative way of moderating chronic kidney disease (CKD). Lactobacillus mixture (Lm) was previously demonstrated to exert a renal-protective function in the CKD mice model. The efficacy of probiotics in pet foods is a relatively new area of study, and thus verifying the potential health benefits is necessary. This study evaluated the efficacy of Lm treats in feline CKD and elucidated the mechanisms underlying host-microbe interactions. CKD cats (2 and 3 stages) were administrated probiotic pet treats daily (10 g) for 8 weeks...
February 16, 2024: Animals: An Open Access Journal From MDPI
https://read.qxmd.com/read/38256206/modulation-of-mir-29a-and-mir-29b-expression-and-their-target-genes-related-to-inflammation-and-renal-fibrosis-by-an-oral-nutritional-supplement-with-probiotics-in-malnourished-hemodialysis-patients
#7
JOURNAL ARTICLE
Corina Verónica Sasso, Said Lhamyani, Francisco Hevilla, Marina Padial, María Blanca, Guillermina Barril, Tamara Jiménez-Salcedo, Enrique Sanz Martínez, Ángel Nogueira, Ana María Lago-Sampedro, Gabriel Olveira
Malnutrition is prevalent in patients with chronic kidney disease (CKD), especially those on hemodialysis. Recently, our group described that a new oral nutritional supplement (ONS), specifically designed for malnourished (or at risk) hemodialysis patients with a "similar to the Mediterranean diet" pattern, improved caloric-protein intake, nutritional status and biomarkers of inflammation and oxidation. Our aim in this study was to evaluate whether the new ONS, associated with probiotics or not, may produce changes in miRNA's expression and its target genes in malnourished hemodialysis patients, compared to individualized diet recommendations...
January 17, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38138114/role-of-probiotics-in-preventing-carbapenem-resistant-enterobacteriaceae-colonization-in-the-intensive-care-unit-risk-factors-and-microbiome-analysis-study
#8
JOURNAL ARTICLE
Jung-Hwan Lee, Jongbeom Shin, Soo-Hyun Park, Boram Cha, Ji-Taek Hong, Don-Haeng Lee, Kye Sook Kwon
Older patients with multiple comorbidities often necessitate prolonged hospital stays and antibiotic treatment in the intensive care unit (ICU), leading to a rise in multidrug-resistant organisms like carbapenem-resistant Enterobacteriaceae (CRE). This study examined risk factors for carbapenem-resistant Enterobacteriaceae colonization in the ICU and assessed probiotics' preventive role. In this single-center, retrospective study, 9099 ICU patients were tested for stool CRE culture from March 2017 to April 2022...
December 12, 2023: Microorganisms
https://read.qxmd.com/read/38088374/oh-my-gut-new-insights-on-the-role-of-the-gastrointestinal-tract-and-the-gut-microbiome-in-chronic-kidney-disease-mineral-and-bone-disorder
#9
JOURNAL ARTICLE
Seyedeh Nooshan Mirmohammadali, Kathleen M Hill Gallant, Annabel Biruete
PURPOSE OF REVIEW: The aim of this review is to highlight recent evidence on the role of the gastrointestinal tract and gut microbiome on chronic kidney disease-mineral bone disorder (CKD-MBD) outcomes, including intestinal phosphorus absorption and sensing, and the effect of gut-oriented therapies. RECENT FINDINGS: Recent evidence has revealed a complex interplay among mineral metabolism and novel gut-related factors, including paracellular intestinal phosphate absorption, the gut microbiome, and the immune system, prompting a reevaluation of treatment approaches for CKD-MBD...
December 14, 2023: Current Opinion in Nephrology and Hypertension
https://read.qxmd.com/read/38022571/intestinal-homeostasis-in-the-gut-lung-kidney-axis-a-prospective-therapeutic-target-in-immune-related-chronic-kidney-diseases
#10
REVIEW
Xinyin Liu, Xiaoran Wang, Peipei Zhang, Yiwen Fang, Yanyan Liu, Yueyue Ding, Wen Zhang
In recent years, the role of intestinal homeostasis in health has received increasing interest, significantly improving our understanding of the complex pathophysiological interactions of the gut with other organs. Microbiota dysbiosis, impaired intestinal barrier, and aberrant intestinal immunity appear to contribute to the pathogenesis of immune-related chronic kidney diseases (CKD). Meanwhile, the relationship between the pathological changes in the respiratory tract (e.g., infection, fibrosis, granuloma) and immune-related CKD cannot be ignored...
2023: Frontiers in Immunology
https://read.qxmd.com/read/38020091/altered-gut-microbiome-plays-an-important-role-in-aki-to-ckd-transition-in-aged-mice
#11
JOURNAL ARTICLE
Myung-Gyu Kim, Won Yong Cho, Suk Min Chung, Young Eun Choi, Yina Fang, Myeong Soo Park, Sang Jun Park, Yoon Sook Ko, Hee Young Lee, Jihyun Yang, Se Won Oh, Sang-Kyung Jo
INTRODUCTION: This study investigated the role of renal-intestinal crosstalk in the transition from acute kidney injury (AKI) to chronic kidney disease (CKD) in elderly individuals. METHODS: Using young and aged mice, we induced bilateral ischemia-reperfusion injury (IRI) and compared intestinal and kidney inflammation over 28 days. To determine the role of the microbiome in gut-kidney crosstalk, we analyzed the microbiome of fecal samples of the young vs...
2023: Frontiers in Medicine
https://read.qxmd.com/read/38002033/an-overview-of-chronic-kidney-disease-pathophysiology-the-impact-of-gut-dysbiosis-and-oral-disease
#12
REVIEW
Serena Altamura, Davide Pietropaoli, Francesca Lombardi, Rita Del Pinto, Claudio Ferri
Chronic kidney disease (CKD) is a severe condition and a significant public health issue worldwide, carrying the burden of an increased risk of cardiovascular events and mortality. The traditional factors that promote the onset and progression of CKD are cardiometabolic risk factors like hypertension and diabetes, but non-traditional contributors are escalating. Moreover, gut dysbiosis, inflammation, and an impaired immune response are emerging as crucial mechanisms in the disease pathology. The gut microbiome and kidney disease exert a reciprocal influence commonly referred to as "the gut-kidney axis" through the induction of metabolic, immunological, and endocrine alterations...
November 12, 2023: Biomedicines
https://read.qxmd.com/read/37967548/gut-frailty-its-concept-and-pathogenesis
#13
REVIEW
Yuji Naito
BACKGROUND: There is still a considerable gap between average life expectancy and healthy life expectancy in Japan. Recent research has revealed that gut frailty may be a worsening factor for various diseases, a cause of chronic inflammation, and a precursor to frailty. SUMMARY: Among self-reported symptoms, constipation is particularly significant as one of the key symptoms of gut frailty. Studies have demonstrated that individuals with constipation have significantly lower survival rates and are also at a higher risk of developing various diseases such as chronic kidney disease, cardiovascular diseases, and neurodegenerative disorders like Parkinson's disease...
November 15, 2023: Digestion
https://read.qxmd.com/read/37917394/effects-of-probiotic-enriched-minas-cheese-lactobacillus-acidophilus-la-05-on-cardiovascular-parameters-in-5-6-nephrectomized-rats
#14
JOURNAL ARTICLE
Nathalia da Silva Costa, Joana Ramos de Araujo, Manuela Fernandes da Silva Melo, Jéssica da Costa Mota, Patricia Pereira Almeida, Karen Salve Coutinho-Wolino, Beatriz Oliveira Da Cruz, Michele Lima Brito, Thaís de Souza Carvalho, Emanuelle Barreto-Reis, Beatriz Gouvêa de Luca, Denise Mafra, D 'Angelo Carlo Magliano, Renato de Souza Abboud, Ramon Silva Rocha, Adriano Gomes da Cruz, Jonas de Toledo Guimarães, Milena Barcza Stockler-Pinto
Dairy foods have become an interest in chronic kidney disease (CKD) due to their nutritional profile, which makes them a good substrate for probiotics incorporation. This study evaluated the effect of probiotic-enriched Minas cheese with Lactobacillus acidophilus La-05 in an experimental rat model for CKD on cardiac, inflammatory, and oxidative stress parameters. Male Wistar rats were divided into 4 groups (n = 7/group): 5/6 nephrectomy + conventional Minas cheese (NxC); 5/6 nephrectomy + probiotic Minas cheese (NxPC); Sham + conventional Minas cheese (ShamC); Sham + probiotic Minas cheese (ShamPC)...
November 2, 2023: Probiotics and Antimicrobial Proteins
https://read.qxmd.com/read/37893201/novel-approaches-in-chronic-renal-failure-without-renal-replacement-therapy-a-review
#15
REVIEW
Sandra Luz Martínez-Hernández, Martín Humberto Muñoz-Ortega, Manuel Enrique Ávila-Blanco, Mariana Yazmin Medina-Pizaño, Javier Ventura-Juárez
Chronic kidney disease (CKD) is characterized by renal parenchymal damage leading to a reduction in the glomerular filtration rate. The inflammatory response plays a pivotal role in the tissue damage contributing to renal failure. Current therapeutic options encompass dietary control, mineral salt regulation, and management of blood pressure, blood glucose, and fatty acid levels. However, they do not effectively halt the progression of renal damage. This review critically examines novel therapeutic avenues aimed at ameliorating inflammation, mitigating extracellular matrix accumulation, and fostering renal tissue regeneration in the context of CKD...
October 18, 2023: Biomedicines
https://read.qxmd.com/read/37870148/synbiotics-prebiotics-and-probiotics-for-people-with-chronic-kidney-disease
#16
REVIEW
Tess E Cooper, Rabia Khalid, Samuel Chan, Jonathan C Craig, Carmel M Hawley, Martin Howell, David W Johnson, Allison Jaure, Armando Teixeira-Pinto, Germaine Wong
BACKGROUND: Chronic kidney disease (CKD) is a major public health problem affecting 13% of the global population. Prior research has indicated that CKD is associated with gut dysbiosis. Gut dysbiosis may lead to the development and/or progression of CKD, which in turn may in turn lead to gut dysbiosis as a result of uraemic toxins, intestinal wall oedema, metabolic acidosis, prolonged intestinal transit times, polypharmacy (frequent antibiotic exposures) and dietary restrictions used to treat CKD...
October 23, 2023: Cochrane Database of Systematic Reviews
https://read.qxmd.com/read/37858192/washed-microbiota-transplantation-improves-renal-function-in-patients-with-renal-dysfunction-a-retrospective-cohort-study
#17
JOURNAL ARTICLE
Hao-Jie Zhong, Xinqiang Xie, Wen-Jia Chen, Yu-Pei Zhuang, Xuan Hu, Ying-Li Cai, Hong-Lie Zeng, Chuanxing Xiao, Ying Li, Yu Ding, Liang Xue, Moutong Chen, Jumei Zhang, Qingping Wu, Xing-Xiang He
BACKGROUND: Changes in the gut microbiota composition is a hallmark of chronic kidney disease (CKD), and interventions targeting the gut microbiota present a potent approach for CKD treatment. This study aimed to evaluate the efficacy and safety of washed microbiota transplantation (WMT), a modified faecal microbiota transplantation method, on the renal activity of patients with renal dysfunction. METHODS: A comparative analysis of gut microbiota profiles was conducted in patients with renal dysfunction and healthy controls...
October 19, 2023: Journal of Translational Medicine
https://read.qxmd.com/read/37836572/prebiotics-probiotics-and-nutrients-in-cardiovascular-and-kidney-disease
#18
EDITORIAL
Zitong Lei, Menglu Xu, Ying Li, Lei Chen, Hongbao Li
Cardiovascular disease (CVD) and chronic kidney disease (CKD) are the leading causes of mortality and health burden worldwide [...].
October 8, 2023: Nutrients
https://read.qxmd.com/read/37806868/a-pilot-study-of-nephrogenic-probiotics-to-further-improve-an-already-stabilized-graft-function-after-kidney-transplantation
#19
JOURNAL ARTICLE
Wai-Nga Chan, Dong-Ru Ho, Yun-Ching Huang, Jian-Hui Lin, Yu-Liang Liu, Ming-Ju Chen, Chih-Shou Chen
BACKGROUND: The majority of kidney recipients are a subset of chronic kidney disease. Our previous study demonstrated that the combination of Lactobacillus plantarum and Lactobacillus paracasei (Lm) had the highest clearance ability of uremic toxins and improved kidney function in a mouse model. This study aimed to evaluate Lm in improving graft function, effects on immunosuppressants, and safety in transplant recipients. METHODS: We retrospectively reviewed 24 patients...
October 6, 2023: Transplantation Proceedings
https://read.qxmd.com/read/37796688/the-effects-of-probiotic-lactobacillus-rhamnosus-gg-on-fecal-flora-and-serum-markers-of-renal-injury-in-mice-with-chronic-kidney-disease
#20
JOURNAL ARTICLE
Lin Zhu, Jie Niu, Xiao-Cun Tang, Li-Hui Shan, Lan Xiao, Yu-Qing Wang, Ling-Yun Yin, Yang-Yang Yu, Xin-Ran Li, Ping Zhou
BACKGROUND: In this study, we analyzed intestinal flora in an experimental mouse model of chronic kidney disease (CKD) and investigated whether oral supplementation with probiotic Lactobacillus rhamnosus GG could slow the decline in renal function and inflammatory status of mice with CKD. METHODS: We surgically induced chronic kidney disease in C57BL/6J male mice aged 8-9 weeks. We used dual-stage 5/6 nephrectomy for this, while the mock group underwent a mock procedure...
September 26, 2023: Frontiers in Bioscience (Landmark Edition)
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