Janos A Barrera, Artem A Trotsyuk, Zeshaan N Maan, Clark A Bonham, Madelyn R Larson, Paul A Mittermiller, Dominic Henn, Kellen Chen, Chyna J Mays, Smiti Mittal, Alana M Mermin-Bunnell, Dharshan Sivaraj, Serena Jing, Melanie Rodrigues, Sun Hyung Kwon, Chikage Noishiki, Jagannath Padmanabhan, Yuanwen Jiang, Simiao Niu, Mohammed Inayathullah, Jayakumar Rajadas, Michael Januszyk, Geoffrey C Gurtner
Burn scars and scar contractures cause significant morbidity for patients. Recently, cell-based therapies have been proposed as an option for improving healing and reducing scarring after burn injury, through their known proangiogenic and immunomodulatory paracrine effects. Our laboratory has developed a pullulan-collagen hydrogel that, when seeded with mesenchymal stem cells (MSCs), improves cell viability and augments their proangiogenic capacity in vivo . Concurrently, recent research suggests that prospective isolation of cell subpopulations with desirable transcriptional profiles can be used to further improve cell-based therapies...
June 2021: Tissue Engineering. Part A