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Acute kidney injury, children

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https://read.qxmd.com/read/30887109/dialysis-modalities-for-the-management-of-pediatric-acute-kidney-injury
#1
Lara de Galasso, Stefano Picca, Isabella Guzzo
Acute kidney injury (AKI) is an increasingly frequent complication among hospitalized children. It is associated with high morbidity and mortality, especially in neonates and children requiring dialysis. The different renal replacement therapy (RRT) options for AKI have expanded from peritoneal dialysis (PD) and intermittent hemodialysis (HD) to continuous RRT (CRRT) and hybrid modalities. Recent advances in the provision of RRT in children allow a higher standard of care for increasingly ill and young patients...
March 18, 2019: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://read.qxmd.com/read/30874941/clinical-course-of-hantavirus-induced-nephropathia-epidemica-in-children-compared-to-adults-in-germany-analysis-of-317-patients
#2
Fabian Echterdiek, Daniel Kitterer, M Dominik Alscher, Vedat Schwenger, Bettina Ruckenbrod, Martin Bald, Joerg Latus
BACKGROUND: Hantavirus infections are endemic worldwide, and its incidence in Europe has been steadily increasing. In Western Europe, hantavirus infections are typically caused by Puumala hantavirus and cause nephropathia epidemica (NE), a mild form of haemorrhagic fever with renal syndrome. Up to now, there is only little data about the course of acute NE in children, but it has been suggested that hantavirus infections take a lighter course in children when compared to adults. We performed a retrospective analysis of adults and children diagnosed with acute NE in two counties in South-Western Germany to investigate if there are differences in the course of the disease...
March 14, 2019: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://read.qxmd.com/read/30871796/acute-kidney-injury-in-pediatric-cancer-patients
#3
Peong Gang Park, Che Ry Hong, Eunjeong Kang, Minsu Park, Hajeong Lee, Hyoung Jin Kang, Hee Young Shin, Il-Soo Ha, Hae Il Cheong, Hyung Jin Yoon, Hee Gyung Kang
OBJECTIVE: To analyze the incidence of acute kidney injury (AKI) in the first year after cancer diagnosis in children and to evaluate the short-term and long-term effects on renal function and proteinuria. STUDY DESIGN: Retrospective review of medical records was done on children who were diagnosed and treated for cancer at Seoul National University Hospital between 2004 and 2013. AKI was defined according to the Kidney Disease: Improving Global Outcomes criteria...
March 11, 2019: Journal of Pediatrics
https://read.qxmd.com/read/30869483/relation-between-fluid-overload-and-mortality-in-children-with-septic-shock
#4
Horacio Márquez-González, Luis Casanova-Bracamontes, C Mireya Muñoz-Ramírez, Leoncio Peregrino-Bejarano, Bárbara Bolaños-Téllez, Lucelli Yáñez-Gutiérrez
INTRODUCTION: Septic shock is one of the main causes of mortality. Fluid replacement stands out as the treatment of choice to reduce mortality. OBJECTIVE: To determine the relation between the percentage of fluid overload (%FO) and mortality in children with septic shock. METHODS: Cohort study in patients aged 1-17 years with septic shock, after fluid replacement with central venous pressure ≥ 5 mmHg, invasive monitoring, and complete recording of %FO up to 96 h...
April 1, 2019: Archivos Argentinos de Pediatría
https://read.qxmd.com/read/30866849/short-term-outcome-associated-with-disease-severity-and-electrolyte-abnormalities-among-critically-ill-children-with-acute-kidney-injury
#5
Osama Y Safder, Khalid A Alhasan, Mohamed A Shalaby, Norah Khathlan, Suleman A Al Rezgan, Amr S Albanna, Jameela A Kari
BACKGROUND: Acute kidney injury (AKI) in critically ill children is associated with increased mortality and morbidity. In this study we evaluated the effect of AKI severity on the incidence of short-term mortality and morbidity. METHODS: Multicenter prospective cohort study was conducted over two years period. We used the Kidney Disease Improving Global Outcomes (KDIGO) to diagnose and stage AKI. RESULTS: A total of 511 out of 1367 included children (37...
March 12, 2019: BMC Nephrology
https://read.qxmd.com/read/30864056/vancomycin-prescribing-and-therapeutic-drug-monitoring-in-children-with-and-without-acute-kidney-injury-after-cardiac-arrest
#6
Julie C Fitzgerald, Nicole R Zane, Adam S Himebauch, Michael D Reedy, Kevin J Downes, Alexis A Topjian, Susan L Furth, Neal J Thomas, Marc H Scheetz, Athena F Zuppa
BACKGROUND: Acute kidney injury (AKI) commonly occurs after cardiac arrest. Those subsequently treated with vancomycin are at additional risk for drug-induced kidney injury. OBJECTIVE: We aimed to determine whether opportunities exist for improved drug monitoring after cardiac arrest. METHODS: This was a retrospective cohort study of children aged 30 days-17 years treated after cardiac arrest in an intensive care unit from January 2010 to September 2014 who received vancomycin within 24 h of arrest...
March 12, 2019: Paediatric Drugs
https://read.qxmd.com/read/30860200/the-pattern-and-outcomes-of-childhood-renal-diseases-at-university-of-abuja-teaching-hospital-abuja-nigeria-a-4-year-retrospective-review
#7
Emmanuel Ademola Anigilaje, Temilade Christianah Adesina
Introduction: Renal disorders contribute to childhood morbidity and mortality in developing countries. Therefore, the knowledge of the burden of childhood renal diseases is required for preventive and management purposes. This article determines the pattern and the outcomes of childhood renal diseases seen at the University of Abuja Teaching Hospital (UATH), Gwagwalada, Abuja, Nigeria. Materials and Methods: This was a retrospective review of children aged 1 month to 17 years, who were seen at the paediatric nephrology clinic, emergency paediatric unit and paediatric ward of the UATH over 4 years from January 2013 to December 2016...
January 2019: Nigerian Postgraduate Medical Journal
https://read.qxmd.com/read/30843114/feeding-modality-is-a-barrier-to-adequate-protein-provision-in-children-receiving-continuous-renal-replacement-therapy-crrt
#8
Molly Wong Vega, Marisa Juarez Calderon, Naile Tufan Pekkucuksen, Poyyapakkam Srivaths, Ayse Akcan Arikan
BACKGROUND: Critically ill children have a high prevalence of malnutrition. Children with acute kidney injury experience high rates of protein debt. Previous research has indicated that protein provision is positively associated with survival. METHODS: This was a prospective observational study of all patients receiving CRRT for greater than 48 h at our tertiary care institution. Patients with inborn errors of metabolism were excluded. Data collection included energy, protein, and fluid volume intakes, anthropometrics, feeding modality, and route of nutrition intake...
March 6, 2019: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://read.qxmd.com/read/30819990/profile-of-acute-kidney-injury-in-hospitalized-children-with-idiopathic-nephrotic-syndrome
#9
B S Prasad, Manish Kumar, Aashima Dabas, Kirtisudha Mishra
OBJECTIVE: To determine the incidence, risk factors and outcome of acute kidney injury (AKI) in hospitalized children with nephrotic syndrome. METHODS: All consecutive hospitalized children (aged 1-14 years) with diagnosis of nephrotic syndrome between February 2016 and February 2017 were enrolled for the study. Children (aged 1-14 years) with features of nephritis, underlying secondary causes of nephrotic syndrome as well as children admitted for diagnostic renal biopsy and intravenous cyclophosphamide or rituximab infusion were excluded...
February 15, 2019: Indian Pediatrics
https://read.qxmd.com/read/30799170/association-between-urodynamic-parameters-and-urine-neutrophil-gelatinase-associated-lipocalin-concentrations-in-children-with-neuropathic-bladders
#10
C S Forster, S Goldstein, H Pohl, E Jackson
BACKGROUND: Neutrophil gelatinase-associated lipocalin (NGAL) is a marker of acute kidney injury, and has been shown to be a sensitive marker of renal damage in urinary tract obstruction. Children with neurogenic bladders are at risk of renal damage as a result of increased pressure within the urinary system. A marker of upper tract deterioration in this population would be useful to guide management. OBJECTIVE: The aim of the study is to compare urinary NGAL (uNGAL) concentrations between children who have elevated and normal detrusor pressure and between those with low and normal compliance, on urodynamics...
January 23, 2019: Journal of Pediatric Urology
https://read.qxmd.com/read/30798259/theophylline-and-aminophylline-for-prevention-of-acute-kidney-injury-in-neonates-and-children-a-systematic-review
#11
Girish Chandra Bhatt, Priya Gogia, Martin Bitzan, Rashmi Ranjan Das
OBJECTIVE: To compare the efficacy and safety of theophylline or aminophylline for prevention of acute kidney injury (AKI) in neonates and children. DESIGN: Systematic review and meta-analysis with application of Grading of Recommendations, Assessment, Development and Evaluation system. DATA SOURCES: PubMed/MEDLINE, Embase, Google Scholar and Cochrane renal group were searched from 1970 to May 2018. ELIGIBILITY CRITERIA: Randomised clinical trials and quasi-randomised trials comparing the efficacy and safety of prophylactic theophylline or aminophylline for prevention of AKI in neonates and children were included...
February 23, 2019: Archives of Disease in Childhood
https://read.qxmd.com/read/30797942/risk-factors-for-development-of-and-progression-of-hepatic-veno-occlusive-disease-sinusoidal-obstruction-syndrome
#12
REVIEW
Selim Corbacioglu, Elias J Jabbour, Mohamad Mohty
Veno-occlusive disease, also known as sinusoidal obstruction syndrome (VOD/SOS), is a potentially life-threatening complication of allogeneic or autologous hematopoietic stem cell transplantation (HSCT), most commonly associated with high-intensity chemotherapies. Since development of VOD/SOS may be rapid and unpredictable, the importance of identifying risk factors to facilitate prompt diagnosis and timely treatment has become increasingly well recognized. Reporting of new retrospective study data for adults and children and emergence of novel anti-cancer therapies that may increase risk of VOD/SOD also necessitate updates on risk factors, as provided in this review...
February 21, 2019: Biology of Blood and Marrow Transplantation
https://read.qxmd.com/read/30792872/a-validation-study-of-administrative-health-care-data-to-detect-acute-kidney-injury-in-the-pediatric-intensive-care-unit
#13
David D'Arienzo, Erin Hessey, Rami Ali, Sylvie Perreault, Susan Samuel, Louise Roy, Jacques Lacroix, Philippe Jouvet, Genevieve Morissette, Marc Dorais, Jean-Philippe Lafrance, Veronique Phan, Michael Pizzi, Rahul Chanchlani, Michael Zappitelli
Background: Large studies evaluating pediatric acute kidney injury (AKI) epidemiology and outcomes are lacking, partially due to underuse of large administrative health care data. Objective: To assess the diagnostic accuracy of administrative health care data-defined AKI in children admitted to the pediatric intensive care unit (PICU). Design: Retrospective cohort study utilizing chart and administrative data. Setting: Children admitted to the PICU at 2 centers in Montreal, QC...
2019: Canadian Journal of Kidney Health and Disease
https://read.qxmd.com/read/30786108/gastrostomy-tubes-appear-to-be-safe-following-pediatric-orthotopic-heart-transplant
#14
Rick D Vavolizza, David F Grabski, Daniel E Levin, Jeffrey W Gander
BACKGROUND: Gastrostomy tube (GT) placement is a common pediatric surgical procedure typically indicated for oral aversion. This may develop in patients with congenital heart disease (CHD) who require an orthotopic heart transplant (OHT). The safety profile of GT placement in OHT patients who are immunosuppressed is unknown. Given the potential increased risk of wound site complications on a patient receiving immunosuppression, we sought to determine the safety profile of GT placement in pediatric patients with OHT...
February 20, 2019: Pediatric Transplantation
https://read.qxmd.com/read/30764902/computed-tomography-with-intravenous-contrast-is-not-associated-with-development-of-acute-kidney-injury-in-severely-injured-pediatric-patients
#15
McGaha Paul K, Jeremy Johnson, Tabitha Garwe, Zoona Sarwar, Prasenjeet Motghare, William Daly, Robert Letton
Data for the incidence of acute kidney injury (AKI) related to intravenous contrast administration in the pediatric trauma population are limited. Obtaining a creatinine value before elective CT scans is a relatively accepted standard of care. We sought to determine whether there was any significant difference in the incidence of AKI between severely injured patients who received IV contrast and those who did not. We reviewed data from the trauma registry at our Level I pediatric trauma center. We limited the patients to severely injured pediatric traumas (<15 years old) directly transported from the scene of injury with a creatinine level measured on arrival...
January 1, 2019: American Surgeon
https://read.qxmd.com/read/30763561/postoperative-acute-kidney-injury-in-young-adults-with-congenital-heart-disease
#16
Dana Y Fuhrman, Lan G Nguyen, Joan Sanchez-de-Toledo, Priyanka Priyanka, John A Kellum
BACKGROUND: There is an increasing number of young adults living with congenital heart disease (CHD). The goal of this study was to ascertain the frequency of acute kidney injury (AKI) as well as the risk factors and outcomes associated with AKI in young adults with CHD after a surgical procedure. METHODS: This was a single center retrospective cohort study including all patients 18-40 years of age with a diagnosis of CHD admitted to a quaternary care children's hospital cardiac intensive care unit postoperatively from 2004-2015...
February 11, 2019: Annals of Thoracic Surgery
https://read.qxmd.com/read/30760357/computed-tomography-with-intravenous-contrast-is-not-associated-with-development-of-acute-kidney-injury-in-severely-injured-pediatric-patients
#17
McGaha Paul K, Jeremy Johnson, Tabitha Garwe, Zoona Sarwar, Prasenjeet Motghare, William Daly, Robert Letton
Data for the incidence of acute kidney injury (AKI) related to intravenous contrast administration in the pediatric trauma population are limited. Obtaining a creatinine value before elective CT scans is a relatively accepted standard of care. We sought to determine whether there was any significant difference in the incidence of AKI between severely injured patients who received IV contrast and those who did not. We reviewed data from the trauma registry at our Level I pediatric trauma center. We limited the patients to severely injured pediatric traumas (<15 years old) directly transported from the scene of injury with a creatinine level measured on arrival...
January 1, 2019: American Surgeon
https://read.qxmd.com/read/30745052/furosemide-response-predicts-acute-kidney-injury-in-children-after-cardiac-surgery
#18
Jamie Penk, Katja M Gist, Eric L Wald, Laura Kitzmiller, Tennille N Webb, Yi Li, David S Cooper, Stuart L Goldstein, Rajit K Basu
OBJECTIVE: A standardized assessment of response to furosemide is predictive of acute kidney injury progression in adults, but a paucity of data exists in pediatric patients. We evaluate furosemide responsiveness in a multicenter cohort of pediatric patients after cardiac surgery. METHODS: Children who underwent cardiac surgery with a Society of Thoracic Surgeons-European Association for Cardiothoracic Surgery score of 3 or greater were retrospectively identified...
January 11, 2019: Journal of Thoracic and Cardiovascular Surgery
https://read.qxmd.com/read/30740947/markers-of-acute-kidney-injury-in-children-undergoing-hematopoietic-stem-cell-transplantation
#19
REVIEW
Monika Augustynowicz, Agnieszka Bargenda-Lange, Krzysztof Kałwak, Danuta Zwolińska, Kinga Musiał
Acute kidney injury (AKI), one of the major complications in children undergoing hematopoietic stem cell transplantation (HSCT), is an independent predictor of the patient's survival and a prognostic factor of progression to chronic kidney disease (CKD). Despite the multifaceted role of AKI, its early diagnosis in the course of HSCT remains a challenge. These difficulties may result from the inefficiency of traditional methods used to assess kidney function, like serum creatinine or estimated glomerular filtration rate...
February 11, 2019: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://read.qxmd.com/read/30737860/paediatric-acute-kidney-injury-induced-by-vancomycin-monotherapy-versus-combined-vancomycin-and-meropenem
#20
Tao Zhang, Hua Cheng, Yuan Li, Yu-Zhu Dong, Ying Zhang, Xiao-Liang Cheng, An-Min Wang, Ya-Lin Dong
WHAT IS KNOWN AND OBJECTIVE: Increasing reports of the combined use of vancomycin (VAN) and piperacillin/tazobactam leading to higher nephrotoxicity have led to carbapenems being recommended as an alternative option to combine with VAN when nephrotoxicity is a major concern. However, whether carbapenems also increase the nephrotoxicity of VAN is unclear. This study aimed to determine whether meropenem is a suitable drug to combine with VAN based on whether meropenem enhances the nephrotoxicity of VAN...
February 8, 2019: Journal of Clinical Pharmacy and Therapeutics
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