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Matthew Lineberry, Eduardo Hornos, Eduardo Pleguezuelos, Jose Mella, Carlos Brailovsky, Georges Bordage
CONTEXT: The script concordance test (SCT), designed to measure clinical reasoning in complex cases, has recently been the subject of several critical research studies. Amongst other issues, response process validity evidence remains lacking. We explored the response processes of experts on an SCT scoring panel to better understand their seemingly divergent beliefs about how new clinical data alter the suitability of proposed actions within simulated patient cases. METHODS: A total of 10 Argentine gastroenterologists who served as the expert panel on an existing SCT re-answered 15 cases 9 months after their original panel participation...
February 18, 2019: Medical Education
Martín Regueiro, Cecilia Homar, Martín Cañás, Virginia Tosello
INTRODUCTION: The information that exists on dementia and cognitive impairment is scarce in Argentina, particularly in Patagonia. OBJECTIVE AND METHODS: The aim of the study was to determine the prevalence of cognitive impairment. A door to door survey was performed to all people over 60 who lived in a high social risk neighborhood in Neuquen city, where geriatric and cognitive variables were evaluated, including Folstein Mini-Mental State Examination, clock test and test set according to the level of instruction...
May 2018: Vertex: Revista Argentina de Psiquiatriá
Marina Aberastury, Romina Fernández, Marta Córdoba, Betiana Comas, Martín Peralta, Guillermo Agosta, Marcelo Kauffman, Walter Silva
Familial focal epilepsy with variable foci is a relatively rare autosomal disease with an unclear incidence, which is characterized by focal seizures arising from different cortical regions in different family members. We describe three members of a two-generation Argentine family with familial focal epilepsy with variable foci syndrome and a DEPDC5 gene mutation. The mean onset age was nine years old. The father experienced episodes with occipital semiology and both siblings exhibited frontal lobe seizures...
February 15, 2019: Epileptic Disorders: International Epilepsy Journal with Videotape
Ana Marandino, Ariel Vagnozzi, María Isabel Craig, Gonzalo Tomás, Claudia Techera, Yanina Panzera, Federico Vera, Ruben Pérez
Infectious bronchitis virus (IBV) is a persistent sanitary problem for the South American poultry industry despite extensive vaccination. The IBV single-stranded RNA genome has high rates of mutation and recombination that generate a notorious virus variability. Since most IBV vaccines are type-specific, there is a need for a constant surveillance of the circulating lineages and knowledge about their genetic and antigenic properties. Here we present an integrative analysis that provides the pattern of genetic variation of the South American IBV strains and information about their antigenic characteristics...
February 14, 2019: Avian Pathology: Journal of the W.V.P.A
Agustín Londonio, Ezequiel Morzán, Patricia Smichowski
A study was undertaken to quantify the concentration of toxic and potentially toxic elements in samples of rice, rice crackers, rice noodles, infant cereals and rice vinegar available in the Argentine market. The determination of nine elements, namely, As, Cd, Cr, Hg, Ni, Pb, Sb, Se, and Zn in 29 samples was performed by inductively coupled plasma-mass spectrometry. Element concentrations spanned the range (ng g-1 ): As, 67-858; Cd, <0.2-24.0; Cr, 36.6-937; Hg, <50; Ni, 38.6-1040; Pb, <2.0-139; Sb, <3...
June 30, 2019: Food Chemistry
André Nicolai Petelski, Célia Fonseca Guerra
Invited for this month's cover picture are Professor Célia Fonseca Guerra from Vrije Universiteit Amsterdam and Leiden University (The Netherlands) and André Nicolai Petelski from UTN-FRRe University of Argentine (Argentina). The cover picture shows a colored pallet of melamine and ammeline tautomers that form hydrogen-bonded hexameric rosettes. When it comes to self-assembling capabilities, one of the ammeline structures (red) is shown to be distinctly superior to melamine, both in the gas phase and in water...
February 2019: ChemistryOpen
C Ferri, N Weich, L Gutiérrez, C De Brasi, M R Bengió, P Zapata, A Fundia, I Larripa
The BCR-ABL1 oncogene is associated with chronic myeloid leukemia (CML) pathogenesis, but the molecular mechanisms that initiate leukemogenesis are still unclear. Cancer pathogenesis has been associated with genetic alterations that may lead to inactivation of tumor suppressor genes. Phosphatase and tensin homolog (PTEN) is frequently deleted or inactivated in various tumors. A recently discovered variant of PTEN, PTEN-Long (PTEN-L), results from an alternative translation initiation site located upstream of the canonic AUG and generates a protein of 576 amino acids instead the expected protein of 403 amino acids...
February 7, 2019: Gene
Laura Casalins, Mora Ibáñez Molina, Mariana Wainer Gullo, Norma Brugni, Gala Ortiz, Valeria Ojeda
We describe pathological aspects of an infection caused by parasitic nematodes in skeletal muscles of a Magellanic woodpecker ( Campephilus magellanicus ), providing the first description of any disease findings in this species. A weakened female with locomotory dysfunction was rescued near Bariloche city (Argentine Patagonia), which soon died. At the necropsy, unexpected masses of tissue were located at three joints (legs and tail). A dissection of these masses exposed numerous nematodes in the musculature surrounding the joints that were identified as Hamatospiculum flagellispiculosum (Nematoda: Diplotriaenidae), a species that was not previously found in Piciformes (woodpeckers, toucans, and allies) of the Neotropical Region...
April 2019: International Journal for Parasitology. Parasites and Wildlife
Javier Farina, Wanda Cornistein, Carina Balasini, Juan Chuluyan, Miriam Blanco
Representatives of the Argentine Society of Infectious Diseases (SADI) and the Argentine Society of Intensive Therapy (SATI) joined together to issue specific recommendations for the diagnosis, treatment, and prevention of intravascular catheter related infections (CRI). The methodology used was the analysis of the literature published in the last 10 years, complemented with the opinion of experts and local data. This document aims to promote effective measures to reduce the risk of CRI and to offer basic tools for diagnosis optimization based on clinical and microbiological criteria, orientation on empirical and targeted antibiotic schemes, posology, and administration of antibiotics in critical patients...
2019: Medicina
Maximiliano Rodríguez Giménez, Monica Ubalde-Lopez, Cecilia Cornelio, Maria López-Ruiz, Manel Plana Almuní, Fernando G Benavides
OBJECTIVES: To describe temporal trends in occupational injuries (OI) and occupational diseases (OD) in Argentina, by severity of the injury, place of occurrence, economic activity and selected provinces, in the period 1997 to 2015. METHODS: The study population consists of the working population covered by the Argentine Law of Occupational Risks system, roughly 4 million people in 1997 and 9.5 million in 2015. The annual incidence rate of the OI and OD was calculated by using the number of reported cases divided by the mean number of employees covered by the system each year...
January 2019: Archivos de Prevención de Riesgos Laborales
Liliana Crocco, Julieta Nattero, Ana López, Miriam Cardozo, Carola Soria, Valeria Ortiz, Claudia S Rodriguez
INTRODUCTION: The domestic and peridomestic presence of Triatoma infestans depends on several factors, such as human behavior, vector behavior, ecology, and the environment. METHODS: This work was conducted in 139 domiciliary units, where triatomines were captured and risk factors in domiciles and peridomicilies were recorded. Household dwellers were interviewed to obtain information about practices regarding this disease and entomological indicators were calculated...
January 14, 2019: Revista da Sociedade Brasileira de Medicina Tropical
Javier Millán, Alejandro Travaini, Aitor Cevidanes, Irene Sacristán, Alejandro Rodríguez
We collected blood and/or ectoparasites from 49 South American grey foxes ( Lycalopex griseus ) and two Andean foxes ( L. culpaeus ) caught in two National Parks of southern Argentine Patagonia (Bosques Petrificados, BPNP; and Monte León, MLNP) where dogs are nearly absent (density < 0.01 dog/km2 ). Common ectoparasites were the flea Pulex irritans (88% prevalence) and the tick Amblyomma tigrinum (29%). Conventional PCR and sequencing of 49 blood samples, 299 fleas analysed in 78 pools, and 21 ticks revealed the presence of DNA of the following canine vector-borne pathogens: in grey foxes, Rickettsia sp...
April 2019: International Journal for Parasitology. Parasites and Wildlife
Mario Contin, Claudia Sepúlveda, Mirta Fascio, Carlos A Stortz, Elsa B Damonte, Norma B D'Accorso
In this work, several ribavirin analogues were synthesized and incorporated into a multivalent arrangement. Both were subsequently modified by the addition of polyhydroxylated residues. Their antiviral activity was tested against Junín virus, etiological agent responsible of Argentine hemorrhagic fever. Some compounds inhibited Junín virus in the range of 13.2-389.1 µM. Two modified ribavirin analogues presented an effective concentration comparable to ribavirin but with a higher selectivity index.
January 2, 2019: Bioorganic & Medicinal Chemistry Letters
Boris Groisman, Rosa Liascovich, María Paz Bidondo, Pablo Barbero, Santiago Duarte, Ana Laura Tellechea, Jorge Holguín, Catherine Rodríguez, Paula Hurtado-Villa, Natalia Caicedo, Gabriela Botta, Ignacio Zarante
Birth defects (BDs) are structural or functional anomalies, sporadic or hereditary, of prenatal origin. Public health surveillance is defined as the ongoing systematic collection, analysis, and interpretation of outcome-specific data for use in the planning, implementation, and evaluation of public health practice. BD surveillance systems may have different characteristics according to design, coverage, type of surveillance, case ascertainment, case definition, BD description, maximum age of diagnosis, pregnancy outcomes, coding systems, and the location of the coding process (central or local)...
January 3, 2019: Journal of Community Genetics
Jesús S Hernández-Orts, Francisco E Montero, Néstor A García, Enrique A Crespo, Juan A Raga, Martín García-Varela, Francisco J Aznar
Acanthocephalans display a two-host life cycle that involves arthropods as intermediate hosts and vertebrates as definitive hosts. Some species also use paratenic hosts to bridge the trophic gap between both obligatory hosts. However, the relative role of these paratenic hosts in the transmission to definitive hosts has seldom been assessed quantitatively. We report on infection patterns of cystacanths of Corynosoma australe Johnston, 1937 in 20 common teleost species and the Argentine shortfin squid Illex argentinus (Castellanos) from the Patagonian shelf of Argentina...
January 4, 2019: Parasitology Research
María C Cecere, Lucía I Rodríguez-Planes, Gonzalo M Vazquez-Prokopec, Uriel Kitron, Ricardo E Gürtler
Prevention of Chagas disease vector-borne transmission mostly relies on the residual application of pyrethroid insecticide. Persistent or recurrent house infestation after insecticide spraying remains a serious challenge in remote, resource-poor rural areas where public health services face substantial constraints. Here we use generalized estimating equations and multimodel inference to model the fine-scale, time-lagged effects of a community-based vector surveillance-and-response strategy on house infestation and abundance of Triatoma infestans in four rural communities of the Argentine Chaco over a five-year period...
December 26, 2018: Acta Tropica
Ikenna G Madu, Megan Files, Dima N Gharaibeh, Amy L Moore, Kie-Hoon Jung, Brian B Gowen, Dongcheng Dai, Kevin F Jones, Shanthakumar R Tyavanagimatt, James R Burgeson, Marcus J Korth, Kristin M Bedard, Shawn P Iadonato, Sean M Amberg
Arenaviruses are a significant cause of hemorrhagic fever, an often-fatal disease for which there is no approved antiviral therapy. Lassa fever in particular generates high morbidity and mortality in West Africa, where the disease is endemic, and a recent outbreak in Nigeria was larger and more geographically diverse than usual. We are developing LHF-535, a small-molecule viral entry inhibitor that targets the arenavirus envelope glycoprotein, as a therapeutic candidate for Lassa fever and other hemorrhagic fevers of arenavirus origin...
December 21, 2018: PLoS Pathogens
Carlos H Rodríguez, Marcela Nastro, Silvia A Flores, Mónica Rodriguez, Mariela Spinozzi, Geni Bruni, Ana L López, Viviana David, Maria S Aiassa, Isabel A Marqués, Osvaldo R Navarro, Laura Paniccia, Angela Famiglietti
One hundred sequential, epidemiologically unrelated carbapenem-resistant- Acinetobacter baumannii isolates from 11 hospitals in 10 Argentine provinces were collected between January and August 2016. Genes coding for Ambler class D and B carbapenemases were investigated by PCR using specific primers. All isolates were typed using the 3-locus sequence typing and blaOXA-51- like sequence-based typing techniques. The blaOXA-23 gene was recovered in all isolates studied. The population of carbapenem-resistant- A...
December 11, 2018: Revista Argentina de Microbiología
Janice Dahmer, Gabriele do Carmo, Marco Aurélio Mostardeiro, Alexandre Tibursky Neto, Ubiratan Flores da Silva, Ionara Irion Dalcol, Ademir Farias Morel
ETHNOPHARMACOLOGY RELEVANCE: Discaria americana Gillies ex Hook (sin. Discaria febrifuga and Discaria longispina) (Rhamnaceae) is a plant native from Rio Grande do Sul (Southern Brazil), Uruguay and Argentine, and has been used in Brazilian traditional medicine as antipyretic agent, and for stomach disorders. In Rio Grande do Sul, Uruguay and Argentine, the roots, in decoction, are used as tonic and febrifuge. Although it is a plant widely used by the population, there are no studies proving this popular use...
December 10, 2018: Journal of Ethnopharmacology
María F Piacenza, Gladys E Calderón, Delia Enría, María C Provensal, Jaime J Polop
BACKGROUND: The Argentine Hemorrhagic Fever (AHF) is a zoonotic disease endemic in a wide area of the humid pampa of Argentina. The etiologic agent is the Junin virus that is maintained in the wild by the rodent Calomys musculinus and transmitted to humans, mainly, through aerosols generated from secretions and excretions. AIMS: To characterize and compare the assemblages of small rodent composition and diversity inside the epidemic, historic and non-endemic zone of AHF and to register C...
August 2018: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
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